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"apellidos" => "Moreno Azcoita" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0009739X01718337?idApp=UINPBA00004N" "url" => "/0009739X/0000007000000001/v1_201307101208/S0009739X01718337/v1_201307101208/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0009739X01718313" "issn" => "0009739X" "doi" => "10.1016/S0009-739X(01)71831-3" "estado" => "S300" "fechaPublicacion" => "2001-07-01" "aid" => "71831" "copyright" => "Asociación Española de Cirujanos" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Cir Esp. 2001;70:3-5" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 5887 "formatos" => array:3 [ "EPUB" => 6 "HTML" => 4728 "PDF" => 1153 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Morbimortalidad atribuible a la fístula esofagoyeyunal tras gastrectomía total por cáncer gástrico" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "3" "paginaFinal" => "5" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Morbidity and Mortality due to Esophagojejunal Anastomotic Fistula after total Gastrectomy for Gastric Cancer" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J.C. Ruiz de Adana, P. Ortega Deballon, M.T. Alonso Garcia, C. León Fernández, V. Jiménez Carneros, J. Marín Lucas, J. López Herrero" "autores" => array:7 [ 0 => array:2 [ "nombre" => "J.C." "apellidos" => "Ruiz de Adana" ] 1 => array:2 [ "nombre" => "P." "apellidos" => "Ortega Deballon" ] 2 => array:2 [ "nombre" => "M.T." "apellidos" => "Alonso Garcia" ] 3 => array:2 [ "nombre" => "C." "apellidos" => "León Fernández" ] 4 => array:2 [ "nombre" => "V." "apellidos" => "Jiménez Carneros" ] 5 => array:2 [ "nombre" => "J." "apellidos" => "Marín Lucas" ] 6 => array:2 [ "nombre" => "J." "apellidos" => "López Herrero" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0009739X01718313?idApp=UINPBA00004N" "url" => "/0009739X/0000007000000001/v1_201307101208/S0009739X01718313/v1_201307101208/es/main.assets" ] "es" => array:13 [ "idiomaDefecto" => true "titulo" => "Valor pronóstico de la pérdida de heterozigosidad en la región 9p21 en el carcinoma broncogénico no microcítico" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "6" "paginaFinal" => "12" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "M.T. Sanz-Casla, M.L. Maestro, A. Godino, I. Zanna, A. Torres, J.L. Balibrea" "autores" => array:6 [ 0 => array:3 [ "nombre" => "M.T." "apellidos" => "Sanz-Casla" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "cor0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] ] ] 1 => array:3 [ "nombre" => "M.L." "apellidos" => "Maestro" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "A." "apellidos" => "Godino" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "I." "apellidos" => "Zanna" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] ] ] 4 => array:3 [ "nombre" => "A." "apellidos" => "Torres" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "aff0010" ] ] ] 5 => array:3 [ "nombre" => "J.L." "apellidos" => "Balibrea" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicios de Análisis Clínicos" "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Cirugía II. Hospital Clínico San Carlos. Madrid" "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "1" "correspondencia" => "Correspondencia: Dra. M.T. Sanz-Casla. Servicio de Análisis Clínicos. Hospital Clínico San Carlos. Dr. Martín Lagos, s/n. 28040 Madrid." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Prognostic value of loss of heterozygosity at chromosome 9p21 in nonsmall cell bronchogenic carcinoma" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaAceptado" => "2001-03-31" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec197389" "palabras" => array:3 [ 0 => "Pérdida de heterozigosidad" 1 => "Cromosoma 9 p16" 2 => "Cáncer de pulmón no microcítico" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec197390" "palabras" => array:3 [ 0 => "Loss of heterozygosity" 1 => "Chromosome 9p16" 2 => "Non-small cell lung cancer" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Resumen</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La importancia sociosanitaria del cáncer de pulmón radica en su elevada incidencia y mortalidad. En la actualidad se considera el cáncer como el resultado de una acumulación de alteraciones que afectan a diversos genes con distintas funciones celulares. Diversos estudios genéticos han demostrado una pérdida de material genético en la región 21 del brazo corto del cromosoma 9 (9p21), siendo una de las alteraciones genéticas más frecuentemente identificadas en el cáncer humano. Esta región contiene un gen supresor llamado p16, que codifica las proteínas p16 y p19.</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se estudió una serie de 98 pacientes diagnosticados de carcinoma de pulmón no microcítico. Se analizó la pérdida de heterozigosidad (LOH) en 9p21 mediante el análisis de polimorfismos de microsatélites. El 23,5% de los pacientes presentaba LOH y/o inestabilidad en 9p21. Contrariamente a lo que se esperaba, los pacientes que no presentaban alteraciones genéticas en p16 tenían un riesgo relativo de fallecer 1,7 veces mayor (p = 0,1) que los que sí presentaban LOH y/o inestabilidad.</p>" ] "en" => array:1 [ "resumen" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">The social and public health importance of lung cancer lies in its very high incidence and mortality rate. Cancer is currently believed to be the result of a cumulative process of genetic alterations affecting different genes with diverse cellular functions. Genetic studies have shown loss of genetic material in region 21 of the short arm of chromosome 9 (9p21). This seems to be one of the commonest alterations identified in human cancer. This region contains a suppressor gene, p16, which codifies the p16 and p19 proteins.</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">We studied 98 spatients with non-small cell lung cancer. Loss of heterozygosity (LOH) in 9p21 was analyzed using trough satellite polymorphism. LOH and/or instability of 9p21 was found in 23.5% of patients. Contrary to what was expected, patients not showing genetic alterations in p16 had a relative risk of death approximately 1.7 times (p = 0.1) higher than those not presenting LOH and/or instability.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:33 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Mina D, Higgins G, Glatstein E. En: DeVita V, editor. Cáncer. Principios y prácticas de oncología. Salvat, 14: 371-445" ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2." 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año/Mes | Html | Total | |
---|---|---|---|
2024 Octubre | 20 | 8 | 28 |
2024 Septiembre | 23 | 7 | 30 |
2024 Agosto | 10 | 9 | 19 |
2024 Julio | 16 | 10 | 26 |
2024 Junio | 17 | 17 | 34 |
2024 Mayo | 16 | 17 | 33 |
2024 Abril | 17 | 10 | 27 |
2024 Marzo | 27 | 28 | 55 |
2024 Febrero | 24 | 16 | 40 |
2024 Enero | 22 | 29 | 51 |
2023 Diciembre | 36 | 46 | 82 |
2023 Noviembre | 23 | 30 | 53 |
