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array:23 [ "pii" => "S1575092215001710" "issn" => "15750922" "doi" => "10.1016/j.endonu.2015.05.010" "estado" => "S300" "fechaPublicacion" => "2015-11-01" "aid" => "707" "copyright" => "SEEN" "copyrightAnyo" => "2015" "documento" => "article" "crossmark" => 1 "subdocumento" => "ssu" "cita" => "Endocrinol Nutr. 2015;62:458-64" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 4221 "formatos" => array:3 [ "EPUB" => 10 "HTML" => 3626 "PDF" => 585 ] ] "itemSiguiente" => array:19 [ "pii" => "S1575092215001734" "issn" => "15750922" "doi" => "10.1016/j.endonu.2015.05.012" "estado" => "S300" "fechaPublicacion" => "2015-11-01" "aid" => "709" "copyright" => "SEEN" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Endocrinol Nutr. 2015;62:465-6" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 10912 "formatos" => array:3 [ "EPUB" => 8 "HTML" => 9991 "PDF" => 913 ] ] "es" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Carta Científica</span>" "titulo" => "Hipertiroidismo inducido por yodo tópico" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "465" "paginaFinal" => "466" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Hyperthyroidism induced by topical iodine" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figura 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 851 "Ancho" => 995 "Tamanyo" => 206910 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Gammagrafía tiroidea con <span class="elsevierStyleSup">99m</span>Tc: exploración de baja calidad por inadecuada captación tiroidea del trazador. La causa puede atribuirse a repetidas curas con povidona yodada, por lesiones en los pies.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "María José Burchés-Feliciano, María Argente-Pla, Katherine García-Malpartida, Matilde Rubio-Almanza, Juan Francisco Merino-Torres" "autores" => array:5 [ 0 => array:2 [ "nombre" => "María José" "apellidos" => "Burchés-Feliciano" ] 1 => array:2 [ "nombre" => "María" "apellidos" => "Argente-Pla" ] 2 => array:2 [ "nombre" => "Katherine" "apellidos" => "García-Malpartida" ] 3 => array:2 [ "nombre" => "Matilde" "apellidos" => "Rubio-Almanza" ] 4 => array:2 [ "nombre" => "Juan Francisco" "apellidos" => "Merino-Torres" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S217350931500121X" "doi" => "10.1016/j.endoen.2015.11.003" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] 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"Caracterización epidemiológica de pacientes diabéticos en terapia con infusión subcutánea continua de insulina y monitorización continua de glucosa en tiempo real" "tienePdf" => "es" "tieneTextoCompleto" => "es" "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "451" "paginaFinal" => "457" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Epidemiological characterization of diabetic patients on therapy with continuous subcutaneous insulin infusion and continuous glucose monitoring in real time" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figura 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1142 "Ancho" => 1556 "Tamanyo" => 149166 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Flujograma de selección de los pacientes del estudio.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Natalia Aristizábal, Alex Ramírez, Jaime Hincapié-García, Estefany Laiton, Carolina Aristizábal, Diana Cuesta, Claudia Monsalve, Gloria Hincapié, Eliana Zapata, Verónica Abad, Maria-Rocio Delgado, José-Luis Torres, Andrés Palacio, José Botero" "autores" => array:15 [ 0 => array:2 [ "nombre" => "Natalia" "apellidos" => "Aristizábal" ] 1 => array:2 [ "nombre" => "Alex" "apellidos" => "Ramírez" ] 2 => array:2 [ "nombre" => "Jaime" "apellidos" => "Hincapié-García" ] 3 => array:2 [ "nombre" => "Estefany" "apellidos" => "Laiton" ] 4 => array:2 [ "nombre" => "Carolina" "apellidos" => "Aristizábal" ] 5 => array:2 [ "nombre" => "Diana" "apellidos" => "Cuesta" ] 6 => array:2 [ "nombre" => "Claudia" "apellidos" => "Monsalve" ] 7 => array:2 [ "nombre" => "Gloria" "apellidos" => "Hincapié" ] 8 => array:2 [ "nombre" => "Eliana" "apellidos" => "Zapata" ] 9 => array:2 [ "nombre" => "Verónica" "apellidos" => "Abad" ] 10 => array:2 [ "nombre" => "Maria-Rocio" "apellidos" => "Delgado" ] 11 => array:2 [ "nombre" => "José-Luis" "apellidos" => "Torres" ] 12 => array:2 [ "nombre" => "Andrés" "apellidos" => "Palacio" ] 13 => array:2 [ "nombre" => "José" "apellidos" => "Botero" ] 14 => array:1 [ "colaborador" => "Grupo de Investigación innovación desarrollos y avances en endocrinología IDEAS" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2173509315001257" "doi" => "10.1016/j.endoen.2015.11.006" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173509315001257?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1575092215002223?idApp=UINPBA00004N" "url" => "/15750922/0000006200000009/v1_201511180040/S1575092215002223/v1_201511180040/es/main.assets" ] "en" => array:19 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Short review</span>" "titulo" => "Different adipose tissue depots: Metabolic implications and effects of surgical removal" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "458" "paginaFinal" => "464" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Aline Marcadenti, Erlon Oliveira de Abreu-Silva" "autores" => array:2 [ 0 => array:4 [ "nombre" => "Aline" "apellidos" => "Marcadenti" "email" => array:1 [ 0 => "marcadenti@yahoo.com.br" ] "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Erlon Oliveira" "apellidos" => "de Abreu-Silva" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Department of Nutrition, Federal University of Health Sciences of Porto Alegre (UFCSPA), Porto Alegre, Rio Grande do Sul, Brazil" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Postgraduate Program in Health Sciences: Cardiology, Institute of Cardiology of Rio Grande do Sul (IC/FUC), Porto Alegre, Rio Grande do Sul, Brazil" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Division of Interventional Cardiology and Postgraduate Program in Cardiology, Federal University of São Paulo (UNIFESP), São Paulo, Brazil" "etiqueta" => "c" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Diferentes depósitos de tejido adiposo: implicaciones metabólicas y efectos de la extirpación quirúrgica" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1144 "Ancho" => 2511 "Tamanyo" => 195122 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Visual classification of body fat according to its distribution. Adapted from Foster et al.<span class="elsevierStyleSup">8</span>. SAT, subcutaneous white adipose tissue.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Obesity is one of the principal modifiable risk factors for an unhealthy status. It plays an important role on the global disease burden and is associated to both all-cause and cardiovascular mortality.<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">1</span></a> Body mass index (BMI) is the universal method used for characterizing the excess of body mass. It is independent of age and has the same cutoff points for both genders; however, the World Health Organization (WHO) specialists committees have proposed distinct cutoff values for BMI according to ethnics, considering their differences in body composition and body fat distribution<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">2</span></a> (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>). Nowadays, the traditional cutoff points for the general population still prevail and it is estimated that by 2030 2.16 billion people worldwide will fit into the “overweight” definition, and 1.12 billion will be obese, according to the BMI.<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">3</span></a></p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Adipose tissue</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Characterization and definition</span><p id="par0010" class="elsevierStylePara elsevierViewall">Adipose tissue has distinct morphological and histological characteristics, and executes a number of activities. In mammals, three types of adipose cells are present: brown, white and beige.