Efecto de asociar una dihidropiridina a la monoterapia antihipertensiva
Effect of incorporating a dihydropiridine to antihypetensive monotherapy
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Resultados del estudio Controlpres 2003" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "5" "paginaFinal" => "14" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Blood pressure control among treated hypertensive patients by Primary Care in Spain. The 2003 Controlpres study" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "A. Coca Payeras" "autores" => array:1 [ 0 => array:2 [ "nombre" => "A." "apellidos" => "Coca Payeras" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S188918370571521X?idApp=UINPBA00004N" "url" => "/18891837/0000002200000001/v1_201307261607/S188918370571521X/v1_201307261607/es/main.assets" ] "es" => array:14 [ "idiomaDefecto" => true "titulo" => "Efecto de asociar una dihidropiridina a la monoterapia antihipertensiva" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "15" "paginaFinal" => "20" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "N. Martell Clarós, A. Navarro, M. Luque" "autores" => array:3 [ 0 => array:3 [ "nombre" => "N." "apellidos" => "Martell Clarós" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "A." "apellidos" => "Navarro" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "M." "apellidos" => "Luque" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Unidad de Hipertensión. Hospital Clínico San Carlos. Madrid. España" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Departamento Médico. Recordati España. Madrid. España" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Correspondencia: Unidad de Hipertensión. Hospital Clínico San Carlos. 28040 Madrid." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Effect of incorporating a dihydropiridine to antihypetensive monotherapy" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2004-01-29" "fechaAceptado" => "2004-11-12" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec218855" "palabras" => array:5 [ 0 => "control" 1 => "asociación" 2 => "doble terapia" 3 => "dihidropiridina" 4 => "lercanidipino" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec218856" "palabras" => array:5 [ 0 => "association" 1 => "combination" 2 => "double therapy" 3 => "dihydropiridine" 4 => "lercanidipine" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Conocer el porcentaje de pacientes que estando sin controlar en monoterapia con betabloqueantes, inhibidores de la enzima conversora de la angiotensina o antagonistas del receptor de la angiotensina II alcanzan el control al añadir un segundo fármaco, concretamente un calcioantagonista (lercanidipino), estudiando si esto aumenta de forma significativa los efectos secundarios y su repercusión sobre la adherencia al tratamiento.</p> <span class="elsevierStyleSectionTitle">Pacientes y métodos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Estudio multicéntrico, abierto, observacional, prospectivo y comparativo. Participan 100 médicos de Atención Primaria. Se incluyeron 884 hipertensos. De ellos, el 53,1 % mujeres; edad: 62,3 ± 9,7 años; con buena tolerabilidad a monoterapia, pero insuficiente control (sistólica: 140- 200 mmHg, y diastólica: 90-114 mmHg). Se administraron 10 mg/día de lercanidipino en asociación al fármaco previamente empleado en monoterapia durante un mes.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Se analizó la respuesta de presión arterial considerando tanto los pacientes respondedores (reducción > 10 mmHg en presión arterial sistólica y > 5 mmHg en presión arterial diastólica) como los pacientes controlados (presión arterial < 140/90 mmHg). Tras un mes de tratamiento presentó presión arterial < 140 y 90 mmHg el 37,4 %. Fue respondedor el 91,1 %. La asociación de lercanidipino a betabloqueantes, inhibidores de la enzima conversora de la angiotensina o antagonistas del receptor de la angiotensina II consigue reducciones medias de sistólica de 18,1 mmHg y de 9,1 mmHg de diastólica. No encontramos diferencias en la magnitud de reducción de presión con ninguna de las combinaciones. El porcentaje de reacciones adversas fue del 3,4 % de intensidad leve- moderada, y en sólo el 0,3 % de los casos obligó a la retirada del tratamiento. El cumplimiento al final del estudio fue del 95,2 %.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La asociación de un segundo fármaco antihipertensivo consigue control de la hipertensión arterial en el 37,4 % de los pacientes no controlados con monoterapia. La asociación de lercanidipino se muestra efectiva y muy bien tolerada con betabloqueantes, inhibidores de la enzima conversora de la angiotensina y antagonistas del receptor de la angiotensina II. Extrapolando los resultados de nuestro estudio tendríamos que, contabilizando los pacientes controlados en monoterapia según los resultados del estudio Controlpres y los que estando en monoterapia no controlados se controlarían añadiendo un segundo fármaco, el 66,8 % de la población hipertensa tratada presentaría cifras inferiores a 140/90 mmHg.