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array:23 [ "pii" => "S0025775300712450" "issn" => "00257753" "doi" => "10.1016/S0025-7753(00)71245-0" "estado" => "S300" "fechaPublicacion" => "2000-01-01" "aid" => "71245" "copyright" => "Elsevier España, S.L.. Todos los derechos reservados" "copyrightAnyo" => "2000" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2000;114:205-8" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 606 "formatos" => array:3 [ "EPUB" => 6 "HTML" => 401 "PDF" => 199 ] ] "itemSiguiente" => array:18 [ "pii" => "S0025775300712462" "issn" => "00257753" "doi" => "10.1016/S0025-7753(00)71246-2" "estado" => "S300" "fechaPublicacion" => "2000-01-01" "aid" => "71246" "copyright" => "Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2000;114:209-10" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2229 "formatos" => array:3 [ "EPUB" => 7 "HTML" => 2086 "PDF" => 136 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Eficacia de una intervención para dejar de fumar en pacientes con infarto de miocardio" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "209" "paginaFinal" => "210" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Efficacy of an intervention in smoking cessation in patients with miocardial infarction" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:2 [ 0 => array:2 [ "autoresLista" => "Alfonso Moreno Ortigosa, Francisco Javier Ochoa Gómez, Iñaki Saralegui Reta, María Victoria Fernández Esteban" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Alfonso" "apellidos" => "Moreno Ortigosa" ] 1 => array:2 [ "nombre" => "Francisco" "apellidos" => "Javier Ochoa Gómez" ] 2 => array:2 [ "nombre" => "Iñaki" "apellidos" => "Saralegui Reta" ] 3 => array:2 [ "nombre" => "María" "apellidos" => "Victoria Fernández Esteban" ] ] ] 1 => array:2 [ "autoresLista" => "Enrique Ramalle-Gómara, Manuel Quintana Díaz" "autores" => array:2 [ 0 => array:2 [ "nombre" => "Enrique" "apellidos" => "Ramalle-Gómara" ] 1 => array:2 [ "nombre" => "Manuel" "apellidos" => "Quintana Díaz" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775300712462?idApp=UINPBA00004N" "url" => "/00257753/0000011400000006/v1_201307291356/S0025775300712462/v1_201307291356/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0025775300712449" "issn" => "00257753" "doi" => "10.1016/S0025-7753(00)71244-9" "estado" => "S300" "fechaPublicacion" => "2000-01-01" "aid" => "71244" "copyright" => "Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2000;114:201-4" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 3085 "formatos" => array:3 [ "EPUB" => 7 "HTML" => 2868 "PDF" => 210 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Infección por citomegalovirus en pacientes con colitis ulcerosa tratados con colectomía" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "201" "paginaFinal" => "204" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Infection by cytomegalovirus in patients with ulcerative colitis requiring colonic resection" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:2 [ 0 => array:2 [ "autoresLista" => "María José Alcalá, Francesc Casellas, Juan-Ramón Malagelada" "autores" => array:3 [ 0 => array:2 [ "nombre" => "María" "apellidos" => "José Alcalá" ] 1 => array:2 [ "nombre" => "Francesc" "apellidos" => "Casellas" ] 2 => array:2 [ "nombre" => "Juan-Ramón" "apellidos" => "Malagelada" ] ] ] 1 => array:2 [ "autoresLista" => "Judith Pallarés, Inés de Torres" "autores" => array:2 [ 0 => array:2 [ "nombre" => "Judith" "apellidos" => "Pallarés" ] 1 => array:2 [ "nombre" => "Inés" "apellidos" => "de Torres" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775300712449?idApp=UINPBA00004N" "url" => "/00257753/0000011400000006/v1_201307291356/S0025775300712449/v1_201307291356/es/main.assets" ] "es" => array:14 [ "idiomaDefecto" => true "titulo" => "Efectividad y seguridad de la palidotomía posteroventral en el tratamiento de la enfermedad de Parkinson avanzada" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "205" "paginaFinal" => "208" ] ] "autores" => array:2 [ 0 => array:4 [ "autoresLista" => "José Luis Molinuevo, Francesc Valldeoriola, Fritz A. Nobbe, Eduardo Tolosa" "autores" => array:4 [ 0 => array:2 [ "nombre" => "José" "apellidos" => "Luis Molinuevo" ] 1 => array:3 [ "nombre" => "Francesc" "apellidos" => "Valldeoriola" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 2 => array:2 [ "nombre" => "Fritz A." "apellidos" => "Nobbe" ] 3 => array:2 [ "nombre" => "Eduardo" "apellidos" => "Tolosa" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "<span class="elsevierStyleItalic">Servicios de Neurología Hospital Clínic. Institut d'Investigacions Biomèdiques August Pi i Sunyer. Universitat de Barcelona.</span>" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Correspondencia: Servicio de Neurología. Hospital Clínic. Villarroel, 170. 