Se presentan 2 casos clínicos de perforación de intestino delgado distal por indometacina. Ambos pacientes eran varones, utilizaban indometacina por vía oral y presentaron un abdomen agudo con peritonitis difusa secundaria a perforaciones localizadas en el borde antimesentérico del íleon terminal. Las lesiones histopatológicas de la pared intestinal demostraron infiltración transmural, congestión y hemorragia; su grado de gravedad estuvo relacionado con un mayor tiempo de administración y dosis de indometacina.
We present two cases of indomethacin-induced perforation of the distal small intestine. Both patients were male and undergoing oral indomethacin therapy. Both presented acute abdomen with diffuse peritonitis secondary to perforations located in the antimesenteric border of the terminal ileum. Histopathological lesions of the intestinal wall showed transmural infiltration, congestion, and hemorrhage; their severity was related to higher doses and longer duration of indomethacin therapy.
