Concentraciones basales de gastrina y pepsinógeno I y II en la úlcera gástrica: influencia de la infección por Helicobacter pylori y utilidad en el control de la erradicación
Basal values of gastrin and pepsinogen I and II in gastric ulcer: Influence of helicobacter pylori infection and usefulness in detection of eradication
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"apellidos" => "Vaquero" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210570501789856?idApp=UINPBA00004N" "url" => "/02105705/0000002400000002/v1_201307171023/S0210570501789856/v1_201307171023/es/main.assets" ] "es" => array:13 [ "idiomaDefecto" => true "titulo" => "Concentraciones basales de gastrina y pepsinógeno I y II en la úlcera gástrica: influencia de la infección por <span class="elsevierStyleItalic">Helicobacter pylori</span> y utilidad en el control de la erradicación" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "56" "paginaFinal" => "62" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "F. Bermejo, D. Boixeda, J.P. Gisbert, J.M. Sanz, V. Defarges, G. Álvarez Calatayud, L. Moreno, C. Martín de Argila" "autores" => array:8 [ 0 => array:4 [ "nombre" => "F." "apellidos" => "Bermejo" "email" => array:1 [ 0 => "fbermejos@medynet.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "D." "apellidos" => "Boixeda" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "J.P." "apellidos" => "Gisbert" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "J.M." "apellidos" => "Sanz" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 4 => array:3 [ "nombre" => "V." "apellidos" => "Defarges" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 5 => array:3 [ "nombre" => "G." "apellidos" => "Álvarez Calatayud" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 6 => array:3 [ "nombre" => "L." "apellidos" => "Moreno" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 7 => array:3 [ "nombre" => "C." "apellidos" => "Martín de Argila" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Gastroenterología. Hospital Ramón y Cajal. Madrid" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Gastroenterología. Hospital La Princesa. Madrid" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Correspondencia: Ríos Rosas, 17, 5.° C. 28003 Madrid." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Basal values of gastrin and pepsinogen I and II in gastric ulcer: Influence of <span class="elsevierStyleItalic">helicobacter pylori</span> infection and usefulness in detection of eradication" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2000-05-23" "fechaAceptado" => "2000-09-04" "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Valorar la influencia de la erradicación de <span class="elsevierStyleItalic">Helicobacter pylori</span> sobre las concentraciones basales de gastrina y pepsinógeno I y II en pacientes con úlcera gástrica, realizando un seguimiento de un año, así como estudiar la utilidad de estas determinaciones para confirmar la erradicación de <span class="elsevierStyleItalic">H. pylori</span> tras el tratamiento.