Originales
Disfunción endotelial, enfermedad coronaria y diabetes mellitus
Endothelial dysfunction, coronary heart disease and diabetes mellitus
Beatriz Virgós Señora,
, Agustín Carlos Nebra Puertasa, Miguel Angel Suárez Pinillab, Rosa Cornudella Lacasac, Pilar Portero Pérezd, Alejandra Morón Gimeneza
Autor para correspondencia
s976358224@wanadoo.es
Correspondencia: Dra. B. Virgós Señor. Av. de Valencia, 51-53, Esc. 1.a, piso 8.°-B. 5005 Zaragoza. España.
Correspondencia: Dra. B. Virgós Señor. Av. de Valencia, 51-53, Esc. 1.a, piso 8.°-B. 5005 Zaragoza. España.
a Servicio de Medicina Intensiva. Hospital Universitario Miguel Servet. Zaragoza. España
b Servicio de Medicina Intensiva. Hospital Clínico de Zaragoza. Zaragoza. España
c Servicio de Hematología. Hospital Clínico de Zaragoza. Zaragoza. España
d Servicio de Cardiología. Hospital Clínico de Zaragoza. Zaragoza. España
Leído
6255
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Hospital Universitario Miguel Servet. Zaragoza. España" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Servicio de Medicina Intensiva. Hospital Clínico de Zaragoza. Zaragoza. España" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] 2 => array:3 [ "entidad" => "Servicio de Hematología. Hospital Clínico de Zaragoza. Zaragoza. España" "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] 3 => array:3 [ "entidad" => "Servicio de Cardiología. Hospital Clínico de Zaragoza. Zaragoza. España" "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff4" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Correspondencia: Dra. B. Virgós Señor. Av. de Valencia, 51-53, Esc. 1.<span class="elsevierStyleSup">a</span>, piso 8.°-B. 5005 Zaragoza. España." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Endothelial dysfunction, coronary heart disease and diabetes mellitus" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2006-12-06" "fechaAceptado" => "2007-07-26" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec135053" "palabras" => array:3 [ 0 => "Factor von Willebrand" 1 => "Diabetes complicada" 2 => "Enfermedad coronaria" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec135054" "palabras" => array:3 [ 0 => "Von Willebrand factor" 1 => "Complicated diabetes" 2 => "Coronary heart disease" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Fundamento y objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">La diabetes mellitus es un factor de riesgo cardiovascular que propicia la aparición de una lesión endotelial, fundamental en la fisiopatología de la cardiopatía isquémica, por lo que sería útil la investigación de marcadores que indiquen la lesión en pacientes diabéticos.</p> <span class="elsevierStyleSectionTitle">Pacientes y método</span><p class="elsevierStyleSimplePara elsevierViewall">Estudio observacional, realizado con 25 pacientes diagnosticados de cardiopatía isquémica y alteración endotelial confirmada mediante coronariografía, cuyo único factor de riesgo cardiovascular es la diabetes mellitus (grupo I). Tomamos 2 grupos control, uno de 10 sujetos diabéticos sin más factores de riesgo ni clínica de cardiopatía isquémica (grupo II), y otro de 17 sujetos sanos sin factores de riesgo cardiovascular (grupo III). Comparamos entre los grupos la actividad del factor de von Willebrand (FvW) antigénico, como marcador de lesión endotelial. Empleamos como herramientas estadísticas la prueba de la t de Student y la de la χ<span class="elsevierStyleSup">2</span>, el coeficiente de correlación y análisis de regresión múltiple, con un intervalo de confianza del 95%.