Información del artículo
Abstract
The use of imatinib in the management of gastrointestinal stromal tumours has radically changed their prognosis, particularly in their advanced forms, whether they are metastasic (the majority) or locally advanced. The high rates of response obtained means that, in many cases, surgery can be performed in situations where it was impossible to do so, even to the extent of considering surgery as a first line therapeutic weapon in combination with imatinib. Even so, it must not be used indiscriminately. It will be the different responses of these tumours to imatinib that will determine its usefulness and the way it is used. The combined use of surgery and imatinib is a clear and successful example of multimodal treatment in the context of the so-called targeted molecular therapy.
Keywords:
GIST
Imatinib
Metastasis
Neoadjuvancy
Resumen
La aplicación clínica del imatinib en el manejo de los tumores de la estroma gastrointestinal ha cambiado radicalmente su pronóstico, especialmente en sus formas avanzadas, ya sean metastásicas, la mayoría, o localmente avanzadas. Las elevadas tasas de respuesta obtenidas permiten, en muchos casos, el empleo de la cirugía en situaciones en que antes era imposible, e incluso se llega a considerar la cirugía como un arma terapéutica de primera línea en combinación con imatinib. Aun así, su empleo no debe ser indiscriminado. Serán las diferentes respuestas que estos tumores poseen al imatinib lo que determine su utilidad y su forma de empleo. El uso combinado de cirugía e imatinib supone un claro y exitoso ejemplo de tratamiento multimodal en el contexto de lo que se ha denominado terapia molecular dirigida.
Palabras clave:
GIST
Imatinib
Metástasis
Neoadyuvancia
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