Genética del cáncer colorrectal
Genetics of colorectal cancer
Francesc Balaguer
Servicio de Gastroenterología, Hospital Clínic, Barcelona, España
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Estas formas hereditarias demandan, en muchas ocasiones, un alto grado de sospecha para su diagnóstico, y requieren de un manejo específico y especializado. Además, el diagnóstico del CCR hereditario tiene importantes consecuencias no sólo para el paciente, para el que hay medidas de prevención altamente efectivas, sino también para los familiares, que pueden ser portadores de la misma condición. Los avances más significativos en el campo del CCR hereditario se han producido en el diagnóstico y caracterización del síndrome de Lynch y el síndrome de poliposis serrada.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Colorectal cancer (CRC) is one of the most frequent neoplasms in developed countries and up to 5% of all cases occur in the context of a hereditary syndrome. These hereditary forms often require a high index of suspicion for their diagnosis and specific and specialized management. Moreover, a diagnosis of hereditary CRC has major consequences not only for the patient –for whom there are highly effective preventive measures– but also for the patient's relatives, who may carry the same condition. The most significant advances in the field of hereditary CRC have been produced in the diagnosis and characterization of Lynch's syndrome and serrated polyposis syndrome.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:31 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Accuracy of revised Bethesda guidelines, microsatellite instability, and immunohistochemistry for the identification of patients with hereditary nonpolyposis colorectal cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "V. Pinol" 1 => "A. 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| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Octubre | 3 | 2 | 5 |
| 2024 Septiembre | 5 | 6 | 11 |
| 2024 Agosto | 6 | 5 | 11 |
| 2024 Julio | 7 | 4 | 11 |
| 2024 Junio | 6 | 3 | 9 |
| 2024 Mayo | 7 | 5 | 12 |
| 2024 Abril | 4 | 3 | 7 |
| 2024 Marzo | 7 | 7 | 14 |
| 2024 Febrero | 3 | 5 | 8 |
| 2024 Enero | 5 | 2 | 7 |
| 2023 Diciembre | 6 | 5 | 11 |
| 2023 Noviembre | 6 | 8 | 14 |
| 2023 Octubre | 5 | 6 | 11 |
| 2023 Septiembre | 1 | 3 | 4 |
| 2023 Agosto | 8 | 6 | 14 |
| 2023 Julio | 7 | 3 | 10 |
| 2023 Junio | 3 | 6 | 9 |
| 2023 Mayo | 4 | 1 | 5 |
| 2023 Abril | 1 | 6 | 7 |
| 2023 Marzo | 4 | 3 | 7 |
| 2023 Febrero | 3 | 4 | 7 |
| 2023 Enero | 1 | 7 | 8 |
| 2022 Diciembre | 9 | 5 | 14 |
| 2022 Noviembre | 6 | 6 | 12 |
| 2022 Octubre | 5 | 7 | 12 |
| 2022 Septiembre | 14 | 13 | 27 |
| 2022 Agosto | 7 | 10 | 17 |
| 2022 Julio | 9 | 16 | 25 |
| 2022 Junio | 6 | 14 | 20 |
| 2022 Mayo | 4 | 12 | 16 |
| 2022 Abril | 6 | 11 | 17 |
| 2022 Marzo | 6 | 9 | 15 |
| 2022 Febrero | 5 | 4 | 9 |