</p> <span class="elsevierStyleSectionTitle">Métodos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se estudiaron prospectivamente 56 ulcerosos gástricos con infección por <span class="elsevierStyleItalic">H. pylori</span>. Al inicio se realizó endoscopia con biopsias para estudio histológico y test de ureasa, prueba del aliento con 13C-urea y extracción de sangre para la determinación de gastrina y pepsinógeno I y II (mediante radioinmunoanálisis) y serología. La histología, la prueba del aliento y las determinaciones analíticas se repitieron transcurridos 1, 6 y 12 meses de la finalización del tratamiento erradicador.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">La erradicación se obtuvo en el 82,1% de los casos. En aquellos pacientes en los que se erradicó <span class="elsevierStyleItalic">H. pylori</span>, el valor medio de gastrina al inicio fue de 75,5 ± 39,1 pg/ml, mientras que al mes de la finalización del tratamiento descendió hasta 49,2 ± 21 pg/ml (p < 0,0001) sin evidenciarse posteriores descensos. En el caso del pepsinógeno I y II los valores iniciales fueron de 104 ± 58 y 15,8 ± 10 ng/ml, respectivamente, mientras que al mes disminuyeron a 77 ± 42 y 7,3 ± 4 ng/ml, respectivamente (p < 0,0001) y a los 6 meses a 72 ± 41 y 6,7 ± 3 ng/ml, respectivamente (p < 0,01), sin objetivarse posteriores variaciones. El área bajo la curva ROC para el diagnóstico de la erradicación mediante el descenso de los valores hormonales fue de 0,70 para la gastrina, 0,78 para el pepsinógeno I, 0,93 para el pepsinógeno II y 0,92 para el cociente pepsinógeno I/II. Transcurridos 6 y 12 meses de la finalización del tratamiento se demostraron diferencias (p < 0,05) entre las cifras medias de gastrina y pepsipepsinógeno I y II de los pacientes con histología normal y las de aquellos que presentaban gastritis crónica.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">a)</span> la erradicación de <span class="elsevierStyleItalic">H. pylori</span> se asocia con un descenso precoz en las concentraciones basales de gastrina y un descenso progresivo en las concentraciones basales de pepsinógeno I y II; <span class="elsevierStyleItalic">b)</span> en los pacientes con úlcera gástrica la comprobación del descenso en las concentraciones basales de pepsinógeno II es un método útil, precoz e indirecto para la confirmación de la erradicación, y <span class="elsevierStyleItalic">c)</span> los valores de gastrina y pepsinógeno I y II podrían ser útiles en la estimación de la mejoría de la gastritis a los 6 meses de finalizar el tratamiento.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Aim</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To study the influence of Helicobacter pylori eradication on basal gastrin and pepsinogen I and II levels in patients with gastric ulcer over a 1-year follow-up period, and to assess the usefulness of these values in confirming <span class="elsevierStyleItalic">H. pylori</span> eradication after treatment.</p> <span class="elsevierStyleSectionTitle">Methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Fifty-six patients with gastric ulcer and <span class="elsevierStyleItalic">H. pylori</span> infection were prospectively studied. At the beginning of the study, endoscopy with biopsies for histologic examination and urease testing was carried out, as were 13C-urea breath test and blood samples for determination of gastrin and pepsinogen I and II values by radioimmunoassay and serology. Histologic study, 13C-urea breath test and laboratory determinations were repeated at months 1, 6 and 12 after completion of eradication treatment.