Compartir
array:23 [ "pii" => "S0025775300715405" "issn" => "00257753" "doi" => "10.1016/S0025-7753(00)71540-5" "estado" => "S300" "fechaPublicacion" => "2000-01-01" "aid" => "71540" "copyright" => "Elsevier España, S.L.. Todos los derechos reservados" "copyrightAnyo" => "2000" "documento" => "article" "crossmark" => 0 "subdocumento" => "sco" "cita" => "Med Clin. 2000;115:299-301" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 814 "formatos" => array:3 [ "EPUB" => 6 "HTML" => 617 "PDF" => 191 ] ] "itemSiguiente" => array:18 [ "pii" => "S0025775300715417" "issn" => "00257753" "doi" => "10.1016/S0025-7753(00)71541-7" "estado" => "S300" "fechaPublicacion" => "2000-01-01" "aid" => "71541" "copyright" => "Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "sco" "cita" => "Med Clin. 2000;115:302-4" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2858 "formatos" => array:3 [ "EPUB" => 5 "HTML" => 2768 "PDF" => 85 ] ] "es" => array:7 [ "idiomaDefecto" => true "titulo" => "La industria del tabaco y la manipulación de la investigación científica. El caso del estudio europeo de la IARC-OMS sobre consumo pasivo de tabaco y cáncer de pulmón" "tienePdf" => "es" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "302" "paginaFinal" => "304" ] ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Carlos A. González, Antonio Agudo" "autores" => array:2 [ 0 => array:2 [ "nombre" => "Carlos A." "apellidos" => "González" ] 1 => array:2 [ "nombre" => "Antonio" "apellidos" => "Agudo" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775300715417?idApp=UINPBA00004N" "url" => "/00257753/0000011500000008/v1_201307291646/S0025775300715417/v1_201307291646/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0025775300715399" "issn" => "00257753" "doi" => "10.1016/S0025-7753(00)71539-9" "estado" => "S300" "fechaPublicacion" => "2000-01-01" "aid" => "71539" "copyright" => "Elsevier España, S.L." "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "edi" "cita" => "Med Clin. 2000;115:297-8" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1280 "formatos" => array:3 [ "EPUB" => 6 "HTML" => 1141 "PDF" => 133 ] ] "es" => array:7 [ "idiomaDefecto" => true "titulo" => "Hepatitis por virus B. Bases moleculares de resistencia a los nuevos fármacos" "tienePdf" => "es" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "297" "paginaFinal" => "298" ] ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Eugenia Quirós, María del Carmen Maroto" "autores" => array:2 [ 0 => array:2 [ "nombre" => "Eugenia" "apellidos" => "Quirós" ] 1 => array:2 [ "nombre" => "María" "apellidos" => "del Carmen Maroto" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775300715399?idApp=UINPBA00004N" "url" => "/00257753/0000011500000008/v1_201307291646/S0025775300715399/v1_201307291646/es/main.assets" ] "es" => array:14 [ "idiomaDefecto" => true "titulo" => "Aplasia medular tras administración de azatioprina: papel del polimorfismo genético de la tiopurina metiltransferasa" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "299" "paginaFinal" => "301" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Héctor Coraminas, Montserrat Domènech, Dolors González-Juan, Begoña González-Suárez, César Díaz, Joan Pujol, Guillermo Vázquez, Montserrat Baiget" "autores" => array:8 [ 0 => array:3 [ "nombre" => "Héctor" "apellidos" => "Coraminas" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 1 => array:3 [ "nombre" => "Montserrat" "apellidos" => "Domènech" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "Dolors" "apellidos" => "González-Juan" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 3 => array:3 [ "nombre" => "Begoña" "apellidos" => "González-Suárez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 4 => array:3 [ "nombre" => "César" "apellidos" => "Díaz" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 5 => array:3 [ "nombre" => "Joan" "apellidos" => "Pujol" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 6 => array:3 [ "nombre" => "Guillermo" "apellidos" => "Vázquez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 7 => array:4 [ "nombre" => "Montserrat" "apellidos" => "Baiget" "email" => array:1 [ 0 => "mbaiget@hsp.santpau.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Servicios de Medicina Interna. Hospital de la Santa Creu i Sant Pau. Barcelona" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicios de Genética. Hospital de la Santa Creu i Sant Pau. Barcelona" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Servicios de Patología Digestiva. Hospital de la Santa Creu i Sant Pau. Barcelona" "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Servei de Genètica. Hospital de la Santa Creu i Sant Pau. Avgda. Sant Antoni M.<span class="elsevierStyleSup">a</span> Claret, 167. 08025 Barcelona." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Aplasia after azathioprine administration: role of the thiopurine methyltransferase genetic polymorphism" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2000-03-02" "fechaAceptado" => "2000-07-04" "PalabrasClave" => array:1 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec222502" "palabras" => array:2 [ 0 => "Azatioprina" 1 => "Tiopurina metiltransferasa" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Fundamento</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La azatioprina es un fármaco inmunodepresor ampliamente utilizado en el tratamiento de diversos procesos autoinmunes. Los efectos adversos del tratamiento están en relación con la actividad de la tiopurina metiltransferasa (TPMT), enzima que interviene en el metabolismo de la azatioprina. La existencia de variantes alélicas del gen que codifica dicha enzima permite clasificar a los pacientes en tres grupos: de riesgo leve, moderado y alto de padecer una mielodepresión tras la administración de azatioprina.