</p><p id="par0015" class="elsevierStylePara elsevierViewall">Brown adipose tissue (BAT), full of mitochondria and specialized in heat production, exerts its thermogenic function mainly in the first years of life. Posteriorly, it transforms into white adipose tissue (WAT). However, BAT increased activity has been demonstrated in adults exposed to low temperatures; interestingly, this thermogenic effect is inversely related to age – older subjects have diminished expression of uncoupling protein 1 (UCP1) – and BMI.<a class="elsevierStyleCrossRefs" href="#bib0170"><span class="elsevierStyleSup">4,5</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Beige adipose tissue, still under investigation, has less well-known functions and it is believed that it originates from white adipocytes trans-differentiation within the same cellular lineage (Pax7/myf5-). In animal models, it was demonstrated that these cells, initially, have a reduced UCP1 expression but, if stimulated, attain the capacity to increase the activity of these thermogenesis-related proteins. Genetically, they have an intermediate behavior between brown and white fat tissues; thus, these cells can store the excess of energy – in form of lipids – in situations where energetic balance is positive, and dissipates energy to produce heat in cases of thermogenesis stimulation.<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">6</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">WAT is the most abundant adipose tissue in human organism and is responsible for lipid storage – in the form of triglycerides, mechanical protection and thermic isolation. However, interest lies on its capacity of secrete a number of substances with important roles in cardiovascular risk and protection, the adipokines. There is no consensus about WAT compartments nomenclature. Based on anatomy and functional properties, Shen et al. proposed a classification for body fat with emphasis on internal compartments, detected by image exams (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>).<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">7</span></a> On the other hand, Foster et al. propose a visual classification, according to body fat distribution (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>).<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">8</span></a></p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">Subcutaneous white adipose tissue (SAT) has different distribution according to gender. In men there is increased accumulation in the trunk compared to limbs, with a decreased rate and a more balanced distribution after the age of 50; in women, accumulation of SAT is similar in abdomen and limbs until adulthood, when there is an increase of speed and amount of SAT accumulated in the abdomen.<a class="elsevierStyleCrossRefs" href="#bib0195"><span class="elsevierStyleSup">9,10</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Visceral adipose tissue (VAT), located between the walls of abdominal cavity, is generally more prevalent in men than in women. There seems to be a proportional accumulation of VAT according to total adiposity in men, but not in women, who tend to accumulate fat in the abdominal cavity after reaching a certain level of total adiposity. Noteworthy is the fact that women also tend to increase the rate of VAT accumulation after menopause.<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">10</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Fat tissue distribution also modifies with aging. In the elderly, while total body fat may remain stable or even reduced, abdominal SAT is redistributed to VAT. During aging, the capacity of replication and differentiation of pre-adipocytes in subcutaneous mature adipocytes during adipogenesis is diminished, creating cells not fully capable of store fatty acids; thus, these cells can expand to visceral compartments.<a class="elsevierStyleCrossRefs" href="#bib0175"><span class="elsevierStyleSup">5,10</span></a></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Metabolic implications</span><p id="par0045" class="elsevierStylePara elsevierViewall">Adipose tissue is directly controlled by the autonomous nervous system, where sympathetic fibers relate to catabolic activities (lipolysis) mediated by catecholamines, beta-adrenergic receptors (β1, 2, 3) and the hormone-sensitive lipase (HSL) enzyme.<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">11</span></a> On the other hand, the parasympathetic fibers modulate anabolic effects in adipocytes (lipogenesis), promoting insulin-mediated fatty acids uptake.<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">12</span></a> It is known, however, that exposure to cold may also indirectly modulate adipose tissue activity (brown and white) through macrophages recruitment and interleukin-4 (IL-4) activation, increasing secretion of lipolysis-inducting catecholamines in WAT and expression of thermogenic genes in BAT.<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">13</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">Excessive nutrient intake (besides a decrease in energy expenditure) can lead to a number of responses in different cells (i.e. endothelial, hepatocytes, adipocytes) and cause a series of metabolic dysfunctions. Specifically regarding endothelial cells, excess of nutrients may induce inflammation and impair nitric oxide (NO) – a potent vasodilator – production and release. Similarly, alterations in adipose tissue perfusion can be present.<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">14</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">In cases of chronic energy imbalance, there is excessive triglyceride accumulation in adipocytes which is translated in augmented intra-cellular fat content, leading to adipocyte growth (hypertrophy) and multiplication (hyperplasia). Hypertrophy, especially if accompanied by vascular supply insufficiency, leads to adipocytes hypoxia and, consequently, production of reactive oxygen species (ROS); this may cause oxidative stress, damaging cell structures and triggering an inflammatory response.<a class="elsevierStyleCrossRefs" href="#bib0220"><span class="elsevierStyleSup">14,15</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">Hypertrophied adipocytes are more fragile and susceptible to rupture, even when exposed to ordinary physical forces; cells in the abdominal cavity are subjected to sudden variations of intra-abdominal pressure (i.e. during cough and/or exercise). Obese individuals have elevated intra-abdominal pressure, putting visceral adipocytes under a higher mechanical stress compared to those in SAT. Macrophage accumulation [major sources of cytokines, like TNF-α and IL-6, which modulate hepatic production of C-reactive protein (CRP)] in the adipose tissue occurs mainly around ruptures adipocytes, where inflammatory cells sequestrate residual lipid droplets. Adipose cells apoptosis starts a cascade of events that lead to a chronic inflammatory state (low grade inflammation) related to obesity complications.<a class="elsevierStyleCrossRefs" href="#bib0170"><span class="elsevierStyleSup">4,15</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">Factors that regulate adipocytes hypertrophy and hyperplasia are yet to be completely clarified; however, insulin and glucocorticoids in high levels seem to stimulate pre-adipocyte differentiation. Hypertrophied cells increase the production of insulin-like growth factor 1 (IGF1) that also stimulates hyperplasia. Thus, as consequence of a number of different processes, production of adipokines is impaired in obese persons.