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Vol. 58. Núm. 5.
Páginas 236-242 (mayo 2011)
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Vol. 58. Núm. 5.
Páginas 236-242 (mayo 2011)
Acceso a texto completo
Efficacy of oral supplementation during dialysis in patients with chronic renal failure
Eficacia de la suplementación oral intradiálisis en pacientes con insuficiencia renal crónica
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Pilar Riobó Servána,
Autor para correspondencia
priobo@telefonica.net

Corresponding author.
, Alberto Ortiz Arduanb
a Jefe Asociado del Servicio de Endocrinología y Nutrición, Fundación Jiménez Díaz, Madrid, Spain
b Jefe Asociado del Servicio de Nefrología, Fundación Jiménez Díaz, Madrid, Spain
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Abstract

Protein-calorie malnutrition is common in hemodialysis patients and is a powerful predictor of morbidity and mortality. Nutritional supplementation, administered orally or parenterally, especially during dialysis, may compensate for a relatively inadequate protein and energy intake and improve net protein anabolism in chronic hemodialysis patients. Intradialytic oral nutrition seems preferable to intradialytic parenteral nutrition (IDPN) due to its lower cost and the persistence of its anabolic effects after infusion is stopped, and because IDPN induces a higher increase in serum glucose and insulin levels and a greater reduction in serum ghrelin concentrations. Further larger scale randomized, controlled trials of nutritional interventions should be performed in maintenance dialysis patients to assess their efficacy in terms of quality of life, morbidity, and mortality.

Keywords:
Protein-energy wasting
Hemodialysis
Morbidity and mortality
Nutritional supplementation
Anabolism
Nutritional therapy
Intradialytic parenteral nutrition
Intradialytic oral nutrition
Resumen

En los pacientes en hemodiálisis (HD) es frecuente la malnutrición calórico-proteica y además es un buen predictor de la morbilidad y mortalidad. La suplementación nutricional mediante la administración oral o parenteral especialmente en el momento de la diálisis puede compensar la ingesta inadecuada de proteínas y de energía y mejorar el anabolismo proteico neto en los pacientes en hemodiálisis crónica. Pero la vía oral parece ser preferible debido al menor coste, a que sus efectos anabólicos persisten una vez que la infusión ha cesado, y a que la nutrición parenteral intradiálisis produce una mayor elevación de las concentraciones de glucemia e insulina séricas, y una mayor reducción de las concentraciones de ghrelina. Son necesarios más estudios sobre las diferentes intervenciones nutricionales en los pacientes de diálisis, para evaluar su eficacia en cuanto a calidad de vida, morbilidad y mortalidad.

Palabras clave:
Malnutrición calóricoproteica
Morbilidad
Mortalidad
Suplementación nutricional
Tratamiento nutricional
Nutrición parenteral intradiálisis
Nutrición oral intradiálisis
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