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This case report (<a class="elsevierStyleCrossRef" href="#fig0005">Image 1</a>) is on a 70-year-old male patient who developed this disease progressively after chronic immunosuppressive therapy with cyclosporin A (10 years) due to liver transplant. The patient was asymptomatic, showing no tooth mobility, bleeding or pain, consulting mainly for aesthetic reasons. The etiology of this disorder remains unknown. However, there is evidence that cyclosporine might act directly on gingival fibroblasts by increasing the secretion of interleukin-6, which in turn would lead to a greater synthesis of collagen and glycosaminoglycans. It was estimated that approximately 25% of patients treated with cyclosporine developed this disorder and that the first symptoms occurred within the first 3 months of treatment, mainly affecting the papillae of the anterior surface of the tongue. The treatment was periodontal surgery of the affected area and subsequent thorough clinical follow-up of the dental plaque.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Sánchez López JD, Cariati P, Rodríguez I. Hiperplasia gingival masivo tras tratamiento con ciclosporina. Med Clin (Barc). 2019;152:e47.</p>" ] ] "multimedia" => array:1 [ 0 => array:6 [ "identificador" => "fig0005" "etiqueta" => "Image 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 605 "Ancho" => 805 "Tamanyo" => 82455 ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/23870206/0000015200000008/v1_201904100623/S238702061930097X/v1_201904100623/en/main.assets" "Apartado" => array:4 [ "identificador" => "51820" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Images in medicine" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/23870206/0000015200000008/v1_201904100623/S238702061930097X/v1_201904100623/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S238702061930097X?idApp=UINPBA00004N" ]
Journal Information
Vol. 152. Issue 8.
Pages e47 (April 2019)
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Vol. 152. Issue 8.
Pages e47 (April 2019)
Image in medicine
Massive gingival hyperplasia due to cyclosporine
Hiperplasia gingival masiva tras tratamiento con ciclosporina
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