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array:23 [ "pii" => "S002577530071640X" "issn" => "00257753" "doi" => "10.1016/S0025-7753(00)71640-X" "estado" => "S300" "fechaPublicacion" => "2000-01-01" "aid" => "71640" "copyright" => "Elsevier España, S.L.. Todos los derechos reservados" "copyrightAnyo" => "2000" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2000;115:617-9" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2985 "formatos" => array:3 [ "EPUB" => 8 "HTML" => 2844 "PDF" => 133 ] ] "itemSiguiente" => array:18 [ "pii" => "S0025775300716411" "issn" => "00257753" "doi" => "10.1016/S0025-7753(00)71641-1" "estado" => "S300" "fechaPublicacion" => "2000-01-01" "aid" => "71641" "copyright" => "Elsevier España, S.L." "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "edi" "cita" => "Med Clin. 2000;115:620-4" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1813 "formatos" => array:3 [ "EPUB" => 7 "HTML" => 1659 "PDF" => 147 ] ] "es" => array:7 [ "idiomaDefecto" => true "titulo" => "Mujer, violencia y salud" "tienePdf" => "es" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "620" "paginaFinal" => "624" ] ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "José Luis Larrión Zugasti, Joaquín de Paúl Ochotorena" "autores" => array:2 [ 0 => array:2 [ "nombre" => "José Luis" "apellidos" => "Larrión Zugasti" ] 1 => array:2 [ "nombre" => "Joaquín" "apellidos" => "de Paúl Ochotorena" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775300716411?idApp=UINPBA00004N" "url" => "/00257753/0000011500000016/v1_201307291652/S0025775300716411/v1_201307291652/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0025775300716393" "issn" => "00257753" "doi" => "10.1016/S0025-7753(00)71639-3" "estado" => "S300" "fechaPublicacion" => "2000-01-01" "aid" => "71639" "copyright" => "Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2000;115:610-6" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2190 "formatos" => array:3 [ "EPUB" => 6 "HTML" => 2009 "PDF" => 175 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Manifestaciones fenotípicas de la cistinuria: estudio de 20 familias en la Comunidad Valenciana" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "610" "paginaFinal" => "616" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Phenotypical traits in cystinuria: a study of 20 families in the Comunidad Valenciana (Spain)" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Marisa Guillén, Dolores Corella, M. Luisa Cabellob, José I. González, José Hernández Yago" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Marisa" "apellidos" => "Guillén" ] 1 => array:2 [ "nombre" => "Dolores" "apellidos" => "Corella" ] 2 => array:2 [ "nombre" => "M." "apellidos" => "Luisa Cabellob" ] 3 => array:2 [ "nombre" => "José I." "apellidos" => "González" ] 4 => array:2 [ "nombre" => "José" "apellidos" => "Hernández Yago" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775300716393?idApp=UINPBA00004N" "url" => "/00257753/0000011500000016/v1_201307291652/S0025775300716393/v1_201307291652/es/main.assets" ] "es" => array:14 [ "idiomaDefecto" => true "titulo" => "Eficacia de una terapia secuencial en la erradicación de <span class="elsevierStyleItalic">Helicobacter pylori:</span> cuádruple terapia con omeprazol, metronidazol, tetraciclina y bismuto tras el fracaso de la combinación de omeprazol, claritromicina y amoxicilina" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "617" "paginaFinal" => "619" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "José Baena Díez, Cristina López Mompó, Francesc Rams Rams, Manuel García Lareo, M. Rosario Hernández Ibáñez, José Teruel Gila" "autores" => array:6 [ 0 => array:4 [ "nombre" => "José" "apellidos" => "Baena Díez" "email" => array:1 [ 0 => "jbaenad@meditex.es" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "Cristina" "apellidos" => "López Mompó" ] 2 => array:2 [ "nombre" => "Francesc" "apellidos" => "Rams Rams" ] 3 => array:2 [ "nombre" => "Manuel" "apellidos" => "García Lareo" ] 4 => array:2 [ "nombre" => "M." "apellidos" => "Rosario Hernández Ibáñez" ] 5 => array:2 [ "nombre" => "José" "apellidos" => "Teruel Gila" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Área Básica de Salud Dr. Carles Ribas. Barcelona" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Correspondencia: Sant Miquel, 52, 2.°4.<span class="elsevierStyleSup">a</span>. 08150 Parets del Vallès. Barcelona." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Efficacy of a multistep strategy for Helicobacter pylori eradication: quadruple therapy with omeprazole, metronidazole, tetracycline and bismuth after failure of combination of omeprazole, clarithromycin and amoxycillin." ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2000-06-01" "fechaAceptado" => "2000-09-26" "PalabrasClave" => array:1 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec222543" "palabras" => array:6 [ 0 => "<span class="elsevierStyleItalic">Helicobacter pylori</span>" 1 => "Erradicación" 2 => "Omeprazol" 3 => "Claritromicina" 4 => "Amoxicilina Tetraciclina Metronidazol" 5 => "Bismuto" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Fundamento</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Evaluar la eficacia de una terapia secuencial para erradicar a <span class="elsevierStyleItalic">Helicobacter pylori</span> (HP).</p> <span class="elsevierStyleSectionTitle">Pacientes y método</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Un total de 151 pacientes, con ulcus péptico o gastritis crónica, infectados por HP, tratados (primera etapa) con una combinación de omeprazol (20 mg/12 h), claritromicina (500 mg/12 h) y amoxicilina (1 g/12 h) (OCA) durante una semana y posteriormente (segunda etapa, si fracasaba la erradicación) con una combinación de omeprazol (20 mg/12 h), metronidazol (500 mg/12 h), tetraciclina (500 mg/6 h) y bismuto (120 mg/6 h) (OMTB) durante 14 días.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Por intención de tratar se erradicó con OCA en el 78,1% (IC del 95%: 71,6–84,7) y con OMTB en el 90,3% (IC del 95%: 74,2–98), siendo la proporción acumulada del 96,7% (IC del 95%: 92,4–98,9).</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La eficacia de la estrategia estudiada es elevada. La combinación OMTB es una buena opción tras el fracaso de la OCA.</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To evaluate the efficacy of a multistep strategy for Helicobacter pyori (HP) eradication.</p> <span class="elsevierStyleSectionTitle">Patients and method</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">151 patients, with peptic ulcer or chronic gastritis, infected by HP, treated (first-step) with omeprazole (20 mg/12 h), clarithromycin (500 mg/12 h) and amoxycillin (1 g/12 h) for a week (OCA) and second-step (first-step failures) with omeprazole (20 mg/12 h), metronidazole (500 mg/12 h), tetracyclin (500 mg/6 h) and bismuth (120 mg/6 h) for two weeks.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Intention-to-treat analysis, eradication was achieved with OCA in 78.1% (CI 95%: 71.6–84.7) and OMTB in 90.3% (CI 95%: 74.2–98), with an cumulative eradication rate of 96.7% (CI95%: 92.4–98.9).</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">The efficacy of multistep strategy is high. 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Navarro" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1572-0241.1998.00281.x" "Revista" => array:6 [ "tituloSerie" => "Am J Gastroenterol" "fecha" => "1998" "volumen" => "93" "paginaInicial" => "932" "paginaFinal" => "934" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9647022" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/00257753/0000011500000016/v1_201307291652/S002577530071640X/v1_201307291652/es/main.assets" "Apartado" => array:4 [ "identificador" => "24087" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Original breve" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/00257753/0000011500000016/v1_201307291652/S002577530071640X/v1_201307291652/es/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S002577530071640X?idApp=UINPBA00004N" ]
