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array:22 [ "pii" => "S002577530474631X" "issn" => "00257753" "doi" => "10.1016/S0025-7753(04)74631-X" "estado" => "S300" "fechaPublicacion" => "2004-10-01" "aid" => "74631" "copyright" => "Elsevier España, S.L.. Todos los derechos reservados" "copyrightAnyo" => "2004" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2004;123:641-5" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2555 "formatos" => array:3 [ "EPUB" => 6 "HTML" => 2213 "PDF" => 336 ] ] "itemSiguiente" => array:18 [ "pii" => "S0025775304753294" "issn" => "00257753" "doi" => "10.1016/S0025-7753(04)75329-4" "estado" => "S300" "fechaPublicacion" => "2004-10-01" "aid" => "75329" "copyright" => "Elsevier España, S.L." "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "mis" "cita" => "Med Clin. 2004;123:645-6" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 396 "formatos" => array:3 [ "EPUB" => 7 "HTML" => 148 "PDF" => 241 ] ] "es" => array:6 [ "idiomaDefecto" => true "titulo" => "Grupo de estudio ARIAM" "tienePdf" => "es" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "645" "paginaFinal" => "646" ] ] "contienePdf" => array:1 [ "es" => true ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775304753294?idApp=UINPBA00004N" "url" => "/00257753/0000012300000017/v1_201307291635/S0025775304753294/v1_201307291635/es/main.assets" ] "es" => array:15 [ "idiomaDefecto" => true "titulo" => "Diferencias en el ritmo circadiano del infarto de miocardio según su extensión electrocardiográfica" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "641" "paginaFinal" => "645" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "José Ramón Garmendia-Leiza, Juan Bautista López-Messa, Jesús María Andrés-de-Llano, Carlos Alberola-López, Julio Ardura-Fernández" "autores" => array:6 [ 0 => array:4 [ "nombre" => "José Ramón" "apellidos" => "Garmendia-Leiza" "email" => array:1 [ 0 => "irgarmenl@tiscali.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Juan" "apellidos" => "Bautista López-Messa" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "Jesús" "apellidos" => "María Andrés-de-Llano" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "Carlos" "apellidos" => "Alberola-López" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 4 => array:3 [ "nombre" => "Julio" "apellidos" => "Ardura-Fernández" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 5 => array:2 [ "colaborador" => "ARIAM" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "fn0005" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Laboratorio de Cronobiología. Facultad de Medicina. Universidad de Valladolid. Valladolid." "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Unidad de Cuidados Intensivos. Complejo Hospitalario de Palencia. Hospital Río Carrión. Palencia. España." "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "ETSI Telecomunicación.Universidad de Valladolid. Valladolid. España." "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "**" "correspondencia" => "Correspondencia: Dr. J.R. Garmendia. Laboratorio de Cronobiología. Facultad de Medicina. Avda. Ramón y Cajal, s/n. 47001 Valladolid. España." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Differential circadian rhythms in myocardial infarction according to its extent by electrocardiogram" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2004-02-19" "fechaAceptado" => "2004-07-13" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec222426" "palabras" => array:3 [ 0 => "Infarto de miocardio (IM)" 1 => "Ritmo circadiano" 2 => "Extensión del IM" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec222427" "palabras" => array:3 [ 0 => "Acute myocardial infarction" 1 => "Circadian rhythm" 2 => "Infarction extension" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Fundamento y objetivo</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Determinar la existencia de ritmo circadiano en la hora de inicio del infarto de miocardio (IM) según su extensión electrocardiográfica Q/no Q.</p> <span class="elsevierStyleSectionTitle">Pacientes y método</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Estudio retrospectivo de una cohorte de pacientes del proyecto ARIAM que incluyó 54.249 IM. Se analizan variables generales del infarto (edad, sexo, cardiopatía isquémica previa, extensión del infarto, localización, supervivencia al alta de la unidad de cuidados intensivos), factores de riesgo cardiovascular y tratamientos farmacológicos previos al episodio estudiado. Para verificar la presencia de ritmo circadiano se ha desarrollado un test simple de igualdad de series basado en el análisis cosinor de múltiples sinusoides, utilizando 3 sinusoides de períodos de 24, 12 y 8 h.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">La hora de inicio de los síntomas del infarto mostró ritmo circadiano (p < 0,0000) tanto en el IM Q como en el IM no Q. Los IM Q presentan un patrón con un único máximo de incidencia matinal y los no Q, un patrón bimodal con doble pico de incidencia. La comparación entre dichos patrones muestra diferencias significativas en su ajuste (p < 0,0000).</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La hora de inicio del IM sigue un patrón circadiano, que también se observa en los subgrupos analizados. Las diferencias entre los ritmos circadianos según el tipo de IM (Q frente a no Q) podrían explicarse por el distinto mecanismo fisiopatológico de ambos subtipos de infarto. El modelo de análisis de cosinor ajustado con 3 componentes (períodos de 24, 12 y 8 h) muestra buena sensibilidad para la detección de ritmo circadiano</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Background and objective</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To determine the existence of circadian rhythm in the time of onset of acute myocardial infarction (AMI) according to their extension type (Q-wave vs. non-Q-wave).</p> <span class="elsevierStyleSectionTitle">Patients and method</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">We studied a retrospective cohort of patients from a multicentre study of myocardial infarction (ARIAM study group). We collected information about 54,249 infarctions from the data base of the ARIAM (Analysis of Delay in AMI) Spanish multicentre study. The following variables were analysed: general variables -age, gender, previous ischemic heart disease, outcome at coronary care unit, infarction electrocardiograph type (Q wave or non-Q wave) and location of AMI-, cardiovascular risk factors, and previous drug treatment of the patients. To verify the presence of circadian rhythm we developed a simple test of equality of time series based on the multiple-sinusoid cosinor analysis. Three sinusoids (24-12-8 h periods) were used</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">The time of pain onset shows circadian rhythm (p < 0.0000), wich also is observed in both infarction electrocardiograph characteristics subgroups (Q-wave infarction and non-Q-wave infarction) (p < 0.0000). Q-wave infarction shows sinusoid curve with one maximum morning peak and non-Q-wave shows bimodal curve, with two peaks. Comparison between their curves shows estatistical signifiance (p < 0.0000).</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">AMI onset follows a circadian ryhthm pattern, which is also observed in analysed subgroups. Differences in the circadian ryhthm according to the Q/non-Q wave infarction characteristics, could be determined by different physiopathologic mechanism. The cosinor model fit with three components (24, 12 and 8-hour-periods) show good sensitivity to determine circadian rhythm.</p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "*" "nota" => "<p class="elsevierStyleNotepara">Al final del artículo se indican los componentes del grupo de estudio ARIAM.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias Bibliográficas" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:37 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Management of acute coronary syndromes: acute coronary syndromes without persistent ST segment elevation; recommendations of the Task Force of the European Society of Cardiology" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M.E. Bertrand" 1 => "M.L. Simoons" 2 => "K.A. Fox" 3 => "L.C. 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