| 2022 Enero | 6 | 4 | 10 |
| 2021 Diciembre | 5 | 14 | 19 |
| 2021 Noviembre | 6 | 5 | 11 |
| 2021 Octubre | 3 | 6 | 9 |
| 2021 Septiembre | 5 | 7 | 12 |
| 2021 Agosto | 4 | 5 | 9 |
| 2021 Julio | 5 | 7 | 12 |
| 2021 Junio | 4 | 2 | 6 |
| 2021 Mayo | 4 | 6 | 10 |
| 2021 Abril | 12 | 5 | 17 |
| 2021 Marzo | 8 | 16 | 24 |
| 2021 Febrero | 4 | 8 | 12 |
| 2021 Enero | 5 | 11 | 16 |
| 2020 Diciembre | 4 | 10 | 14 |
| 2020 Noviembre | 5 | 7 | 12 |
| 2020 Octubre | 2 | 7 | 9 |
| 2020 Septiembre | 4 | 11 | 15 |
| 2020 Agosto | 5 | 8 | 13 |
| 2020 Julio | 3 | 1 | 4 |
| 2020 Junio | 4 | 1 | 5 |
| 2020 Mayo | 2 | 5 | 7 |
| 2020 Abril | 2 | 4 | 6 |
| 2020 Marzo | 8 | 4 | 12 |
| 2020 Febrero | 3 | 5 | 8 |
| 2020 Enero | 7 | 6 | 13 |
| 2019 Diciembre | 9 | 9 | 18 |
| 2019 Noviembre | 5 | 6 | 11 |
| 2019 Octubre | 4 | 6 | 10 |
| 2019 Septiembre | 4 | 3 | 7 |
| 2019 Agosto | 8 | 6 | 14 |
| 2019 Julio | 17 | 7 | 24 |
| 2019 Junio | 17 | 29 | 46 |
| 2019 Mayo | 50 | 49 | 99 |
| 2019 Abril | 6 | 32 | 38 |
| 2019 Marzo | 3 | 8 | 11 |
| 2019 Febrero | 5 | 14 | 19 |
| 2019 Enero | 2 | 12 | 14 |
| 2018 Diciembre | 2 | 8 | 10 |
| 2018 Noviembre | 2 | 11 | 13 |
| 2018 Octubre | 5 | 11 | 16 |
| 2018 Septiembre | 7 | 7 | 14 |
| 2018 Agosto | 0 | 4 | 4 |
| 2018 Julio | 1 | 12 | 13 |
| 2018 Junio | 0 | 9 | 9 |
| 2018 Mayo | 4 | 9 | 13 |
| 2018 Abril | 2 | 10 | 12 |
| 2018 Marzo | 0 | 14 | 14 |
| 2018 Febrero | 3 | 6 | 9 |
| 2018 Enero | 2 | 9 | 11 |
| 2017 Diciembre | 7 | 6 | 13 |
| 2017 Noviembre | 4 | 14 | 18 |
| 2017 Octubre | 3 | 10 | 13 |
| 2017 Septiembre | 3 | 10 | 13 |
| 2017 Agosto | 0 | 7 | 7 |
| 2017 Julio | 8 | 16 | 24 |
| 2017 Junio | 6 | 46 | 52 |
| 2017 Mayo | 5 | 16 | 21 |
| 2017 Abril | 7 | 4 | 11 |
| 2017 Marzo | 12 | 8 | 20 |
| 2017 Febrero | 19 | 10 | 29 |
| 2017 Enero | 10 | 8 | 18 |
| 2016 Diciembre | 14 | 10 | 24 |
| 2016 Noviembre | 24 | 10 | 34 |
| 2016 Octubre | 21 | 12 | 33 |
| 2016 Septiembre | 30 | 9 | 39 |
| 2016 Agosto | 31 | 4 | 35 |
| 2016 Julio | 15 | 1 | 16 |
| 2016 Junio | 18 | 19 | 37 |
| 2016 Mayo | 14 | 13 | 27 |
| 2016 Abril | 14 | 13 | 27 |
| 2016 Marzo | 5 | 6 | 11 |
| 2016 Febrero | 10 | 14 | 24 |
| 2016 Enero | 5 | 4 | 9 |
| 2015 Diciembre | 8 | 8 | 16 |
| 2015 Noviembre | 14 | 7 | 21 |
| 2015 Octubre | 14 | 7 | 21 |
| 2015 Septiembre | 20 | 6 | 26 |
| 2015 Agosto | 11 | 4 | 15 |
| 2015 Julio | 5 | 1 | 6 |
| 2015 Junio | 8 | 1 | 9 |
| 2015 Mayo | 10 | 6 | 16 |
| 2015 Abril | 10 | 7 | 17 |
| 2015 Marzo | 12 | 4 | 16 |
| 2015 Febrero | 16 | 6 | 22 |
| 2015 Enero | 26 | 2 | 28 |
| 2014 Diciembre | 36 | 2 | 38 |
| 2014 Noviembre | 34 | 2 | 36 |
| 2014 Octubre | 35 | 5 | 40 |
| 2014 Septiembre | 40 | 3 | 43 |
| 2014 Junio | 1 | 0 | 1 |
| 2014 Abril | 2 | 0 | 2 |
| 2013 Noviembre | 0 | 1 | 1 |
| 2013 Octubre | 1 | 0 | 1 |
| 2013 Agosto | 1 | 1 | 2 |
| 2012 Agosto | 322 | 0 | 322 |
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