metricas
covid
Buscar en
Enfermedades Infecciosas y Microbiología Clínica
Toda la web
Inicio Enfermedades Infecciosas y Microbiología Clínica Uso prudente de antibióticos y propuestas de mejora desde la atención primaria
Información de la revista
Vol. 28. Núm. S4.
Uso prudente de antimicrobianos
Páginas 17-22 (noviembre 2010)
Compartir
Compartir
Descargar PDF
English PDF
Más opciones de artículo
Vol. 28. Núm. S4.
Uso prudente de antimicrobianos
Páginas 17-22 (noviembre 2010)
Acceso a texto completo
Uso prudente de antibióticos y propuestas de mejora desde la atención primaria
Prudent use of antibiotics and suggestions for improvement in the primary health care system
Visitas
5327
Carles Llor
Centro de Salud Jaume I, Universidad Rovira i Virgili, Tarragona, España
Este artículo ha recibido
Información del artículo
Resumen

Una tercera parte de las consultas en atención primaria (AP) obedece a una enfermedad infecciosa y en más de la mitad de éstas se debe a una infección del tracto respiratorio. Los datos procedentes de la historia clínica y de la exploración física no ayudan, en la mayoría de las ocasiones, a discernir si la etiología de la infección es bacteriana o no y, en caso de duda, el médico de familia acostumbra a prescribir antibióticos a pesar del efecto marginal de estos medicamentos en la mayoría de las infecciones respiratorias. Además, los médicos de AP sobrestimamos la proporción de pacientes con infecciones que esperan recibir un antibiótico y, a menudo, esta percepción resulta ser errónea basándose en la literatura científica. Además, las expectativas de los pacientes suelen basarse en falsas asunciones o experiencias de consultas previas. Distintas estrategias han resultado ser útiles para hacer un uso más prudente de antibióticos en AP. La prescripción diferida de antibióticos se recomienda principalmente en infecciones no graves de supuesta etiología viral en los pacientes que manifiestan su preferencia por recibir antibióticos. La mejora de las habilidades comunicativas también ha mostrado ser útil para reducir la prescripción antibiótica así como la utilización de pruebas de diagnóstico rápido en la consulta, principalmente técnicas antigénicas rápidas para el diagnóstico de la faringitis estreptocócica y la determinación de la proteína C reactiva. Los resultados del estudio Happy Audit, realizado recientemente en nuestro país, así lo confirman.

Palabras clave:
Atención primaria
Prescripción diferida de antibióticos
Pruebas de diagnóstico rápido
Uso racional
Abstract

A third of all primary care (PC) visits are due to infectious diseases and more than half of these are due to respiratory tract infections. In most cases, data from the clinical history and physical examinations do not help discern whether the aetiology of the infection is bacterial or not and, when in doubt, the family doctor tends to prescribe antibiotics despite the marginal effect that these drugs have on most respiratory infections. Moreover, PC physicians overestimate the proportion of patients with infections who expect to receive antibiotics and according to the scientific literature this perception is often wrong. In addition, patient expectations are often based on false assumptions or experiences from previous visits. Various strategies have proven useful in promoting more prudent use of antibiotics in PC. Delayed prescription of antibiotics is recommended mainly in non-serious infections of suspected viral aetiology in patients who express a preference for antibiotics. Improving communication skills has also proven useful in reducing prescriptions of antibiotics as has the use of rapid diagnostic tests in the doctor's office, mainly rapid antigen techniques for diagnosis of strep throat and determination of C-reactive protein. The results of the Happy Audit study recently conducted in Spain confirm these findings.

Keywords:
Primary health care
Delayed prescription of antibiotics
Rapid diagnostic tests
Prudent use
El Texto completo está disponible en PDF
Bibliografía
[1.]
C. Llor, S. Hernández.
Enfermedad infecciosa en atención primaria: estudio prospectivo efectuado durante un año.
Enferm Infecc Microbiol Clin, 28 (2010), pp. 222-226
[2.]
B. Arroll, T. Kenealy.
Antibiotics for the common cold.
Cochrane Database Syst Rev, 3 (2002), pp. CD000247
[3.]
