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"apellidos" => "Parrilla" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0009739X01717071?idApp=UINPBA00004N" "url" => "/0009739X/0000006900000002/v1_201307101139/S0009739X01717071/v1_201307101139/es/main.assets" ] "es" => array:13 [ "idiomaDefecto" => true "titulo" => "Miltefosina (Miltex®) en el tratamiento tópico de las recidivas cutáneas del cáncer de mama posmastectomía radical modificada" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "121" "paginaFinal" => "123" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "J.M. del Val Gil, M. López Bañeres, J. Rebollo López, A.C. Utrillas Martínez, A. Minguillón Serrano, M. González Penabad, A. Bermejo Zapatero, J. Torcal Aznar" "autores" => array:8 [ 0 => array:3 [ "nombre" => "J.M." "apellidos" => "del Val Gil" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "M." "apellidos" => "López Bañeres" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "J." "apellidos" => "Rebollo López" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "A.C." "apellidos" => "Utrillas Martínez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">***</span>" "identificador" => "aff0015" ] ] ] 4 => array:3 [ "nombre" => "A." "apellidos" => "Minguillón Serrano" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "aff0010" ] ] ] 5 => array:3 [ "nombre" => "M." "apellidos" => "González Penabad" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "aff0010" ] ] ] 6 => array:3 [ "nombre" => "A." "apellidos" => "Bermejo Zapatero" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "aff0010" ] ] ] 7 => array:3 [ "nombre" => "J." "apellidos" => "Torcal Aznar" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">****</span>" "identificador" => "aff0020" ] ] ] ] "afiliaciones" => array:4 [ 0 => array:3 [ "entidad" => "Jefe de Servicio" "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Facultativos especialistas de área" "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Médico residente" "etiqueta" => "<span class="elsevierStyleSup">***</span>" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Facultativo especialista contratado. Servicio de Cirugía General y Aparato Digestivo. Hospital General Obispo Polanco. Teruel." "etiqueta" => "****" "identificador" => "aff0020" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "1" "correspondencia" => "Correspondencia: Dr. J.M. del Val Gil. Argentina, 1, 6.o A. 44002 Teruel." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Miltefosine (miltex®) in the topical treatment of recurrent cutaneous breast cancer after modified radical mastectomy" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaAceptado" => "2000-07-31" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec197016" "palabras" => array:3 [ 0 => "Miltefosina" 1 => "Recidiva cutánea" 2 => "Cáncer de mama" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec197017" "palabras" => array:3 [ 0 => "Miltefosine" 1 => "Cutaneous relapse" 2 => "Breast cancer" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Las recidivas cutáneas del cáncer de mama posmastectomía radical modificada son difíciles de tratar y de controlar, tanto con el tratamiento quirúrgico como con el tratamiento radioterápico, quimioterápico u hormonoterápico, solos o asociados entre sí.</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Estudiamos 5 casos de recidiva cutánea tras mastectomía radical modificada por cáncer de mama que, tras distintos tratamientos locorregionales y sistémicos, han sido tratados tópicamente con miltefosina.</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Con este tratamiento hemos conseguido un control local de la enfermedad durante una media de 6 meses en el momento actual, sin toxicidad general en ningún caso y sólo con discretas reacciones locales, como enrojecimiento de la piel, descamación y discreto prurito. En algunos casos se ha asociado a tratamiento quimioterápico sistémico y en otros hormonoterápico, obteniendo una mejora en la calidad de vida importante.</p>" ] "en" => array:1 [ "resumen" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Recurrence of cutaneous breast cancer after modified radical mastectomy is difficult to treat and control, irrespective of whether surgical treatment, radiotherapy, chemotherapy or hormonotherapy are used alone or in combination.