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array:23 [ "pii" => "S0025775301717617" "issn" => "00257753" "doi" => "10.1016/S0025-7753(01)71761-7" "estado" => "S300" "fechaPublicacion" => "2001-01-01" "aid" => "71761" "copyright" => "Elsevier España, S.L.. Todos los derechos reservados" "copyrightAnyo" => "2001" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2001;116:167-73" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1993 "formatos" => array:3 [ "EPUB" => 6 "HTML" => 1756 "PDF" => 231 ] ] "itemSiguiente" => array:18 [ "pii" => "S0025775301717629" "issn" => "00257753" "doi" => "10.1016/S0025-7753(01)71762-9" "estado" => "S300" "fechaPublicacion" => "2001-01-01" "aid" => "71762" "copyright" => "Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2001;116:174-8" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1998 "formatos" => array:3 [ "EPUB" => 8 "HTML" => 1762 "PDF" => 228 ] ] "es" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Originales</span>" "titulo" => "Incidencia y supervivencia de las leucemias según el tipo histológico en Tarragona, en el período 1980-1994" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "174" "paginaFinal" => "178" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Incidence and survival of leukemias according to the different histologic subsets, in tarragona, spain, between 1980-1994" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Juan R. González, Víctor Moreno, Josep Maria Borràs, Joan Borràs, Jaume Galceran, Albert Grañena, Francesc Xavier Bosch" "autores" => array:7 [ 0 => array:2 [ "nombre" => "Juan R." "apellidos" => "González" ] 1 => array:2 [ "nombre" => "Víctor" "apellidos" => "Moreno" ] 2 => array:2 [ "nombre" => "Josep" "apellidos" => "Maria Borràs" ] 3 => array:2 [ "nombre" => "Joan" "apellidos" => "Borràs" ] 4 => array:2 [ "nombre" => "Jaume" "apellidos" => "Galceran" ] 5 => array:2 [ "nombre" => "Albert" "apellidos" => "Grañena" ] 6 => array:2 [ "nombre" => "Francesc" "apellidos" => "Xavier Bosch" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775301717629?idApp=UINPBA00004N" "url" => "/00257753/0000011600000005/v1_201307291416/S0025775301717629/v1_201307291416/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0025775301717605" "issn" => "00257753" "doi" => "10.1016/S0025-7753(01)71760-5" "estado" => "S300" "fechaPublicacion" => "2001-01-01" "aid" => "71760" "copyright" => "Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2001;116:161-6" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 3463 "formatos" => array:3 [ "EPUB" => 11 "HTML" => 3218 "PDF" => 234 ] ] "es" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Originales</span>" "titulo" => "Estudio prospectivo de 221 neumonías adquiridas en la comunidad seguidas de forma ambulatoria. Etiología y evolución clinicorradiológica" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "161" "paginaFinal" => "166" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Prospective study of 221 community acquired pneumonias followed up in an outpatient clinic. Etiology and clinical-radiological progression" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Francisco Javier Álvarez Gutiérrez, Daniel del Castillo Otero, Alberto García Fernández, Beatriz Romero Romero, Juan José del Rey Pérez, Gregorio Soto Campos, José Castillo Gómez" "autores" => array:7 [ 0 => array:2 [ "nombre" => "Francisco" "apellidos" => "Javier Álvarez Gutiérrez" ] 1 => array:2 [ "nombre" => "Daniel" "apellidos" => "del Castillo Otero" ] 2 => array:2 [ "nombre" => "Alberto" "apellidos" => "García Fernández" ] 3 => array:2 [ "nombre" => "Beatriz" "apellidos" => "Romero Romero" ] 4 => array:2 [ "nombre" => "Juan" "apellidos" => "José del Rey Pérez" ] 5 => array:2 [ "nombre" => "Gregorio" "apellidos" => "Soto Campos" ] 6 => array:2 [ "nombre" => "José" "apellidos" => "Castillo Gómez" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775301717605?idApp=UINPBA00004N" "url" => "/00257753/0000011600000005/v1_201307291416/S0025775301717605/v1_201307291416/es/main.assets" ] "es" => array:16 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Originales</span>" "titulo" => "Diagnóstico y tratamiento de la tuberculosis en España: resultados del Proyecto Multicéntrico de Investigación en Tuberculosis (PMIT)" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "167" "paginaFinal" => "173" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "M. Díez Ruiz-Navarro" "autores" => array:2 [ 0 => array:2 [ "colaborador" => "Grupo de Trabajo del PMIT" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "fn0005" ] ] ] 1 => array:4 [ "nombre" => "M." "apellidos" => "Díez Ruiz-Navarro" "email" => array:1 [ 0 => "mdiez@isciii.es" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "cor0005" ] ] ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "**" "correspondencia" => "Correspondence: Unidad de Investigación en Tuberculosis. Instituto de Salud Carlos III. Sinesio Delgado, 6. 