</p>" ] "en" => array:2 [ "titulo" => "Aim" "resumen" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To determine the percentage of hypertensive patients unable to be controlled monotherapeutically through the use of beta-blockers (ACEI or ARAII), but who are successfully controlled upon the addition of a second drug, namely a calcioantagonist (lercanidipine) to the treatment. The study is performed with a view toward any significant increases in side effects, as well as any repercussions for adherence to the treatment.</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">An open, multicenter study which is observational, prospective and comparative. One hundred Primary Health Care physicians participated. There were included 884 hypertensive patients, 53.1% women; 62.3±9.7 years old; good tolerability to monotherapy but insufficient control (systolic: 140-200 mmHg; diastolic: 90-114 mmHg). 10 mg/day lercanidipine was administered for one month in association with that drug which had been being used monotherapeutically.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">>BP response was analyzed taking into consideration both responsive patients (reduction > 10 mmHg in SBP, and >5 mmHg in DBP) and controlled patients (BP<140/90 mmHg). After one month of treatment, 37.4 % of patients showed BP values of < 140/90 mmHg. 91.1% of patients were responsive. The combination of lercanidipine and betablockers, either ACEI or ARAII, obtained average reductions of 18.1 mmHg and 9.1 mmHg in SBP and DBP, respectively. No differences in reduction were observed from any one combination to another. There was a 3.4 % rate of adverse reaction (all light-to-moderate), and only 0.3 % of patients was obliged to withdraw from treatment. Compliance at the end of the study was 95.2 %.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">The addition of a second antihypertensive drug controls hypertension in 37.4 % of patients unable to be controlled monotherapeutically. Lercanidipine in combination with beta-blockers (either ACEI or ARAII) appears to be effective and well-tolerated. Taking into account the percentage of monotherapeutically-treated patients who are controlled (according to the Controlpres study) and those such non-controlled patients who could benefit from the addition of a second drug, our results could be extrapolated to assert that 66.8 % of the treated hypertensive population would present BP levels under 140/90 mmHg.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:17 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mortalidad relacionada con la presión arterial y la hipertensión en España" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J.R. Banegas" 1 => "F. Artalejo Rodríguez" 2 => "J.J. Cruz" 3 => "B. de Andrés" 4 => "J. 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| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Octubre | 0 | 3 | 3 |
| 2024 Septiembre | 0 | 2 | 2 |
| 2024 Agosto | 0 | 2 | 2 |
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| 2024 Febrero | 0 | 1 | 1 |
| 2024 Enero | 0 | 2 | 2 |
| 2023 Diciembre | 0 | 3 | 3 |
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| 2023 Septiembre | 0 | 3 | 3 |
| 2023 Agosto | 0 | 1 | 1 |
| 2023 Julio | 0 | 4 | 4 |
| 2023 Junio | 15 | 2 | 17 |
| 2023 Marzo | 1 | 0 | 1 |
| 2023 Febrero | 0 | 5 | 5 |
| 2023 Enero | 0 | 2 | 2 |
| 2022 Noviembre | 0 | 5 | 5 |
| 2022 Agosto | 0 | 6 | 6 |
| 2022 Julio | 0 | 2 | 2 |
| 2022 Junio | 0 | 1 | 1 |
| 2022 Mayo | 0 | 3 | 3 |
| 2022 Abril | 0 | 5 | 5 |
| 2021 Octubre | 0 | 1 | 1 |
| 2021 Septiembre | 0 | 3 | 3 |
| 2021 Junio | 0 | 1 | 1 |
| 2021 Marzo | 0 | 1 | 1 |
| 2021 Enero | 0 | 1 | 1 |
| 2020 Agosto | 0 | 1 | 1 |
| 2020 Julio | 0 | 2 | 2 |
| 2020 Junio | 0 | 1 | 1 |
| 2020 Mayo | 0 | 1 | 1 |
| 2020 Abril | 0 | 1 | 1 |
| 2020 Enero | 0 | 2 | 2 |
| 2019 Diciembre | 0 | 7 | 7 |
| 2019 Octubre | 0 | 4 | 4 |
| 2019 Septiembre | 0 | 4 | 4 |
| 2019 Agosto | 0 | 1 | 1 |
| 2019 Julio | 0 | 4 | 4 |
| 2019 Junio | 0 | 9 | 9 |
| 2019 Mayo | 0 | 23 | 23 |
| 2018 Mayo | 0 | 2 | 2 |
| 2018 Abril | 3 | 1 | 4 |
| 2018 Marzo | 5 | 0 | 5 |
| 2018 Febrero | 2 | 0 | 2 |
| 2018 Enero | 0 | 1 | 1 |
| 2017 Diciembre | 3 | 0 | 3 |
| 2017 Noviembre | 3 | 1 | 4 |
| 2017 Octubre | 6 | 3 | 9 |
| 2017 Septiembre | 4 | 3 | 7 |
| 2017 Agosto | 3 | 0 | 3 |
| 2017 Julio | 9 | 2 | 11 |
| 2017 Junio | 11 | 6 | 17 |
| 2017 Mayo | 9 | 18 | 27 |
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| 2017 Marzo | 6 | 39 | 45 |
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| 2017 Enero | 11 | 1 | 12 |
| 2016 Diciembre | 21 | 5 | 26 |
| 2016 Noviembre | 33 | 5 | 38 |
| 2016 Octubre | 42 | 5 | 47 |
| 2016 Septiembre | 20 | 4 | 24 |
| 2016 Agosto | 9 | 5 | 14 |
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| 2016 Junio | 29 | 10 | 39 |
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| 2015 Febrero | 29 | 9 | 38 |
| 2015 Enero | 35 | 5 | 40 |
| 2014 Diciembre | 35 | 6 | 41 |
| 2014 Noviembre | 21 | 7 | 28 |
| 2014 Octubre | 38 | 3 | 41 |
| 2014 Septiembre | 34 | 1 | 35 |
| 2014 Agosto | 40 | 3 | 43 |
| 2014 Julio | 30 | 5 | 35 |
| 2014 Junio | 36 | 3 | 39 |
| 2014 Mayo | 24 | 2 | 26 |
| 2014 Abril | 35 | 2 | 37 |
| 2014 Marzo | 39 | 1 | 40 |
| 2014 Febrero | 28 | 4 | 32 |
| 2014 Enero | 27 | 3 | 30 |
| 2013 Diciembre | 32 | 4 | 36 |
| 2013 Noviembre | 36 | 3 | 39 |
| 2013 Octubre | 36 | 3 | 39 |
| 2013 Septiembre | 23 | 5 | 28 |
| 2013 Agosto | 33 | 6 | 39 |
| 2013 Julio | 36 | 1 | 37 |
| 2005 Enero | 654 | 0 | 654 |
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