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Los pacientes diabéticos tienen mayores concentraciones de FvW que los sujetos sanos; además, los sujetos con cardiopatía isquémica presentan valores más elevados que los diabéticos sin complicaciones vasculares. Se comprueba cierto grado de relación entre las concentracions de FvW y fibrinógeno en el grupo I.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">El FvW es un factor de riesgo de lesión endotelial en diabéticos, y un marcador de riesgo de complicaciones vasculares.</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Background and objective</span><p class="elsevierStyleSimplePara elsevierViewall">Diabetes mellitus is a cardiovascular risk factor that promotes the development of endothelial injury, which is fundamental in the physiopathology of ischemic heart disease. Therefore, investigation of markers indicating the presence of endothelial injury in diabetic patients would be useful.</p> <span class="elsevierStyleSectionTitle">Patients and method</span><p class="elsevierStyleSimplePara elsevierViewall">We performed an observational study of 25 patients with ischemic heart disease and coronary atherosclerosis, diagnosed by coronary angiography, whose only cardiovascular risk factor was diabetes mellitus (group I). There were 2 control groups, one with 10 diabetic controls without ischemic heart disease or other cardiovascular risk factors (group II) and another group with 17 healthy controls (group III). Activity of von Willebrand factor (vWf) antigen, as a marker of endothelial injury, was compared among the groups. Student's t-test, the x<span class="elsevierStyleSup">2</span> test, the coefficient of correlation, and multiple regression analysis, with a 95% confidence interval, were used in the statistical analysis.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">Diabetic patients had highervWf levels than healthy controls. Diabetic patients with coronary atherosclerosis had higher vWf levels than diabetics without vascular complications. There was a correlation between vWF and fibrinogen concentrations in group I.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">vWf is a risk factor for the development of endothelial injury in diabetics and is also a marker of risk for the development of vascular complications in these patients.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:23 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The pathogenesis of coronary artery disease and the acute coronary syndromes (1)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "V. Fuster" 1 => "L. Badimon" 2 => "J.J. Badimon" 3 => "J.H. 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| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 1 | 0 | 1 |
| 2024 Octubre | 17 | 5 | 22 |
| 2024 Septiembre | 16 | 9 | 25 |
| 2024 Agosto | 28 | 4 | 32 |
| 2024 Julio | 18 | 8 | 26 |
| 2024 Junio | 15 | 6 | 21 |
| 2024 Mayo | 15 | 7 | 22 |
| 2024 Abril | 15 | 8 | 23 |
| 2024 Marzo | 19 | 19 | 38 |
| 2024 Febrero | 41 | 18 | 59 |
| 2024 Enero | 13 | 12 | 25 |
| 2023 Diciembre | 15 | 8 | 23 |
| 2023 Noviembre | 27 | 26 | 53 |
| 2023 Octubre | 23 | 27 | 50 |
| 2023 Septiembre | 18 | 9 | 27 |
| 2023 Agosto | 14 | 10 | 24 |
| 2023 Julio | 11 | 11 | 22 |
| 2023 Junio | 37 | 15 | 52 |
| 2023 Mayo | 53 | 15 | 68 |
| 2023 Abril | 47 | 7 | 54 |
| 2023 Marzo | 31 | 10 | 41 |
| 2023 Febrero | 19 | 24 | 43 |
| 2023 Enero | 6 | 9 | 15 |
| 2022 Diciembre | 9 | 11 | 20 |
| 2022 Noviembre | 13 | 6 | 19 |
| 2022 Octubre | 14 | 21 | 35 |
| 2022 Septiembre | 9 | 29 | 38 |
| 2022 Agosto | 8 | 11 | 19 |
| 2022 Julio | 13 | 6 | 19 |
| 2022 Junio | 47 | 5 | 52 |
| 2022 Mayo | 15 | 10 | 25 |
| 2022 Abril | 33 | 12 | 45 |
| 2022 Marzo | 17 | 17 | 34 |
| 2022 Febrero | 18 | 7 | 25 |
| 2022 Enero | 10 | 8 | 18 |
| 2021 Diciembre | 9 | 15 | 24 |
| 2021 Noviembre | 23 | 6 | 29 |
| 2021 Octubre | 30 | 20 | 50 |
| 2021 Septiembre | 25 | 13 | 38 |
| 2021 Agosto | 21 | 7 | 28 |
| 2021 Julio | 28 | 15 | 43 |
| 2021 Junio | 18 | 9 | 27 |
| 2021 Mayo | 96 | 7 | 103 |
| 2021 Abril | 65 | 11 | 76 |
| 2021 Marzo | 43 | 18 | 61 |
| 2021 Febrero | 38 | 4 | 42 |
| 2021 Enero | 27 | 10 | 37 |
| 2020 Diciembre | 35 | 8 | 43 |
| 2020 Noviembre | 50 | 15 | 65 |
| 2020 Octubre | 26 | 5 | 31 |
| 2020 Septiembre | 32 | 17 | 49 |
| 2020 Agosto | 31 | 23 | 54 |
| 2020 Julio | 15 | 8 | 23 |
| 2020 Junio | 18 | 14 | 32 |
| 2020 Mayo | 31 | 11 | 42 |
| 2020 Abril | 47 | 6 | 53 |
| 2020 Marzo | 22 | 6 | 28 |
| 2020 Febrero | 28 | 10 | 38 |
| 2020 Enero | 29 | 11 | 40 |
| 2019 Diciembre | 29 | 17 | 46 |
| 2019 Noviembre | 15 | 8 | 23 |
| 2019 Octubre | 22 | 16 | 38 |
| 2019 Septiembre | 24 | 13 | 37 |
| 2019 Agosto | 16 | 9 | 25 |
| 2019 Julio | 26 | 11 | 37 |
| 2019 Junio | 48 | 38 | 86 |
| 2019 Mayo | 116 | 57 | 173 |
| 2019 Abril | 46 | 29 | 75 |
| 2019 Marzo | 16 | 2 | 18 |
| 2019 Febrero | 11 | 6 | 17 |
| 2019 Enero | 9 | 9 | 18 |
| 2018 Diciembre | 7 | 5 | 12 |
| 2018 Noviembre | 4 | 15 | 19 |
| 2018 Octubre | 13 | 7 | 20 |
| 2018 Septiembre | 17 | 0 | 17 |
| 2018 Agosto | 4 | 25 | 29 |
| 2018 Julio | 3 | 11 | 14 |
| 2018 Junio | 2 | 4 | 6 |
| 2018 Mayo | 4 | 18 | 22 |
| 2018 Abril | 2 | 16 | 18 |
| 2018 Marzo | 5 | 12 | 17 |
| 2018 Febrero | 5 | 6 | 11 |
| 2018 Enero | 3 | 5 | 8 |
| 2017 Diciembre | 5 | 2 | 7 |
| 2017 Noviembre | 10 | 5 | 15 |
| 2017 Octubre | 8 | 2 | 10 |
| 2017 Septiembre | 5 | 13 | 18 |
| 2017 Agosto | 8 | 21 | 29 |
| 2017 Julio | 12 | 23 | 35 |
| 2017 Junio | 11 | 31 | 42 |
| 2017 Mayo | 9 | 23 | 32 |
| 2017 Abril | 8 | 13 | 21 |
| 2017 Marzo | 12 | 40 | 52 |
| 2017 Febrero | 21 | 26 | 47 |
| 2017 Enero | 24 | 9 | 33 |
| 2016 Diciembre | 35 | 8 | 43 |
| 2016 Noviembre | 39 | 7 | 46 |
| 2016 Octubre | 51 | 8 | 59 |
| 2016 Septiembre | 29 | 4 | 33 |
| 2016 Agosto | 15 | 2 | 17 |
| 2016 Julio | 20 | 1 | 21 |
| 2016 Junio | 25 | 11 | 36 |
| 2016 Mayo | 19 | 20 | 39 |
| 2016 Abril | 16 | 12 | 28 |
| 2016 Marzo | 21 | 16 | 37 |
| 2016 Febrero | 18 | 13 | 31 |
| 2016 Enero | 25 | 10 | 35 |
| 2015 Diciembre | 18 | 11 | 29 |
| 2015 Noviembre | 23 | 15 | 38 |
| 2015 Octubre | 48 | 17 | 65 |
| 2015 Septiembre | 26 | 13 | 39 |
| 2015 Agosto | 48 | 3 | 51 |
| 2015 Julio | 44 | 5 | 49 |
| 2015 Junio | 19 | 8 | 27 |
| 2015 Mayo | 36 | 6 | 42 |
| 2015 Abril | 39 | 13 | 52 |
| 2015 Marzo | 33 | 5 | 38 |
| 2015 Febrero | 33 | 2 | 35 |
| 2015 Enero | 41 | 4 | 45 |
| 2014 Diciembre | 53 | 10 | 63 |
| 2014 Noviembre | 35 | 2 | 37 |
| 2014 Octubre | 50 | 0 | 50 |
| 2014 Septiembre | 51 | 2 | 53 |
| 2014 Agosto | 59 | 6 | 65 |
| 2014 Julio | 63 | 3 | 66 |
| 2014 Junio | 64 | 1 | 65 |
| 2014 Mayo | 48 | 1 | 49 |
| 2014 Abril | 48 | 2 | 50 |
| 2014 Marzo | 39 | 2 | 41 |
| 2014 Febrero | 48 | 2 | 50 |
| 2014 Enero | 24 | 1 | 25 |
| 2013 Diciembre | 39 | 1 | 40 |
| 2013 Noviembre | 42 | 4 | 46 |
| 2013 Octubre | 50 | 5 | 55 |
| 2013 Septiembre | 26 | 9 | 35 |
| 2013 Agosto | 22 | 3 | 25 |
| 2013 Julio | 27 | 1 | 28 |
| 2007 Noviembre | 1179 | 0 | 1179 |
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