metricas
covid
Buscar en
Cirugía Española (English Edition)
Toda la web
Inicio Cirugía Española (English Edition) Rectal cancer: Which patients benefit from radiotherapy
Información de la revista
Vol. 87. Núm. 6.
Páginas 350-355 (junio 2010)
Compartir
Compartir
Descargar PDF
Más opciones de artículo
Vol. 87. Núm. 6.
Páginas 350-355 (junio 2010)
Special article
Acceso a texto completo
Rectal cancer: Which patients benefit from radiotherapy
Cáncer de recto: qué pacientes se benefician de la radioterapia
Visitas
1549
Guillermo Ais Condea,
Autor para correspondencia
guillermoais@hotmail.com

Corresponding author.
, Begoña Fadrique Fernándeza, Pablo Vázquez Santosa, Juan López Péreza, Miguel Picatoste Merinoa, Javier Manzanares Sacristánb
a Unidad de Coloproctología, Hospital General de Segovia, Segovia, Spain
b Servicio de Cirugía General, Hospital General de Segovia, Segovia, Spain
Este artículo ha recibido
Información del artículo
Abstract

The prognosis of patients with rectal cancer has improved in recent years, particularly as regards the lower probability of local recurrence. These positive results are obtained through correct preoperative staging and an adequate surgical resection of the affected lesion, as well as a multidisciplinary therapeutic approach. Based on the available scientific evidence, our aim is to clarify the framework in which options for the right therapy can be taken, especially in relation to the preoperative staging and its limitations, with regards to radiotherapy and its indications. We also emphasize the need of a tailor-made approach for each case.

Keywords:
Rectal cancer
Radiotherapy
Preoperative staging
Resumen

El pronóstico de los pacientes con cáncer de recto ha mejorado en los últimos años, sobre todo en relación con la menor probabilidad de recidiva local. Estos resultados se consiguen con una correcta estadificación preoperatoria, una adecuada escisión quirúrgica de la lesión y un abordaje terapéutico multidisciplinar. Basándonos en la evidencia científica disponible, nuestro propósito es tratar de clarificar el marco en el cual se toman las decisiones terapéuticas, especialmente en relación con la estadificación preoperatoria y sus limitaciones y con el tratamiento con radioterapia y sus indicaciones, así como resaltar la necesidad de un enfoque individualizado en cada caso.