08036 Barcelona." ] ] ] 1 => array:3 [ "autoresLista" => "Jordi Rumià, Enric Ferrer" "autores" => array:2 [ 0 => array:3 [ "nombre" => "Jordi" "apellidos" => "Rumià" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff00005" ] ] ] 1 => array:3 [ "nombre" => "Enric" "apellidos" => "Ferrer" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff00005" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:3 [ "entidad" => "<span class="elsevierStyleItalic">Neurocirugía. Hospital Clínic. Institut d'Investigacions Biomèdiques August Pi i Sunyer. Universitat de Barcelona</span>" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff00005" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Efficacy and safety of posteroventral pallidotomy for the treatment of advanced parkinson's disease" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "1999-02-22" "fechaAceptado" => "1999-05-11" "PalabrasClave" => array:1 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec220528" "palabras" => array:3 [ 0 => "Enfermedad de Parkinson" 1 => "Palidotomía" 2 => "Discinesias" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Fundamento</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">: Analizar la efectividad y seguridad de la palidotomía unilateral guiada por microrregistroen el tratamiento de la enfermedad de Parkinson (EP) avanzada después de 3 mesesy al año de la intervención.</p> <span class="elsevierStyleSectionTitle">Pacientes y métodos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">: Se intervinieron 23 pacientes con EP avanzada (edad media, 58,9 años;duración media de la enfermedad, 14,4 años). La evaluación clínica, a los 3 meses (n = 23) yal año (n = 16) de la intervención, se efectuó por la mañana 12 h después de la última dosisde medicación (off) y tras la administración de un 100-150% de la dosis habitual (on). Encada una de las evaluaciones se administraron escalas para valoración de las actividades de lavida diaria, evaluación motora y discinesias, así como pruebas cronometradas de la actividadmotora.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">: Las discinesias contralaterales al hemisferio intervenido se redujeron un 92% a los3 meses y un 89% al año. Los síntomas motores de la enfermedad mejoraron un 36,5% a los 3meses y un 26,7% al año de la intervención. En el análisis anual apareció una mejoría en eltemblor contralateral del 48%, en la rigidez del 36,2% y en la bradicinesia del 37,4% Todoslos cambios observados fueron estadísticamente significativos (p < 0,01). Los efectos adversosfueron leves o transitorios. La dosis de medicación antiparkinsoniana no se modificó durante eltiempo de seguimiento.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">: La palidotomía unilateral guiada por microrregistro es un método seguro y eficazpara mejorar los síntomas de la EP contralaterales, siendo especialmente eficaz en el tratamientode las discinesias inducidas por L-dopa.</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objectives</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">: To analyze the results, efficacy and safety of unilateral microelectrode guided pallidotomyfor the treatment of advanced Parkinson's disease, three months and one year after surgery.</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">: 23 patients with advanced Parkinson's disease (mean age 58,9 years andmean disease duration 14,4 years) were submitted to pallidotomy. Neurological evaluation, threemonths (n = 23) and one year (n = 16) after surgery, was performed during the morning inovernight «off» condition and after receiving 100-150% of their usual l-dopa dose. Parkinsoniansymptoms were evaluated in each follow up visit through motor scales, activities of dailyliving scales, a dyskinesia rating scale and motor timed tests.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">: Contralateral dyskinesias improved 92% three months after surgery and 89% at oneyear. Parkinsonian motor scores were reduced by 36.5% after three months and by 26.7% oneyear after surgery. In the one year follow up visit, contralateral tremor improved 48%, rigidity36.2% and bradykinesia 37.4%. All these changes were statistically significant (p < 0.01). Adverseeffects were minor or transient. Antiparkinsonian medication dosage did not significantlychange during the study period.</p> <span class="elsevierStyleSectionTitle">Conclusion</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">: Microelectrode guided unilateral pallidotomy is an effective and safe procedure toimprove contralateral motor symptoms in Parkinson's disease, being specially useful for the treatmentof l-dopa induced dyskinesias.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias Bibliográficas" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:38 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Procaine-oil blocking of the globus pallidus for the treatment of rigidity and tremor of parkinsonism" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "H. Narabayashi" 1 => "T. 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