<a class="elsevierStyleCrossRefs" href="#bib0220"><span class="elsevierStyleSup">14,15</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">Both subcutaneous and visceral adipose tissues have a differentiated behavior when it comes to adipokines. In VAT, there is predominance of β1, 2 and 3 adrenergic receptors compared to α2 ones, which make it extremely sensitive to catecholamine-induced lipolysis (with consequent increase in free fatty acids release directly into portal circulation). There is also a minor effect in insulin signaling with a reduction in anti-lipolytic effects, due to a decrease in insulin receptors substrate 1 (IRS-1). Additionally, there is augmented expression of 11-Beta hydroxysteroid dehydrogenase type 1 (11β-HSDH1), responsible for conversion of cortisone into cortisol, enhancing the response to glucocorticoids and, consequently, fat accumulation. Production of pro-inflammatory adipokines is greater in VAT. SAT, in turn, fundamentally regulates appetite, energy expenditure and fat deposits through increased production of leptin. Compared to VAT, lipolysis rates are nearly 50% inferior – gluteo-femoral compartments of subcutaneous fat have decreased response to catecholamines, lower density of adrenergic receptors and diminished HSL expression.<a class="elsevierStyleCrossRefs" href="#bib0220"><span class="elsevierStyleSup">14,15</span></a><a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a> presents some adipokines secreted by adipose tissue and their respective functions.</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0075" class="elsevierStylePara elsevierViewall">Some myokines (polypeptides secreted by muscles) are also produced by adipose tissue and have a duo effect: when there is adiposity excess, these proteins exert a pro-inflammatory role; on the other hand, after physical exercise, they have beneficial properties. Interleukin-6 is one of these adipomyokines; its effect in insulin resistance and lipogenesis is completely counteracted after exercise, increasing insulin sensitivity and lipid oxidation in striate muscle.<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">16</span></a> Another peptide secreted by muscle after physical exercise, irisin (expressed by the fibronectin type III domain containing 5 – FNDC5 – gene) was recently discovered and is regulated by peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC1-α). Irisin activates thermogenesis in adipose tissue, stimulates beige adipose tissue and the “darkening” capacity of WAT in vivo and in vitro, promoting some metabolic functions and energy dissipation in thus cells through an increase in UCP1 expression.<a class="elsevierStyleCrossRefs" href="#bib0230"><span class="elsevierStyleSup">16,17</span></a> Recently, irisin was found to be secreted by adipocytes as well, mainly in subcutaneous tissue; in fact, endurance exercises acutely stimulate irisin secretion by VAT and SAT.<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">17</span></a> Obese animals have an over-expression of this peptide, which suggests some level of resistance to its effects in obesity.</p><p id="par0080" class="elsevierStylePara elsevierViewall">It is suggested that altered fatty acids and glucose metabolism may not be a direct consequence of VAT activity, but a reflex of abdominal SAT lack o capacity to adapt and expand through hyperplasia. Morphological and physiological characteristics of SAT could be responsible for its cells multiplication capacity in order to accommodate the excess of circulating fatty acids (from the positive energy balance) and to build a protector energy deposit. However, in cases of tissue hypoxia, the excess of circulating triglycerides would automatically migrate to the intra-abdominal compartment and accumulate in organs like liver, heart and pancreas (i.e. ectopic fat deposition). Women have higher degrees of lipolysis and free fatty acids mobilization from VAT compared to men.<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">18</span></a></p><p id="par0085" class="elsevierStylePara elsevierViewall">Therefore, abdominal deposits of visceral and subcutaneous fat may have different characteristics and exert unequal roles in cardiometabolic profile. This hypothesis was evaluated in men and women from Framingham in whom abdominal SAT and VAT were detected by image exams and analyzed separately in relation to hypertension (HTN), type-2 diabetes mellitus (T2DM) and metabolic syndrome (MS). VAT was more strongly associated to all co-morbidities than abdominal SAT, especially in women.<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">19</span></a> Similar results were seen in more than 2400 subjects from the Jackson Heart Study cohort, where visceral and subcutaneous fat compartments were associated to HTN, T2DM and MS, with a higher risk for those with increased VAT compartments.<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">20</span></a></p><p id="par0090" class="elsevierStylePara elsevierViewall">The INternational Study of Prediction of Intra-abdominal adiposity and its RElationships with cardioMEtabolic risk/Intra-Abdominal Adiposity (INSPIRE ME IAA) study, which allocated patients from 29 countries, also determined VAT contribution on T2DM. Higher levels of visceral obesity (VAT area >204.9<span class="elsevierStyleHsp" style=""></span>cm<span class="elsevierStyleSup">2</span> in men and >167.3<span class="elsevierStyleHsp" style=""></span>cm<span class="elsevierStyleSup">2</span> in women) detected by computed tomography scan were associated to higher risk for T2DM in both genders, while SAT was not related to diabetes in men and had an inverse relationship with the disease in women (20% risk reduction).<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">21</span></a></p><p id="par0095" class="elsevierStylePara elsevierViewall">There is also evidence of the association between VAT and cardiovascular disease, regardless of general obesity and abdominal SAT. Among Brazilian subjects in whom coronary angio-computed tomography scan was performed, a VAT area ≥145<span class="elsevierStyleHsp" style=""></span>cm<span class="elsevierStyleSup">2</span> was associated to the presence of coronary artery disease; the same was not observed with conventional anthropometric measures (waist circumference, waist-hip ratio and BMI).<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">22</span></a></p><p id="par0100" class="elsevierStylePara elsevierViewall">Adiposity excess can be evaluated by methods capable of detecting total body fat, body fat distribution and body composition (direct or indirect measurement of fat percentage). <a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a> shows some of these methods and their use in clinical practice.</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Effects of adipose tissue removal</span><p id="par0105" class="elsevierStylePara elsevierViewall">Considering the beneficial effects of SAT, the cardiometabolic safety of procedures in which part of this tissue is removed – such as lipectomy and liposuction – has been questioned. VAT remains intact during liposuction in contrast to SAT and it is concern that removal of these portions of WAT could result in substantial increase of VAT volume. Studies in animals showed that mice in a lipid-rich diet, and in which lipectomy was performed, had insulin resistance (IR), high triglyceride levels and hepatic steatosis 90 days after the procedure.<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">24</span></a></p><p id="par0110" class="elsevierStylePara elsevierViewall">In humans, results are controversial once many studies did not demonstrate harmful cardiometabolic effects of lipectomy neither showed benefits. Klein et al. demonstrated in obese women without glucose intolerance (BMI 35.1<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>2.4<span class="elsevierStyleHsp" style=""></span>kg/m<span class="elsevierStyleSup">2</span>) and with T2DM (BMI 39.9<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>5.6<span class="elsevierStyleHsp" style=""></span>kg/m<span class="elsevierStyleSup">2</span>) that after three months of SAT removal through lipectomy, despite the significant reduction of weight, general and abdominal adiposity and improvement in leptin levels, there was no improvement in insulin sensitivity. Moreover, no change was seen in fast plasma glucose, TNF-α, IL-6, adiponectin, CRP, lipid profile and blood pressure.<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">25</span></a> Another study, conducted with eutrophic women who had small amounts of SAT removed, did not show changes in weight, insulin levels and insulin sensitivity by HOMA-IR 21 days after surgery; however, there was an improvement in lipid profile.