Palabras clave:
Cáncer de recto
Radioterapia
Estadificación preoperatoria
El Texto completo está disponible en PDF
References
[1.]
R.K.S. Phillips, R. Hittinger, L. Blesovsky, J.S. Fry, L.P. Fielding.
Local recurrence following “curative” surgery for large bowel cancer: 1. The overall picture.
Br J Surg, 71 (1984), pp. 12-16
[2.]
R.J. Heald, E.M. Husband, R.D. Ryall.
The mesorectum in rectal cancer surgery-the clue to pelvic recurrence?.
Br J Surg, 69 (1982), pp. 613-616
[3.]
P. Quirke, P. Durdey, M.F. Dixon, M.S. Williams.
Local recurrence of rectal adenocarcinoma due to inadequate surgical resection: histopathological study of lateral tumor spread and surgical excision.
Lancet, 2 (1986), pp. 996-999
[4.]
I.D. Nagtegaal, P. Quirke.
What is the role for the circumferential margin in the modern treatment of rectal cancer?.
J Clin Oncol, 26 (2008), pp. 303-312
[5.]
T. Wiggers.
Staging of rectal cancer.
Br J Surg, 90 (2003), pp. 895-896
[6.]
J. Walter, P. Quirke.
Prognosis and response to therapy in colorectal cancer.
Eur J Cancer, 38 (2002), pp. 880-886
[7.]
K.K. Sasapu, D. Sebag-Montefiore, A.G. Chalmers, P.M. Sagar, D. Burke, P.J. Finan.
Evaluation of a protocol-based management of rectal cancer.
Dis Colon rectum, 49 (2006), pp. 1703-1709
[8.]
B. Glimelius.
Radiotherapy in rectal cancer.
Br Med Bull, 64 (2002), pp. 141-157
[9.]
S.H. Lee, E. Hernández de Anda, Finne ChO, R.D. Madoff, J. García-Aguilar.
The effect of circunferencial tumor location in clinical outcomes of rectal cancer patients treated with total mesorectal escisión.
Dis Colon Rectum, 48 (2005), pp. 2249-2257
[10.]
I.D. Nagtegaal, C.A.M. Marijnen, E.K. Kranenbarg, C.J.H. Van de Velde, J.H.J.M. Van Krieken.
Circumferential margin involvement is still an important predictor of local recurrence in rectal carcinoma. Not one millimeter but two millimeters is the limit.
Am J Surg Pathol, 26 (2002), pp. 350-357
[11.]
B. Glimelius, J. Oliveira.
Rectal cancer: ESMO clinical recommendations for diagnosis, treatment and follow-up.
Ann Oncol, 19 (2008), pp. ii31-ii32
[12.]
A.L. Martling, T. Hola, L.E. Rutqvist, B.J. Moran, R.J. Heald, B. Cedermark.
Effect of a surgical training programme on outcome of rectal cancer in the county of Stockholm.
Lancet, 356 (2000), pp. 93-96
[13.]
A. Ulrich, J. Schmidt, J. Weitz, M.W. Büchler.
Total mesorectal excision: the Heildelberg results after TME.
Recent Results Cancer Res, 165 (2005), pp. 112-119
[14.]
C.A. Marijnen, C.J. Van de Velde, H. Putter.
Impact of short-term preoperative radiotherapy on health-related quality of life and sexual functioning in primary rectal cancer: report of a multicenter randomized trial.
J Clin Oncol, 23 (2005), pp. 1847-1858
[15.]
C.A. Marijnen, E. Kapteijn, C.J. Van de Velde.
Acute side-effects and complications after short-term preoperative radiotherapy combined with total mesorectal excision in primary rectal cancer: report of a multicenter randomized trial.
J Clin Oncol, 20 (2002), pp. 817-825
[16.]
C.F. Kollmorgen, A.P. Meagher, B.G. Wolf, J.H. Pemberton, J.A. Martensen.
The long-term effect of adjuvant postoperative chemoradiotherapy for rectal carcinoma on bowel function.
Ann Surg, 220 (1994), pp. 676-682
[17.]
M. Dahlberg, B. Glimelius, W. Graf, L. Palman.
Preoperative irradiation affects functional results alter surgery for rectal cancer: results from a randomized study.
Dis Colon Rectum, 41 (1998), pp. 543-551
[18.]
J. García-Aguilar, J. Pollack, S.H. Lee, E. Hernández de Anda, A. Mellgren, W.D. Wong, et al.
Accuracy of endorectal ultrasonography in preoperative staging of rectal tumors.
Dis Colon Rectum, 45 (2002), pp. 10-15
[19.]
J. Strassberg.
Magnetic resonante imaging in rectal cancer: the MERCURY experience.
Tech Coloproctol, 8 (2004), pp. S16-S18
[20.]
R.G. Beets-Tan.
MRI in rectal cancer: the T stage and circumferential resection margin.
Colorectal Dis, 90 (2003), pp. 895-896
[21.]
H.A. Wieder, R. Rosenberg, L. Florian, H. Geinitz, A. Ber, K. Becker, et al.
Rectal cancer: MR imaging before neoadjuvant chemotherapy and radiation therapy for prediction of tumorfree circumferential resection margins and long-term survival.
Radiology, 243 (2007), pp. 744-751
[22.]
Wu L, Cao Y, Liao C, Huang J, Gao F. Diagnostic performance of USPIO-enhanced MRI for lymph-node metastases in different body regions: a meta-analysis. Eur J Radiol. 2010 [Epub ahead of print].
[23.]
J.G. Guillem, J.A. Díaz-González, B.D. Minsky, V. Valentini, J. Seung-Yong, M.A. Rodríguez-Bigas, et al.
cT3N0 rectal cancer: potential overtreatment with preoperative chemoradiotherapy is warranted.
J Clin Oncol, 26 (2008), pp. 368-373
[24.]
M.T. Eriksen, A. Wibe, J. Haffner, J.N. Wiig.
Prognostic groups in 1,676 patients with T3 rectal cancer treated without preoperative radiotherapy.
