array:23 [ "pii" => "S2387020615000364" "issn" => "23870206" "doi" => "10.1016/j.medcle.2014.05.002" "estado" => "S300" "fechaPublicacion" => "2015-01-20" "aid" => "3038" "copyright" => "Elsevier España, S.L.U.. All rights reserved" "copyrightAnyo" => "2014" "documento" => "article" "crossmark" => 1 "subdocumento" => "sco" "cita" => "Med Clin. 2015;144:e3" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 90 "formatos" => array:2 [ "HTML" => 61 "PDF" => 29 ] ] "Traduccion" => array:1 [ "es" => array:19 [ "pii" => "S0025775314004588" "issn" => "00257753" "doi" => "10.1016/j.medcli.2014.05.032" "estado" => "S300" "fechaPublicacion" => "2015-01-20" "aid" => "3038" "copyright" => "Elsevier España, S.L.U." "documento" => "article" "crossmark" => 1 "subdocumento" => "sco" "cita" => "Med Clin. 2015;144:e3" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 559 "formatos" => array:2 [ "HTML" => 501 "PDF" => 58 ] ] "es" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Imagen de la semana</span>" "titulo" => "Pápulas faciales con múltiples neoplasias asociadas" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "e3" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Facial papules with multiple associated neoplasms" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:6 [ "identificador" => "fig0020" "etiqueta" => "Figura 4" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr4.jpeg" "Alto" => 600 "Ancho" => 450 "Tamanyo" => 135119 ] ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Ignacio Hernández Aragüés, Juncal Ruiz Rivero, Verónica Parra Blanco, Cristina Ciudad Blanco" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Ignacio" "apellidos" => "Hernández Aragüés" ] 1 => array:2 [ "nombre" => "Juncal" "apellidos" => "Ruiz Rivero" ] 2 => array:2 [ "nombre" => "Verónica" "apellidos" => "Parra Blanco" ] 3 => array:2 [ "nombre" => "Cristina" "apellidos" => "Ciudad Blanco" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2387020615000364" "doi" => "10.1016/j.medcle.2014.05.002" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2387020615000364?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775314004588?idApp=UINPBA00004N" "url" => "/00257753/0000014400000002/v2_201506091725/S0025775314004588/v2_201506091725/es/main.assets" ] ] "itemAnterior" => array:19 [ "pii" => "S2387020615000327" "issn" => "23870206" "doi" => "10.1016/j.medcle.2014.07.003" "estado" => "S300" "fechaPublicacion" => "2015-01-20" "aid" => "3087" "copyright" => "Elsevier España, S.L.U." "documento" => "article" "crossmark" => 1 "subdocumento" => "sco" "cita" => "Med Clin. 2015;144:96" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 68 "formatos" => array:2 [ "HTML" => 52 "PDF" => 16 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Image of the week</span>" "titulo" => "Gorham's disease (disappearing bone syndrome)" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "96" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Enfermedad de Gorham (síndrome del hueso evanescente)" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:6 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 639 "Ancho" => 358 "Tamanyo" => 34989 ] ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Sonia María San Miguel López de Uralde" "autores" => array:1 [ 0 => array:2 [ "nombre" => "Sonia María" "apellidos" => "San Miguel López de Uralde" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0025775314005855" "doi" => "10.1016/j.medcli.2014.07.023" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775314005855?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2387020615000327?idApp=UINPBA00004N" "url" => "/23870206/0000014400000002/v1_201509250127/S2387020615000327/v1_201509250127/en/main.assets" ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Image of the week</span>" "titulo" => "Facial papules with multiple associated neoplasms" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "e3" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Ignacio Hernández Aragüés, Juncal Ruiz Rivero, Verónica Parra Blanco, Cristina Ciudad Blanco" "autores" => array:4 [ 0 => array:4 [ "nombre" => "Ignacio" "apellidos" => "Hernández Aragüés" "email" => array:1 [ 0 => "ignaciohdezaragues@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Juncal" "apellidos" => "Ruiz Rivero" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 2 => array:3 [ "nombre" => "Verónica" "apellidos" => "Parra Blanco" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "Cristina" "apellidos" => "Ciudad Blanco" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Dermatología, Hospital General Universitario Gregorio Marañón, Madrid, Spain" "etiqueta" => "a" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Servicio de Anatomía Patológica, Hospital General Universitario Gregorio Marañón, Madrid, Spain" "etiqueta" => "b" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Pápulas faciales con múltiples neoplasias asociadas" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:6 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 420 "Ancho" => 532 "Tamanyo" => 56435 ] ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">A 28-year old female, with a history of craniofacial malformation, right-side parotidectomy as a result of a mucoepidermoid carcinoma, thyroidectomy as a result of follicular adenoma, and prophylactic bilateral mastectomy, who consulted about numerous papules of normal colour and verrucous appearance scattered over her face, predominantly on the perioral (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>) and submental (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>) areas, that she had had for 5 years. A biopsy was made on one of these injuries, showing diffuse proliferation in the form of solid lobes that are connected with the epidermis (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>), and that consist of a thick peripheral layer of picket-fence squamous cells (<a class="elsevierStyleCrossRef" href="#fig0020">Fig. 4</a>), and scarce areas of clear cytoplasm, compatible with trichilemmoma diagnosis.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><elsevierMultimedia ident="fig0020"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">Cowden syndrome is an autosomal dominant disease caused by the mutation in the <span class="elsevierStyleItalic">PTEN</span> tumour suppressor gene, characterised by the development of benign and malignant neoplasms, especially in thyroid and breasts. Furthermore, cutaneous injuries are present in up to 80% of affected patients. The most frequent ones are multiple facial trichilemmomas, which constitute Cowden syndrome's pathognomonic lesions.</p><p id="par0015" class="elsevierStylePara elsevierViewall">It is vital for patients with Cowden syndrome to have a multidisciplinary follow-up for the early detection of malignant neoplasms, frequently associated with this condition.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Hernández Aragüés I, Ruiz Rivero J, Parra Blanco V, Ciudad Blanco C. Pápulas faciales con múltiples neoplasias asociadas. Med Clin (Barc). 2015;144:e3.</p>" ] ] "multimedia" => array:4 [ 0 => array:6 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 420 "Ancho" => 532 "Tamanyo" => 56435 ] ] ] 1 => array:6 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 479 "Ancho" => 596 "Tamanyo" => 56090 ] ] ] 2 => array:6 [ "identificador" => "fig0015" "etiqueta" => "Fig. 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 600 "Ancho" => 450 "Tamanyo" => 122848 ] ] ] 3 => array:6 [ "identificador" => "fig0020" "etiqueta" => "Fig. 4" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr4.jpeg" "Alto" => 600 "Ancho" => 450 "Tamanyo" => 141833 ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/23870206/0000014400000002/v1_201509250127/S2387020615000364/v1_201509250127/en/main.assets" "Apartado" => array:4 [ "identificador" => "43312" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Image of the week" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/23870206/0000014400000002/v1_201509250127/S2387020615000364/v1_201509250127/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2387020615000364?idApp=UINPBA00004N" ]
Journal Information
Vol. 144. Issue 2.
Pages e3 (January 2015)
Share
Download PDF
More article options
Vol. 144. Issue 2.
Pages e3 (January 2015)
Image of the week
Facial papules with multiple associated neoplasms
Pápulas faciales con múltiples neoplasias asociadas
Visits
91
This item has received
Article information
These are the options to access the full texts of the publication Medicina Clínica (English Edition)
Subscriber
Subscribe
Purchase
Contact
Phone for subscriptions and reporting of errors
From Monday to Friday from 9 a.m. to 6 p.m. (GMT + 1) except for the months of July and August which will be from 9 a.m. to 3 p.m.
Calls from Spain
932 415 960
Calls from outside Spain
+34 932 415 960
E-mail