Valor de la mamografía isotópica en el diagnóstico del cáncer de mama
Value of scintimammography in the diagnosis of breast cancer
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"apellidos" => "Giménez Climent" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "M.V." "apellidos" => "Fliquete Péris" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "C.A." "apellidos" => "Fuster Diana" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "C." "apellidos" => "Vázquez Forner" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "aff0010" ] ] ] 4 => array:3 [ "nombre" => "F." "apellidos" => "Sancho Merle" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] ] ] 5 => array:3 [ "nombre" => "J." "apellidos" => "Campos Mañez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] ] ] 6 => array:3 [ "nombre" => "C." "apellidos" => "Vázquez Albaladejo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">***</span>" "identificador" => "aff0015" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Servicios de Cirugía" "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Medicina Nuclear" "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Jefe de Servicio de Cirugía. Fundación Instituto Valenciano de Oncología. Valencia" "etiqueta" => "<span class="elsevierStyleSup">***</span>" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "1" "correspondencia" => "Correspondencia: Dra. J. Giménez Climent. Servicio de Cirugía. Fundación Instituto Valenciano de Oncología. Prof. Beltrán Báguena, 19. 46009 Valencia." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Value of scintimammography in the diagnosis of breast cancer" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaAceptado" => "2000-06-30" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec196921" "palabras" => array:3 [ 0 => "Cáncer de mama" 1 => "Mamografía isotópica" 2 => "Técnicas diagnósticas" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec196920" "palabras" => array:3 [ 0 => "Breast cancer" 1 => "Scintimammography" 2 => "Diagnostic techniques" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La mamografía es la técnica diagnóstica más utilizada en el cáncer de mama, pero en ocasiones debe complementarse con otras exploraciones para intentar llegar a un diagnóstico correcto.</p> <span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Valorar la utilidad del estudio isotópico con <span class="elsevierStyleSup">99m</span> Tcsestamibi en el diagnóstico del cáncer de mama.</p> <span class="elsevierStyleSectionTitle">Material y métodos</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Se han estudiado 120 pacientes con sospecha clínica y/o radiológica de patología maligna. Se administraron 20 mCi (740 MBq) de <span class="elsevierStyleSup">99m</span> Tc-sestamibi i.v. en el brazo contralateral a la lesión, obteniendo imágenes a los 10 min en proyecciones anteroposterior y lateral en decúbito prono (mama péndula).</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">El 74% de las lesiones fueron histológicamente malignas. Los resultados fueron para el tumor: sensibilidad 90%, especificidad 83%, valor predictivo positivo 94%, valor predictivo negativo 74%, precisión 88%, prevalencia de enfermedad maligna 74%; para la afectación ganglionar: sensibilidad 41%, especificidad 99%, valor predictivo positivo 93%, valor predictivo negativo 81%, precisión 82,5%, prevalencia de afectación metastásica ganglionar 32%. En las 45 lesiones no palpables estudiadas se obtuvieron los siguientes resultados: sensibilidad 61%, especificidad 100%, valor predictivo positivo 100%, valor predictivo negativo 61%, precisión 69% y prevalencia 80%. En 11 pacientes existía sospecha de recidiva local tras tratamiento conservador. La sensibilidad fue del 50%, la especificidad del 89%, el valor predictivo positivo del 50% y el valor predictivo negativo del 89%. Se valoraron como parámetros que pudieran incidir en la captación isotópica: el tamaño del tumor, el tipo histológico y el grado de Scarff-Bloom-Richardson.