28029 Madrid." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Diagnosis and treatment of tuberculosis in Spain: results from the Multicenter Project for Tuberculosis Research (MPTR)" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2000-09-05" "fechaAceptado" => "2000-11-21" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec220795" "palabras" => array:2 [ 0 => "Tuberculosis" 1 => "Retraso terapéutico" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec220796" "palabras" => array:3 [ 0 => "Tuberculosis" 1 => "Treatment delay" 2 => "Patient delay" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Fundamento</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Analizar la práctica clínica con respecto a la tuberculosis.Material Y Método: En 13 comunidades autónomas (67% del total de la población española) se realizó una búsqueda activa de los casos de tuberculosis en 14 registros desde mayo de 1996 hasta abril de 1997, y se obtuvo información de la historia clínica.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Casi el 80% de los 10.053 casos incluidos se diagnosticaron en el hospital, y la mayoría (91,7%) fueron sintomáticos. Las medianas de demora desde el inicio de los síntomas hasta la primera consulta y el tratamiento fueron de 22 y 41 días, respectivamente. Se realizaron baciloscopia y cultivo al 82% de los enfermos pulmonares, y al 75,5% de los extrapulmonares se les efectuó al menos un cultivo; como consecuencia se confirmaron bacteriológicamente el 72,5% de los casos pulmonares y el 39,7% de los extrapulmonares. Más del 76% de los enfermos se trataron con tres fármacos, pero la información sobre la duración del tratamiento no es buena. Se utilizaron preparados combinados en el 86,8% de los enfermos y sólo en el 5,4% se realizó tratamiento observado directamente. La información sobre indicación del estudio de contactos fue pobre.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Se ha mejorado la utilización del cultivo para el diagnóstico de la tuberculosis y la prescripción de pautas cortas para el tratamiento. Sin embargo, todavía hay aspectos en la práctica clínica de la enfermedad susceptibles de mejora.</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">To analyze clinical practice regarding tuberculosis in Spain. Material And Method: After active search in 14 registries, cases of tuberculosis were identified in 13 autonomous regions, representing almost 67% of the total Spanish population. The study period was May 1996-April 1997.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">10,053 cases were identified. Almost 80% were diagnosed at the hospital and most of the patients (91.7%) were symptomatic. Median patient delay was 21 days and median delay between symptoms and treatment was 41 days. Smear and culture was performed in 82% of pulmonary cases while at least a culture was performed in 75.5% of extrapulmonary cases. 72.5% of pulmonary cases and 39.7% of extrapulmonary cases were culture positive. More than 76% of the subjects were treated with 3 drugs, generally rifampin, isoniazid and pirazinamide in agreement with Spanish guidelines; however, the information on duration of treatment was insuficient. Combined tablets were usually prescribed (86.8% of patients) and use of DOT was scarce (5.4% of cases). The information on contact investigation was poor.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Diagnostic and treatment practices regarding tuberculosis have clearly improved in Spain, but patient management has still to improve.</p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "*" "nota" => "<p class="elsevierStyleNotepara">Los componentes del Grupo de Trabajo del PMIT aparecen relacionados en el «Addendum».</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias Bibliográficas" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:48 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "WHO tuberculosis programme. Framework for an effective tuberculosis control. WHO/TB/94.179" ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2." 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