2023 Octubre | 46 | 26 | 72 |
2023 Septiembre | 19 | 5 | 24 |
2023 Agosto | 19 | 15 | 34 |
2023 Julio | 30 | 30 | 60 |
2023 Junio | 37 | 8 | 45 |
2023 Mayo | 18 | 9 | 27 |
2023 Abril | 21 | 1 | 22 |
2023 Marzo | 18 | 9 | 27 |
2023 Febrero | 18 | 4 | 22 |
2023 Enero | 13 | 12 | 25 |
2022 Diciembre | 20 | 6 | 26 |
2022 Noviembre | 39 | 28 | 67 |
2022 Octubre | 31 | 16 | 47 |
2022 Septiembre | 21 | 15 | 36 |
2022 Agosto | 19 | 14 | 33 |
2022 Julio | 18 | 13 | 31 |
2022 Junio | 25 | 18 | 43 |
2022 Mayo | 17 | 9 | 26 |
2022 Abril | 33 | 21 | 54 |
2022 Marzo | 20 | 9 | 29 |
2022 Febrero | 27 | 5 | 32 |
2022 Enero | 37 | 10 | 47 |
2021 Diciembre | 32 | 9 | 41 |
2021 Noviembre | 30 | 9 | 39 |
2021 Octubre | 14 | 8 | 22 |
2021 Septiembre | 10 | 11 | 21 |
2021 Agosto | 10 | 3 | 13 |
2021 Julio | 19 | 10 | 29 |
2021 Junio | 18 | 7 | 25 |
2021 Mayo | 22 | 12 | 34 |
2021 Abril | 40 | 25 | 65 |
2021 Marzo | 35 | 15 | 50 |
2021 Febrero | 27 | 15 | 42 |
2021 Enero | 15 | 18 | 33 |
2020 Diciembre | 16 | 19 | 35 |
2020 Noviembre | 12 | 20 | 32 |
2020 Octubre | 26 | 23 | 49 |
2020 Septiembre | 14 | 8 | 22 |
2020 Agosto | 16 | 15 | 31 |
2020 Julio | 10 | 15 | 25 |
2020 Junio | 9 | 14 | 23 |
2020 Mayo | 14 | 20 | 34 |
2020 Abril | 12 | 8 | 20 |
2020 Marzo | 16 | 27 | 43 |
2020 Febrero | 12 | 8 | 20 |
2020 Enero | 14 | 23 | 37 |
2019 Diciembre | 15 | 25 | 40 |
2019 Noviembre | 6 | 10 | 16 |
2019 Octubre | 5 | 6 | 11 |
2019 Septiembre | 11 | 20 | 31 |
2019 Agosto | 7 | 10 | 17 |
2019 Julio | 10 | 21 | 31 |
2019 Junio | 52 | 32 | 84 |
2019 Mayo | 117 | 156 | 273 |
2019 Abril | 9 | 39 | 48 |
2019 Marzo | 3 | 6 | 9 |
2019 Febrero | 7 | 11 | 18 |
2019 Enero | 5 | 10 | 15 |
2018 Diciembre | 6 | 11 | 17 |
2018 Noviembre | 3 | 11 | 14 |
2018 Octubre | 8 | 11 | 19 |
2018 Septiembre | 3 | 6 | 9 |
2018 Agosto | 4 | 4 | 8 |
2018 Julio | 2 | 6 | 8 |
2018 Junio | 1 | 4 | 5 |
2018 Mayo | 2 | 12 | 14 |
2018 Abril | 6 | 1 | 7 |
2018 Marzo | 0 | 2 | 2 |
2018 Febrero | 1 | 1 | 2 |
2018 Enero | 6 | 3 | 9 |
2017 Noviembre | 7 | 4 | 11 |
2017 Octubre | 5 | 2 | 7 |
2017 Septiembre | 5 | 8 | 13 |
2017 Agosto | 10 | 0 | 10 |
2017 Julio | 7 | 3 | 10 |
2017 Junio | 4 | 4 | 8 |
2017 Mayo | 5 | 3 | 8 |
2017 Abril | 9 | 0 | 9 |
2017 Marzo | 9 | 17 | 26 |
2017 Febrero | 9 | 1 | 10 |
2017 Enero | 5 | 0 | 5 |
2016 Diciembre | 15 | 4 | 19 |
2016 Noviembre | 26 | 3 | 29 |
2016 Octubre | 26 | 2 | 28 |
2016 Septiembre | 20 | 7 | 27 |
2016 Agosto | 14 | 1 | 15 |
2016 Julio | 11 | 7 | 18 |
2016 Junio | 20 | 7 | 27 |
2016 Mayo | 14 | 4 | 18 |
2016 Abril | 14 | 6 | 20 |
2016 Marzo | 15 | 3 | 18 |
2016 Febrero | 19 | 5 | 24 |
2016 Enero | 15 | 4 | 19 |
2015 Diciembre | 8 | 1 | 9 |
2015 Noviembre | 19 | 3 | 22 |
2015 Octubre | 14 | 1 | 15 |
2015 Septiembre | 24 | 13 | 37 |
2015 Agosto | 13 | 10 | 23 |
2015 Julio | 6 | 4 | 10 |
2015 Junio | 6 | 2 | 8 |
2015 Mayo | 19 | 1 | 20 |
2015 Abril | 8 | 8 | 16 |
2015 Marzo | 14 | 13 | 27 |
2015 Febrero | 13 | 3 | 16 |
2015 Enero | 38 | 1 | 39 |
2014 Diciembre | 49 | 4 | 53 |
2014 Noviembre | 25 | 0 | 25 |
2014 Octubre | 29 | 0 | 29 |
2014 Septiembre | 37 | 0 | 37 |
2014 Agosto | 24 | 0 | 24 |
2014 Julio | 31 | 2 | 33 |
2014 Junio | 46 | 1 | 47 |
2014 Mayo | 23 | 1 | 24 |
2014 Abril | 19 | 2 | 21 |
2014 Marzo | 14 | 1 | 15 |
2014 Febrero | 21 | 0 | 21 |
2014 Enero | 15 | 1 | 16 |
2013 Diciembre | 8 | 2 | 10 |
2013 Noviembre | 20 | 4 | 24 |
2013 Octubre | 12 | 1 | 13 |
2013 Septiembre | 11 | 6 | 17 |
2013 Agosto | 19 | 3 | 22 |
2013 Julio | 8 | 0 | 8 |
2001 Junio | 561 | 0 | 561 |