<a class="elsevierStyleCrossRef" href="#bib0280"><span class="elsevierStyleSup">26</span></a></p><p id="par0115" class="elsevierStylePara elsevierViewall">A meta-analysis with 15 studies and 357 subjects showed that, after adjusting for post-surgery follow-up time (mean: 3 months) and BMI, only leptin and insulin serum levels were significantly related to the amount of aspirated fat; no association for CRP, IL-6, adiponectin, resistin, TNF-α, HOMA index, total, HDL and LDL cholesterols, triglycerides, blood pressure and free fatty acids. Based on the results, authors concluded that there is no evidence to support the hypothesis that subcutaneous fat removal reduces early cardiovascular or metabolic disease, its markers or its risk factors.<a class="elsevierStyleCrossRef" href="#bib0285"><span class="elsevierStyleSup">27</span></a> One hypothesis is that the decrease in abdominal SAT, although substantial after liposuction, may have been insufficient enough to overcome the negative effects of the excess visceral fat on insulin sensitivity, cytokine production and lipid profile in individuals with excess of adiposity.<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">24</span></a></p><p id="par0120" class="elsevierStylePara elsevierViewall">Effects of lipectomy on body fat distribution have been evaluated. According to the “lipostatic” theory,<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">28</span></a> in the long term, energy balance is regulated by a number of feedback systems that favor regulates body fat deposits. A sudden decrease/removal of adipose tissue (as in lipectomy) can activate feedback mechanisms that favor the recovery of this “eliminated” fat, by reducing energy expenditure and increasing food intake. In a number of species, when adipose tissue is surgically removed, this recovery happens in weeks to months and because of an increase in fat located in intact deposits – and not because of reaccumulation of aspirated deposits.<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">24</span></a></p><p id="par0125" class="elsevierStylePara elsevierViewall">In animal models, this compensatory ability is not uniform and depends on the place where adipose tissue was extracted from. Similarly, mode of compensation can be different according to the location of aspirated deposits: intra-abdominal fat tissue reaccumulates trough adipocytes hypertrophy while subcutaneous fat reccumulates through hyperplasia.<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">24</span></a> Leptin seems to be the main inductor of compensatory responses and reaccumulation of fat mass; its levels are significantly reduced short after lipectomy and remain low until three months after surgery. This response is expected because SAT adipocytes are the primary source of leptin in humans. This hormone acts in the hypothalamus inhibiting food intake, increasing energy expenditure and balancing adiposity levels; in the periphery, its actions are increase in lipolysis and free fatty acids oxidation in striate muscle.<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">29</span></a> Decreased levels of leptin after lipectomy could activate compensatory responses that enhance food intake and decrease energy expenditure, which would facilitate weight and fat regain.<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">24</span></a> Further, lipectomy results in decreased norepinephrine turnover in non-excised adipose tissue pads, implying that decreased sympathetic tone may contribute to lipectomy-induced compensatory increases of fat mass by means of promoting lipid accretion through decreased basal lipolysis.<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">8</span></a></p><p id="par0130" class="elsevierStylePara elsevierViewall">In humans, a randomized trial with non-obese women (BMI 24.5<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>2<span class="elsevierStyleHsp" style=""></span>kg/m<span class="elsevierStyleSup">2</span>) in whom DEXA and cutaneous folds measurement (determination of body composition), and waist circumference and MRI (detection of abdominal obesity) were performed, evaluated the effects of removing small volumes of subcutaneous tissue by lipectomy (thighs and abdomen). Follow-up was performed in 6 weeks, 6 months and 1 year after the procedure. After 6 weeks, total body fat percentage was significantly reduced in those located to the “lipectomy” group, but this difference did not exist after 6 months. Reaccumulation of fat tissue was different according to the analyzed body region; after 1 year, gluteofemoral subcutaneous tissue in those women who performed surgery was unaltered, while abdominal fat percetage was significantly increased.<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">30</span></a> Authors concluded that following suction lipectomy, body fat was restored and redistributed from the thigh to the abdomen.</p></span></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusion</span><p id="par0135" class="elsevierStylePara elsevierViewall">Obesity is a chronic disease associated with higher risk for metabolic disorders; however, adipose tissue has different characteristics according to its location and morphology. Subcutaneous adipose tissue depots seem to be negatively correlated with cardiovascular risk factors while higher levels of visceral adipose tissue have been strongly associated with metabolic dysregulation. Fat manipulation such as lipectomy and liposuction have been utilized as alternatives for improvement of both body composition and cardiometabolic factors; however, the results of studies investigating the effects of liposuction on the metabolic profile are inconsistent and most reporting either no change or improvements in one or more cardiovascular risk factors. Besides, it is suggested that subcutaneous adipose tissue excision may lead to increased visceral accumulation. Thus, there is insufficient evidence to support the hypothesis that subcutaneous fat removal reduces early cardiovascular or metabolic disease, its markers or its risk factors.</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Source(s) of support</span><p id="par0140" class="elsevierStylePara elsevierViewall">None.</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Conflict of interest</span><p id="par0145" class="elsevierStylePara elsevierViewall">None.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:10 [ 0 => array:3 [ "identificador" => "xres580213" "titulo" => "Abstract" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0005" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec596784" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres580214" "titulo" => "Resumen" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0010" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec596785" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:3 [ "identificador" => "sec0010" "titulo" => "Adipose tissue" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0015" "titulo" => "Characterization and definition" ] 1 => array:2 [ "identificador" => "sec0020" "titulo" => "Metabolic implications" ] 2 => array:2 [ "identificador" => "sec0025" "titulo" => "Effects of adipose tissue removal" ] ] ] 6 => array:2 [ "identificador" => "sec0030" "titulo" => "Conclusion" ] 7 => array:2 [ "identificador" => "sec0035" "titulo" => "Source(s) of support" ] 8 => array:2 [ "identificador" => "sec0040" "titulo" => "Conflict of interest" ] 9 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2015-04-13" "fechaAceptado" => "2015-05-29" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec596784" "palabras" => array:4 [ 0 => "Obesity" 1 => "Adipose tissue" 2 => "Metabolism" 3 => "Lipectomy" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec596785" "palabras" => array:4 [ 0 => "Obesidad" 1 => "Tejido adiposo" 2 => "Metabolismo" 3 => "Lipectomía" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Increased adiposity has been associated to worse metabolic profile, cardiovascular disease, and mortality. There are two main adipose tissue depots in the body, subcutaneous and visceral adipose tissue, which differ in anatomical location. A large body of evidence has shown the metabolic activity of adipose tissue; lipectomy and/or liposuction therefore appear to be alternatives for improving metabolic profile through rapid loss of adipose tissue. However, surgical removal of adipose tissue may be detrimental for metabolism, because subcutaneous adipose tissue has not been associated to metabolic disorders such as insulin resistance and type 2 diabetes mellitus. In addition, animal studies have shown a compensatory growth of adipose tissue in response to lipectomy. This review summarizes the implications of obesity-induced metabolic dysfunction, its relationship with the different adipose tissue depots, and the effects of lipectomy on cardiometabolic risk factors.