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array:23 [ "pii" => "S0025775323006668" "issn" => "00257753" "doi" => "10.1016/j.medcli.2023.09.025" "estado" => "S300" "fechaPublicacion" => "2024-04-26" "aid" => "6470" "copyright" => "Elsevier España, S.L.U.. All rights reserved" "copyrightAnyo" => "2023" "documento" => "article" "crossmark" => 1 "subdocumento" => "sco" "cita" => "Med Clin. 2024;162:406" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "itemSiguiente" => array:19 [ "pii" => "S002577532300667X" "issn" => "00257753" "doi" => "10.1016/j.medcli.2023.09.026" "estado" => "S300" "fechaPublicacion" => "2024-04-26" "aid" => "6471" "copyright" => "Elsevier España, S.L.U." "documento" => "article" "crossmark" => 1 "subdocumento" => "sco" "cita" => "Med Clin. 2024;162:407" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "es" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Imagen médica</span>" "titulo" => "Síndrome de los dedos púrpura por embolia de cristales de colesterol" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "407" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Blue toe syndrome due to crystal cholesterol embolism" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:6 [ "identificador" => "fig0005" "etiqueta" => "Figura 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 953 "Ancho" => 3542 "Tamanyo" => 837385 ] ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Omar Alwattar-Ceballos, Laura Martínez-Montalvo, Marina Montero-García, Mónica Gómez-Manzanares, Minerva Arambarri-Segura" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Omar" "apellidos" => "Alwattar-Ceballos" ] 1 => array:2 [ "nombre" => "Laura" "apellidos" => "Martínez-Montalvo" ] 2 => array:2 [ "nombre" => "Marina" "apellidos" => "Montero-García" ] 3 => array:2 [ "nombre" => "Mónica" "apellidos" => "Gómez-Manzanares" ] 4 => array:2 [ "nombre" => "Minerva" "apellidos" => "Arambarri-Segura" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2387020624001141" "doi" => "10.1016/j.medcle.2024.04.001" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2387020624001141?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S002577532300667X?idApp=UINPBA00004N" "url" => "/00257753/0000016200000008/v2_202404281220/S002577532300667X/v2_202404281220/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0025775323007601" "issn" => "00257753" "doi" => "10.1016/j.medcli.2023.11.025" "estado" => "S300" "fechaPublicacion" => "2024-04-26" "aid" => "6514" "copyright" => "Elsevier España, S.L.U." "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "cor" "cita" => "Med Clin. 2024;162:404-5" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>" "titulo" => "Atypic onset of multiple sclerosis mimicking Susac's Syndrome" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "404" "paginaFinal" => "405" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Presentación atípica de esclerosis múltiple que imita el síndrome de Susac" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 555 "Ancho" => 1674 "Tamanyo" => 116812 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(a) Sagittal T2-weighted (T2W) images reveal hyperintense lesions in the periventricular region, left cerebellar hemisphere, and corpus callosum. Furthermore, bilateral polymicrogyria is demonstrated involving both cerebral hemispheres. These lesions exhibit no enhancement following intravenous contrast agent administration (not illustrated). (b) Axial T2-weighted (T2W) images depict the presence of new lesions in the right middle cerebellar peduncle and the superior frontal subcortical white matter. The middle cerebellar pedincule shows contrast enhancement. (c) 3D CUBE FLAIR, the spinal cord lesion at the C2 cervical vertebra level is highlighted with white arrows.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Asuman Orhan Varoglu, Mehmet Akif Balci, Basak Atalay" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Asuman" "apellidos" => "Orhan Varoglu" ] 1 => array:2 [ "nombre" => "Mehmet Akif" "apellidos" => "Balci" ] 2 => array:2 [ "nombre" => "Basak" "apellidos" => "Atalay" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775323007601?idApp=UINPBA00004N" "url" => "/00257753/0000016200000008/v2_202404281220/S0025775323007601/v2_202404281220/en/main.assets" ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Image in medicine</span>" "titulo" => "Bleomycin-induced flagellate dermatitis in a patient with Hodgkin lymphoma" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "406" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Nicolò Danesin, Alessandro Cellini, Francesco Piazza, Livio Trentin, Andrea Visentin" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Nicolò" "apellidos" => "Danesin" ] 1 => array:2 [ "nombre" => "Alessandro" "apellidos" => "Cellini" ] 2 => array:2 [ "nombre" => "Francesco" "apellidos" => "Piazza" ] 3 => array:2 [ "nombre" => "Livio" "apellidos" => "Trentin" ] 4 => array:4 [ "nombre" => "Andrea" "apellidos" => "Visentin" "email" => array:1 [ 0 => "andrea.visentin@unipd.it" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Hematology Unit, Department of Medicine, University of Padova, Italy" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Dermatitis flagelada causada por bleomicina en un paciente con linfoma de Hodgkin" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:6 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 864 "Ancho" => 1340 "Tamanyo" => 105121 ] ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">A 46 years old woman was referred to our clinic due to cough and multiple lymphadenopathies. No systemic symptoms were notified. Lymph node biopsy revealed a classical Hodgkin lymphoma (HL) nodular sclerosis type according to 5th WHO classification, stage IIA. At diagnosis, blood exams were unremarkable. The IPS (International Prognostic Scoring) for Hodgkin lymphoma was calculated at 1. Patients started treatment according to the ABVD (doxorubicin–bleomycin–vinblastine–dacarbazine) protocol. A painless papular-erythematous rash without blisters (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>) was seen 6 days after the first administration. She reported itching but not fever. Blood analysis showed mild eosinophilia (0.430<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">3</span>/μL), but normal neutrophils count, bilirubin, C3, C4 and CRP levels. Antihistamine drugs and antiviral were not useful. Infective and rheumatological etiologies were excluded. Skin toxicity have been reported in <1% of patients with HL treated with bleomycin-based protocols such as ABVD or BEACOPP escalated. Lesions are usually linear, dose-dependent and itching-related, mimic a “whipping” lesion. In this clinical case, a diagnosis of flagellate dermatitis was made and bleomycin was discontinued. Symptoms improved with topical steroids and omitting the bleomycin to the remaining cycles. Flagellate dermatitis and eosinophilia completely resolved after several weeks. Despite the lack of bleomycin she was able to achieve the complete remission.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Inform consent</span><p id="par0015" class="elsevierStylePara elsevierViewall">The patient authorized the publication of this report.</p></span><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Authors’ contributions</span><p id="par0010" class="elsevierStylePara elsevierViewall">ND, AC, AV conceived the study and visited the patient; FP, LT and AV revised the manuscript.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Funding</span><p id="par0020" class="elsevierStylePara elsevierViewall">None declared.</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Conflict of interest</span><p id="par0025" class="elsevierStylePara elsevierViewall">The authors reported no conflict of interest within this report.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:4 [ 0 => array:2 [ "identificador" => "sec0010" "titulo" => "Inform consent" ] 1 => array:2 [ "identificador" => "sec0005" "titulo" => "Authors’ contributions" ] 2 => array:2 [ "identificador" => "sec0015" "titulo" => "Funding" ] 3 => array:2 [ "identificador" => "sec0020" "titulo" => "Conflict of interest" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "multimedia" => array:1 [ 0 => array:6 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 864 "Ancho" => 1340 "Tamanyo" => 105121 ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/00257753/0000016200000008/v2_202404281220/S0025775323006668/v2_202404281220/en/main.assets" "Apartado" => array:4 [ "identificador" => "64289" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Imágenes médicas" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/00257753/0000016200000008/v2_202404281220/S0025775323006668/v2_202404281220/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775323006668?idApp=UINPBA00004N" ]
