We would like to share ideas on the publication “Humoral response to vaccination against SARS-CoV-2 in patients undergoing maintenance hemodialysis (HD).1” Delgado Urena et al. concluded that chronic HD patients developed a substantial humoral immune response after the full vaccination dose. Delgado Urena et al. noted that this finding is reassuring and should encourage HD patients and their caregivers to receive the vaccine, however, it remains to continue with the research to be able to understand the mechanism of action and humoral defense against SARS-CoV-2 as well as promote the idea of reinforcing the dose or vaccination program in hemodialysis patients.1
We both believe that those with underlying medical conditions might respond to the vaccine differently from those who are in good health. To get at the correct interpretation, a number of factors must be taken into account. A genuine bad reaction was one of the possible confounding factors that might have had an impact on the results of the initial dose. The absence of clinical symptoms and asymptomatic COVID-19 may be related.2 If neither the past symptoms nor the current clinical symptoms exist, a COVID-19 must be ruled out. The chance of cross-contamination with an unidentified SARS-Co-V2 infection cannot be completely ruled out. It is impossible to completely rule out an unidentified SARS-Co-V2 infection. According to reports, inherited genetic diversity affects how the immune systems of vaccination recipients respond.3 To ascertain whether the current publication's conclusions and clinical findings are substantiated, more empirical clinical research is required.
Authors’ contributionsRM 50% – 1a Substantial contributions to study conception and design. 1b. Substantial contributions to acquisition of data. 1c. Substantial contributions to analysis and interpretation of data. 2. Drafting the article or revising it critically for important intellectual content. 3. Final approval of the version of the article to be published.
VW 50% – 1a Substantial contributions to study conception and design. 1b. Substantial contributions to acquisition of data. 1c. Substantial contributions to analysis and interpretation of data. 2. Drafting the article or revising it critically for important intellectual content. 3. Final approval of the version of the article to be published.
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Conflict of interestNone.