</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">We studied 5 cases of recurrent cutaneous breast cancer following modified radical mastectomy that, after several locoregional and systemic treatments, were treated topically with miltefosine.</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">At the time of writing, this treatment has achieved local control of the disease for a mean of 6 months. No general toxicity and only mild local reactions such as skin reddening, desquamation and mild pruritus have been observed. In a few cases, this treatment has been combined with systemic chemotherapy or hormone therapy, thus producing a significant improvement in quality of life.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:13 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Miltefosine as a topical treatment for cutaneous metastases in breast carcinoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S. Clive" 1 => "J. Gardiner" 2 => "R.C. 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2022 Abril | 39 | 28 | 67 |
2022 Marzo | 39 | 19 | 58 |
2022 Febrero | 40 | 13 | 53 |
2022 Enero | 56 | 16 | 72 |
2021 Diciembre | 39 | 27 | 66 |
2021 Noviembre | 36 | 26 | 62 |
2021 Octubre | 37 | 31 | 68 |
2021 Septiembre | 43 | 22 | 65 |
2021 Agosto | 48 | 29 | 77 |
2021 Julio | 32 | 22 | 54 |
2021 Junio | 44 | 14 | 58 |
2021 Mayo | 56 | 15 | 71 |
2021 Abril | 144 | 39 | 183 |
2021 Marzo | 55 | 7 | 62 |
2021 Febrero | 62 | 9 | 71 |
2021 Enero | 70 | 29 | 99 |
2020 Diciembre | 49 | 19 | 68 |
2020 Noviembre | 34 | 5 | 39 |
2020 Octubre | 45 | 12 | 57 |
2020 Septiembre | 26 | 18 | 44 |
2020 Agosto | 55 | 23 | 78 |
2020 Julio | 38 | 8 | 46 |
2020 Junio | 34 | 11 | 45 |
2020 Mayo | 55 | 18 | 73 |
2020 Abril | 29 | 17 | 46 |
2020 Marzo | 44 | 21 | 65 |
2020 Febrero | 45 | 13 | 58 |
2020 Enero | 54 | 20 | 74 |
2019 Diciembre | 55 | 28 | 83 |
2019 Noviembre | 89 | 19 | 108 |
2019 Octubre | 66 | 12 | 78 |
2019 Septiembre | 62 | 14 | 76 |
2019 Agosto | 35 | 14 | 49 |
2019 Julio | 49 | 29 | 78 |
2019 Junio | 100 | 45 | 145 |
2019 Mayo | 238 | 145 | 383 |
2019 Abril | 118 | 65 | 183 |
2019 Marzo | 46 | 25 | 71 |
2019 Febrero | 53 | 23 | 76 |
2019 Enero | 45 | 20 | 65 |
2018 Diciembre | 23 | 25 | 48 |
2018 Noviembre | 43 | 25 | 68 |
2018 Octubre | 81 | 16 | 97 |
2018 Septiembre | 28 | 17 | 45 |
2018 Agosto | 16 | 21 | 37 |
2018 Julio | 16 | 10 | 26 |
2018 Junio | 25 | 13 | 38 |
2018 Mayo | 17 | 9 | 26 |
2018 Abril | 22 | 7 | 29 |
2018 Marzo | 18 | 7 | 25 |
2018 Febrero | 21 | 3 | 24 |
2018 Enero | 8 | 6 | 14 |
2017 Diciembre | 15 | 6 | 21 |
2017 Noviembre | 22 | 25 | 47 |
2017 Octubre | 11 | 15 | 26 |
2017 Septiembre | 20 | 28 | 48 |
2017 Agosto | 12 | 20 | 32 |
2017 Julio | 14 | 33 | 47 |
2017 Junio | 23 | 28 | 51 |
2017 Mayo | 11 | 15 | 26 |
2017 Abril | 7 | 1 | 8 |
2017 Marzo | 26 | 17 | 43 |
2017 Febrero | 17 | 5 | 22 |
2017 Enero | 37 | 1 | 38 |
2016 Diciembre | 32 | 4 | 36 |
2016 Noviembre | 51 | 4 | 55 |
2016 Octubre | 51 | 6 | 57 |
2016 Septiembre | 24 | 1 | 25 |
2016 Agosto | 13 | 2 | 15 |
2016 Julio | 29 | 1 | 30 |
2016 Junio | 66 | 0 | 66 |
2016 Mayo | 48 | 3 | 51 |
2016 Abril | 50 | 0 | 50 |
2016 Marzo | 56 | 0 | 56 |
2016 Febrero | 52 | 1 | 53 |
2016 Enero | 46 | 0 | 46 |
2015 Diciembre | 110 | 0 | 110 |
2015 Noviembre | 54 | 0 | 54 |
2015 Octubre | 79 | 0 | 79 |
2015 Septiembre | 58 | 0 | 58 |
2015 Agosto | 45 | 0 | 45 |
2015 Julio | 80 | 0 | 80 |
2015 Junio | 54 | 0 | 54 |
2015 Mayo | 88 | 0 | 88 |
2015 Abril | 56 | 0 | 56 |
2015 Marzo | 79 | 0 | 79 |
2015 Febrero | 57 | 0 | 57 |
2015 Enero | 67 | 0 | 67 |
2014 Diciembre | 80 | 0 | 80 |
2014 Noviembre | 69 | 0 | 69 |
2014 Octubre | 88 | 0 | 88 |
2014 Septiembre | 80 | 0 | 80 |
2014 Agosto | 51 | 0 | 51 |
2014 Julio | 92 | 0 | 92 |
2014 Junio | 94 | 0 | 94 |
2014 Mayo | 73 | 0 | 73 |
2014 Abril | 47 | 0 | 47 |
2014 Marzo | 50 | 0 | 50 |
2014 Febrero | 43 | 0 | 43 |
2014 Enero | 31 | 0 | 31 |
2013 Diciembre | 30 | 0 | 30 |
2013 Noviembre | 39 | 0 | 39 |
2013 Octubre | 48 | 0 | 48 |
2013 Septiembre | 32 | 0 | 32 |
2013 Agosto | 26 | 0 | 26 |
2013 Julio | 19 | 0 | 19 |
2001 Febrero | 2321 | 0 | 2321 |