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Painful ulcers are observed on the fingertips (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>D), which on polarized light dermoscopy are shown as whitish atrophic scarring areas, with increased perilesional vascular structures in the form of irregular linear and dot-like vessels (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>A).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">In the presence of subcutaneous indurations on the inside of both feet, X-rays were taken showing extensive plaque calcification on the inside of the left foot, as well as heterogeneous calcifications in the distal phalanx of the 5th° metatarsal bone of the right foot (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>B).</p><p id="par0015" class="elsevierStylePara elsevierViewall">Anti-MDA5 antibody-positive dermatomyositis has an increased risk of developing oral ulcers, palmar papules, hand oedema, skin ulcerations, mechanic's hands, arthralgias, and diffuse hair loss in the scalp, constituting a characteristic mucocutaneous phenotype. Furthermore, anti-MDA5 and anti-Ro-52 antibodies have been associated with the presence of calcinosis cutis.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Funding</span><p id="par0020" class="elsevierStylePara elsevierViewall">No support or financial funding has been received from public or private entities for the preparation of this article.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Authorship</span><p id="par0025" class="elsevierStylePara elsevierViewall">Conception and design of the manuscript, data collection, analysis and interpretation of data and writing, review, and approval of the submitted manuscript: Miguel Fernando García-Gil and Begoña de Escalante Yangüela.</p><p id="par0030" class="elsevierStylePara elsevierViewall">Writing, review, and approval of the submitted manuscript: Ana Luisa Morales-Moya.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Funding" ] 1 => array:2 [ "identificador" => "sec0010" "titulo" => "Authorship" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: García-Gil MF, de Escalante Yangüela B, Morales-Moya AL. Dermatomiositis anti-MDA5 (CADM-140) positiva: manifestaciones mucocutáneas y de partes blandas. Med Clin (Barc). 2020;155:569.</p>" ] ] "multimedia" => array:2 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 630 "Ancho" => 787 "Tamanyo" => 92756 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Fig. " "rol" => "short" ] ] ] 1 => array:8 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 538 "Ancho" => 860 "Tamanyo" => 55024 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">.</p>" ] ] ] ] "idiomaDefecto" => "en" "url" => "/23870206/0000015500000012/v1_202012131835/S2387020620305362/v1_202012131835/en/main.assets" "Apartado" => array:4 [ "identificador" => "51820" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Images in medicine" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/23870206/0000015500000012/v1_202012131835/S2387020620305362/v1_202012131835/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2387020620305362?idApp=UINPBA00004N" ]
Journal Information
Vol. 155. Issue 12.
Pages 569 (December 2020)
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Vol. 155. Issue 12.
Pages 569 (December 2020)
Image in medicine
Anti-MDA5 (CADM-140) positive dermatomyositis: Mucocutaneous and soft tissue manifestations
Dermatomiositis anti-MDA5 (CADM-140) positiva: manifestaciones mucocutáneas y de partes blandas.
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