Virus del dengue: estructura y ciclo viral
Dengue virus: structure and viral cycle
Myriam L. Velandia1, Jaime E. Castellanos1,2,
Autor para correspondencia
jecastellanosp@unal.edu.co
Correspondencia: Carrera 30 N° 45-03, Facultad de Odontología, Edificio 210, Oficina 210, Bogotá, D.C., Colombia. Tel.:éfono: (571) 316-5555; fax: (571) 648-9066.
Correspondencia: Carrera 30 N° 45-03, Facultad de Odontología, Edificio 210, Oficina 210, Bogotá, D.C., Colombia. Tel.:éfono: (571) 316-5555; fax: (571) 648-9066.
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Tel.:éfono: (571) 316-5555; fax: (571) 648-9066." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Dengue virus: structure and viral cycle" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2010-11-09" "fechaAceptado" => "2011-02-03" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec290528" "palabras" => array:4 [ 0 => "virus del dengue" 1 => "estructura" 2 => "ensamblaje" 3 => "inmunopatogenia" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec290527" "palabras" => array:4 [ 0 => "Dengue Virus" 1 => "structure" 2 => "assembly" 3 => "immunopathogenesis" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">El virus del dengue (DENV) es el agente causal de la enfermedad conocida como dengue, que es la principal enfermedad viral transmitida por artrópodos en el mundo. El DENV es un flavivirus que ingresa por endocitosis y se replica en el citoplasma de la célula infectada, originando tres proteínas estructurales y siete proteínas no estructurales, sobre las cuales se conocen sólo algunas de sus funciones en la replicación viral o en la infección. El ciclo viral que ocurre en las células infectadas hasta ahora está comenzando a aclararse y su conocimiento permitirá en el futuro próximo diseñar racionalmente moléculas que lo intervengan y eviten la replicación del virus. Durante la infección, el individuo puede presentar fiebre indiferenciada o, en otros casos, puede presentar un proceso generalizado de activación de la respuesta inmunitaria innata y adquirida, lo cual provoca la liberación de factores inflamatorios solubles que alteran la fisiología de los tejidos, principalmente el endotelio, conllevando al desarrollo de manifestaciones clínicas graves. Aunque se ha identificado un gran número de factores del individuo asociados al desarrollo de la enfermedad por DENV, queda por identificar el papel de las diferentes proteínas virales en la patogenia de la enfermedad. En la presente revisión, se presenta una breve actualización sobre la estructura y biología del DENV, de su ciclo viral intracelular y, finalmente, se introducen algunos conceptos sobre la inmunopatogenia de la enfermedad producida por este agente.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Dengue virus (DENV) is responsible for the clinical entity known as dengue that is a great concern for economy and public health of tropical countries. This flavivirus is a single strand RNA virus that after their translation and replication in host cells produces three structural and seven non-structural proteins with specific function in replication or cell binding process that we will describe here. Intracellular viral cycle has begun to be described and this knowledge will impact the rational design of new antiviral drugs. Patients suffering dengue can have an undifferentiated fever or in the severe cases, show an aberrant immunological activation process that lead to soluble inflammatory mediators secretion, affecting tissue function, mainly endothelium. This organ dysfunction is associated with plasma leakage and coagulatory imbalance. Despite it has been recently described some host factors associated with severity of infection, it remains unknown some aspects of viral biology or the role of DENV proteins in disease pathogenesis. 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| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Octubre | 846 | 182 | 1028 |
| 2024 Septiembre | 1468 | 275 | 1743 |
| 2024 Agosto | 788 | 203 | 991 |
| 2024 Julio | 675 | 187 | 862 |