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">H. pylori</span> infection was eradicated in 82.1% of patients. In patients with successful <span class="elsevierStyleItalic">H. pylori</span> eradication, the initial mean gastrin value was 75.5 ± 39.1 pg/ml, while at 1 month after treatment this value decreased to 49.2 ± 21 pg/ml (p < 0.0001). No further reductions were noted. Initial pepsinogen I and II values were 104 ± 58 and 15.8 ± 10 ng/ml, respectively, whereas at month 1 after treatment these values were 77 ± 42 and 7.3 ± 4 ng/ml, respectively (p < 0.0001) and were 72 ± 41 and 6.7 ± 3 ng/ml respectively at month 6 (p < 0.01); no further variations were observed thereafter. The area under the ROC curve which reveals eradication through reductions in hormonal values was 0.70 for gastrin, 0.78 for pepsinogen I, 0.93 for pepsinogen II and 0.92 for the pepsinogen I/II ratio. At months 6 and 12 after treatment completion, differences in mean gastrin and pepsinogen I and II values between the patients with normal histologic findings and those with chronic gastritis were significant (p < 0.05).</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">a) H. pylori</span> eradication is associated with an early fall in basal gastrin values and a progressive decrease in basal pepsinogen I and II values. <span class="elsevierStyleItalic">b)</span> In patients with gastric ulcer, determination of the decrease in basal pepsinogen II levels is a useful and early non-invasive method for confirming eradication. <span class="elsevierStyleItalic">c)</span> Determination of gastrin and pepsinogen I and II values may be useful for assessing improvement in gastritis 6 months after treatment completion.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliogrífia" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:39 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." 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| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Octubre | 17 | 5 | 22 |
| 2024 Septiembre | 55 | 24 | 79 |
| 2024 Agosto | 22 | 12 | 34 |
| 2024 Julio | 27 | 10 | 37 |
| 2024 Junio | 51 | 24 | 75 |
| 2024 Mayo | 52 | 20 | 72 |
| 2024 Abril | 29 | 26 | 55 |
| 2024 Marzo | 54 | 112 | 166 |
| 2024 Febrero | 46 | 9 | 55 |
| 2024 Enero | 48 | 11 | 59 |
| 2023 Diciembre | 63 | 8 | 71 |
| 2023 Noviembre | 45 | 11 | 56 |
| 2023 Octubre | 77 | 15 | 92 |
| 2023 Septiembre | 30 | 7 | 37 |
| 2023 Agosto | 39 | 9 | 48 |
| 2023 Julio | 59 | 20 | 79 |
| 2023 Junio | 63 | 20 | 83 |
| 2023 Mayo | 62 | 10 | 72 |
| 2023 Abril | 49 | 12 | 61 |
| 2023 Marzo | 63 | 14 | 77 |
| 2023 Febrero | 43 | 5 | 48 |
| 2023 Enero | 47 | 13 | 60 |
| 2022 Diciembre | 43 | 6 | 49 |
| 2022 Noviembre | 54 | 16 | 70 |
| 2022 Octubre | 46 | 9 | 55 |
| 2022 Septiembre | 51 | 17 | 68 |
| 2022 Agosto | 48 | 8 | 56 |
| 2022 Julio | 33 | 6 | 39 |
| 2022 Junio | 34 | 8 | 42 |
| 2022 Mayo | 32 | 12 | 44 |
| 2022 Abril | 37 | 10 | 47 |
| 2022 Marzo | 66 | 11 | 77 |
| 2022 Febrero | 39 | 6 | 45 |
| 2022 Enero | 60 | 10 | 70 |
| 2021 Diciembre | 42 | 16 | 58 |
