Estadísticas

 array:20 [
  "pii" => "X1665920109500693"
  "issn" => "16659201"
  "estado" => "S300"
  "fechaPublicacion" => "2009-07-01"
  "documento" => "article"
  "crossmark" => 0
  "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
  "subdocumento" => "fla"
  "cita" => "GAMO. 2009;8 Supl 3:68-77"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 2103
    "formatos" => array:3 [
      "EPUB" => 39
      "HTML" => 1368
      "PDF" => 696
    ]
  ]
  "itemSiguiente" => array:16 [
    "pii" => "X1665920109500708"
    "issn" => "16659201"
    "estado" => "S300"
    "fechaPublicacion" => "2009-07-01"
    "documento" => "article"
    "crossmark" => 0
    "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
    "subdocumento" => "fla"
    "cita" => "GAMO. 2009;8 Supl 3:78-80"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 1363
      "formatos" => array:3 [
        "EPUB" => 36
        "HTML" => 953
        "PDF" => 374
      ]
    ]
    "es" => array:10 [
      "idiomaDefecto" => true
      "titulo" => "Cardioprotección en el niño con síndrome de Down"
      "tienePdf" => "es"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "78"
          "paginaFinal" => "80"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Cardioprotection in Down syndrome"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Enrique López Aguilar"
          "autores" => array:1 [
            0 => array:2 [
              "nombre" => "Enrique"
              "apellidos" => "López Aguilar"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X1665920109500708?idApp=UINPBA00004N"
    "url" => "/16659201/00000008000000S3/v0_201306121413/X1665920109500708/v0_201306121413/es/main.assets"
  ]
  "itemAnterior" => array:16 [
    "pii" => "X1665920109500685"
    "issn" => "16659201"
    "estado" => "S300"
    "fechaPublicacion" => "2009-07-01"
    "documento" => "article"
    "crossmark" => 0
    "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
    "subdocumento" => "fla"
    "cita" => "GAMO. 2009;8 Supl 3:60-7"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 1872
      "formatos" => array:3 [
        "EPUB" => 34
        "HTML" => 1130
        "PDF" => 708
      ]
    ]
    "es" => array:10 [
      "idiomaDefecto" => true
      "titulo" => "Estrategias de prevención de cardiotoxicidad"
      "tienePdf" => "es"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "60"
          "paginaFinal" => "67"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Preventive strategies of cardiotoxicity"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Eduardo Meaney, Alejandra Meaney, Guillermo Ceballos"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "Eduardo"
              "apellidos" => "Meaney"
            ]
            1 => array:2 [
              "nombre" => "Alejandra"
              "apellidos" => "Meaney"
            ]
            2 => array:2 [
              "nombre" => "Guillermo"
              "apellidos" => "Ceballos"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X1665920109500685?idApp=UINPBA00004N"
    "url" => "/16659201/00000008000000S3/v0_201306121413/X1665920109500685/v0_201306121413/es/main.assets"
  ]
  "es" => array:11 [
    "idiomaDefecto" => true
    "titulo" => "Medición y monitorización del daño cardiaco por antraciclinas"
    "tieneTextoCompleto" => 0
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "68"
        "paginaFinal" => "77"
      ]
    ]
    "autores" => array:1 [
      0 => array:3 [
        "autoresLista" => "Eduardo Meaney, Alejandra Meaney, Guillermo Ceballos"
        "autores" => array:3 [
          0 => array:3 [
            "nombre" => "Eduardo"
            "apellidos" => "Meaney"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "affa"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Alejandra"
            "apellidos" => "Meaney"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "affa"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Guillermo"
            "apellidos" => "Ceballos"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "affb"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "1 Unidad cardiovascular, Hospital Regional Metropolitano 1º de Octubre, Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado (ISSSTE). México, DF. Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional. México, DF."
            "etiqueta" => "<span class="elsevierStyleSup">a</span>"
            "identificador" => "affa"
          ]
          1 => array:3 [
            "entidad" => "Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional. México, DF."
