Estadísticas

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      "titulo" => "Historia natural, complicaciones, seguridad y embarazo en la enfermedad inflamatoria intestinal"
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          "autoresLista" => "María Chaparro"
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    "titulo" => "Tratamiento de las enfermedades inflamatorias intestinales"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Adem&#225;s de los anti-TNF y los inmunosupresores&#44; poco a poco se va disponiendo de nuevas opciones en el tratamiento de las enfermedades inflamatorias intestinales&#46; El vedolizumab ya ha sido aprobado por la Food and Drug Administration y la European Medicines Agency&#44; y est&#225; demostrando su utilidad en el tratamiento de la colitis ulcerosa y la enfermedad de Crohn incluso en casos refractarios a los anti-TNF&#46; Otros anticuerpos dirigidos a otras dianas como el PF-00547659 &#40;anti-MAd-CAM-1&#41;&#44; el ustekinumab &#40;anti-IL23&#47;IL12&#41; o el MEDI2070 &#40;anti-IL23&#41; muestran resultados esperanzadores en diversas situaciones cl&#237;nicas&#46; Mongersen &#40;oligonucle&#243;tido antisentido&#44; anti-Smad7&#41; y ozanimod &#40;modulador del SP-1&#41; son nuevas alternativas que tambi&#233;n han demostrado eficacia en condiciones de ensayo cl&#237;nico en la enfermedad de Crohn y la colitis ulcerosa&#44; respectivamente&#46; Algunos datos sugieren que el trasplante fecal podr&#237;a ser eficaz en algunos pacientes&#44; aunque globalmente no ha demostrado todav&#237;a su eficacia en las enfermedades inflamatorias intestinales&#46; El trasplante aut&#243;logo de &#8220;<span class="elsevierStyleItalic">stem-cells&#8221;</span> ha probado su eficacia a medio plazo en la enfermedad de Crohn refractaria&#46; El abanico de posibles tratamientos es cada vez m&#225;s amplio&#44; y la investigaci&#243;n futura debe concentrarse en la selecci&#243;n del tratamiento m&#225;s adecuado para cada paciente y en los estudios comparativos entre las diversas opciones&#46;</p></span>"
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        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">In addition to immunosuppressive drugs and anti-TNF&#44; there are a number of new options in the treatment of inflammatory bowel diseases&#46; Vedolizumab has been approved by the FDA and EMA and has demonstrated utility both in the treatment of ulcerative colitis &#40;UC&#41; and Crohn&#39;s disease &#40;CD&#41;&#44; even in anti-TNF refractory patients&#46; Other monoclonal antibodies with different targets such as PF-005447659 &#40;antiMAd-CAM1&#41;&#44; ustekinumab &#40;anti-IL23&#47;IL12&#41; or MEDI2070 &#40;anti-IL23&#41; have shown promising results in distinct clinical scenarios&#46; Mongersen &#40;antisense oligonucleotide anti-Smad7&#41; and oznimod &#40;an SP-1 modulator&#41; are new alternatives with proven efficacy in clinical trials in CD and UC&#44; respectively&#46; Some data suggest that faecal microbiota transplantation could be efficacious in individual patients&#44; although controlled data do not show clear differences with placebo&#46; Autologous stem-cell transplantation has shown long-term efficacy in &#8220;ultra-refractory&#8221; CD&#46; The number of possible treatments is constantly increasing&#44; and future research should focus both on the selection of the most appropriate treatment for any given patient and on comparative trials between options&#46;</p></span>"
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