</p> <span class="elsevierStyleSectionTitle">Pacientes y método</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se ha realizado el estudio de las variantes alélicas del gen de la TPMT en las posiciones 460 y 719 mediante reacción en cadena de la polimerasa y digestión con enzimas de restricción, en un enfermo con enfermedad de Crohn que presentó aplasia tras la administración de azatioprina, así como de sus familiares directos disponibles.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">En la muestra del caso en estudio se identificó la variante alélica más frecuente del gen de la TPMT asociada a una actividad enzimática disminuida. La madre del paciente, así como su hermana, también presentaron esta variante.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La identificación genotipica de las variantes alélicas del gen TPMT es un método eficaz para identificar a los pacientes con riesgo leve, moderado o grave de padecer una mielo-depresión tras la administración de azatioprina.</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Azathioprine is an immunosuppressor drug widely used in the treatment of autoimmune diseases. Adverse effects during treatment are related to the activity of thiopurine methyltransferase (TPMT), an enzyme which plays a role in azathioprine metabolism. The presence of the allelic variants of the TPMT gene allows us to classify patients into three different groups: high, moderate and low risk of myelosuppression after receiving standard doses of azat-hioprine.</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Study of the allelic variants of the TPMT gene in the positions 460 and 719 with PCR methods in a patient with Crohn's disease, who developed aplasia after receiving azathioprine. The study was extended to his relatives.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">The patient under study carried the most frequent variant allele of the TPMT gene associated with low enzymatic activity. The mother and one sister of the patient were also carriers of this allelic variant.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Genotyping the allelic variants of the TPMT gene is a useful method to identify patients at moderate or high risk of myelosuppression after administration of azathioprine.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias Bibliográficas" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:14 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "6-Mercaptopurine and other immu-nosuppressive agents in the treatment of Crohn's disease and ulcerative colitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "D.H. Present" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Gastroentrol Clin N Am" "fecha" => "1989" "volumen" => "18" "paginaInicial" => "57" "paginaFinal" => "71" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "An Intravenous loading dose of azathioprine decreases the time to response in patients with Crohn's disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "W.J. Sandborn" 1 => "O.E. Van" 2 => "B.J. Zins" 3 => "W.J. Tremaine" 4 => "D.C. Mays" 5 => "J.J. Lipsky" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Gastro- enterology" "fecha" => "1995" "volumen" => "109" "paginaInicial" => "1808" "paginaFinal" => "1817" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Healing of severe recurrent ileitis with azathioprine therapy in patients with Crohn's disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "G. D'Haens" 1 => "K. Geboes" 2 => "E. Ponette" 3 => "F. Penninckx" 4 => "P. Rutgeerts" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Gastroenterology" "fecha" => "1997" "volumen" => "112" "paginaInicial" => "1475" "paginaFinal" => "1481" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9136824" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The role of genetic variation in thiopurine methyltransferase activity and the efficacy and/or side effects of azathioprine therapy in dermatologic patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.L. Snow" 1 => "L.E. Gibson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Dermatol" "fecha" => "1995" "volumen" => "131" "paginaInicial" => "193" "paginaFinal" => "197" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7857117" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Metabolism of thiopyrimidines and thyopurines: S-methylation with S-adenosylmethionine transmethylase and catabolism in mammalin tissue" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "C.N. Remy" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Biol Chem" "fecha" => "1963" "volumen" => "238" "paginaInicial" => "1078" "paginaFinal" => "1084" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/13981612" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Molecular diagnosis of thiopurine S-methyltransferase deficiency: genetic basis for azathioprine and mercaptopurine intolerance" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C.R. Yates" 1 => "E.Y. Krynetski" 2 => "T. Loennechen" 3 => "M.Y. Fessing" 4 => "J.L. Tai" 5 => "C.H. Pui" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Intern Med" "fecha" => "1997" "volumen" => "126" "paginaInicial" => "608" "paginaFinal" => "614" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9103127" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pharmacogenetics of acute azathioprine toxicity: relationship to thiopurine methyltransferase genetic polymorphism" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "L. Lennard" 1 => "J.A. Van Loon" 2 => "R.M. Weinshilboum" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Pharmacol Ther" "fecha" => "1989" "volumen" => "46" "paginaInicial" => "149" "paginaFinal" => "154" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2758725" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mercaptopurine pharmacogenetics: monogenic inheritance of erythrocyte thiopurine methyltransferasa activity" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "R.M. Weinshilboum" 1 => "S.L. Sladek" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Hum Genet" "fecha" => "1980" "volumen" => "32" "paginaInicial" => "651" "paginaFinal" => "662" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7191632" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Thiopurine methyltransferase activity in American white subjects and black subjects" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "H.L. McLeod" 1 => "J.S. Lin" 2 => "E.P. Scott" 3 => "C.H. Pui" 4 => "W.E. Evans" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Pharmacol Ther" "fecha" => "1994" "volumen" => "55" "paginaInicial" => "15" "paginaFinal" => "20" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8299312" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Thiopurine S-methyltransferase deficiency: two nucleotide transitions define the most prevalent mutant allele associated with loss of catalytic activity in Caucasians" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "H.L. Tai" 1 => "E.Y. Krynetski" 2 => "C.R. Yates" 3 => "T. Loennechen" 4 => "M.Y. Fessing" 5 => "N.F. Krynetskaia" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Hum Genet" "fecha" => "1996" "volumen" => "58" "paginaInicial" => "694" "paginaFinal" => "702" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8644731" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Human thiopurine methyltransferase pharmacogenetics. Kindred with a terminal exon splice junction mutation that results in loss of activity" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "D.M. Otterness" 1 => "C.L. Szumlanski" 2 => "T.C. Wood" 3 => "R.M. Weinshilboum" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1172/JCI1004" "Revista" => array:6 [ "tituloSerie" => "J Clin Invest" "fecha" => "1998" "volumen" => "101" "paginaInicial" => "1036" "paginaFinal" => "1044" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9486974" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0060" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Detection of known and new mutations in the thiopurine S-methyltransferase gene by single-strand conformation polymorphism analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C. Spire-Vayron de la Moureyre" 1 => "H. Debuysere" 2 => "N. Sabbagh" 3 => "D. Marez" 4 => "E. Vinner" 5 => "E.D. Chevalier" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/(SICI)1098-1004(1998)12:3<177::AID-HUMU5>3.0.CO;2-E" "Revista" => array:6 [ "tituloSerie" => "Hum Mutat" "fecha" => "1990" "volumen" => "12" "paginaInicial" => "177" "paginaFinal" => "185" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9711875" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0065" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A simple salting out procedure for extracting DNA from human nucleated cells" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S.A. Miller" 1 => "D.D. Dykes" 2 => "H.F. Polesky" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Nucleic Acids Res" "fecha" => "1988" "volumen" => "16" "paginaInicial" => "1215" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3344216" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0070" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Thiopurine methyltranferase levels should be measured before commencing patients on azathioprine" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A.P. Jackson" 1 => "A.G. Hall" 2 => "J. McLelland" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "1997" "volumen" => "136" "paginaInicial" => "132" "paginaFinal" => "148" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9039313" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/00257753/0000011500000008/v1_201307291646/S0025775300715405/v1_201307291646/es/main.assets" "Apartado" => array:4 [ "identificador" => "34461" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Nota clínica" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/00257753/0000011500000008/v1_201307291646/S0025775300715405/v1_201307291646/es/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775300715405?idApp=UINPBA00004N" ]