Dis Colon Rectum, 50 (2007), pp. 156-167
[25.]
R.F.A. Vliegen, G.L. Beets, G. Lammering, R.C. Dresen, H.J. Rutten, A.G. Kessels, et al.
Mesorectal fascia invasion after neoadjuvant chemotherapy and radiation therapy for locally advanced rectal cancer: accuracy of MR imaging for prediction.
Radiology, 246 (2008), pp. 454-462
[26.]
J.H. Kim, G.L. Beets, M.J. Kim, A.G.H. Kessels, R.G.H. Beets-Tan.
High-resolution MR imaging for nodal staging in rectal cancer: are there any criteria in addition to the size?.
Eur J Radiol, 52 (2004), pp. 78-83
[27.]
A. Martling, T. Holm, H. Johansson, L.E. Rutqvist, B. Cedermark.
The Stockholm II trial on preoperative radiotherapy in rectal carcinoma: long term follow up of a population-based study.
Cancer, 92 (2001), pp. 896-902
[28.]
A. Martling, T. Holm, L.E. Rutqvist, H. Johansson, B.J. Moran, R.J. Heald, et al.
Impact of a surgical training programme on rectal cancer outcomes in Stockholm.
Br J Surg, 92 (2005), pp. 225-229
[29.]
E. García-Granero, R. Martí-Obiol, J. Gómez-Barabadillo, J. García-Armengol, P. Esclápez, A. Espí, et al.
Impact of surgeon organization and specialization in rectal cancer outcome.
Colorectal Dis, 3 (2001), pp. 179-184
[30.]
K.C.M.J. Peeters, C.A.M. Marijnen, I.D. Nagtegaal, E.K. Kranenbarg, H. Putter, T. Wiggers, et al.
The TME trial after a median follow-up of 6 years. Increased control but no survival benefit in irradiated patients with resectable rectal carcinoma.
[31.]
I.D. Nagtegaal, C.J. van de Velde, E. ven der Worp, E. Kapiteijn, P. Quirke, J.H. Van Krieken.
Macroscopic evaluation of rectal cancer resection specimen: clinical significance of the pathologist in quality control.
J Clin Oncol, 20 (2002), pp. 1729-1734
[32.]
Nccn.org [web ] National comprehensive cancer network. Practice guidelines in oncology. Rectal cancer-v.1.2009. Available from: www.nccn.org
[33.]
V. Valentín, C. Aristeo, B. Glimelius, B.D. Minsky, R. Beets-Tan, J.M. Borras.
Multidisciplinary rectal cancer management: 2nd European Rectal Cancer Consensus Conference (EURECACC2).
Radiother Oncol, 92 (2009), pp. 148-163
[34.]
B. Glimelius, J. Oliveira.
Rectal cancer: ESMO clinical recommendations for diagnosis, treatment and follow-up.
Ann Oncol, 19 (2008), pp. ii31-ii32
[35.]
D. Sebag-Montefiori, R.J. Stephens, R. Steele, J. Monson, R. Grieve, S. Khanna, et al.
Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial.
[36.]
Y. Kariv, R. Kariv, J.P. Hammel, I.C. Lavery.
Postoperative radiotherapy for stage IIIA rectal cancer: Is it justified?.
Dis Colon Rectum, 51 (2008), pp. 1459-1466
[37.]
A. Wibe, P.R. Rendedal, E. Svensson, J. Norstein, T.J. Eide, H.E. Myrvold, et al.
Prognostic significance of the circumferential resection margin following total mesorectal excision for rectal cancer.
[38.]
W.L. Law, J.W.C. Ho, R. Chan, G. Au, K.W. Chu, Stage II.
rectal cancer without radiation: the role of adjuvant chemotherapy.
Dis Colon Rectum, 48 (2005), pp. 218-226
[39.]
T.E. Bernstein, B.H. Endreseth, P. Romundstad, A. Wibe.
Circumferential resection margin as a prognostic factor in rectal cancer.
Br J Surg, 96 (2009), pp. 1348-1357
[40.]
J.G. Guillem.
As in fly fishing, “matching the hatch” should govern the management of locally advanced rectal cancer.
Ann Surg, 246 (2007), pp. 702-704
[41.]
T. Watanabe, K. Matsuda, K. Nozawa, T. Kobunai.
Lateral pelvic lymph node dissection or chemoradiotherapy: wich is the procedure of choice to reduce local recurrence rate in lower rectal cancer?.
Ann Surg, 246 (2007), pp. 754-762
[42.]
X. Serra, J. Bombardó, L. Mora, M. Alcántara, I. Ayguavives, A. Damell, et al.
Lugar de la cirugía local en el adenocarcinoma de recto T2N0M0.
[43.]
M. Guerrieri, M. Baldarelli, L. Organetti, F. Grillo Ruggeri, G. Mantello, S. Bartolacci, et al.
Transanal endoscopic microsurgery for the treatment of selected patients with distal rectal cancer: 15 years experience.
Surg Endosc, 22 (2008), pp. 2030-2035
[44.]
R. Glynne-Jones, M. Wallace, J.I. Livingstone, J. Meyrick-Thomas.
Complete clinical response after preoperative chemoradiation in rectal cancer: is a “wait and see” policy justified?.
Dis Colon Rectum, 51 (2008), pp. 10-20
[45.]
R. Rosenberg, K. Herrmann, R. Gertler, B. Küntzli, M. Essler, F. Lordick, et al.
The predictive value of metabolic response to preoperative radiochemotherapy in locally advanced rectal cancer measured by PET/CT.
Int J Colorectal Dis, 24 (2009), pp. 191-200
[46.]
J.G. Kuremsky, J.E. Tepper, H.L. McLeod.
Biomarkers for response to neoadjuvant chemoradiation for rectal cancer.
Int J Radia Oncol Biol Phys, 74 (2009), pp. 673-688
Copyright © 2010. Asociación Española de Cirujanos
Descargar PDF
Opciones de artículo
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos