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Inicio Medicina Clínica (English Edition) Occupational semicircular lipoatrophy associated with serum adipokine abnormalit...
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Vol. 145. Issue 8.
Pages 338-340 (October 2015)
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Vol. 145. Issue 8.
Pages 338-340 (October 2015)
Brief report
Occupational semicircular lipoatrophy associated with serum adipokine abnormalities
Lipoatrofia semicircular de etiología laboral asociada a alteraciones séricas de adipocinas
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Luis Reinoso-Barberoa,b,
Corresponding author
lreinoso@bancopopular.es

Corresponding author.
, Ramón Díaz-Garridoa, María-Fernanda González-Gómezc, José Olarread, Félix Gómez-Gallegob, Fernando Bandrése
a Medicina del Trabajo, Servicio de Prevención de Riesgos Laborales, Grupo Banco Popular (GBP), Madrid, Spain
b Departamento de Ciencias Morfológicas y Biomedicina, Facultad de Ciencias de la Salud, Universidad Europea de Madrid (UEM), Villaviciosa de Odón, Madrid, Spain
c Salud Laboral, Consejería de Sanidad, Comunidad de Madrid, Madrid, Spain
d Departamento de Matemática Aplicada y Estadística, Escuela Técnica Superior de Ingenieros Aeronáuticos, Universidad Politécnica de Madrid (UPM), Madrid, Spain
e Departamento de Toxicología y Legislación Sanitaria, Facultad de Medicina, Universidad Complutense de Madrid (UCM), Madrid, Spain
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Table 1. Distribution of sex and age between cases and controls. Population characteristics and variables to be studied. Summary table.
Abstract
Objectives

The aim of this study was to examine the relationship between semicircular lipoatrophy (SL), inflammation marker (high sensibility C-reactive protein [hs-CRP]), adipokines (leptine, chemerine and vaspine) and autoimmune markers (rheumatoid factor [RF], C3 and C4 complement fractions, antinuclear antibodies [ANA], HLA DR3, and DR4). Chemerine is an adipokine, but also is an immunity marker.

Methods

A case–control study was performed in May 2013; 21 cases were included. The closest healthy coworker to each case was used as a control. We calculated Kruskal–Wallis nonparametric test.

Results

We found statistical significance (p<0.05) between SL and raised hs-CRP, raised leptine and low chemerine.

Conclusions

(i) There seems to be an underlying inflammatory component (raised hs-CRP) in SL; (ii) adipokine alteration (raised leptine and low chemerine) supports the idea that adipocytic differentiation is affected in SL, and (iii) we have not found any immune marker associated with SL, except chemerine itself, which could explain a possible association between SL and immunity.

Keywords:
Semicircular lipoatrophy
Adipocytic differentiation
Adipokines and electrohypersensitivity
Resumen
Objetivos

El objetivo de este estudio es examinar la relación entre lipoatrofia semicircular (LS), marcadores de inflamación (proteína C reactiva ultrasensible, [PCRus]), adipocinas (leptina, quemerina y vaspina) y marcadores inmunitarios (factor reumatoide [FR], fracciones de complemento C3 y C4, anticuerpos antinucleares [ANA], HLA DR3 y DR4). La quemerina es una adipocina, pero también es un marcador de inmunidad.

Métodos

Estudio de casos y controles realizado en mayo de 2013. Participaron 21 casos, y como control participó el empleado sano más cercano a cada caso. Se utilizaron test no paramétricos (Kruskal–Wallis).

Resultados

Se observó una relación estadísticamente significativa (p<0,05) entre LS y niveles séricos de PCRus elevados, de leptina elevados y de quemerina disminuidos.

Conclusiones

i) Parece haber un componente inflamatorio subyacente (PCRus elevada) en la LS; ii) la alteración de las adipocinas (leptina elevada y quemerina disminuida) apoyan la teoría de que la diferenciación adipocítica esté afectada en la LS, y iii) no hemos encontrado ningún marcador inmunitario (FR, etc.) asociado con LS, excepto la misma quemerina, que podría explicar una posible asociación entre LS y autoinmunidad.

Palabras clave:
Lipoatrofia semicircular
Diferenciación adipocítica
Adipocinas y electrosensibilidad

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