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">El estudio isotópico con <span class="elsevierStyleSup">99m</span> Tc-sestamibi es una técnica complementaria válida en el diagnóstico del cáncer de mama, especialmente en los casos en los que la clínica y la radiología no son concluyentes.</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Mammography is the most widely employed diagnostic technique in breast cancer, although, on occasion, it may be necessary to perform other tests to reach the correct diagnosis.</p> <span class="elsevierStyleSectionTitle">Objective</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">To assess the utility of <span class="elsevierStyleSup">99m</span> Tc sestamibi in the diagnosis of breast cancer.</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">The authors studied 120 patients with clinical and/or radiological evidence of malignant breast disease. The patients received intravenous injections of 20 mCi (740 MB1) of <span class="elsevierStyleSup">99m</span> Tc sestamibi in the arm contralateral to the lesion, and images in anteroposterior and prone (dependent) position were taken 10 minutes later.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Malignant disease was detected in 74% of the patients. The sensitivity was 90%, the specificity 8%, the positive predictive value 94%, the negative predictive value 74%, the accuracy 88% and the prevalence of malignant disease 74%. The sensitivity for lymph node involvement was 41%, the specificity 99%, the positive predictive value 93%, the negative predictive value 81%, the accuracy 82.5% and the prevalence of metastatic nodal involvement 32%.</p><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">For nonpalpable lesions, the following results were obtained: sensitivity 61%, specificity 100%, positive predictive value 100%, negative predictive value 61%, accuracy 69% and prevalence 80%. After conservative management, local recurrence was suspected in 11 patients. In these cases, the sensitivity was 50%, the specificity 89%, the positive predictive value 50% and the negative predictive value 89%.</p><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">The parameters that were taken into account with respect to uptake of the radionuclide were tumor size, histological type and the Scarff-Bloom-Richardson score.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">The scintigraphic study with <span class="elsevierStyleSup">99m</span> Tc sestamibi is a valid complementary technique in the diagnosis of breast cancer, especially when the clinical and radiological findings are inconclusive.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:30 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." 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| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Octubre | 41 | 7 | 48 |
| 2024 Septiembre | 54 | 21 | 75 |
| 2024 Agosto | 48 | 23 | 71 |
| 2024 Julio | 30 | 10 | 40 |
| 2024 Junio | 57 | 20 | 77 |
| 2024 Mayo | 50 | 16 | 66 |
| 2024 Abril | 36 | 15 | 51 |
| 2024 Marzo | 39 | 42 | 81 |
| 2024 Febrero | 49 | 10 | 59 |
| 2024 Enero | 55 | 19 | 74 |
| 2023 Diciembre | 62 | 28 | 90 |
| 2023 Noviembre | 63 | 44 | 107 |
| 2023 Octubre | 89 | 36 | 125 |
| 2023 Septiembre | 44 | 12 | 56 |
| 2023 Agosto | 86 | 8 | 94 |
| 2023 Julio | 82 | 27 | 109 |
| 2023 Junio | 61 | 6 | 67 |
| 2023 Mayo | 73 | 6 | 79 |