| 2021 Noviembre | 39 | 12 | 51 |
| 2021 Octubre | 52 | 27 | 79 |
| 2021 Septiembre | 37 | 23 | 60 |
| 2021 Agosto | 51 | 9 | 60 |
| 2021 Julio | 31 | 15 | 46 |
| 2021 Junio | 29 | 7 | 36 |
| 2021 Mayo | 35 | 18 | 53 |
| 2021 Abril | 63 | 20 | 83 |
| 2021 Marzo | 67 | 22 | 89 |
| 2021 Febrero | 32 | 10 | 42 |
| 2021 Enero | 37 | 15 | 52 |
| 2020 Diciembre | 30 | 26 | 56 |
| 2020 Noviembre | 48 | 24 | 72 |
| 2020 Octubre | 27 | 15 | 42 |
| 2020 Septiembre | 41 | 36 | 77 |
| 2020 Agosto | 32 | 11 | 43 |
| 2020 Julio | 27 | 8 | 35 |
| 2020 Junio | 19 | 9 | 28 |
| 2020 Mayo | 82 | 16 | 98 |
| 2020 Abril | 22 | 11 | 33 |
| 2020 Marzo | 29 | 18 | 47 |
| 2020 Febrero | 37 | 21 | 58 |
| 2020 Enero | 40 | 26 | 66 |
| 2019 Diciembre | 39 | 33 | 72 |
| 2019 Noviembre | 28 | 25 | 53 |
| 2019 Octubre | 59 | 28 | 87 |
| 2019 Septiembre | 65 | 26 | 91 |
| 2019 Agosto | 27 | 17 | 44 |
| 2019 Julio | 43 | 28 | 71 |
| 2019 Junio | 101 | 75 | 176 |
| 2019 Mayo | 247 | 209 | 456 |
| 2019 Abril | 113 | 90 | 203 |
| 2019 Marzo | 36 | 23 | 59 |
| 2019 Febrero | 34 | 52 | 86 |
| 2019 Enero | 31 | 36 | 67 |
| 2018 Diciembre | 35 | 29 | 64 |
| 2018 Noviembre | 30 | 55 | 85 |
| 2018 Octubre | 39 | 12 | 51 |
| 2018 Septiembre | 16 | 46 | 62 |
| 2018 Agosto | 12 | 86 | 98 |
| 2018 Julio | 6 | 56 | 62 |
| 2018 Junio | 8 | 64 | 72 |
| 2018 Mayo | 13 | 92 | 105 |
| 2018 Abril | 31 | 69 | 100 |
| 2018 Marzo | 15 | 39 | 54 |
| 2018 Febrero | 14 | 31 | 45 |
| 2018 Enero | 18 | 15 | 33 |
| 2017 Diciembre | 32 | 29 | 61 |
| 2017 Noviembre | 39 | 40 | 79 |
| 2017 Octubre | 33 | 43 | 76 |
| 2017 Septiembre | 33 | 55 | 88 |
| 2017 Agosto | 23 | 57 | 80 |
| 2017 Julio | 23 | 60 | 83 |
| 2017 Junio | 19 | 96 | 115 |
| 2017 Mayo | 35 | 49 | 84 |
| 2017 Abril | 21 | 35 | 56 |
| 2017 Marzo | 34 | 95 | 129 |
| 2017 Febrero | 31 | 29 | 60 |
| 2017 Enero | 34 | 28 | 62 |
| 2016 Diciembre | 48 | 16 | 64 |
| 2016 Noviembre | 77 | 17 | 94 |
| 2016 Octubre | 82 | 16 | 98 |
| 2016 Septiembre | 18 | 28 | 46 |
| 2016 Agosto | 15 | 10 | 25 |
| 2016 Julio | 36 | 4 | 40 |
| 2016 Junio | 90 | 27 | 117 |
| 2016 Mayo | 68 | 22 | 90 |
| 2016 Abril | 72 | 25 | 97 |
| 2016 Marzo | 56 | 24 | 80 |
| 2016 Febrero | 67 | 22 | 89 |
| 2016 Enero | 40 | 23 | 63 |
| 2015 Diciembre | 40 | 12 | 52 |
| 2015 Noviembre | 65 | 24 | 89 |
| 2015 Octubre | 66 | 30 | 96 |
| 2015 Septiembre | 53 | 16 | 69 |
| 2015 Agosto | 78 | 20 | 98 |
| 2015 Julio | 47 | 7 | 54 |
| 2015 Junio | 32 | 10 | 42 |
| 2015 Mayo | 34 | 14 | 48 |
| 2015 Abril | 45 | 14 | 59 |
| 2015 Marzo | 25 | 9 | 34 |
| 2015 Febrero | 32 | 3 | 35 |
| 2015 Enero | 12 | 1 | 13 |
| 2014 Diciembre | 13 | 1 | 14 |
| 2014 Noviembre | 4 | 1 | 5 |
| 2014 Octubre | 21 | 0 | 21 |
| 2014 Septiembre | 14 | 2 | 16 |
| 2014 Agosto | 7 | 0 | 7 |
| 2014 Julio | 9 | 2 | 11 |
| 2014 Junio | 12 | 0 | 12 |
| 2014 Mayo | 6 | 0 | 6 |
| 2014 Abril | 11 | 1 | 12 |
| 2014 Marzo | 10 | 2 | 12 |
| 2014 Febrero | 4 | 1 | 5 |
| 2014 Enero | 5 | 1 | 6 |
| 2013 Diciembre | 13 | 3 | 16 |
| 2013 Noviembre | 14 | 9 | 23 |
| 2013 Octubre | 26 | 8 | 34 |
| 2013 Septiembre | 12 | 9 | 21 |
| 2013 Agosto | 19 | 9 | 28 |
| 2013 Julio | 4 | 0 | 4 |
| 2001 Febrero | 1445 | 0 | 1445 |
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