C.B. Del Mar, P.P. Glasziou, A.B. Spinks.
Antibiotics for sore throat.
Cochrane Database Syst Rev, 2 (2004), pp. CD000023
[4.]
J. Smucny, T. Fahey, L. Becker, R. Glazier.
Antibiotics for acute bronchitis.
Cochrane Database Syst Rev, 4 (2004), pp. CD000245
[5.]
P.P. Glasziou, C.B. Del Mar, S.L. Sanders, M. Hayem.
Treatment for acute otitis media in children.
Cochrane Database Syst Rev, 1 (2004), pp. CD000219
[6.]
J. Young, A. De Sutter, D. Merenstein, G.A. Van Essen, L. Kaiser, H. Varonen, et al.
Antibiotics for adults with clinically diagnosed acute rhinosinusitis: a meta-analysis of individual patient data.
[7.]
C. Llor, J.M. Cots, L. Bjerrum, M. Cid, G. Guerra, X. Arranz, Grupo de estudio Happy Audit España, et al.
Prescripción de antibióticos en las infecciones del tracto respiratorio y factores predictores de su utilización.
Aten Primaria, 42 (2010), pp. 28-35
[8.]
V. Palop Larrea, A. Melchor Penella, I. Martínez Mir.
Reflexiones sobre la utilización de antibióticos en atención primaria.
Aten Primaria, 32 (2003), pp. 42-47
[9.]
C.C. Butler, S. Rollnick, P. Kinnersley, A. Jones, N.C.H. Stott.
Reducing antibiotics for respiratory tract symptoms in primary care; consolidating ‘why’ and considering ‘how’.
Br J Gen Pract, 48 (1998), pp. 1865-1870
[10.]
P.S. Little, C. Gould, I. Williamson, G. Warner, M. Gantley, A.L. Kinmonth.
Reattendance and complications in a randomised trial of prescribing strategies for sore throat: the medicalising effect of prescribing antibiotics.
BMJ, 315 (1997), pp. 350-352
[11.]
C.C. Butler, S. Rollnick, F. Maggs-Rapport, R.M. Pill, N. Stott.
Understanding the culture of prescribing: qualitative study of general practitioners’ and patients’ perceptions of antibiotics for sore throats.
BMJ, 317 (1998), pp. 637-642
[12.]
C. Costelloe, C. Metcalfe, A. Lovering, D. Mant, A.D. Hay.
Effect of antibiotic 12 prescribing in primary care on antimicrobial resistance in individual patients: systematic review and meta-analysis.
BMJ, 340 (2010), pp. c2096
[13.]
L. Bjerrum, A. Boada, J.M. Cots, C. Llor, D. Fores García, B. Gahrn-Hansen, et al.
Respiratory tract infections in general practice: considerable differences in prescribing habits between general practitioners in Denmark and Spain.
Eur J Clin Pharmacol, 60 (2004), pp. 23-28
[14.]
A. Yagüe.
Variabilidad en la prescripción de antibióticos.
Enferm Infecc Microbiol Clin, 20 (2002), pp. 78-84
[15.]
N.P. Van Duijn, H.J. Brouwer, H. Lamberts.
Use of symptoms and signs to diagnose maxillary sinusitis in general practice: comparison with ultrasonography.
BMJ, 305 (1992), pp. 684-687
[16.]
A.L. Bisno, M.A. Gerber, J.M. Gwaltney, E.L. Kaplan, R.H. Schwartz.
Diagnosis and management of Group A streptococcal pharyngitis: A practice guideline.
Clin Infect Dis, 25 (1997), pp. 574-583
[17.]
Commission on Acute Respiratory Diseases.
Endemic exudative pharyngitis and tonsillitis. Etiology and clinical characteristics.
JAMA, 125 (1994), pp. 1161-1169
[18.]
M.H. Ebell, M.A. Smith, H.C. Barry, K. Ives, M. Carey.
The rational clinical examination. Does this patient have strep throat?.
JAMA, 284 (2000), pp. 2912-2918
[19.]
F.L. Van Buchem, M.F. Peeters, M.A. Van’t Hof.
Acute otitis media: a new treatment strategy.
BMJ, 290 (1985), pp. 1033-1037
[20.]
P. Diehr, R.W. Wood, J. Bushyhead, L. Krueger, B. Walcott, R.K. Tompkins.
Prediction of pneumonia in outpatients with acute cough--a statistical approach.
J Chronic Dis, 37 (1984), pp. 215-225
[21.]
H. Melbye, B. Straume, U. Aasebø, K. Dale.
Diagnosis of pneumonia in adults in general practice. Relative importance of typical symptoms and abnormal chest signs evaluated against a radiographic reference standard.
Scand J Prim Health Care, 10 (1992), pp. 226-233
[22.]
M.A. González Ortiz, M. Carnicero Bujarrabal, M. Varela Entrecanales.
Predicción de la presencia de neumonía en el adulto con fiebre.
Med Clin (Barc), 105 (1995), pp. 521-524
[23.]
R.M. Hopstaken, J.W. Muris, J.A. Knottnerus, A.D. Kester, P.E. Rinkens, G.J. Dinant.
Contributions of symptoms, signs, erythrocyte sedimentation rate, and C-reactive protein to a diagnosis of pneumonia in acute lower respiratory tract infection.
Br J Gen Pract, 53 (2003), pp. 358-364
[24.]
P. Saldías, D. Cabrera, I. De Solminihac, P. Hernández, A. Gederlini, A. Díaz.
Valor predictivo de la historia clínica y examen físico en el diagnóstico de neumonía del adulto adquirida en la comunidad.
Rev Med Chile, 135 (2007), pp. 143-152
[25.]
A. Khalil, G. Kelen, R.E. Rothman.
A simple screening tool for identification of community-acquired pneumonia in an inner city emergency department.
Emerg Med J, 24 (2007), pp. 336-338
[26.]
J.E. Wipf, B.A. Lipsky, J.V. Hirschmann, E.J. Boyko.
Diagnosing pneumonia by physical examination.
Arch Intern Med, 159 (1999), pp. 1082-1087
[27.]
P.S. Heckerling, T.G. Tape, R.S. Wigton, K.K. Hissong, J.B. Leikin, J.P. Ornato, et al.
Clinical prediction rule for pulmonary infiltrates.
Ann Intern Med, 113 (1990), pp. 664-670
[28.]
N. Summerton.
Making a diagnosis in primary care: symptoms and context.
Br J Gen Pract, 54 (2004), pp. 570-571
[29.]
R.M. Centor, J.M. Witherspoon, H.P. Dalton, C.E. Brody, K. Link.
The diagnosis of strep throat in adults in the emergency room.
Med Decis Making, 1 (1981), pp. 239-246
[30.]
N.C. Stott, R.R. West.
Randomised controlled trial of antibiotics in patients with cough and purulent sputum.
Br Med J, 2 (1976), pp. 556-559
[31.]
E. Miller, L.D. MacKeigan, W. Rosser, J. Marshman.
Effects of perceived patient demand on prescribing anti-infective drugs.
CMAJ, 161 (1999), pp. 139-142
[32.]
C. Ochoa, J.M. Eiros, L. Inglada, A. Vallano, L. Guerra.
Assessment of antibiotic prescription in acute respiratory infections in adults. The Spanish Group on Antibiotic Treatments.
J Infect, 41 (2000), pp. 73-83
[33.]
N. Britten, F.A. Stevenson, C.A. Barry, N. Barber, C.P. Bradley.
Misunderstandings in prescribing decisions in general practice: qualitative study.
BMJ, 320 (2000), pp. 484-488
[34.]
C.A. Barry, C.P. Bradley, N. Britten, F.A. Stevenson, N. Barber.
Patients’ unvoiced agendas in general practice consultations: qualitative study.
BMJ, 320 (2000), pp. 1246-1250
[35.]
R.L. Kravitz, D.W. Cope, V. Bhrany, B. Leake.
Internal medicine patients’ expectations for care during office visits.
J Gen Intern Med, 9 (1994), pp. 75-81
[36.]
J. Cockburn, S. Pit.
Prescribing behaviour in clinical practice: Patients’ expectations and doctors’ perceptions of patients’ expectations – a questionnaire study.
BMJ, 315 (1997), pp. 520-523
[37.]
N. Britten, O. Ukoumunne.
The influence of patients’ hopes of receiving a prescription on doctors’ perceptions and the decision to prescribe: a questionnaire survey.
BMJ, 315 (1997), pp. 1506-1510
[38.]
R. Mangione-Smith, E.A. McGlynn, M.N. Elliot, P. Krogstad, R.H. Brook.
The relationship between perceived parental expectations and pediatrician antimicrobial prescribing behaviour.
Pediatrics, 103 (1999), pp. 711-718
[39.]
P. Little, M. Dorward, G. Warner, K. Stephens, J. Senior, M. Moore.
Importance of patient pressure and perceived pressure and perceived medical need for investigations, referral, and prescribing in primary care: nested observational study.
[40.]
S. Coenen, B. Michiels, D. Renard, J. Denekens, P. Van Royen.
Antibiotic prescribing for acute cough: the effect of perceived patient demand.
Br J Gen Pract, 56 (2006), pp. 183-190
[41.]
D.C. Vinson, L.J. Lutz.
The effect of parental expectation on treatment of children with a cough: a report from ASPN.
J Fam Pract, 37 (1993), pp. 23-27
[42.]
J.T. MacFarlane, W.F. Holmes, R.M. Macfarlane.
Reducing reconsultations for acute lower respiratory tract illness with an information leaflet: a randomized controlled study of patients in primary care.
Br J Gen Pract, 47 (1997), pp. 719-722
[43.]
A.D. Hay, A. Wilson, T. Fahey, T.J. Peters.
The duration of acute cough in pre-school children presenting to primary care: a prospective cohort study.
Fam Pract, 20 (2003), pp. 696-705
[44.]
C.C. Butler, S. Rollnick, P. Kinnersley, L. Tapper-Jones, H. Houston.
Communicating about expected course and re-consultation for respiratory tract infections in children: an exploratory study.
Br J Gen Pract, 54 (2004), pp. 536-538
[45.]
S.R. Arnold, S.E. Straus.
Interventions to improve antibiotic prescribing practices in ambulatory care.
Cochrane Database Syst Rev, 4 (2005), pp. CD003539
[46.]
M. Gulliford, R. Latinovic, J. Charlton, P. Little, T. Van Staa, M. Ashworth.
Selective decrease in consultations and antibiotic prescribing for acute respiratory tract infections in UK primary care up to 2006.
J Public Health (Oxf), 31 (2009), pp. 512-520
[47.]
B. Arroll, T. Kenealy, F. Goodyear-Smith, N. Kerse.
Delayed prescriptions.
BMJ, 327 (2003), pp. 1361-1362
[48.]
G.K. Spurling, C.B. Del Mar, L. Dooley, R. Foxlee.
Delayed antibiotics for symptoms and complications of respiratory infections.
Cochrane Database Syst Rev, 4 (2004), pp. CD004417
[49.]
P. Little, K. Rumsby, J. Kelly, L. Watson, M. Moore, G. Warner, et al.
Information leaflet and antibiotic prescribing strategies for acute lower respiratory tract infection: a randomized controlled trial.
JAMA, 293 (2005), pp. 3029-3035
[50.]
J. Dowell, M. Pitkethly, J. Bain, S. Martin.
A randomised controlled trial of delayed antibiotic prescribing as a strategy for managing uncomplicated respiratory tract infection in primary care.
Br J Gen Pract, 51 (2001), pp. 200-205
[51.]
B. Arroll, T. Kenealy, N. Kerse.
Do delayed prescriptions reduce antibiotic use in respiratory tract infections? A systematic review.
Br J Gen Pract, 53 (2003), pp. 871-877
[52.]
P. Little, M.V. Moore, S. Turner, K. Rumsby, G. Warner, J.A. Lowes, et al.
Effectiveness of five different approaches in management of urinary tract infection: randomised controlled trial.
BMJ, 340 (2010), pp. c346
[53.]
C. Llor, S. Hernández, O. Calviño, A. Moragas.
Prescripción diferida de antibióticos en España.
Med Clin (Barc), 125 (2005), pp. 76
[54.]
J.W. Cals, C.C. Butler, R.M. Hopstaken, K. Hood, G.J. Dinant.
Effect of point of care testing for C reactive protein and training in communication skills on antibiotic use in lower respiratory tract infections: cluster randomised trial.
BMJ, 338 (2009), pp. b1374
[55.]
A. Altiner, S. Brockmann, M. Sielk, S. Wilm, K. Wegscheider, H.H. Abholz.
Reducing antibioitc prescriptions for acute cough by motivating GPs toc hange their attitudes to communication and empowering patients: a cluster-randomized intrevention study.
J Antimicrob Chemother, 60 (2007), pp. 638-644
[56.]
H.M. Smeets, M.M. Kuyvenhoven, A.E. Akkerman, I. Welschen, G.P. Schouten, G.A. Van Essen, et al.
Intervention with educational outreach at large scale to reduce antibiotics for respiratory tract infections: a controlled before and after study.
Fam Pract, 26 (2009), pp. 183-187
[57.]
S.A. Flanders, J. Stein, G. Shochat, K. Sellers, M. Holland, J. Maselli, et al.
Performance of a bedside C-reactive protein test in the diagnosis of community-acquired pneumonia in adults with acute cough.
Am J Med, 116 (2004), pp. 529-535
[58.]
V. Van der Meer, A.K. Neven, P.J. Van den Broek, W.J. Assendelft.
Diagnostic value of C reactive protein in infections of the lower respiratory tract: systematic review.
[59.]
G. Falk, T. Fahey.
C-reactive protein and community-acquired pneumonia in ambulatory care: systematic review of diagnostic accuracy studies.
Fam Pract, 26 (2009), pp. 10-21
[60.]
J.W.L. Cals, M.J.C. Chot, S.A.M. De Jong, G.J. Dinant, R.M. Hopstaken.
Point-of-care C-reactive proteína testing and antibiotic prescribing for respiratory tract infections: a randomized controlled trial.
Ann Fam Med, 8 (2010), pp. 124-133
[61.]
L. Bjerrum, B. Gahrn-Hansen, A.P. Munck.
C-reactive protein measurement in general practice may lead to lower antibiotic prescribing for sinusitis.
Br J Gen Pract, 54 (2004), pp. 659-662
[62.]
H.C. Maltezou, V. Tasgris, A. Antoniadou, L. Galani, C. Douros, I. Katsarolis, et al.
Evaluation of a rapid antigen detection test in the diagnosis of streptococcal pharyngitis in children and its impact on antibiotic prescription.
J Antimicrob Chemother, 62 (2008), pp. 1407-1412
[63.]
H.J. Kolmos, P. Little.
Controversies in management: should general practitioners perform diagnostic tests on patients before prescribing antibiotics?.
BMJ, 318 (1999), pp. 799-802
[64.]
C. Llor, S. Hernández, N. Sierra, A. Moragas, M. Hernández, C. Bayona.
Association between use of rapid antigen detection tests and adherence to antibiotics in suspected streptococcal pharyngitis.
Scand J Prim Health Care, 28 (2010), pp. 12-17
[65.]
L. Bjerrum, A. Munck, B. Gahrn-Hansen, M.P. Hansen, C. Llor, J.M. Cots, et al.
Health Alliance for Prudent Prescribing. Yield and Use of Antimicrobial Drugs in the Treatment of Respiratory Tract Infections (HAPPY AUDIT).
BMC Fam Pract, 11 (2010), pp. 29
[66.]
Llor C. La utilización de PCR y StrepA en atención primaria reduce la prescripción antibiótica en las infecciones del tracto respiratorio. Barcelona: XXIX Congreso de la Sociedad Española de Medicina de Familia y Comunitaria; 2009. p. 75.
[67.]
R. Finch, P.A. Hunter.
Antibiotic resistance - action to promote new technologies: report of an EU Intergovernmental Conference held in Birmingham, UK 12-13 December 2005.
J Antimicrob Chemother, 58 (2006), pp. i3-i22
Copyright © 2010. Elsevier España S.L.. Todos los derechos reservados
Descargar PDF
Opciones de artículo
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos