array:23 [ "pii" => "S0025775301720659" "issn" => "00257753" "doi" => "10.1016/S0025-7753(01)72065-9" "estado" => "S300" "fechaPublicacion" => "2001-01-01" "aid" => "72065" "copyright" => "Elsevier España, S.L.. Todos los derechos reservados" "copyrightAnyo" => "2001" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2001;117:211-5" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 5020 "formatos" => array:3 [ "EPUB" => 5 "HTML" => 4813 "PDF" => 202 ] ] "itemSiguiente" => array:18 [ "pii" => "S0025775301720660" "issn" => "00257753" "doi" => "10.1016/S0025-7753(01)72066-0" "estado" => "S300" "fechaPublicacion" => "2001-01-01" "aid" => "72066" "copyright" => "Elsevier España, S.L." "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "edi" "cita" => "Med Clin. 2001;117:216-7" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1680 "formatos" => array:3 [ "EPUB" => 5 "HTML" => 1480 "PDF" => 195 ] ] "es" => array:7 [ "idiomaDefecto" => true "titulo" => "¿Es posible la eliminación de la transmisión vertical del VIH?" "tienePdf" => "es" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "216" "paginaFinal" => "217" ] ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Jordi Casabona Barbarà, Maite García Fructuoso" "autores" => array:2 [ 0 => array:2 [ "nombre" => "Jordi" "apellidos" => "Casabona Barbarà" ] 1 => array:2 [ "nombre" => "Maite" "apellidos" => "García Fructuoso" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775301720660?idApp=UINPBA00004N" "url" => "/00257753/0000011700000006/v1_201307291658/S0025775301720660/v1_201307291658/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0025775301720647" "issn" => "00257753" "doi" => "10.1016/S0025-7753(01)72064-7" "estado" => "S300" "fechaPublicacion" => "2001-01-01" "aid" => "72064" "copyright" => "Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2001;117:207-10" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1996 "formatos" => array:3 [ "EPUB" => 5 "HTML" => 1790 "PDF" => 201 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Cumplimiento del tratamiento hormonal sustitutivo en mujeres menopáusicas" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "207" "paginaFinal" => "210" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Compliance of hormone replacement therapy in menopausal women" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Inmaculad Pereiró Berenguera, José Sanfélix Genovés, Joaquín García Cervera, Silvia Furió Bonet, José María Vicente Polo, Inocencia Martínez Mir" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Inmaculad" "apellidos" => "Pereiró Berenguera" ] 1 => array:2 [ "nombre" => "José" "apellidos" => "Sanfélix Genovés" ] 2 => array:2 [ "nombre" => "Joaquín" "apellidos" => "García Cervera" ] 3 => array:2 [ "nombre" => "Silvia" "apellidos" => "Furió Bonet" ] 4 => array:2 [ "nombre" => "José" "apellidos" => "María Vicente Polo" ] 5 => array:2 [ "nombre" => "Inocencia" "apellidos" => "Martínez Mir" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775301720647?idApp=UINPBA00004N" "url" => "/00257753/0000011700000006/v1_201307291658/S0025775301720647/v1_201307291658/es/main.assets" ] "es" => array:14 [ "idiomaDefecto" => true "titulo" => "Efecto del ácido levofolínico sobre las concentraciones de homocisteína plasmática en la mujer joven y sana en la consulta preconcepcional" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "211" "paginaFinal" => "215" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Ernesto Fabre, Manuel Gallo, Ana Cristina Lou, Gertrudis Juste, María Soledad Romero, Carmen Blasco, Rafael González de Agüero, Mercedes Sobreviela, Armando Reyes-Engel" "autores" => array:9 [ 0 => array:4 [ "nombre" => "Ernesto" "apellidos" => "Fabre" "email" => array:1 [ 0 => "efabreg@sego.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Manuel" "apellidos" => "Gallo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "Ana" "apellidos" => "Cristina Lou" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "Gertrudis" "apellidos" => "Juste" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 4 => array:3 [ "nombre" => "María" "apellidos" => "Soledad Romero" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] ] ] 5 => array:3 [ "nombre" => "Carmen" "apellidos" => "Blasco" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">e</span>" "identificador" => "aff0025" ] ] ] 6 => array:3 [ "nombre" => "Rafael" "apellidos" => "González de Agüero" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 7 => array:3 [ "nombre" => "Mercedes" "apellidos" => "Sobreviela" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 8 => array:3 [ "nombre" => "Armando" "apellidos" => "Reyes-Engel" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] ] ] ] "afiliaciones" => array:5 [ 0 => array:3 [ "entidad" => "Departamento de Obstetricia y Ginecología. Hospital Clínico Universitario Lozano Blesa. Zaragoza." "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Hospital Clínico Universitario Carlos Haya. Málaga." "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Laboratorio de Hormonología." "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Servicio de Hematología Hospital Clínico Universitario Lozano Blesa Zaragoza." "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] 4 => array:3 [ "entidad" => "Departamento de Bioquímica y Biología Molecular. Facultad de Medicina. Málaga." "etiqueta" => "<span class="elsevierStyleSup">e</span>" "identificador" => "aff0025" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Correspondencia: Dr. E. Fabre. Departamento de Obstetricia y Ginecología. Hospital Clánico Universitario Lozano Blesa. Avda. de San Juan Bosco, 15. 50009 Zaragoza." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Effects of levofolinic acid on plasma homocysteine concentrations in healthy and young women in preconceptional care" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2001-02-20" "fechaAceptado" => "2001-06-12" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec222619" "palabras" => array:7 [ 0 => "Homocisteína" 1 => "Á;cido levofolínico" 2 => "Ácido formiltetrahidrofólico" 3 => "Folatos" 4 => "Ácido fólico" 5 => "Consulta preconcepcional" 6 => "Defectos del tubo neural" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec222620" "palabras" => array:7 [ 0 => "Homocysteine" 1 => "Levofolinic acid" 2 => "Formyltetrahydrofolic acid" 3 => "Folates" 4 => "Folic acid" 5 => "Preconceptional care" 6 => "Neural tube defects" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Fundamento</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">El aumento de la homocisteína plasmática total (tHcy) es un factor de riesgo para los defectos del tubo neural. Se estudia el efecto de la suplementación con ácido levofolínico (l,5-formil-tetrahidrofólico) sobre los valores de la tHCy plasmática en la mujer en edad reproductiva.</p> <span class="elsevierStyleSectionTitle">Pacientes y método</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Treinta mujeres sanas de 18 a 35 años recibieron 5 mg/día de ácido levofolínico por vía oral durante 30 días. La tHcy y los folatos intraeritrocitarios se determinaron antes de la suplementación (día 0), los días 2, 5, 10 y 30 durante el tratamiento, y 30 (día 60) y 60 días (día 90) después de finalizado. La tHcy plasmática se determinó por inmunoanálisis de polarización de fluorescencia (coeficiente de variación [CV] intraanálisis e interanálisis < 8%) y el ácido fólico intraeritrocitario, mediante inmunoanálisis quimioluminiscente (CV intraanálisis e interanálisis < 5%).</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">La tHCy plasmática disminuye a partir del segundo día de tratamiento (día 0 frente a 2: media de la diferencia, –1,24 μmol/l; intervalo de confianza [IC] del 95%, –0,84 a –1,63; p < 0,001). El descenso máximo (32,3%) se observa a los 30 días (media de la diferencia, –2,72 μmol/l; IC del 95%, –2,20 a –3,24; p < 0,001). Tras finalizar el tratamiento el efecto hipohomocisteinémico persiste el día 60 (media de la diferencia, –2,67 μmol/l; IC del 95%, –2,07 a –3,26; p < 0,001) y 90 (media de la diferencia, –1,49 μmol/l; IC del 95%, –0,94 a –2,03; p < 0,001). La respuesta fue mayor cuando la tHcy plasmática fue de 9 μmol/l o más.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">El ácido levofolínico provoca un descenso temprano, intenso y persistente de las concentraciones de tHcy plasmática.</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Increases in total plasmatic homocysteine (tHcy) represents a risk factor for neural tube defects. We studied the effects of levofolinic acid (l,5-formyl-tetrahydrofolic) on the plasmatic tHcy levels in women of child-bearing age.</p> <span class="elsevierStyleSectionTitle">Materials and method</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Healthy women aged 18-35 years (n = 30) received levofolinic acid, 5 mg/day, orally for 30 days. Both tHcy and intraerythrocytic folate levels were measured before treatment (day 0), on days 2, 5, 10 and 30 within the treatment period and on days 30 (day 60) and 60 (day 90) after the treatment was finished. Plasmatic tHcy was measured by fluorescence polarisation immunoassay and intraerythrocytic folates by chemiluminescent immunoassay.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Plasmatic tHcy decreased from the second day of treatment onwards (day 0 vs. 2: mean of difference: –1.24 μmol/l; CI 95% = –0.84 to –1.63; p < 0.001). The maximum decline (32.3%) was observed after 30 days (mean of difference = –2.72 μmol/l; CI 95% = –2.20 to –3.24; p < 0.001). After finishing the treatment, the hypohomocysteinic effect persisted up to days 60 (mean of difference = –2.67 μmol/l; CI 95% = –2.07 to –3.26; p < 0.001) and 90 (mean of difference = –1.49 μmol/l; CI 95% = –0.94 to –2.03; p < 0.001). The response was greater when the plasmatic tHcy concentration was ? 9 μmol/l.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Levofolinic acid leads to a earlier, intense and persistent drop of the plasmatic tHcy levels.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias Bibliográficas" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:30 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Uso de los folatos en la gestación" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "E. Fabre González" 1 => "R. González de Agüero" 2 => "M. Sobreviela Laserrada" 3 => "C. Loú Mercadé" 4 => "M. Sánchez- Dehesa" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Rev Gin Obst" "fecha" => "2000" "volumen" => "1" "paginaInicial" => "245" "paginaFinal" => "260" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prevention of neural tube defects: results of the Medical Research Council vitamin study" "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "MRC Vitamin Study Research Group" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "1991" "volumen" => "338" "paginaInicial" => "131" "paginaFinal" => "137" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1677062" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A.E. Czeizel" 1 => "I. Dudas" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM199212243272602" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "1992" "volumen" => "327" "paginaInicial" => "1832" "paginaFinal" => "1835" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1307234" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Consulta Preconcepcional. Protocolos Asistenciales en Ginecología y Obstetricia. Sociedad Española de Ginecología y Obstetricia. Protocolo 2- bis, 1998" ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Homocisteína y gestación" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "E.L. López-Quesada" 1 => "M.A. Vilaseca" 2 => "S. González" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Med Clin (Barc)" "fecha" => "2000" "volumen" => "115" "paginaInicial" => "352" "paginaFinal" => "356" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The metabolism of homocysteine pathways and regulation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J.D. Finkelstein" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur J Pediatr" "fecha" => "1998" "volumen" => "157" "numero" => "Supl 2" "paginaInicial" => "40" "paginaFinal" => "44" ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Vitamin status and intake as primary determinants of homocysteinemia in an elderly popuation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J. Selhub" 1 => "P.F. Jacques" 2 => "P.W. Wilson" 3 => "D. Rush" 4 => "I.H. Rosenberg" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "JAMA" "fecha" => "1993" "volumen" => "270" "paginaInicial" => "2693" "paginaFinal" => "2698" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8133587" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "P.F. Jacques" 1 => "A.G. Bostom" 2 => "R.R. Williams" 3 => "R.C. Ellison" 4 => "J.H. Eckfeldt" 5 => "I.H. Rosenberg" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Circulation" "fecha" => "1996" "volumen" => "93" "paginaInicial" => "7" "paginaFinal" => "9" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8616944" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Maternal hyperhomocysteinemia: a risk factor for neural-tube defects?" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R.P.M. Steegers-Theunissen" 1 => "G.H.J. Boers" 2 => "F.J.M. Trijbels" 3 => "J.D. Finkelstein" 4 => "H.J. Blom" 5 => "C.M.G. Thomas" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Metabolism" "fecha" => "1994" "volumen" => "43" "paginaInicial" => "1475" "paginaFinal" => "1480" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7990699" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Homocysteine metabolism in pregnancies complicated by neural-tube defects" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.L. Mills" 1 => "J.M. McPartlin" 2 => "P.N. Kirke" 3 => "Y.J. Lee" 4 => "M.R. Conley" 5 => "D.G. Weir" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "1995" "volumen" => "345" "paginaInicial" => "149" "paginaFinal" => "151" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7741859" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Neural tube defects and elevated homocysteine levels in amniotic fluid" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R.P. Steegers-Theunissen" 1 => "G.H. Boers" 2 => "H.J. Blom" 3 => "J.G. Nijhuis" 4 => "C.M.G. Thomas" 5 => "G.F. Borm" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Obstet Gynecol" "fecha" => "1995" "volumen" => "172" "paginaInicial" => "1436" "paginaFinal" => "1441" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7755050" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0060" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mutated methylenetetrahydrofolate reductase as a risk factor for spina bifida" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "N.M. Van der Put" 1 => "R.P. Steegers-Theunissen" 2 => "P. Frosst" 3 => "F.J. Trijbels" 4 => "T.K. Eskes" 5 => "L.P. Van den Heuvel" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "1995" "volumen" => "346" "paginaInicial" => "1070" "paginaFinal" => "1071" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7564788" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0065" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Genetic polymorphisms in methylenetetrahydrofolate reductase and methionine synthetase, folate levels in red blood cells, and risk of neural tube defects" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "B. Christensen" 1 => "L. Arbour" 2 => "P. Tran" 3 => "D. Leclerc" 4 => "N. Sabbaghian" 5 => "R. Platt" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Med Genet" "fecha" => "1999" "volumen" => "84" "paginaInicial" => "151" "paginaFinal" => "157" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10323741" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0070" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Homocysteine induces congenital defects of the heart and neural tube: effect of folic acid" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "T.H. Rosenquist" 1 => "S.N. Ratashak" 2 => "J. Selhub" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Proc Natl Acad Sci" "fecha" => "1996" "volumen" => "93" "paginaInicial" => "15227" "paginaFinal" => "15232" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8986792" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0075" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "titulo" => "Homocysteine Lowering Trialists’ Collaboration. Lowering blood homocysteine with folic acid based supplements: meta-analysis of randomised trials" ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Br Med J" "fecha" => "1998" "volumen" => "316" "paginaInicial" => "894" "paginaFinal" => "898" ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0080" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pharmacokinetics of the diastereoisomers of leucovorin after intravenous and oral administration to normal subjects" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J.A. Straw" 1 => "D. Szapary" 2 => "W.T. Wynn" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Res" "fecha" => "1984" "volumen" => "44" "paginaInicial" => "3114" "paginaFinal" => "3119" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6609768" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0085" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effective absorption and utilization of oral formyltetrahydrofolate in man" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "P.F. Nixon" 1 => "J.R. Bertino" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM197201272860402" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "1972" "volumen" => "286" "paginaInicial" => "175" "paginaFinal" => "179" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4536622" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0090" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Conversión of 5-formyltetrahydrofolic acid to 5- methyltetrahydrofolic acid in unimpaired in folate- adequate persons homozygous for the C677T mutation in the methylenetetrahydrofolate reductase gene" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "L.L. Stern" 1 => "P. Bagley" 2 => "I.H. Rosenberg" 3 => "J. Selhub" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Nutr" "fecha" => "2000" "volumen" => "130" "paginaInicial" => "2238" "paginaFinal" => "2242" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10958818" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0095" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Rapid, fully automated measurement of plasma homocysteine with the Abbot IMX analyser" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M.T. Schipchandler" 1 => "E.G. Moore" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Chem" "fecha" => "1995" "volumen" => "41" "paginaInicial" => "991" "paginaFinal" => "994" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7600701" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0100" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Determinats and vitamin responsiveness of intermediate hyperhomocysteinemia (≥40 micromol/liter). The Hordaland Homocysteine Study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "A.B. Guttormsen" 1 => "P.M. Ueland" 2 => "I. Nesthus" 3 => "O. Nygard" 4 => "J. Schneede" 5 => "S.E. Vollset" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1172/JCI119024" "Revista" => array:6 [ "tituloSerie" => "J Clin Invest" "fecha" => "1996" "volumen" => "98" "paginaInicial" => "2174" "paginaFinal" => "2183" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8903338" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0105" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effects of vitamina B12, folate, and vitamina B<span class="elsevierStyleInf">6</span> supplements in elderly people with normal serum vitamins concentrations" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "H.K. Naurath" 1 => "E. Joosten" 2 => "R. Riezler" 3 => "S.P. Stabler" 4 => "R.H. Allen" 5 => "J. Lindenbaum" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "1995" "volumen" => "346" "paginaInicial" => "85" "paginaFinal" => "89" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7603218" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib0110" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Reducción de concentraciones elevadas de homocisteína con ácido fólico y vitaminas B en pacientes con tromboembolia venosa: relación entre la respuesta y genotipo C677T de la metilén tetrahidrofólico reductasa (MTHFR)" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A.J. González Ordóñez" 1 => "J.M. Medina Rodríguez" 2 => "C.R. Fernández Álvarez" 3 => "J. Sánchez García" 4 => "J.M. Fernández Carreira" 5 => "M.V. álvarez Martínez" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Med Clin (Barc)" "fecha" => "2000" "volumen" => "114" "paginaInicial" => "7" "paginaFinal" => "12" ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib0115" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Plasma homocysteine in acute myocardial infarction: homocysteine- lowering effect of folic acid" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "F. Landgren" 1 => "B. Israelsson" 2 => "A. Lindgren" 3 => "B. Hultberg" 4 => "A. Andersson" 5 => "L. Brattstrom" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Intern Med" "fecha" => "1995" "volumen" => "237" "paginaInicial" => "381" "paginaFinal" => "388" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7714461" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib0120" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pietrzik. Effects of folic acid and combinations of folic acid and vitamina B<span class="elsevierStyleInf">12</span> on plasma homocysteine concentrations in healthy, young women" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A. Brönstrup" 1 => "M. Hages" 2 => "R. Prinz-Langenohl" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Clin Nutr" "fecha" => "1998" "volumen" => "68" "paginaInicial" => "1104" "paginaFinal" => "1110" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9808229" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib0125" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Folic acid and vitamin B<span class="elsevierStyleInf">6</span> supplementation and plasma homocysteine concentrations in healthy young women" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J. Dierkes" 1 => "M. Kroesen" 2 => "K. Pietrzik" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Int J Vitamin Nutr Res" "fecha" => "1998" "volumen" => "68" "paginaInicial" => "98" "paginaFinal" => "103" ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib0130" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The effect of a subnormal vitamin B<span class="elsevierStyleInf">6</span> status on homocysteine metabolism" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.B. Ubbink" 1 => "A. Van der Merwe" 2 => "R. Delport" 3 => "R.H. Allen" 4 => "S.P. Stabler" 5 => "R. Riezler" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1172/JCI118763" "Revista" => array:6 [ "tituloSerie" => "J Clin Invest" "fecha" => "1996" "volumen" => "98" "paginaInicial" => "177" "paginaFinal" => "184" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8690790" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib0135" "etiqueta" => "27." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Nonsyndromic orofacial clefts: association with maternal hyperhomocysteinemia" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "W.Y. Wong" 1 => "T.K. Eskes" 2 => "A.M. Kuijpers-Jagtman" 3 => "P.H. Spauwen" 4 => "E.A. Steegers" 5 => "C.M. Thomas" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/(SICI)1096-9926(199911)60:5<253::AID-TERA4>3.0.CO;2-V" "Revista" => array:6 [ "tituloSerie" => "Teratology" "fecha" => "1999" "volumen" => "60" "paginaInicial" => "253" "paginaFinal" => "257" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10525201" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib0140" "etiqueta" => "28." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Congenital heart defects and maternal derangement of homocysteine metabolism" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "L. Kapusta" 1 => "M.L. Haagmans" 2 => "E.A. Steegers" 3 => "M.H. Cuypers" 4 => "H.J. Blom" 5 => "T.K. Eskes" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Pediatr" "fecha" => "1999" "volumen" => "135" "paginaInicial" => "773" "paginaFinal" => "774" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10586186" "web" => "Medline" ] ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib0145" "etiqueta" => "29." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Homocysteine and folate levels as risk factors for recurrent early pregnancy loss" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "W.L. Nelen" 1 => "H.J. Blom" 2 => "E.A. Steegers" 3 => "M. Den Heijer" 4 => "C.M. Thomas" 5 => "T.K. Eskes" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Obstet Gynecol" "fecha" => "2000" "volumen" => "95" "paginaInicial" => "519" "paginaFinal" => "524" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10725483" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib0150" "etiqueta" => "30." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Rapid communication: Lfolinic acid versus folic acid for the treatment of hyperhomocysteinemia in hemodialysis patients" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Yango" 1 => "D. Shemin" 2 => "N. Hsu" 3 => "P.F. Jacques" 4 => "L. Dwoiekin" 5 => "J. Selhub" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1046/j.1523-1755.2001.00507.x" "Revista" => array:6 [ "tituloSerie" => "Kidney Int" "fecha" => "2001" "volumen" => "59" "paginaInicial" => "324" "paginaFinal" => "327" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11135086" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/00257753/0000011700000006/v1_201307291658/S0025775301720659/v1_201307291658/es/main.assets" "Apartado" => array:4 [ "identificador" => "24087" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Original breve" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/00257753/0000011700000006/v1_201307291658/S0025775301720659/v1_201307291658/es/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775301720659?idApp=UINPBA00004N" ]
Información de la revista
Compartir
Descargar PDF
Más opciones de artículo
Efecto del ácido levofolínico sobre las concentraciones de homocisteína plasmática en la mujer joven y sana en la consulta preconcepcional
Effects of levofolinic acid on plasma homocysteine concentrations in healthy and young women in preconceptional care
Ernesto Fabrea,
, Manuel Gallob, Ana Cristina Loua, Gertrudis Justec, María Soledad Romerod, Carmen Blascoe, Rafael González de Agüeroa, Mercedes Sobrevielaa, Armando Reyes-Engeld
Autor para correspondencia
efabreg@sego.es
Correspondencia: Dr. E. Fabre. Departamento de Obstetricia y Ginecología. Hospital Clánico Universitario Lozano Blesa. Avda. de San Juan Bosco, 15. 50009 Zaragoza.
Correspondencia: Dr. E. Fabre. Departamento de Obstetricia y Ginecología. Hospital Clánico Universitario Lozano Blesa. Avda. de San Juan Bosco, 15. 50009 Zaragoza.
a Departamento de Obstetricia y Ginecología. Hospital Clínico Universitario Lozano Blesa. Zaragoza.
b Hospital Clínico Universitario Carlos Haya. Málaga.
c Laboratorio de Hormonología.
d Servicio de Hematología Hospital Clínico Universitario Lozano Blesa Zaragoza.
e Departamento de Bioquímica y Biología Molecular. Facultad de Medicina. Málaga.