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array:22 [ "pii" => "S002577530171771X" "issn" => "00257753" "doi" => "10.1016/S0025-7753(01)71771-X" "estado" => "S300" "fechaPublicacion" => "2001-01-01" "aid" => "71771" "copyright" => "Elsevier España, S.L.. Todos los derechos reservados" "copyrightAnyo" => "2001" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2001;116:201-5" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2142 "formatos" => array:3 [ "EPUB" => 5 "HTML" => 1903 "PDF" => 234 ] ] "itemSiguiente" => array:18 [ "pii" => "S0025775301717721" "issn" => "00257753" "doi" => "10.1016/S0025-7753(01)71772-1" "estado" => "S300" "fechaPublicacion" => "2001-01-01" "aid" => "71772" "copyright" => "Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2001;116:206-8" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1802 "formatos" => array:3 [ "EPUB" => 4 "HTML" => 1427 "PDF" => 371 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Influencia de la menopausia en la concentración plasmática de homocisteína" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "206" "paginaFinal" => "208" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Influence of menopausal status in homocysteine plasma levels" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Consuelo Fernández-Miranda, María de la Calle, José Manuel Bris, Mercedes Muelas, Pilar Gómez, Pilar Díaz-Rubio" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Consuelo" "apellidos" => "Fernández-Miranda" ] 1 => array:2 [ "nombre" => "María" "apellidos" => "de la Calle" ] 2 => array:2 [ "nombre" => "José" "apellidos" => "Manuel Bris" ] 3 => array:2 [ "nombre" => "Mercedes" "apellidos" => "Muelas" ] 4 => array:2 [ "nombre" => "Pilar" "apellidos" => "Gómez" ] 5 => array:2 [ "nombre" => "Pilar" "apellidos" => "Díaz-Rubio" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775301717721?idApp=UINPBA00004N" "url" => "/00257753/0000011600000006/v1_201307291450/S0025775301717721/v1_201307291450/es/main.assets" ] "es" => array:14 [ "idiomaDefecto" => true "titulo" => "Características clínicas y prevalencia de los estados de hipercoagulabilidad en pacientes con enfermedad tromboembólica venosa" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "201" "paginaFinal" => "205" ] ] "autores" => array:2 [ 0 => array:4 [ "autoresLista" => "Andrés Briones, Dolores Nauffal, Miguel Ángel Martínez, Rosario Menéndez, Miguel Perpiñá" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Andrés" "apellidos" => "Briones" ] 1 => array:4 [ "nombre" => "Dolores" "apellidos" => "Nauffal" "email" => array:1 [ 0 => "med013409@nacom.es" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 2 => array:2 [ "nombre" => "Miguel" "apellidos" => "Ángel Martínez" ] 3 => array:2 [ "nombre" => "Rosario" "apellidos" => "Menéndez" ] 4 => array:2 [ "nombre" => "Miguel" "apellidos" => "Perpiñá" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Neumología. Hospital Universitario La Fe. Valencia" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Correspondencia: Dra. D. Nauffal. Servicio de Neumología. Hospital Universitario La Fe. Avda. Campanar, 21. 46009 Valencia." ] ] ] 1 => array:3 [ "autoresLista" => "Piedad Villa" "autores" => array:1 [ 0 => array:3 [ "nombre" => "Piedad" "apellidos" => "Villa" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:3 [ "entidad" => "Unidad de Hemostasia. Hospital Universitario La Fe. Valencia" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Clinical manifestations and prevalence of hypercoagulable states in patients with venous thromboembolic disease" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2001-01-10" "fechaAceptado" => "2001-02-09" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec221352" "palabras" => array:5 [ 0 => "Enfermedad tromboembólica venosa" 1 => "Trombofilia" 2 => "Estados de hipercoagulabilidad" 3 => "Embolia de pulmón" 4 => "PAI-1" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec221353" "palabras" => array:5 [ 0 => "Venous thromboembolic disease" 1 => "Thrombophilia" 2 => "Hypercoagulables states" 3 => "Pulmonary embolism" 4 => "PAI-1" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Fundamento</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La enfermedad tromboembólica venosa (ETV) puede deberse a tres mecanismos fundamentales: la estasis venosa, una alteración en el proceso de la coagulación o una lesión del endotelio. Uno o más de estos elementos constituyen los denominados estados de hipercoagulabilidad (EH), que se clasifican en primarios (EHP) y secundarios (EHS), algunos de los cuales son medibles. El objetivo fue conocer la prevalencia de EH en pacientes ingresados por ETV que cumplían criterios para realizar el estudio y las características clínicas de la embolia de pulmón en los pacientes en que se halló un EH.</p> <span class="elsevierStyleSectionTitle">Pacientes y método</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se practicó el estudio de trombofilia a 60 de los 175 pacientes diagnosticadosde trombosis venosa profunda y embolia de pulmón que cumplían los criterios de inclusión.El análisis se realizó un mes después de terminar el tratamiento anticoagulante.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Se encontró un EH en 17 de los 60 pacientes (28,3%), de los cuales 14 eran EHPy tres EHS. El EHP más frecuente fue el aumento del inhibidor del activador tisular del plasminógenotipo 1 (PAI-1). La embolia de pulmón fue masiva en 2 pacientes con un EH, hubo recidivasen cinco y se halló afección de varios miembros de una misma familia en cinco.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La prevalencia de EH en pacientes ingresados por ETV es alta. Las característicasclínicas fueron parcialmente comparables a los pacientes de otras series, y el aumento delPAI-1 fue el marcador de hipercoagulabilidad más frecuente.</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Blood flow stasis, an alteration in the coagulation process or endothelium injurythe most common mechanisms involved in venous thromboembolic diseases (TED) and constitutethe so-called hypercoagulable states (HS). The HS have been classified into two groups:primary and secondary and several of them can be measured. Our purpose was to investigatethe prevalence in Spain of measurable HS in patients with venous TED and to know the clinicalpicture of pulmonary embolism in these patients.</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Sixty of 175 consecutive patients diagnosed with deep venous thrombosisand pulmonary embolism fulfilled criteria to study a HS. The study was performed 1 month afteranticoagulant therapy was finished.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar035" class="elsevierStyleSimplePara elsevierViewall">Seventeen (28%) of the 60 patients had one HS that was a primary disorder in 14 anda secondary one in 3. The increase of PAI-1 level was the most common; recurrence of thromboticevents and familial history were frequent in these selected patients.</p> <span class="elsevierStyleSectionTitle">Conclusion</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">The prevalence of hypercoagulable states in venous thromboembolic disease washigh in this series. The clinical picture was similar to those to be expected and PAI-1 was themost frequent marker of hypercoagulable states.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias Bibliográficas" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:26 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Vascular-bed-specific hemostasis and hypercoagulable states" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "R.D. 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