Actualización en inhibidores de la bomba de protones
Seguridad e interacciones de los inhibidores de la bomba de protones: lecciones aprendidas en millones de pacientes
Safety and interactions of proton pump inhibitors: lessons learned in millions of patients
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"documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Gastroenterol Hepatol. 2010;33 Supl 1:11-4" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 4913 "formatos" => array:3 [ "EPUB" => 11 "HTML" => 2275 "PDF" => 2627 ] ] "es" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Actualización en inhibidores de la bomba de protones</span>" "titulo" => "Nuevos datos sobre la eficacia de los inhibidores de la bomba de protones en la hemorragia digestiva alta" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "11" "paginaFinal" => "14" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "New data on the efficacy of proton pump inhibitors in upper gastrointestinal bleeding" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Xavier Calvet" "autores" => array:1 [ 0 => array:2 [ "nombre" => "Xavier" "apellidos" => "Calvet" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210570510700030?idApp=UINPBA00004N" "url" => "/02105705/00000033000000S1/v1_201305141318/S0210570510700030/v1_201305141318/es/main.assets" ] "es" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Actualización en inhibidores de la bomba de protones</span>" "titulo" => "Seguridad e interacciones de los inhibidores de la bomba de protones: lecciones aprendidas en millones de pacientes" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "15" "paginaFinal" => "21" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Juan V. Esplugues, Miguel Martí-Cabrera" "autores" => array:2 [ 0 => array:4 [ "nombre" => "Juan V." "apellidos" => "Esplugues" "email" => array:1 [ 0 => "juan.v.esplugues@uv.es" ] "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "Miguel" "apellidos" => "Martí-Cabrera" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Departamento de Farmacología, Facultad de Medicina, Universidad de Valencia, Valencia, España" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd)" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Autor para correspondencia." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Safety and interactions of proton pump inhibitors: lessons learned in millions of patients" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec151501" "palabras" => array:11 [ 0 => "Secreción ácida" 1 => "inhibidores de la bomba de protones (IBP)" 2 => "farmacología" 3 => "seguridad" 4 => "interacciones" 5 => "clopidogrel" 6 => "toxicidad" 7 => "reacciones adversas" 8 => "utilización en situaciones especiales" 9 => "embarazo" 10 => "lactancia" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec151500" "palabras" => array:11 [ 0 => "Acid secretion" 1 => "proton pump inhibitors" 2 => "pharmacology" 3 => "safety" 4 => "interactions" 5 => "clopidogrel" 6 => "toxicity" 7 => "adverse reactions" 8 => "use in special situations" 9 => "pregnancy" 10 => "breastfeeding" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">Los IBP han demostrado ser fármacos relativamente seguros después de muchos años de una amplia utilización. Las reacciones adversas con las que más frecuentemente se han asociado son leves y con escasa repercusión clínica. Inducen hipergastrinemia pero esta no se ha relacionado con una capacidad para inducir lesiones malignas Parece que pueden facilitar determinadas infecciones bacterianas a nivel digestivo y del aparato respiratorio, aunque este hecho no limita su prescripción dada la facilidad de su tratamiento.</p><p class="elsevierStyleSimplePara elsevierViewall">Desde el punto de vista farmacocinético se han descrito la posibilidad de interacciones con otros fármacos a nivel del citocromo P450, pero ello no parece tener mayor trascendencia clínica y terapéutica en general. Sin embargo, recientemente se está incidiendo por las agencias reguladoras en la hipotética interacción de los IBP (sobre todo omeprazol) con el clopidogrel generando una reducción en su efecto antiagregante. Aunque se debe seguir esta recomendación, necesitaria ser evaluado de forma específica para poder determinar su realidad clínica y las posibles alternativas existentes en los pacientes con riesgo de sangrado gastrointestinal.</p><p class="elsevierStyleSimplePara elsevierViewall">En último lugar se revisa su administración en situaciones especiales, objeto de discusión, como en la mujer embarazada o durante la lactancia materna.