| 2024 Junio | 767 | 203 | 970 |
| 2024 Mayo | 893 | 268 | 1161 |
| 2024 Abril | 1399 | 338 | 1737 |
| 2024 Marzo | 1266 | 319 | 1585 |
| 2024 Febrero | 625 | 157 | 782 |
| 2024 Enero | 454 | 128 | 582 |
| 2023 Diciembre | 438 | 199 | 637 |
| 2023 Noviembre | 976 | 354 | 1330 |
| 2023 Octubre | 794 | 281 | 1075 |
| 2023 Septiembre | 641 | 225 | 866 |
| 2023 Agosto | 435 | 214 | 649 |
| 2023 Julio | 352 | 93 | 445 |
| 2023 Junio | 582 | 347 | 929 |
| 2023 Mayo | 660 | 266 | 926 |
| 2023 Abril | 318 | 145 | 463 |
| 2023 Marzo | 221 | 196 | 417 |
| 2023 Febrero | 172 | 144 | 316 |
| 2023 Enero | 146 | 127 | 273 |
| 2022 Diciembre | 170 | 314 | 484 |
| 2022 Noviembre | 254 | 197 | 451 |
| 2022 Octubre | 182 | 110 | 292 |
| 2022 Septiembre | 190 | 100 | 290 |
| 2022 Agosto | 146 | 132 | 278 |
| 2022 Julio | 119 | 105 | 224 |
| 2022 Junio | 101 | 67 | 168 |
| 2022 Mayo | 174 | 98 | 272 |
| 2022 Abril | 85 | 75 | 160 |
| 2022 Marzo | 131 | 122 | 253 |
| 2022 Febrero | 115 | 86 | 201 |
| 2022 Enero | 114 | 108 | 222 |
| 2021 Diciembre | 128 | 84 | 212 |
| 2021 Noviembre | 190 | 136 | 326 |
| 2021 Octubre | 173 | 153 | 326 |
| 2021 Septiembre | 167 | 167 | 334 |
| 2021 Agosto | 135 | 70 | 205 |
| 2021 Julio | 177 | 105 | 282 |
| 2021 Junio | 236 | 140 | 376 |
| 2021 Mayo | 215 | 106 | 321 |
| 2021 Abril | 417 | 127 | 544 |
| 2021 Marzo | 278 | 119 | 397 |
| 2021 Febrero | 157 | 74 | 231 |
| 2021 Enero | 185 | 56 | 241 |
| 2020 Diciembre | 224 | 103 | 327 |
| 2020 Noviembre | 333 | 139 | 472 |
| 2020 Octubre | 323 | 80 | 403 |
| 2020 Septiembre | 317 | 124 | 441 |
| 2020 Agosto | 259 | 60 | 319 |
| 2020 Julio | 301 | 115 | 416 |
| 2020 Junio | 362 | 103 | 465 |
| 2020 Mayo | 482 | 146 | 628 |
| 2020 Abril | 660 | 157 | 817 |
| 2020 Marzo | 605 | 146 | 751 |
| 2020 Febrero | 244 | 91 | 335 |
| 2020 Enero | 164 | 70 | 234 |
| 2019 Diciembre | 226 | 97 | 323 |
| 2019 Noviembre | 471 | 166 | 637 |
| 2019 Octubre | 389 | 128 | 517 |
| 2019 Septiembre | 284 | 109 | 393 |
| 2019 Agosto | 219 | 57 | 276 |
| 2019 Julio | 290 | 89 | 379 |
| 2019 Junio | 391 | 79 | 470 |
| 2019 Mayo | 480 | 157 | 637 |
| 2019 Abril | 471 | 138 | 609 |
| 2019 Marzo | 298 | 98 | 396 |
| 2019 Febrero | 296 | 97 | 393 |
| 2019 Enero | 181 | 79 | 260 |
| 2018 Diciembre | 280 | 57 | 337 |
| 2018 Noviembre | 378 | 113 | 491 |
| 2018 Octubre | 501 | 81 | 582 |
| 2018 Septiembre | 381 | 67 | 448 |
| 2018 Agosto | 251 | 13 | 264 |
| 2018 Julio | 134 | 9 | 143 |
| 2018 Junio | 224 | 11 | 235 |
| 2018 Mayo | 381 | 26 | 407 |
| 2018 Abril | 247 | 17 | 264 |
| 2018 Marzo | 176 | 3 | 179 |
| 2018 Febrero | 142 | 9 | 151 |
| 2018 Enero | 85 | 1 | 86 |
| 2017 Diciembre | 87 | 46 | 133 |
| 2017 Noviembre | 229 | 11 | 240 |
| 2017 Octubre | 135 | 8 | 143 |
| 2017 Septiembre | 83 | 10 | 93 |
| 2017 Agosto | 69 | 13 | 82 |
| 2017 Julio | 77 | 17 | 94 |
| 2017 Junio | 143 | 27 | 170 |
| 2017 Mayo | 145 | 34 | 179 |
| 2017 Abril | 85 | 16 | 101 |
| 2017 Marzo | 78 | 62 | 140 |
| 2017 Febrero | 54 | 7 | 61 |
| 2017 Enero | 41 | 7 | 48 |
| 2016 Diciembre | 43 | 13 | 56 |
| 2016 Noviembre | 78 | 8 | 86 |
| 2016 Octubre | 66 | 14 | 80 |
| 2016 Septiembre | 75 | 14 | 89 |
| 2016 Agosto | 77 | 13 | 90 |
| 2016 Julio | 19 | 3 | 22 |
| 2016 Junio | 25 | 16 | 41 |
| 2016 Mayo | 14 | 21 | 35 |
| 2016 Abril | 17 | 29 | 46 |
| 2016 Marzo | 12 | 12 | 24 |
| 2016 Febrero | 12 | 15 | 27 |
| 2016 Enero | 13 | 8 | 21 |
| 2015 Diciembre | 12 | 11 | 23 |
| 2015 Noviembre | 20 | 17 | 37 |
| 2015 Octubre | 17 | 14 | 31 |
| 2015 Septiembre | 19 | 11 | 30 |
| 2015 Agosto | 10 | 7 | 17 |
| 2015 Julio | 8 | 3 | 11 |
| 2015 Junio | 5 | 5 | 10 |
| 2015 Mayo | 5 | 3 | 8 |
| 2015 Abril | 8 | 8 | 16 |
| 2015 Marzo | 5 | 3 | 8 |
| 2015 Febrero | 8 | 2 | 10 |
| 2015 Enero | 14 | 4 | 18 |
| 2014 Diciembre | 9 | 2 | 11 |
| 2014 Noviembre | 5 | 3 | 8 |
| 2014 Octubre | 7 | 1 | 8 |
| 2014 Septiembre | 7 | 1 | 8 |
| 2014 Agosto | 6 | 0 | 6 |
| 2014 Julio | 9 | 1 | 10 |
| 2014 Junio | 7 | 2 | 9 |
| 2014 Mayo | 1 | 2 | 3 |
| 2014 Marzo | 0 | 1 | 1 |
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