| 2023 Abril | 57 | 11 | 68 |
| 2023 Marzo | 65 | 1 | 66 |
| 2023 Febrero | 43 | 6 | 49 |
| 2023 Enero | 43 | 2 | 45 |
| 2022 Diciembre | 38 | 5 | 43 |
| 2022 Noviembre | 58 | 24 | 82 |
| 2022 Octubre | 39 | 10 | 49 |
| 2022 Septiembre | 49 | 24 | 73 |
| 2022 Agosto | 41 | 19 | 60 |
| 2022 Julio | 37 | 21 | 58 |
| 2022 Junio | 24 | 8 | 32 |
| 2022 Mayo | 46 | 20 | 66 |
| 2022 Abril | 33 | 22 | 55 |
| 2022 Marzo | 54 | 14 | 68 |
| 2022 Febrero | 38 | 8 | 46 |
| 2022 Enero | 57 | 9 | 66 |
| 2021 Diciembre | 50 | 10 | 60 |
| 2021 Noviembre | 52 | 10 | 62 |
| 2021 Octubre | 45 | 11 | 56 |
| 2021 Septiembre | 37 | 13 | 50 |
| 2021 Agosto | 40 | 4 | 44 |
| 2021 Julio | 29 | 8 | 37 |
| 2021 Junio | 21 | 18 | 39 |
| 2021 Mayo | 39 | 6 | 45 |
| 2021 Abril | 43 | 37 | 80 |
| 2021 Marzo | 67 | 19 | 86 |
| 2021 Febrero | 47 | 11 | 58 |
| 2021 Enero | 48 | 14 | 62 |
| 2020 Diciembre | 37 | 19 | 56 |
| 2020 Noviembre | 22 | 12 | 34 |
| 2020 Octubre | 12 | 7 | 19 |
| 2020 Septiembre | 26 | 17 | 43 |
| 2020 Agosto | 24 | 14 | 38 |
| 2020 Julio | 14 | 6 | 20 |
| 2020 Junio | 2 | 11 | 13 |
| 2020 Mayo | 12 | 14 | 26 |
| 2020 Abril | 7 | 10 | 17 |
| 2020 Marzo | 18 | 21 | 39 |
| 2020 Febrero | 13 | 21 | 34 |
| 2020 Enero | 18 | 34 | 52 |
| 2019 Diciembre | 29 | 25 | 54 |
| 2019 Noviembre | 9 | 6 | 15 |
| 2019 Octubre | 6 | 11 | 17 |
| 2019 Septiembre | 6 | 13 | 19 |
| 2019 Agosto | 5 | 13 | 18 |
| 2019 Julio | 13 | 33 | 46 |
| 2019 Junio | 43 | 57 | 100 |
| 2019 Mayo | 121 | 231 | 352 |
| 2019 Abril | 41 | 57 | 98 |
| 2019 Marzo | 6 | 11 | 17 |
| 2019 Febrero | 8 | 23 | 31 |
| 2019 Enero | 7 | 10 | 17 |
| 2018 Diciembre | 10 | 14 | 24 |
| 2018 Noviembre | 5 | 18 | 23 |
| 2018 Octubre | 13 | 11 | 24 |
| 2018 Septiembre | 23 | 13 | 36 |
| 2018 Agosto | 3 | 40 | 43 |
| 2018 Julio | 1 | 35 | 36 |
| 2018 Junio | 1 | 24 | 25 |
| 2018 Mayo | 12 | 19 | 31 |
| 2018 Abril | 4 | 19 | 23 |
| 2018 Marzo | 8 | 17 | 25 |
| 2018 Febrero | 5 | 20 | 25 |
| 2018 Enero | 4 | 15 | 19 |
| 2017 Diciembre | 5 | 9 | 14 |
| 2017 Noviembre | 10 | 20 | 30 |
| 2017 Octubre | 18 | 14 | 32 |
| 2017 Septiembre | 14 | 21 | 35 |
| 2017 Agosto | 6 | 19 | 25 |
| 2017 Julio | 13 | 9 | 22 |
| 2017 Junio | 14 | 8 | 22 |
| 2017 Mayo | 20 | 4 | 24 |
| 2017 Abril | 21 | 24 | 45 |
| 2017 Marzo | 9 | 9 | 18 |
| 2017 Febrero | 18 | 3 | 21 |
| 2017 Enero | 4 | 7 | 11 |
| 2016 Diciembre | 23 | 7 | 30 |
| 2016 Noviembre | 43 | 5 | 48 |
| 2016 Octubre | 80 | 8 | 88 |
| 2016 Septiembre | 40 | 5 | 45 |
| 2016 Agosto | 25 | 6 | 31 |
| 2016 Julio | 18 | 6 | 24 |
| 2016 Junio | 27 | 15 | 42 |
| 2016 Mayo | 30 | 18 | 48 |
| 2016 Abril | 26 | 10 | 36 |
| 2016 Marzo | 32 | 11 | 43 |
| 2016 Febrero | 22 | 16 | 38 |
| 2016 Enero | 15 | 15 | 30 |
| 2015 Diciembre | 18 | 15 | 33 |
| 2015 Noviembre | 22 | 14 | 36 |
| 2015 Octubre | 39 | 12 | 51 |
| 2015 Septiembre | 37 | 7 | 44 |
| 2015 Agosto | 48 | 4 | 52 |
| 2015 Julio | 51 | 5 | 56 |
| 2015 Junio | 54 | 4 | 58 |
| 2015 Mayo | 29 | 9 | 38 |
| 2015 Abril | 19 | 8 | 27 |
| 2015 Marzo | 15 | 6 | 21 |
| 2015 Febrero | 13 | 2 | 15 |
| 2015 Enero | 19 | 2 | 21 |
| 2014 Diciembre | 21 | 4 | 25 |
| 2014 Noviembre | 16 | 2 | 18 |
| 2014 Octubre | 23 | 2 | 25 |
| 2014 Septiembre | 15 | 2 | 17 |
| 2014 Agosto | 12 | 3 | 15 |
| 2014 Julio | 18 | 2 | 20 |
| 2014 Junio | 21 | 2 | 23 |
| 2014 Mayo | 8 | 1 | 9 |
| 2014 Abril | 4 | 2 | 6 |
| 2014 Marzo | 6 | 1 | 7 |
| 2014 Febrero | 3 | 1 | 4 |
| 2014 Enero | 8 | 3 | 11 |
| 2013 Diciembre | 2 | 3 | 5 |
| 2013 Noviembre | 3 | 5 | 8 |
| 2013 Octubre | 10 | 2 | 12 |
| 2013 Septiembre | 14 | 6 | 20 |
| 2013 Agosto | 9 | 8 | 17 |
| 2013 Julio | 3 | 2 | 5 |
| 2001 Enero | 2367 | 0 | 2367 |
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