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">After many years of widespread use, proton pump inhibitors (PPI) have been demonstrated to be relatively safe. The most frequently associated adverse reactions are mild with scarce clinical effects. These agents produce hypergastrinemia but this adverse effect has not been related to the development of malignancies. PPI seem to facilitate certain bacterial infections in the gastrointestinal and respiratory tracts. However, these infections are easily treated and therefore do not limit the prescription of PPI.</p><p class="elsevierStyleSimplePara elsevierViewall">From the pharmacokinetic point of view, the possibility of interactions with other drugs metabolized by the cytochrome P450 system has been described but these interactions generally seem to have little clinical or therapeutic importance. However, regulatory agencies are currently stressing the hypothetical interaction between PPI (especially omeprazole) and clopidogrel, which reduces the latter's antiplatelet effect. Although this recommendation should be followed, this interaction should be specifically evaluated to determine its clinical effect and the possible alternatives in patients at risk of gastrointestinal bleeding.</p><p class="elsevierStyleSimplePara elsevierViewall">Lastly, the present article reviews PPI administration in special, currently debated situations, such as in pregnant or breastfeeding women.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:46 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Acid suppressive therapy use on an inpatient internal medicine service" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "C.Q. Pharm" 1 => "R.E. Regal" 2 => "T.R. Bostwick" 3 => "K.S. Knauf" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1345/aph.1G703" "Revista" => array:6 [ "tituloSerie" => "Ann Pharmacother" "fecha" => "2006" "volumen" => "40" "paginaInicial" => "1261" "paginaFinal" => "1266" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16804095" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The rates of common adverse events reported during treatment with proton pump inhibitors used in general practice in England: cohort studies" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "R.M. Martin" 1 => "N.R. Dunn" 2 => "S. Freemantle" 3 => "S. Shakir" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Clin Pharmacol" "fecha" => "2000" "volumen" => "50" "paginaInicial" => "366" "paginaFinal" => "372" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11012560" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lack of effect of acid suppression therapy on gastric atrophy. Nordic Gerd Study Group" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "L. Lundell" 1 => "P. Miettinen" 2 => "H.E. Myrvold" 3 => "S.A. Pederssen" 4 => "K. Thor" 5 => "A. Andersson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Gastroenterology" "fecha" => "1999" "volumen" => "117" "paginaInicial" => "319" "paginaFinal" => "326" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10419912" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Indicaciones y consecuencias de la erradicación de <span class="elsevierStyleItalic">Helicobacter pylori</span> en la enfermedad por reflujo gastroesofágico" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.P. Gisbert" 1 => "J.M. Piqué" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Med Clin (Barc)" "fecha" => "2005" "volumen" => "124" "paginaInicial" => "697" "paginaFinal" => "709" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Atrophic gastritis and <span class="elsevierStyleItalic">H. pylori</span> infection in patients with reflux esophagitis treated with omeprazole or fundoplication" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "E.J. Kuipers" 1 => "L. Lundell" 2 => "E.C. Klinkenberg-Knol" 3 => "N. Havu" 4 => "H.P. Festen" 5 => "B. Liedman" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM199604183341603" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "1996" "volumen" => "334" "paginaInicial" => "1018" "paginaFinal" => "1022" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8598839" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Supression of gastric acid secretion in patients with gastroesophageal reflux disease results in gastric bacterial overgrowth and deconjugation of bile acids" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J. Theisen" 1 => "D. Nehra" 2 => "D. Citron" 3 => "J. Johansson" 4 => "J.A. Hagen" 5 => "P.F. Crookes" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Gastrointest Surg" "fecha" => "2000" "volumen" => "4" "paginaInicial" => "50" "paginaFinal" => "54" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10631362" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Changes in acid secretion over the years. A 30-year longitudinal study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G. Trey" 1 => "I.N. Marks" 2 => "J.A. Louw" 3 => "K. Jaskiewicz" 4 => "P. Sipponen" 5 => "B.H. Novis" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Clin Gastroenterol" "fecha" => "1997" "volumen" => "25" "paginaInicial" => "499" "paginaFinal" => "502" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9412964" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The effect of proton pump inhibitors on the human microbiota" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "B.J. Vesper" 1 => "A. Jawdi" 2 => "K.W. Altman" 3 => "G.K. Haines" 4 => "L. Tao" 5 => "J.A. Radosevich" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Curr Drug Metab" "fecha" => "2009" "volumen" => "10" "paginaInicial" => "84" "paginaFinal" => "89" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19149516" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Gastric acidity inhibitors and the risk of intestinal infections" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "R.B. Canani" 1 => "G. Terrin" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/MOG.0b013e328333d781" "Revista" => array:6 [ "tituloSerie" => "Curr Opin Gastroenterol" "fecha" => "2010" "volumen" => "26" "paginaInicial" => "31" "paginaFinal" => "35" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19907324" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Risk of community acquiered pneumonia and use of gastric acid suppressive drugs" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "R.J.F. Laheij" 1 => "M.C.J. Sturkenboom" 2 => "R.J. Hassing" 3 => "J. Dieleman" 4 => "B.H.C. Stricker" 5 => "J.B.M.J. Jansen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1001/jama.292.16.1955" "Revista" => array:6 [ "tituloSerie" => "JAMA" "fecha" => "2004" "volumen" => "292" "paginaInicial" => "1955" "paginaFinal" => "1960" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15507580" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Systematic review of the risk of enteric infection in patients taking acid supresion" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J. Leonard" 1 => "J.K. Marshall" 2 => "P. Moayyedi" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1572-0241.2007.01275.x" "Revista" => array:6 [ "tituloSerie" => "Am J Gastroenterol" "fecha" => "2007" "volumen" => "102" "paginaInicial" => "2047" "paginaFinal" => "2056" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17509031" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Long-term safety concerns with proton pump inhibitors" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "T. Ali" 1 => "D.N. Roberts" 2 => "W.M. Tierney" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.amjmed.2009.04.014" "Revista" => array:6 [ "tituloSerie" => "Am J Med" "fecha" => "2009" "volumen" => "122" "paginaInicial" => "896" "paginaFinal" => "903" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19786155" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "<span class="elsevierStyleItalic">Clostridium difficile</span> colitis: Wash your hands before stopping the proton pump inhibitors" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "D.C. Metz" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Gastroenterol" "fecha" => "2008" "volumen" => "103" "paginaInicial" => "2314" "paginaFinal" => "2316" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18924259" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diferencias en la liberación de omeprazol en cuatro preparados comerciales: influencia del pH y la concentración iónica" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.A. Navarro" 1 => "N. Raei" 2 => "F. Torres" 3 => "L. Granero" 4 => "E. Garcia-Zaragoza" 5 => "J.V. Esplugues" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Gastroenterol Hepatol" "fecha" => "1998" "volumen" => "21" "paginaInicial" => "63" "paginaFinal" => "70" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9549180" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Oral pharmacokinetics of omeprazole and lansoprazole after single and repeated doses as intact capsules or as suspensions in sodium bicarbonate" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "V.K. Sharma" 1 => "B. Peyton" 2 => "T. Spears" 3 => "J.P. Raufman" 4 => "C.W. Howden" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Aliment Pharmacol Ther" "fecha" => "2000" "volumen" => "14" "paginaInicial" => "887" "paginaFinal" => "892" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10886044" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Long-term proton pump inhibitor therapy and risk of hip fracture" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "Y.X. Yang" 1 => "J.D. Lewis" 2 => "S. Epstein" 3 => "D.C. Metz" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "JAMA" "fecha" => "2006" "volumen" => "296" "paginaInicial" => "2947" "paginaFinal" => "2953" ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Proton pump inhibitors, histamine H2 receptor antagonists, and other antacid medications and the risk of hip fracture" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "P. Vestergaard" 1 => "L. Rejnmark" 2 => "L. Mosekilde" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00223-006-0021-7" "Revista" => array:6 [ "tituloSerie" => "Calcif Tissue Int" "fecha" => "2006" "volumen" => "79" "paginaInicial" => "76" "paginaFinal" => "83" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16927047" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The effect of proton pump-inhibiting drugs on mineral metabolism" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "K.L. Insogna" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/ajg.2009.44" "Revista" => array:7 [ "tituloSerie" => "Am J Gastroenterol" "fecha" => "2009" "volumen" => "104" "numero" => "Suppl 2" "paginaInicial" => "S2" "paginaFinal" => "4" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19262542" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Iron absorption in patients treated with long-term gastric acid antisecretory therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "C.A. Stewart" 1 => "B. Termanini" 2 => "V.E. Sutliff" 3 => "J. Serrano" 4 => "F. Yu" 5 => "F. Gibril" 6 => "R.T. Jensen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Aliment Pharmacol Ther" "fecha" => "1998" "volumen" => "12" "paginaInicial" => "83" "paginaFinal" => "98" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9701006" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Vitamin B12 deficiency in hypersecretors during long-term acid suppression with proton pump inhibitors" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "B.I. Hirschowitz" 1 => "J. Worthington" 2 => "J. Mohnen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2036.2008.03658.x" "Revista" => array:6 [ "tituloSerie" => "Aliment Pharmacol Ther" "fecha" => "2008" "volumen" => "27" "paginaInicial" => "1110" "paginaFinal" => "1121" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18315582" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A pharmacological approach to gastric acid inhibition" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J.V. Esplugues" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Drugs" "fecha" => "2005" "volumen" => "65" "numero" => "Suppl 1" "paginaInicial" => "7" "paginaFinal" => "12" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16335853" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib22" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Farmacología de la secreción gastrointestinal y de la ulceración mucosa digestiva" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J.V. Esplugues" 1 => "M. Marti-Cabrera" 2 => "J. Flórez" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:5 [ "titulo" => "Farmacología humana" "paginaInicial" => "867" "paginaFinal" => "888" "edicion" => "5.ª ed." "serieFecha" => "2008" ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib23" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Drug metabolism and variability among patients in drug response" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "G.R. Wilkinson" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMra032424" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "2005" "volumen" => "352" "paginaInicial" => "2211" "paginaFinal" => "2222" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15917386" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib24" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Safety of potent gastric acid inhibition" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "C. Martín de Argila" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Drugs" "fecha" => "2005" "volumen" => "65" "numero" => "Suppl 1" "paginaInicial" => "97" "paginaFinal" => "104" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16335863" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib25" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Comparison of inhibitory effects of the proton pump-inhibiting drugs omeprazole, esomeprazole, lansoprazole, pantoprazole, and rabeprazole on human cytochrome P450 acttivities" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "X.Q. Li" 1 => "T.B. Andersson" 2 => "M. Ahlström" 3 => "L. Weidolf" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Drug Metab Dispos" "fecha" => "2004" "volumen" => "32" "paginaInicial" => "821" "paginaFinal" => "827" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15258107" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0140673600021140" "estado" => "S300" "issn" => "01406736" ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib26" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A summary of Food and Drug and Administration-reported adverse events and drug interactions occurring during therapy with omeprazole, lansoprazole and pantoprazole" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J. Labenz" 1 => "K.U. Petersen" 2 => "W. Rösch" 3 => "H.R. Koelz" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Aliment Pharmacol Ther" "fecha" => "2003" "volumen" => "17" "paginaInicial" => "1015" "paginaFinal" => "1019" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12694083" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib27" "etiqueta" => "27." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Influence of omeprazol on the antiplatelet action of clopidogrel associated with aspirin: the randomized, double-blind OCLA (Omeprazole Clopidogrel Aspirin) study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Gilard" 1 => "B. Arnaud" 2 => "J.C. Cornily" 3 => "G. Le Gal" 4 => "K. Lacut" 5 => "G. Le Calvez" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jacc.2007.06.064" "Revista" => array:6 [ "tituloSerie" => "J Am Coll Cardiol" "fecha" => "2008" "volumen" => "51" "paginaInicial" => "256" "paginaFinal" => "260" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18206732" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib28" "etiqueta" => "28." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effect of pantoprazole and esomeprazole on platelet inhibition by clopidogrel" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J.M. Siller-Matula" 1 => "A.O. Spiel" 2 => "I.M. Lang" 3 => "G. Kreiner" 4 => "G. Christ" 5 => "B. Jilma" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Am Heart J" "fecha" => "2009" "volumen" => "157" "paginaInicial" => "148e1-5" ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib29" "etiqueta" => "29." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A population-based study of the drug interaction between proton pump inhibitors and clopidogrel" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "D.N. Juurlink" 1 => "T. Gomez" 2 => "D.T. Ko" 3 => "P.E. Szmitko" 4 => "P.C. Austin" 5 => "J.V. Tu" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1503/cmaj.082001" "Revista" => array:6 [ "tituloSerie" => "CMAJ" "fecha" => "2009" "volumen" => "180" "paginaInicial" => "713" "paginaFinal" => "718" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19176635" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib30" "etiqueta" => "30." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Risk of adverse outcomes associated with concomitant use of clopidogrel and proton pump inhibitors following acute coronary syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "P.M. Ho" 1 => "T.M. Maddox" 2 => "L. Wang" 3 => "S.D. Fihn" 4 => "R.L. Jesse" 5 => "E.D. Peterson" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1001/jama.2009.261" "Revista" => array:6 [ "tituloSerie" => "JAMA" "fecha" => "2009" "volumen" => "301" "paginaInicial" => "937" "paginaFinal" => "944" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19258584" "web" => "Medline" ] ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib31" "etiqueta" => "31." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Inhibidores de la bomba de protones y clopidogrel en el paciente cardiovascular: ¿riesgo vascular versus riesgo gastrointestinal?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "A. Lanas" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0210-5705(10)70001-7" "Revista" => array:7 [ "tituloSerie" => "Gastroenterol Hepatol" "fecha" => "2010" "volumen" => "33" "paginaInicial" => "1" "paginaFinal" => "5" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20728782" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0140673603141177" "estado" => "S300" "issn" => "01406736" ] ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib32" "etiqueta" => "32." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Proton pump inhibitor and clopidogrel interaction: Fact or fiction?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "L. Laine" 1 => "C. Hennekens" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/ajg.2009.638" "Revista" => array:6 [ "tituloSerie" => "Am J Gastroenterol" "fecha" => "2010" "volumen" => "105" "paginaInicial" => "34" "paginaFinal" => "41" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19904241" "web" => "Medline" ] ] ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib33" "etiqueta" => "33." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cytochrome P450 2C19 loss of function polymorphism is a major determinant of clopidogrel responsiveness in healthy subjects" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.S. Hulot" 1 => "A. Bura" 2 => "E. Villard" 3 => "M. Azizi" 4 => "V. Remones" 5 => "C. Goyenvalle" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1182/blood-2006-04-013052" "Revista" => array:6 [ "tituloSerie" => "Blood" "fecha" => "2006" "volumen" => "108" "paginaInicial" => "2244" "paginaFinal" => "2247" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16772608" "web" => "Medline" ] ] ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib34" "etiqueta" => "34." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cytochrome P450 2C19 polymorphism in young patients treated with clopidogrel after myocardial infarction: a cohort study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.P. Collet" 1 => "J.S. Hulot" 2 => "A. Pena" 3 => "E. Villard" 4 => "J.B. Esteve" 5 => "J. Silvain" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Lancet" "fecha" => "2009" "volumen" => "373" "paginaInicial" => "309" "paginaFinal" => "317" ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib35" "etiqueta" => "35." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Genetic determinants of response to clopidogrel and cardiovascular events" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "T. Simon" 1 => "C. Verstuyft" 2 => "M. Mary-Krause" 3 => "L. Quteineh" 4 => "E. Drouet" 5 => "N. Méneveau" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMoa0808227" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "2009" "volumen" => "360" "paginaInicial" => "363" "paginaFinal" => "375" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19106083" "web" => "Medline" ] ] ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bib36" "etiqueta" => "36." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Initial assessment of clinical impact of a drug interaction between clopidogrel and proton pump inhibitors" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "E. Pezalla" 1 => "D. Day" 2 => "A. Pulliadath" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jacc.2007.06.064" "Revista" => array:6 [ "tituloSerie" => "J Am Coll Cardiol" "fecha" => "2008" "volumen" => "51" "paginaInicial" => "256" "paginaFinal" => "260" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18206732" "web" => "Medline" ] ] ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bib37" "etiqueta" => "37." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effects of the proton pump inhibitor lansoprazole on the pharmacokinetics and pharmacodynamics of prasugrel and clopidogrel" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "D.S. Small" 1 => "N.A. Farid" 2 => "C.D. Payne" 3 => "G.J. Weerakkody" 4 => "Y.G. Li" 5 => "J.T. Brandt" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1177/0091270008315310" "Revista" => array:6 [ "tituloSerie" => "J Clin Pharmacol" "fecha" => "2008" "volumen" => "48" "paginaInicial" => "475" "paginaFinal" => "484" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18303127" "web" => "Medline" ] ] ] ] ] ] ] ] 37 => array:3 [ "identificador" => "bib38" "etiqueta" => "38." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pharmacodynamic effect and clinical efficacy of clopidogrel and prasugrel with or without a protonpump inhibitor: an analysis of two randomised trials" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.L. O’Donoghue" 1 => "E. Braunwald" 2 => "E.M. Antman" 3 => "S.A. Murphy" 4 => "E.R. Bates" 5 => "Y. Rozenman" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0140-6736(09)61525-7" "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "2009" "volumen" => "374" "paginaInicial" => "989" "paginaFinal" => "997" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19726078" "web" => "Medline" ] ] ] ] ] ] ] ] 38 => array:3 [ "identificador" => "bib39" "etiqueta" => "39." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pharmacokinetics of omeprazole given by continuous intravenous infusion to patients with varying degrees of hepatic dysfunction" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J.M. Pique" 1 => "F. Feu" 2 => "G. De Prada" 3 => "K. Ross" 4 => "G. Hasselgren" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2165/00003088-200241120-00004" "Revista" => array:6 [ "tituloSerie" => "Clin Pharmacokinet" "fecha" => "2002" "volumen" => "41" "paginaInicial" => "999" "paginaFinal" => "1004" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12222996" "web" => "Medline" ] ] ] ] ] ] ] ] 39 => array:3 [ "identificador" => "bib40" "etiqueta" => "40." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effect of genetic differences in omeprazole metabolism on cure rates for <span class="elsevierStyleItalic">Helicobacter pylori</span> infection and peptic ulcer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "T. Furuta" 1 => "K. Ohashi" 2 => "T. Kamata" 3 => "M. Takashima" 4 => "K. Kosuge" 5 => "T. Kawasaki" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Intern Med" "fecha" => "1998" "volumen" => "129" "paginaInicial" => "1027" "paginaFinal" => "1030" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9867757" "web" => "Medline" ] ] ] ] ] ] ] ] 40 => array:3 [ "identificador" => "bib41" "etiqueta" => "41." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Gestational and postpartum gastroesophageal reflux disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J. Willey" 1 => "J.E. Richter" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Women¿s Health Prim Car" "fecha" => "2001" "volumen" => "4" "paginaInicial" => "709" "paginaFinal" => "714" ] ] ] ] ] ] 41 => array:3 [ "identificador" => "bib42" "etiqueta" => "42." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Drugs in pregnancy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "G. Koren" 1 => "A. Pastuszaka" 2 => "S. Ito" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "N Eng J Med" "fecha" => "1998" "volumen" => "338" "paginaInicial" => "1128" "paginaFinal" => "1131" ] ] ] ] ] ] 42 => array:3 [ "identificador" => "bib43" "etiqueta" => "43." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Gastric and duodenal ulcers during pregnancy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M.S. Cappell" 1 => "A. Garcia" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Gastroenterol Clin North Am" "fecha" => "1998" "volumen" => "27" "paginaInicial" => "169" "paginaFinal" => "195" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9546089" "web" => "Medline" ] ] ] ] ] ] ] ] 43 => array:3 [ "identificador" => "bib44" "etiqueta" => "44." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Omeprazole: an update of its pharmacology and therapeutic use in acid related disorders" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M.I. Wilde" 1 => "D. McTavish" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Drugs" "fecha" => "1994" "volumen" => "48" "paginaInicial" => "91" "paginaFinal" => "132" ] ] ] ] ] ] 44 => array:3 [ "identificador" => "bib45" "etiqueta" => "45." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Contemporary understanding and management of reflux and constipation in the general population and pregnancy: A consensus meeting" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G.N. Tytgat" 1 => "R.C. Heading" 2 => "S. Müller-Lissner" 3 => "M.N. Kamm" 4 => "J. Schölmerich" 5 => "A. Berstad" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Aliment Pharmacol Ther" "fecha" => "2003" "volumen" => "18" "paginaInicial" => "291" "paginaFinal" => "301" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12895213" "web" => "Medline" ] ] ] ] ] ] ] ] 45 => array:3 [ "identificador" => "bib46" "etiqueta" => "46." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Use of proton pump inhibitors during pregnancy and rates of major malformations: A meta-analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S. Nikfar" 1 => "M. Abdollahi" 2 => "M.E. Moretti" 3 => "L.A. Magee" 4 => "G. Koren" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Dig Dis Sci" "fecha" => "2002" "volumen" => "47" "paginaInicial" => "1526" "paginaFinal" => "1529" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12141812" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/02105705/00000033000000S1/v1_201305141318/S0210570510700042/v1_201305141318/es/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/02105705/00000033000000S1/v1_201305141318/S0210570510700042/v1_201305141318/es/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210570510700042?idApp=UINPBA00004N" ]
| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Octubre | 61 | 8 | 69 |
| 2024 Septiembre | 76 | 11 | 87 |
| 2024 Agosto | 48 | 8 | 56 |
| 2024 Julio | 35 | 4 | 39 |
| 2024 Junio | 40 | 15 | 55 |
| 2024 Mayo | 64 | 14 | 78 |
| 2024 Abril | 41 | 17 | 58 |
| 2024 Marzo | 55 | 19 | 74 |
| 2024 Febrero | 48 | 10 | 58 |
| 2024 Enero | 43 | 20 | 63 |
| 2023 Diciembre | 53 | 8 | 61 |
| 2023 Noviembre | 60 | 11 | 71 |
| 2023 Octubre | 95 | 17 | 112 |
| 2023 Septiembre | 44 | 9 | 53 |
| 2023 Agosto | 49 | 1 | 50 |
| 2023 Julio | 71 | 8 | 79 |
| 2023 Junio | 67 | 3 | 70 |
| 2023 Mayo | 78 | 6 | 84 |
| 2023 Abril | 59 | 7 | 66 |
| 2023 Marzo | 61 | 13 | 74 |
| 2023 Febrero | 30 | 3 | 33 |
| 2023 Enero | 31 | 8 | 39 |
| 2022 Diciembre | 33 | 15 | 48 |
| 2022 Noviembre | 49 | 11 | 60 |
| 2022 Octubre | 50 | 23 | 73 |
| 2022 Septiembre | 32 | 20 | 52 |
| 2022 Agosto | 87 | 24 | 111 |
| 2022 Julio | 97 | 17 | 114 |
| 2022 Junio | 33 | 11 | 44 |
| 2022 Mayo | 54 | 23 | 77 |
| 2022 Abril | 33 | 15 | 48 |
| 2022 Marzo | 59 | 16 | 75 |
| 2022 Febrero | 39 | 12 | 51 |
| 2022 Enero | 49 | 18 | 67 |
| 2021 Diciembre | 65 | 17 | 82 |
| 2021 Noviembre | 70 | 21 | 91 |
| 2021 Octubre | 62 | 36 | 98 |
| 2021 Septiembre | 67 | 31 | 98 |
| 2021 Agosto | 60 | 21 | 81 |
| 2021 Julio | 28 | 23 | 51 |
| 2021 Junio | 40 | 20 | 60 |
| 2021 Mayo | 37 | 16 | 53 |
| 2021 Abril | 112 | 69 | 181 |
| 2021 Marzo | 83 | 33 | 116 |
| 2021 Febrero | 52 | 22 | 74 |
| 2021 Enero | 43 | 16 | 59 |
| 2020 Diciembre | 44 | 12 | 56 |
| 2020 Noviembre | 46 | 8 | 54 |
| 2020 Octubre | 22 | 10 | 32 |
| 2020 Septiembre | 42 | 12 | 54 |
| 2020 Agosto | 36 | 13 | 49 |
| 2020 Julio | 33 | 10 | 43 |
| 2020 Junio | 33 | 28 | 61 |
| 2020 Mayo | 40 | 47 | 87 |
| 2020 Abril | 42 | 15 | 57 |
| 2020 Marzo | 32 | 7 | 39 |
| 2020 Febrero | 46 | 27 | 73 |
| 2020 Enero | 48 | 20 | 68 |
| 2019 Diciembre | 49 | 16 | 65 |
| 2019 Noviembre | 44 | 17 | 61 |
| 2019 Octubre | 27 | 13 | 40 |
| 2019 Septiembre | 36 | 19 | 55 |
| 2019 Agosto | 23 | 8 | 31 |
| 2019 Julio | 32 | 34 | 66 |
| 2019 Junio | 83 | 40 | 123 |
| 2019 Mayo | 230 | 118 | 348 |
| 2019 Abril | 116 | 59 | 175 |
| 2019 Marzo | 34 | 26 | 60 |
| 2019 Febrero | 39 | 26 | 65 |
| 2019 Enero | 35 | 12 | 47 |
| 2018 Diciembre | 31 | 15 | 46 |
| 2018 Noviembre | 54 | 16 | 70 |
| 2018 Octubre | 62 | 16 | 78 |
| 2018 Septiembre | 48 | 16 | 64 |
| 2018 Agosto | 18 | 5 | 23 |
| 2018 Julio | 28 | 9 | 37 |
| 2018 Junio | 21 | 8 | 29 |
| 2018 Mayo | 32 | 11 | 43 |
| 2018 Abril | 34 | 4 | 38 |
| 2018 Marzo | 19 | 6 | 25 |
| 2018 Febrero | 8 | 2 | 10 |
| 2018 Enero | 24 | 4 | 28 |
| 2017 Diciembre | 13 | 2 | 15 |
| 2017 Noviembre | 26 | 10 | 36 |
| 2017 Octubre | 15 | 4 | 19 |
| 2017 Septiembre | 23 | 11 | 34 |
| 2017 Agosto | 12 | 7 | 19 |
| 2017 Julio | 14 | 3 | 17 |
| 2017 Junio | 25 | 32 | 57 |
| 2017 Mayo | 17 | 10 | 27 |
| 2017 Abril | 12 | 7 | 19 |
| 2017 Marzo | 18 | 43 | 61 |
| 2017 Febrero | 22 | 3 | 25 |
| 2017 Enero | 21 | 8 | 29 |
| 2016 Diciembre | 27 | 10 | 37 |
| 2016 Noviembre | 40 | 8 | 48 |
| 2016 Octubre | 32 | 5 | 37 |
| 2016 Septiembre | 43 | 14 | 57 |
| 2016 Agosto | 36 | 11 | 47 |
| 2016 Julio | 20 | 3 | 23 |
| 2016 Junio | 20 | 13 | 33 |
| 2016 Mayo | 21 | 12 | 33 |
| 2016 Abril | 16 | 16 | 32 |
| 2016 Marzo | 20 | 19 | 39 |
| 2016 Febrero | 10 | 17 | 27 |
| 2016 Enero | 16 | 17 | 33 |
| 2015 Diciembre | 18 | 18 | 36 |
| 2015 Noviembre | 23 | 21 | 44 |
| 2015 Octubre | 24 | 18 | 42 |
| 2015 Septiembre | 28 | 16 | 44 |
| 2015 Agosto | 38 | 14 | 52 |
| 2015 Julio | 30 | 4 | 34 |
| 2015 Junio | 10 | 8 | 18 |
| 2015 Mayo | 13 | 13 | 26 |
| 2015 Abril | 31 | 11 | 42 |
| 2015 Marzo | 12 | 3 | 15 |
| 2015 Febrero | 13 | 4 | 17 |
| 2015 Enero | 14 | 9 | 23 |
| 2014 Diciembre | 30 | 4 | 34 |
| 2014 Noviembre | 23 | 1 | 24 |
| 2014 Octubre | 25 | 5 | 30 |
| 2014 Septiembre | 22 | 4 | 26 |
| 2014 Agosto | 24 | 5 | 29 |
| 2014 Julio | 38 | 4 | 42 |
| 2014 Junio | 29 | 4 | 33 |
| 2014 Mayo | 25 | 4 | 29 |
| 2014 Abril | 20 | 2 | 22 |
| 2014 Marzo | 20 | 3 | 23 |
| 2014 Febrero | 32 | 6 | 38 |
| 2014 Enero | 23 | 4 | 27 |
| 2013 Diciembre | 51 | 10 | 61 |
| 2013 Noviembre | 31 | 5 | 36 |
| 2013 Octubre | 34 | 4 | 38 |
| 2013 Septiembre | 11 | 4 | 15 |
| 2013 Agosto | 17 | 7 | 24 |
| 2013 Julio | 14 | 4 | 18 |
| 2010 Abril | 760 | 0 | 760 |
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