covid
Buscar en
Endocrinología y Nutrición
Toda la web
Inicio Endocrinología y Nutrición Obesidad y síndrome metabólico en la infancia
Información de la revista
Vol. 52. Núm. 2.
Páginas 65-74 (febrero 2005)
Compartir
Compartir
Descargar PDF
Más opciones de artículo
Vol. 52. Núm. 2.
Páginas 65-74 (febrero 2005)
Curso de la SEEN
Acceso a texto completo
Obesidad y síndrome metabólico en la infancia
Obesity and metabolic syndrome in childhood
Visitas
5128
R. Barrio
Autor para correspondencia
rbarrio.hrc@salud.madrid.org

Correspondencia: Raquel Barrio. Hospital Ramón y Cajal Madrid. España.
, M. López-Capapé, E. Colino, C. Mustieles, M. Alonso
Unidad de Endocrinología y Diabetes Pediátrica. Hospital Ramón y Cajal. Universidad de Alcalá. Madrid. España
Este artículo ha recibido
Información del artículo

La obesidad está aumentando de manera ostensible en el niño y en el adolescente en la última década en todos los países. En estos pacientes, sobre todo los de ciertas etnias, se han comenzado a encontrar alteraciones del metabolismo hidrocarbonado y se ha llegado incluso a presentar diabetes tipo 2. También muestran signos precoces de insulinorresistencia y factores de riesgo cardiovascular. La presencia de diferentes factores de riesgo tiene un efecto aditivo.

Palabras clave:
Diabetes tipo 2
Obesidad
Insulinorresistencia
Factores de riesgo cardiovascular
Infancia
Adolescencia

In the last decade, overweight and obesity have increased in children and adolescents in all countries. These patients, especially those from certain ethnic groups, are now being diagnosed with impaired glucose tolerance and even type 2 diabetes. Early signs of insulin resistance syndrome and cardiovascular risk are also present. These risk factors appear to act in an additive fashion.

Key words:
Type 2 diabetes
Obesity
Insulin resistance
Cardiovascular risk factors
Childhood
Adolescence
El Texto completo está disponible en PDF
Bibliografía
[1.]
J. Miller, A. Rosenbloom, J. Silverstein.
Childhood obesity.
J Clin Endocrinol Metab, 89 (2004), pp. 4211-4218
[2.]
K.M. Flegal, M.D. Carroll, C.l. Ogden, C.L. Jonson.
Prevalence and trends in obesity among US adults, 1999-2000.
JAMA, 288 (2002), pp. 1723-1727
[3.]
C.L. Ogden, K.M. Flegal, M.D. Carroll, C.L. Jonson.
Prevalence and trends in overweight among US children and adolescents, 1999-2000.
JAMA, 288 (2002), pp. 1728-1732
[4.]
A.A. Hedley, C.L. Ogden, C.L. Johnson, M.D. Carroll, L.R. Curtin, K.M. Flegal.
Prevalence of overweight and obesity among US children, adolescents and adults, 1999-2002.
JAMA, 291 (2004), pp. 2847-2850
[5.]
H. Thibault, M.F. Rolland-Cachera.
Prevention strategies of childhood obesity.
Arch Pediatr, 10 (2003), pp. 1100-1108
[6.]
R.J. Deckelbaum, C.L. Williams.
Childhood obesity: the health issue.
Obes Rev, 9 (2001), pp. S239-S243
[7.]
R.J. Kuczmarski, M.D. Carroll, K.M. Flegal, R.P. Troyano.
Varying body mass index cut-off points to describe overweight prevalence among US adults: NHANES III (1988 to 1994).
Obes Res, 5 (1997), pp. 542-548
[8.]
C. Maffeis, P. Moghetti, A. Grezzani, M. Clementi, R. Gaudino, L. Tato.
Insulin resistance and the persistence of obesity from childhood into adulthood.
J Clin Endocrinol Metab, 87 (2002), pp. 71-76
[9.]
D.J. Gunnell, S.J. Frankel, K. Nanchahal, T.J. Peters, G. Davey Smith.
Childhood obesity and adult cardiovascular, mortality: a 57 y follow-up study based on the Boyd Orr cohort.
Am J Clin Nutr, 67 (1998), pp. 1111-1118
[10.]