</p></span>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">El aumento de la adiposidad se ha asociado con un peor perfil metabólico, enfermedad cardiovascular y mortalidad. Hay 2 depósitos principales de tejido adiposo en el cuerpo, el tejido adiposo subcutáneo y el tejido adiposo visceral, y difieren en la localización anatómica. Un gran cuerpo de evidencia ha demostrado la actividad metabólica del tejido adiposo; por lo tanto, la lipectomía y/o la liposucción parecen ser alternativas para mejorar el perfil metabólico a través de la pérdida rápida de tejido adiposo. Sin embargo, la extirpación quirúrgica del tejido adiposo podría ser perjudicial para el metabolismo, ya que el tejido adiposo subcutáneo no ha sido asociado con trastornos metabólicos, tales como resistencia a la insulina y diabetes mellitus tipo 2. Además, estudios en animales han demostrado un crecimiento compensatorio del tejido adiposo en respuesta a la lipectomía. Esta revisión resume las implicaciones de la disfunción metabólica inducida por la obesidad, su relación con los diferentes depósitos de tejido adiposo y los efectos de la lipectomía sobre los factores de riesgo cardiometabólico.</p></span>" ] ] "multimedia" => array:4 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1144 "Ancho" => 2511 "Tamanyo" => 195122 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Visual classification of body fat according to its distribution. Adapted from Foster et al.<span class="elsevierStyleSup">8</span>. SAT, subcutaneous white adipose tissue.</p>" ] ] 1 => array:7 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Adapted from Shen et al.<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">7</span></a></p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">1. Total adipose tissue \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">2. Subcutaneous adipose tissue \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>2.1 Superficial subcutaneous adipose tissue \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>2.2 Deep subcutaneous adipose tissue \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">3. Internal adipose tissue \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>3.1 Visceral adipose tissue \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>3.1.1 Intrathoracic adipose tissue \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>3.1.1.1 Intrapericardial \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>3.1.1.2 Extrapericardial \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>3.1.2 Intraabdominopelvic adipose tissue \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>3.1.2.1 Intraperitoneal \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>3.1.2.2 Extraperitoneal \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>3.1.2.2.1 Intraabdominal \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>3.1.2.2.2 Preperitoneal \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>3.1.2.2.3 Retroperitoneal \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>3.1.2.3 Intrapelvic \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>3.2 Nonvisceral adipose tissue \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>3.2.1 Intramuscular adipose tissue \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>3.2.2 Perimuscular adipose tissue \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>3.2.2.1 Intermuscular adipose tissue \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>3.2.2.2 Paraosseal adipose tissue \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>3.3 Other nonvisceral adipose tissue \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab946564.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Proposed classification of total body adipose tissue.<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">7</span></a></p>" ] ] 2 => array:7 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Adapted from Fonseca-Alaniz et al. WAT, white adipose tissue; VAT, visceral adipose tissue; ASP, acylation-stimulating protein; HGF, hepatocyte growth factor; IGF-1, insulin-like growth factor-1; MCP-1, monocyte chemotactic protein 1; PAI-1, plasminogen activator inhibitor-1; Sfrp5, secreted frizzled-related protein 5; TNF-α, tumor necrosis factor alpha; VEGF, vascular endothelial growth factor.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Adipokine \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Biologic effect \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Adiponectin \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Increases sensitivity to insulin; anti-inflammatory, anti-atherogenic \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Adipsin \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Activates complement alternative pathway \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Angiotensinogen \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Precursor of angiotensin; blood pressure regulation \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Apelin \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Control body energy stores; endothelial cell proliferation \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">ASP \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Stimulates triglyceride synthesis in WAT \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">HGF \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Stimulation of adipocytes differentiation and development \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">IGF1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Stimulation of adipocytes proliferation and differentiation \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Interleukin-10 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Anti-inflammatory; inhibits TNF-α production \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Interleukin-6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Pro-inflammatory; lipolysis; decreases sensitivity to insulin \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Leptin \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Signaling body energy stores \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">MCP-1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Pro-inflammatory; insulin resistance; atherosclerosis \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">PAI-1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Inhibits plasminogen activation (blocks fibrinolysis) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Resistin \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Increases resistance to insulin \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Sfrp5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Anti-inflammatory; increases sensitivity to insulin \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Tecidual factor \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Starts coagulation cascade \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">TNF-α \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Lipolysis; increases energy consumption; decreases sensitivity to insulin \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">VEGF \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Stimulation of vascular proliferation (angiogenensis) in WAT \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Visfatin \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Insulin-like; produced mainly by VAT \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab946562.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Adipokines produced and secreted by adipocyte.<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">15</span></a></p>" ] ] 3 => array:7 [ "identificador" => "tbl0015" "etiqueta" => "Table 3" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">+++ widely accepted method; ++ accepted method; + unusual/rarely used method; − not recommended. Adapted from Cornier et al.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Method \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Clinical use \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry " colspan="2" align="left" valign="top"><span class="elsevierStyleItalic">Evaluation of total body adiposity</span></td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Body mass index (BMI) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">+++ \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Body adiposity index (BAI) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">+ \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="2" align="left" valign="top"><span class="elsevierStyleItalic">Evaluation of body fat distribution</span></td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Waist circumference (WC) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">+++ \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Neck circumference (NC) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">+ \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Waist–hip ratio (WHR) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">++ \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Waist-height ratio (WHtR) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">+ \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Sagital abdominal diameter (SAD) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">+ \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Computed tomography (CT) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">− \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Magnetic resonance imaging (MRI) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">− \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="2" align="left" valign="top"><span class="elsevierStyleItalic">Evaluation of body composition</span></td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Cutaneous folds \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">++ \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Hydrostatic weighing \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">+ \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Air displacement plethysmography (ADP) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">+ \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Dual-energy X-ray absorptiometry (DEXA) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">+ \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Bioelectrical impedance \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">++ \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>CT/MRI \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">− \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="2" align="left" valign="top"><span class="elsevierStyleItalic">Others</span></td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Lipid accumulation product index (LAP) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">+ \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Visceral adiposity index (VAI) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">+ \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab946563.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Methods for body fat evaluation and use in clinical practice.<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">23</span></a></p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:30 [ 0 => array:3 [ "identificador" => "bib0155" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "Prospective Studies Collaboration" 1 => "G. Whitlock" 2 => "S. Lewington" 3 => "P. Sherliker" 4 => "R. Clarke" 5 => "J. Emberson" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0140-6736(09)60318-4" "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "2009" "volumen" => "373" "paginaInicial" => "1083" "paginaFinal" => "1096" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19299006" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0160" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "World Health Organization (WHO). BMI Classification. Available from: <a href="http://www.who.int/bmi/index.jsp?introPage=intro_3.html">http://www.who.int/bmi/index.jsp?introPage=intro_3.html</a> [accessed 10.05.12]." ] ] ] 2 => array:3 [ "identificador" => "bib0165" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9.1 million participants" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.M. Finucane" 1 => "G.A. Stevens" 2 => "M.J. Cowan" 3 => "G. Danaei" 4 => "J.K. Lin" 5 => "C.J. Paciorek" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0140-6736(10)62037-5" "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "2011" "volumen" => "377" "paginaInicial" => "557" "paginaFinal" => "567" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21295846" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0170" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Brown adipose tissue: function and physiological significance" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "B. Cannon" 1 => "J. Nedergaard" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1152/physrev.00015.2003" "Revista" => array:6 [ "tituloSerie" => "Physiol Rev" "fecha" => "2004" "volumen" => "84" "paginaInicial" => "277" "paginaFinal" => "359" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14715917" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0175" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The adipocyte: a model for integration of endocrine and metabolic signaling in energy metabolism regulation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "G. Frühbeck" 1 => "J. Gómez-Ambrosi" 2 => "F.J. Muruzábal" 3 => "M.A. Burrell" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Am J Physiol Endocrinol Metab" "fecha" => "2001" "volumen" => "280" "paginaInicial" => "827" "paginaFinal" => "847" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0180" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Adaptive thermogenesis in adipocytes: is beige the new brown" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J. Wu" 1 => "P. Cohen" 2 => "B.M. Spiegelman" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1101/gad.211649.112" "Revista" => array:6 [ "tituloSerie" => "Genes Dev" "fecha" => "2013" "volumen" => "27" "paginaInicial" => "234" "paginaFinal" => "250" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23388824" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0185" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Adipose tissue quantification by imaging methods: a proposed classification" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "W. Shen" 1 => "Z.M. Wang" 2 => "M. Punyanita" 3 => "J. Lai" 4 => "A. Sinav" 5 => "J.G. Oral" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Obesity Res" "fecha" => "2003" "volumen" => "11" "paginaInicial" => "5" "paginaFinal" => "16" ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0190" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Metabolic alterations following visceral fat removal and expansion: beyond anatomic location" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M.T. Foster" 1 => "M.J. Pagliassotti" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.4161/adip.21756" "Revista" => array:6 [ "tituloSerie" => "Adipocyte" "fecha" => "2012" "volumen" => "1" "paginaInicial" => "192" "paginaFinal" => "199" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23700533" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0195" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sex differences in the relation of visceral adipose tissue accumulation to total body fatness" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S. Lemieux" 1 => "D. Prud’homme" 2 => "C. Bouchard" 3 => "A. Tremblay" 4 => "J.P. Després" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Clin Nutr" "fecha" => "1993" "volumen" => "58" "paginaInicial" => "463" "paginaFinal" => "467" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8379501" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0200" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Fat tissue, aging, and cellular senescence" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "T. Tchkonia" 1 => "D.E. Morbeck" 2 => "T. Von Zglinicki" 3 => "J. Van Deursen" 4 => "J. Lustgarten" 5 => "H. Scrable" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1474-9726.2010.00608.x" "Revista" => array:6 [ "tituloSerie" => "Aging Cell" "fecha" => "2010" "volumen" => "9" "paginaInicial" => "667" "paginaFinal" => "684" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20701600" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0205" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The autonomic nervous system, adipose tissue plasticity, and energy balance" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "L. Pénicaud" 1 => "B. Cousin" 2 => "C. Leloup" 3 => "A. Lorsignol" 4 => "L. Casteilla" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Nutrition" "fecha" => "2000" "volumen" => "16" "paginaInicial" => "903" "paginaFinal" => "908" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11054595" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0210" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Selective parasympathetic innervations of subcutaneous and intra-abdominal fat – functional implications" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "F. Kreier" 1 => "E. Fliers" 2 => "P.J. Voshol" 3 => "C.G. van Eden" 4 => "L.M. Havekes" 5 => "A. Kalsbeek" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1172/JCI15736" "Revista" => array:6 [ "tituloSerie" => "J Clin Invest" "fecha" => "2002" "volumen" => "110" "paginaInicial" => "1243" "paginaFinal" => "1250" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12417562" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0215" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "K.D. Nguyen" 1 => "Y. Qiu" 2 => "X. Cui" 3 => "Y.P. Goh" 4 => "J. Mwangi" 5 => "T. David" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/nature10653" "Revista" => array:6 [ "tituloSerie" => "Nature" "fecha" => "2011" "volumen" => "480" "paginaInicial" => "104" "paginaFinal" => "108" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22101429" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0220" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Papel do tecido adiposo na inflamação e metabolismo do doente obeso" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "V. Moura" 1 => "R. Monteiro" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Revista da SPCNA" "fecha" => "2010" "volumen" => "16" "paginaInicial" => "15" "paginaFinal" => "22" ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0225" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The adipose tissue as a regulatory center of the metabolism" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M.H. Fonseca-Alaniz" 1 => "J. Takada" 2 => "M.I.C. Alonso-Vale" 3 => "F.B. Lima" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Arq Bras Endocrinol Metab" "fecha" => "2006" "volumen" => "50" "paginaInicial" => "216" "paginaFinal" => "229" ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0230" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Adipo-myokines: two sides of the same coin-mediators of inflammation and mediators of exercise" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "S. Raschke" 1 => "J. Eckel" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1155/2013/320724" "Revista" => array:5 [ "tituloSerie" => "Mediators Inflamm" "fecha" => "2013" "volumen" => "2013" "paginaInicial" => "320724" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23861558" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0235" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "FNDC5/Irisin is not only a myokine but also an adipokine" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Roca-Rivada" 1 => "C. Castelao" 2 => "L.L. Senin" 3 => "M.O. Landrove" 4 => "J. Baltar" 5 => "A.B. Crujeiras" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1371/journal.pone.0060563" "Revista" => array:5 [ "tituloSerie" => "PLOS ONE" "fecha" => "2013" "volumen" => "8" "paginaInicial" => "e60563" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23593248" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0240" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "B.L. Wajchenberg" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1210/edrv.21.6.0415" "Revista" => array:6 [ "tituloSerie" => "Endocr Rev" "fecha" => "2000" "volumen" => "21" "paginaInicial" => "697" "paginaFinal" => "738" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11133069" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0245" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Abdominal visceral and subcutaneous adipose tissue compartments: association with metabolic risk factors in the Framingham Heart Study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C.S. Fox" 1 => "J.M. Massaro" 2 => "U. Hoffmann" 3 => "K.M. Pou" 4 => "P. Maurovich-Horvat" 5 => "C.Y. Liu" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1161/CIRCULATIONAHA.106.675355" "Revista" => array:6 [ "tituloSerie" => "Circulation" "fecha" => "2007" "volumen" => "116" "paginaInicial" => "39" "paginaFinal" => "48" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17576866" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0250" "etiqueta" => "20" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Impact of abdominal visceral and subcutaneous adipose tissue on cardiometabolic risk factors: the Jackson Heart Study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J. Liu" 1 => "C.S. Fox" 2 => "D.A. Hickson" 3 => "W.D. May" 4 => "K.G. Hairston" 5 => "J.J. Carr" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1210/jc.2010-1378" "Revista" => array:6 [ "tituloSerie" => "J Clin Endocrinol Metab" "fecha" => "2010" "volumen" => "95" "paginaInicial" => "5419" "paginaFinal" => "5426" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20843952" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0255" "etiqueta" => "21" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Visceral adipose tissue indicates the severity of cardiometabolic risk in patients with and without type 2 diabetes: results from the INSPIRE ME IAA Study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.D. Smith" 1 => "A.L. Borel" 2 => "J.A. Nazare" 3 => "S.M. Haffner" 4 => "B. Balkau" 5 => "R. Ross" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1210/jc.2011-2550" "Revista" => array:6 [ "tituloSerie" => "J Clin Endocrinol Metab" "fecha" => "2012" "volumen" => "97" "paginaInicial" => "1517" "paginaFinal" => "1525" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22337910" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib0260" "etiqueta" => "22" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Relation between visceral fat and coronary artery disease evaluated by multidetector computed tomography" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.D. Marques" 1 => "R.D. Santos" 2 => "J.R. Parga" 3 => "J.A. Rocha-Filho" 4 => "L.A. Quaglia" 5 => "M.H. Miname" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.atherosclerosis.2009.10.023" "Revista" => array:6 [ "tituloSerie" => "Atherosclerosis" "fecha" => "2010" "volumen" => "209" "paginaInicial" => "481" "paginaFinal" => "486" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19922936" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib0265" "etiqueta" => "23" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Assessing adiposity. A Scientific Statement from the American Heart Association" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.A. Cornier" 1 => "J.P. Després" 2 => "N. Davis" 3 => "D.A. Grossniklaus" 4 => "S. Klein" 5 => "B. Lamarche" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1161/CIR.0b013e318233bc6a" "Revista" => array:6 [ "tituloSerie" => "Circulation" "fecha" => "2011" "volumen" => "124" "paginaInicial" => "1996" "paginaFinal" => "2019" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21947291" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib0270" "etiqueta" => "24" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Strategies for reducing body fat mass: effects of liposuction and exercise on cardiovascular risk factors and adiposity" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "F.B. Benatti" 1 => "F.S. Lira" 2 => "L.M. Oyama" 3 => "C.M.P.O. Nascimento" 4 => "A.H. Lancha Junior" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2147/DMSO.S12143" "Revista" => array:6 [ "tituloSerie" => "Diabetes Metab Syndr Obes" "fecha" => "2011" "volumen" => "4" "paginaInicial" => "141" "paginaFinal" => "154" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21779146" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib0275" "etiqueta" => "25" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Absence of an effect of liposuction on insulin action and risk factors for coronary heart disease" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. Klein" 1 => "L. Fontana" 2 => "V.L. Young" 3 => "A.R. Coggan" 4 => "C. Kilo" 5 => "B.W. Patterson" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMoa033179" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "2004" "volumen" => "350" "paginaInicial" => "2549" "paginaFinal" => "2557" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15201411" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib0280" "etiqueta" => "26" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Modification of insulin, glucose and cholesterol levels in nonobese women undergoing liposuction: is liposuction metabolically safe?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J.A. Robles-Cervantes" 1 => "S. Yanez-Diaz" 2 => "L. Cardenas-Camarena" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/01.sap.0000096448.59407.43" "Revista" => array:6 [ "tituloSerie" => "Ann Plast Surg" "fecha" => "2004" "volumen" => "52" "paginaInicial" => "64" "paginaFinal" => "67" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14676702" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib0285" "etiqueta" => "27" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Suction-assisted lipectomy fails to improve cardiovascular metabolic markers of disease: a meta-analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. Danilla" 1 => "C. Longton" 2 => "K. Valenzuela" 3 => "G. Cavada" 4 => "H. Norambuena" 5 => "C. Tabilo" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.bjps.2013.07.001" "Revista" => array:6 [ "tituloSerie" => "J Plast Reconstr Aesthet Surg" "fecha" => "2013" "volumen" => "66" "paginaInicial" => "1557" "paginaFinal" => "1563" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23899478" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib0290" "etiqueta" => "28" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The role of depot fat in the hypothalamic control of food intake in the rat" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "G.C. Kennedy" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Proc R Soc Lond B Biol Sci" "fecha" => "1953" "volumen" => "140" "paginaInicial" => "578" "paginaFinal" => "596" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/13027283" "web" => "Medline" ] ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib0295" "etiqueta" => "29" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Leptin: a review of its peripheral actions and interactions" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "S. Margetic" 1 => "C. Gazzola" 2 => "G.G. Pegg" 3 => "R.A. Hill" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/sj.ijo.0802142" "Revista" => array:6 [ "tituloSerie" => "Int J Obes Relat Metab Disord" "fecha" => "2002" "volumen" => "26" "paginaInicial" => "1407" "paginaFinal" => "1433" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12439643" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib0300" "etiqueta" => "30" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Fat redistribution following suction lipectomy: defense of body fat and patterns of restoration" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "T.L. Hernandez" 1 => "J.M. Kittelson" 2 => "C.K. Law" 3 => "L.L. Ketch" 4 => "N.R. Stob" 5 => "R.C. Lindstrom" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Obesity (Silver Spring)" "fecha" => "2011" "volumen" => "19" "paginaInicial" => "1388" "paginaFinal" => "1395" ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15750922/0000006200000009/v1_201511180040/S1575092215001710/v1_201511180040/en/main.assets" "Apartado" => array:4 [ "identificador" => "8578" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Revisión" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/15750922/0000006200000009/v1_201511180040/S1575092215001710/v1_201511180040/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1575092215001710?idApp=UINPBA00004N" ]
año/Mes | Html | Total | |
---|---|---|---|
2024 Octubre | 48 | 1 | 49 |
2024 Septiembre | 104 | 9 | 113 |
2024 Agosto | 60 | 7 | 67 |
2024 Julio | 89 | 8 | 97 |
2024 Junio | 60 | 4 | 64 |
2024 Mayo | 66 | 9 | 75 |
2024 Abril | 80 | 14 | 94 |
2024 Marzo | 107 | 13 | 120 |
2024 Febrero | 126 | 14 | 140 |
2024 Enero | 124 | 19 | 143 |
2023 Diciembre | 129 | 17 | 146 |
2023 Noviembre | 137 | 13 | 150 |
2023 Octubre | 178 | 24 | 202 |
2023 Septiembre | 107 | 10 | 117 |
2023 Agosto | 85 | 16 | 101 |
2023 Julio | 127 | 12 | 139 |
2023 Junio | 74 | 7 | 81 |
2023 Mayo | 113 | 11 | 124 |
2023 Abril | 92 | 19 | 111 |
2023 Marzo | 116 | 13 | 129 |
2023 Febrero | 74 | 8 | 82 |
2023 Enero | 106 | 9 | 115 |
2022 Diciembre | 71 | 20 | 91 |
2022 Noviembre | 88 | 9 | 97 |
2022 Octubre | 93 | 17 | 110 |
2022 Septiembre | 83 | 13 | 96 |
2022 Agosto | 79 | 17 | 96 |
2022 Julio | 88 | 14 | 102 |
2022 Junio | 68 | 21 | 89 |
2022 Mayo | 72 | 22 | 94 |
2022 Abril | 71 | 18 | 89 |
2022 Marzo | 88 | 15 | 103 |
2022 Febrero | 72 | 16 | 88 |
2022 Enero | 95 | 37 | 132 |
2021 Diciembre | 113 | 24 | 137 |
2021 Noviembre | 91 | 23 | 114 |
2021 Octubre | 97 | 17 | 114 |
2021 Septiembre | 87 | 26 | 113 |
2021 Agosto | 54 | 9 | 63 |
2021 Julio | 50 | 23 | 73 |
2021 Junio | 80 | 23 | 103 |
2021 Mayo | 91 | 13 | 104 |
2021 Abril | 198 | 64 | 262 |
2021 Marzo | 102 | 19 | 121 |
2021 Febrero | 105 | 12 | 117 |
2021 Enero | 107 | 23 | 130 |
2020 Diciembre | 97 | 20 | 117 |
2020 Noviembre | 149 | 29 | 178 |
2020 Octubre | 93 | 24 | 117 |
2020 Septiembre | 98 | 51 | 149 |
2020 Agosto | 143 | 40 | 183 |
2020 Julio | 142 | 29 | 171 |
2020 Junio | 154 | 32 | 186 |
2020 Mayo | 270 | 49 | 319 |
2020 Abril | 319 | 59 | 378 |
2020 Marzo | 239 | 22 | 261 |
2020 Febrero | 192 | 25 | 217 |
2020 Enero | 194 | 41 | 235 |
2019 Diciembre | 181 | 33 | 214 |
2019 Noviembre | 206 | 32 | 238 |
2019 Octubre | 230 | 31 | 261 |
2019 Septiembre | 165 | 26 | 191 |
2019 Agosto | 118 | 14 | 132 |
2019 Julio | 99 | 35 | 134 |
2019 Junio | 156 | 25 | 181 |
2019 Mayo | 356 | 46 | 402 |
2019 Abril | 165 | 5 | 170 |
2019 Marzo | 61 | 23 | 84 |
2019 Febrero | 57 | 17 | 74 |
2019 Enero | 53 | 17 | 70 |
2018 Diciembre | 34 | 4 | 38 |
2018 Noviembre | 46 | 4 | 50 |
2018 Octubre | 115 | 8 | 123 |
2018 Septiembre | 112 | 8 | 120 |
2018 Agosto | 87 | 3 | 90 |
2018 Julio | 32 | 2 | 34 |
2018 Junio | 47 | 4 | 51 |
2018 Mayo | 37 | 5 | 42 |
2018 Abril | 39 | 8 | 47 |
2018 Marzo | 40 | 4 | 44 |
2018 Febrero | 22 | 5 | 27 |
2018 Enero | 26 | 5 | 31 |
2017 Diciembre | 24 | 12 | 36 |
2017 Noviembre | 27 | 4 | 31 |
2017 Octubre | 35 | 7 | 42 |
2017 Septiembre | 48 | 10 | 58 |
2017 Agosto | 44 | 8 | 52 |
2017 Julio | 40 | 4 | 44 |
2017 Junio | 55 | 5 | 60 |
2017 Mayo | 54 | 5 | 59 |
2017 Abril | 38 | 4 | 42 |
2017 Marzo | 26 | 21 | 47 |
2017 Febrero | 58 | 1 | 59 |
2017 Enero | 20 | 0 | 20 |
2016 Diciembre | 33 | 4 | 37 |
2016 Noviembre | 47 | 7 | 54 |
2016 Octubre | 63 | 8 | 71 |
2016 Septiembre | 57 | 7 | 64 |
2016 Agosto | 37 | 6 | 43 |
2016 Julio | 32 | 3 | 35 |
2016 Junio | 47 | 13 | 60 |
2016 Mayo | 30 | 17 | 47 |
2016 Marzo | 0 | 1 | 1 |
2016 Febrero | 0 | 2 | 2 |
2016 Enero | 0 | 1 | 1 |
2015 Diciembre | 0 | 1 | 1 |
2015 Noviembre | 8 | 9 | 17 |