            "etiqueta" => "<span class="elsevierStyleSup">b</span>"
            "identificador" => "affb"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "en" => array:1 [
        "titulo" => "Measurement and monitorization of cardiac damage with anthracyclines"
      ]
    ]
    "pdfFichero" => "305v08nSupl.3a13150069pdf001.pdf"
    "tienePdf" => true
    "PalabrasClave" => array:2 [
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec176519"
          "palabras" => array:1 [
            0 => "antrac&#237;clicos&#44; doxorrubicina&#44; miocardiopat&#237;a dilatada&#44; insuficiencia cardiaca&#44; dexrazoxane&#44; M&#233;xico"
          ]
        ]
      ]
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec176520"
          "palabras" => array:1 [
            0 => "anthracyclines&#44; doxorubicin&#44; dilated cardiomyopathy&#44; heart failure&#44;dexrazoxane&#44; Mexico"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "es" => array:1 [
        "resumen" => "Los antrac&#237;clicos&#44; doxorubicina y sus an&#225;logos&#44; &#250;tiles en el tratamiento de ciertas neoplasias&#44; pueden producir cardiotoxicidad a&#241;os despu&#233;s de la exposici&#243;n&#46; El riesgo de insuficiencia cardiaca es dependiente de la dosis acumulada &#40;26&#37;-36&#37; con 550 mg&#47;m2&#41;&#44; y se incrementa por diversos factores como&#58; rapidez en la administraci&#243;n&#44; edades extremas&#44; g&#233;nero femenino&#44; raza negra&#44; s&#237;ndrome de Down&#44; radiaci&#243;n&#44; uso de otros antitumorales y ciertos polimorfismos&#46; La regeneraci&#243;n de semiquinona a quinona forma super&#243;xido&#44; que por acci&#243;n de la enzima dismutasa convierte en H2O2&#44; al que la catalasa &#40;escasa en el miocardio&#41; y peroxidasa de glutati&#243;n reducen a agua y ox&#237;geno molecular&#46; La oxidaci&#243;n forma alcohol de doxorrubicina y facilita la formaci&#243;n de complejos oxidantes antraciclinas-hierro que&#44; almacenados en el miocito&#44; da&#241;an e inducen apoptosis precedida por disfunci&#243;n asintom&#225;tica&#59; la miocardiopat&#237;a dilatada productora de insuficiencia cardiaca en ocasiones requiere de trasplante&#59; su manejo incluye&#58; evaluaci&#243;n cardiovascular&#44; y medici&#243;n basal por ecocardiograf&#237;a de la fracci&#243;n de expulsi&#243;n y posteriormente con el uso por a&#241;os de antrac&#237;clicos liposomales y pegilado&#44; bimestralmente realizar medici&#243;n peri&#243;dica del p&#233;ptido natriur&#233;tico cerebral y troponina&#44; y uso temprano de moduladores del eje reninaangiotensina&#46; El quelante dexrazoxane inhibe el da&#241;o de doxorrubicina-hierro y reduce la mortalidad cardiovascular en pacientes adultos y ni&#241;os&#44; sin que disminuya la actividad antitumoral de antraciclinas&#46;"
      ]
      "en" => array:1 [
        "resumen" => "Anthracyclines&#44; doxorubicin and its analogues&#44; useful in the treatment of certain neoplasias&#44; can produce cardiotoxicity years after drug exposition&#46; The risk of developing heart failure is dose-dependent &#40;26&#37;-36&#37; with 550 mg&#47;m2&#41;&#44; and increase further with velocity infusion&#44; extreme ages&#44; black race&#44; Down syndrome&#44; radiation therapy&#44; the use of other antitumoral drugs and some polymorphisms&#46; The regeneration of semiquinone moiety to quinone&#44; produces superoxide&#44; converted by superoxide dismutase in H2O2&#44; converted by catalase &#40;scarce in the myocardium&#41; and glutation peroxidase in water and molecular oxygen&#46; Oxidation builds-up alcohol compounds of doxorubicin and stimulates the production of oxidant anthracycline-iron compounds&#44; which are stored into the cardiac myocite&#44; damaging its structure and causing apoptosis&#46; Preceded by asymptomatic dysfunction&#44; dilated cardiomyopathy causes at last heart failure&#44; sometimes needing heart transplant&#46; Management includes basal cardiovascular evaluation and echocardiographic measurement of ejection fraction&#44; and afterward bianually serial evaluations&#44; for long time&#46; It is advisable the use of liposomales and pegylated anthracyclines formulations&#44; the serial measurement of brain natriuretic peptide and troponin&#44; as well an early use of renin angiotensin axis modulators&#46; Chelating agent dexrazoxane inhibits the damage of the doxorubicin-iron compounds&#44; reducing cardiovascular mortality in adults and children&#44; without interference with objective tumor response&#46;"
      ]
    ]
  ]
  "idiomaDefecto" => "es"
  "url" => "/16659201/00000008000000S3/v0_201306121413/X1665920109500693/v0_201306121413/es/main.assets"
  "Apartado" => array:4 [
    "identificador" => "11782"
    "tipo" => "SECCION"
    "es" => array:2 [
      "titulo" => "Gu&#237;as para la prevenci&#243;n de la cardiotoxicidad en oncolog&#237;a y hematolog&#237;a"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "es"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/16659201/00000008000000S3/v0_201306121413/X1665920109500693/v0_201306121413/es/305v08nSupl.3a13150069pdf001.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X1665920109500693?idApp=UINPBA00004N"
]