M.B. Livingstone, P.J. Robson, J.M. Wallace, M.C. McKinley.
How active are we? Levels of routine physical activity in children and adults.
Proc Nutr Soc, 62 (2003), pp. 681-701
[11.]
P. Poulsen, A. Vaag.
The impact of genes and pre and postnatal environment on the metabolic syndrome. Evidence from twin studies.
Panminerva Med, 45 (2003), pp. 109-115
[12.]
W.H. Dietz, T.N. Robinson.
Use of the body mass index as a measure of overweight in children and adolescent.
J Pediatr, 132 (1998), pp. 191-193
[13.]
T. Cole, M. Bellizzi, K. Flegal, W.H. Dietz.
Establishing a standard definition for child overweight and obesity worldwide: international survey.
BMJ, 320 (2000), pp. 1240-1243
[14.]
S. Ten, N. Maclaren.
Insulin resistance syndrome in children.
J Clin Endocrinol Metab, 89 (2004), pp. 2526-2539
[15.]
S.M. Grundy, H.B. Brewer Jr, J.I. Cleeman, S.C. Smith Jr, C. Lenfant.
Definition of metabolic syndrome: report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition.
Arterioscler Throm Vas Biol, 24 (2004), pp. E13-E18
[16.]
S.E. Ozane, C.N. Hales.
Early programming of glucose-insulin metabolism.
Trends Endocrinol Metab, 13 (2002), pp. 368-373
[17.]
National Cholesterol Education Panel (NCEP) Adult Treatment Panel III (ATP III). JAMA. 2001;285:2486.
[18.]
S. Cook, M. Weitzman, P. Auinger, M. Nguyen, W.H. Dietz.
Prevalence of a metabolic syndrome phenotype in adolescents. Findings from the Third National Health and Nutrition Examination Survey, 1988-1994.
Arch Pediatr Adolesc Med, 157 (2003), pp. 821-827
[19.]
M.I. Goran, G.D.C. Ball, M.L. Cruz.
Cardiovascular endocrinology 2: obesity and risk of type 2 diabetes and cardiovascular disease in children and adolescents.
J Clin Endocrinol Metab, 88 (2003), pp. 1417-1427
[20.]
J. Steinberger.
Diagnosis of the metabolic syndrome in children.
Curr Opin Lipidol, 14 (2003), pp. 555-559
[21.]
G.S. Berenson, Sr. Srinivasan, W.A. Wattigney, D.W. Harsha.
Obesity and cardiovascular risk in children.
Ann NY Acad Sci, 699 (1993), pp. 93-100
[22.]
D.S. Freedman, W. Dietz, S.R. Srinivasan, G.S. Berenson.
The relation of overweight to cardiovascular risk factors among children and adolescents: the Bogalusa Heart Study.
Pediatrics, 103 (1999), pp. 1175-1182
[23.]
E.S.G. Ford.
Prevalence of the metabolic syndrome among US adults: findings from the Third National Health and Nutrition Examination Survey.
JAMA, 287 (2002), pp. 356-359
[24.]
R. Weiss, J. Dziura, T.S. Burgert, W.V. Tamborlane, S.E. Taksali, C.W. Yeckel, et al.
Obesity and the metabolic syndrome in children and adolescents.
N Engl J Med, 350 (2004), pp. 2362-2374
[25.]
J. Steinberger.
Insulin resistance and cardiovascular risk in the pediatric patient.
Prog Pediatr Cardiol, 12 (2002), pp. 169-175
[26.]
T. McLaughlin, F. Abbasi, K. Cheal, J. Chu, C. Lamendola, G. Reaven.
Use of metabolic markers to identify overweight individuals who are insulin resistant.
Ann Intern Med, 139 (2003), pp. 802-809
[27.]
Reaven GM. Insulin resistance, compensatory hyperinsulinemia, and coronary heart disease syndrome X revisited. En: Jefferson LS, Cherrington AD, editors. Handbook of physiology: Section 7. The Endocrine System. Vol II. The Endocrine Pancreas and Regulation of Metabolism. Oxford: Oxford University Press; 2001. p. 1169-97.
[28.]
S. Lillioja, D.M. Mott, M. Spraul, R. Ferraro, J.E. Foley, E. Ravussin, et al.
Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. Prospective studies of Pima Indians.
N Engl J Med, 329 (1993), pp. 1988-1992
[29.]
I. Zavaroni, I. Bonni, P. Gasparini, A.L. Barilli, A. Zuccarelli, E. DallÁglio, et al.
Hyperinsulinemia in normal population as a predictor of non-insulin-dependent diabetes mellitus, hypertension and coronary heart disease; the Barilla factory revisited.
Metabolism, 48 (1999), pp. 989-994
[30.]
J.F. Ascaso, S. Pardo, J.T. Real, R.I. Lorente, A. Priego, R. Carmena.
Diagnosis insulin resistance by simple quantitative methods in subjects with normal glucose metabolism.
Diabetes Care, 26 (2003), pp. 3320-3325
[31.]
Expert Committee on Diagnosis and Classification of Diabetes Mellitus. Follow-up report on the diagnosis of diabetes. Diabetes Care. 2003;26:3160-7.
[32.]
F. Jeppensen, H.O. Hein, P. Suadicani, F. Gyntelberg.
Low triglycerides-high density lipoprotein cholesterol and risk ischemic heart disease.
Arch Intern Med, 161 (2001), pp. 361-366
[33.]
S.A. Amiel, R.S. Sherwin, D.C. Simonson, A.A. Lauritano, W.V. Tamborlane.
Impaired insulin action in puberty: a contributing factors to poor glycemic control in adolescents with diabetes.
N Engl J Med, 315 (1986), pp. 215-219
[34.]
M.L. Cruz, M. Weigensberg, T. Huang, G. Ball, G. Shabi, M. Goran.
The metabolic syndrome in overweight hispanic youth and the role of insulin sensitivity.
J Clin Endocrinol Metab, 89 (2004), pp. 108-113
[35.]
S. Arslanian.
Type 2 diabetes in children: clinical aspects and risk factors.
Horm Res, 57 (2002), pp. 19-28
[36.]
R. Lipton, H. Keenan, K.U. Onyemere, S. Freels.
Incidence and onset features of diabetes in African-American and Latino children in Chicago, 1985-1994.
Diabetes Metab Res Rev, 18 (2002), pp. 135-142
[37.]
R. Bonadonna, L. Groop, N. Kraemer, R.A. DeFronzo.
Obesity and insulin resistance in man: a dose response study.
Metabolism, 39 (1990), pp. 452-459
[38.]
O. Pinhas-Hamiel, L.M. Dolan, S.R. Daniels, D. Standiford, P.R. Khoury, P. Zeitler.
Increased incidence of non-insulin-dependent diabetes mellitus among adolescents.
J Pediatr, 128 (1996), pp. 608-615
[39.]
R. Sinha, G. Fish, B. Teague, W.V. Tamborlane, B. Banyas, K. Allen, et al.
Prevalence of impaired glucose tolerance among children and adolescents with marked obesity.
N Engl J Med, 346 (2002), pp. 802-810
[40.]
E.P. Paulsen, L. Richenderfer, F. Ginsberg-Fellner.
Plasma glucose, free fatty acids and immunoreactive insulin in sixty-six obese children.
Diabetes, 17 (1968), pp. 261-269
[41.]
S.R. Srinivasan, M.G. Frontón, G.S. Berenson.
Longitudinal changes in risk variables of insulin resistance syndrome from childhood to young adulthood in offspring of parents with type 2 diabetes: the Begolusa Heart study.
Metabolism, 52 (2003), pp. 443-450
[42.]
M.I. Goran, R.N. Bergman, Q. Ávila, M. Watkins, G. Ball, G.Q. Shaibi, et al.
Impaired glucose tolerance and reduced b-cell function in overweight latino children with a positive family history for type 2 diabetes.
J Clin Endocrinol Metab, 89 (2004), pp. 207-212
[43.]
P.H. Davis, J.D. Dawson, W.A. Riley, R.M. Lauer.
Carotid intimalmedial thickness is related to cardiovascular risk factors measured fron childohood through middle age: the Muscatin Study.
Circulation, 104 (2001), pp. 2815-2819
[44.]
G.S. Berenson, Sr. Srinivasan, W. Bao, W.P. Newman 3rd, R.E. Tracy, W.A. Watligney.
Association between multiple cardiovascular risk factors and atherosclerosis in children and young adults.
N Engl J Med, 338 (1998), pp. 1650-1656
[45.]
C.L. Willians, L.L. Hayman, S.R. Daniels, T.N. Robinson, J. Steinberger, S. Paridon, et al.
Cardiovascular health in childhood: a statement for health professionals from the Committee on Atherosclerosis, Hypertension, and obesity in the Young (AHOY) of the Council on cardiovascular disease in young. American Heart Association.
Circulation, 106 (2002), pp. 143-160
[46.]
J. Steinberger, S.R. Daniels.
Obesity, insulin resistance, diabetes, and cardiovascular risk in children: an American Heart Association scientific statement from the Atherosclerosis, Hypertension, and Obesity in the Young Committee (Council on Cardiovascular Disease in the Young) and the Diabetes Committee (Council on Nutrition, Physical Activity and Metabolism).
Circulation, 107 (2003), pp. 1448-1453
[47.]
M.I. Goran, B.A. Gower.
Relation between visceral fat and disease risk in children.
Am J Clin Nutr, 70 (1999), pp. S149-S156
[48.]
J.M. Kotchen, T.A. Kotchen, G.P. Guthrie, D.M. Cottrill, H.E. McKean.
Correlates of adolescent blood pressure at five year follow-up.
Hypertension, 2 (1980), pp. 124-129
[49.]
H.C. McGill, C.A. McMahan, E.E. Herderick, A.W. Zieske, G.T. Malcom, R.E. Tracy, Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Research Group, et al.
Obesity accelerates the progression of coronary atherosclerosis in young men.
Circulation, 105 (2002), pp. 2712-2718
[50.]
M.D. Becque, V.L. Katch, A.P. Rocchinni, C.R. Marks, C. Moorehead.
Coronary risk incidence of obese adolescents: reduction by exercise plus diet intervention.
Pediatrics, 81 (1988), pp. 605-612
[51.]
R. Tracy, W.P. Newman 3rd, W.A. Wattihney, G.S. Berenson.
Risk factors and atherosclerosis in youth autopsy findings of the Bogalusa Heart Study.
Am J Med Sci, 310 (1995), pp. S37-41
[52.]
M.A. Ferguson, B. Gutin, S. Owens, M. Litaker, R.P. Tracy, J. Allison.
Fat distribution and hemostatic measures in obese children.
Am J Clin Nutr, 67 (1998), pp. 1136-1140
[53.]
Update on the 1987 Task Force Report on High Blood Pressure in Children and Adolescents: a working group report from the National High Blood Pressure Education Program. National High Blood Pressure Education Program Working Group on Hipertensión Control in Children and Adolescents. Pediatrics. 1996;98:649-58.
[54.]
J. Sorof, S. Daniels.
Obesity hypertension in children: a problem of epidemic proportions.
Hypertension, 40 (2002), pp. 441-447
[55.]
A.R. Sinaiko, J. Steinberger, A.M. Moran, R.J. Prineas, D.R. Jacobs Jr.
Relation of insulin resistance to blood pressure in childhood.
J Hypertens, 20 (2002), pp. 509-517
[56.]
R. Kohen-Avramoglu, A. Theriault, K. Adeli.
Emergence of the metabolic syndrome in childhood: an epidemiological overview and mechanistic link to dyslipemia.
Clinical Biochemistry, 36 (2003), pp. 413-420
[57.]
S.R. Srinivasan, M. Myers, G.S. Berenson.
Predictability of childhood adiposity and insulin for developing insulin resistance syndrome in young adulthood: the Bogalusa Heart Study.
Diabetes, 51 (2002), pp. 204-209
[58.]
S. Arslanian, C. Suprasongsin.
Insulin sensitivity, lipids and body composition in childhood: is “syndrome X” present?.
J Clin Endocrinol Metab, 81 (1996), pp. 1058-1062
[59.]
D. Einhorm.
American College of Endocrinology Position Statement on the insulin resistant syndrome.
Endocr Pract, 9 (2003), pp. 7-19
Copyright © 2005. Sociedad Española de Endocrinología y Nutrición
Opciones de artículo
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos