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array:23 [ "pii" => "S0025775300716162" "issn" => "00257753" "doi" => "10.1016/S0025-7753(00)71616-2" "estado" => "S300" "fechaPublicacion" => "2000-01-01" "aid" => "71616" "copyright" => "Elsevier España, S.L.. Todos los derechos reservados" "copyrightAnyo" => "2000" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2000;115:534-9" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 28608 "formatos" => array:3 [ "EPUB" => 6 "HTML" => 28411 "PDF" => 191 ] ] "itemSiguiente" => array:18 [ "pii" => "S0025775300716174" "issn" => "00257753" "doi" => "10.1016/S0025-7753(00)71617-4" "estado" => "S300" "fechaPublicacion" => "2000-01-01" "aid" => "71617" "copyright" => "Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2000;115:540-1" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 3720 "formatos" => array:3 [ "EPUB" => 8 "HTML" => 3509 "PDF" => 203 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Distribución del genotipo A(TA)<span class="elsevierStyleInf">7</span>TAA asociado al síndrome de Gilbert en la población española" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "540" "paginaFinal" => "541" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Variability in the <span class="elsevierStyleItalic">UGT-1</span> gene promoter and Gilbert's syndrome" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "José Miguel Fernán:dez Salazar, Ángel Remacha Sevilla, Elisabeth del Río Conde, Montserrat Baiget Bastús" "autores" => array:4 [ 0 => array:2 [ "nombre" => "José" "apellidos" => "Miguel Fernán:dez Salazar" ] 1 => array:2 [ "nombre" => "Ángel" "apellidos" => "Remacha Sevilla" ] 2 => array:2 [ "nombre" => "Elisabeth" "apellidos" => "del Río Conde" ] 3 => array:2 [ "nombre" => "Montserrat" "apellidos" => "Baiget Bastús" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775300716174?idApp=UINPBA00004N" "url" => "/00257753/0000011500000014/v1_201307291650/S0025775300716174/v1_201307291650/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0025775300716150" "issn" => "00257753" "doi" => "10.1016/S0025-7753(00)71615-0" "estado" => "S300" "fechaPublicacion" => "2000-01-01" "aid" => "71615" "copyright" => "Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2000;115:530-3" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 4201 "formatos" => array:3 [ "EPUB" => 5 "HTML" => 4012 "PDF" => 184 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Intoxicación por paraquat. Estudio de 29 casos y evaluación del tratamiento con la «pauta caribeña»" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "530" "paginaFinal" => "533" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Paraquat intoxication. A study of 29 cases with an evaluation of the effectivity of the «Caribbean scheme»" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Javier Botella de Maglia, José Enrique Belenguer Tarín" "autores" => array:2 [ 0 => array:2 [ "nombre" => "Javier" "apellidos" => "Botella de Maglia" ] 1 => array:2 [ "nombre" => "José" "apellidos" => "Enrique Belenguer Tarín" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775300716150?idApp=UINPBA00004N" "url" => "/00257753/0000011500000014/v1_201307291650/S0025775300716150/v1_201307291650/es/main.assets" ] "es" => array:14 [ "idiomaDefecto" => true "titulo" => "Estudio prospectivo a 10 años sobre la incidencia y factores de riesgo de diabetes mellitus tipo 2" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "534" "paginaFinal" => "539" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "José Antonio Vázquez, Sonia Gaztambide, Enrique Soto-Pedre" "autores" => array:3 [ 0 => array:3 [ "nombre" => "José" "apellidos" => "Antonio Vázquez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 1 => array:4 [ "nombre" => "Sonia" "apellidos" => "Gaztambide" "email" => array:1 [ 0 => "jvazquez@hcru.osakidetza.net" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 2 => array:3 [ "nombre" => "Enrique" "apellidos" => "Soto-Pedre" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Endocrinología. Hospital de Cruces Baracaldo Vizcaya." "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Epidemiólogo. Biomitec S.L. Madrid." "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Correspondencia: Dr. J.A. Vázquez. Servicio de Endocrinología. Hospital de Cruces. Plaza de Cruces, s/n. 48903 Baracaldo. Vizcaya." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Incidence and risk factors for type 2 diabetes mellitus: a 10-year prospective study" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2000-04-27" "fechaAceptado" => "2000-09-04" "PalabrasClave" => array:1 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras claves" "identificador" => "xpalclavsec222528" "palabras" => array:5 [ 0 => "Diabetes mellitus tipo 2" 1 => "Tolerancia a la glucosa" 2 => "Incidencia" 3 => "Mortalidad" 4 => "Factores de riesgo" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Fundamento</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Conocer la incidencia de diabetes mellitus tipo 2 en nuestro medio y los posibles factores de riesgo implicados.</p> <span class="elsevierStyleSectionTitle">Pacientes y método</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Estudio prospectivo a 10 años realizado en Lejona (Vizcaya) en una población de más de 30 años de edad (n = 584). Tras un estudio de prevalencia efectuado en 1985, se revaluó 10 años más tarde a la misma población. Se recogieron datos sobre edad, sexo, índice de masa corporal, antecedentes familiares de diabetes, presión arterial sistólica y diastólica y glucemia en sangre capilar tras sobrecarga oral de glucosa que se valoró según criterios de la Organización Mundial de la Salud.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">La incidencia anual acumulada de diabetes mellitus tipo 2 fue de 8 casos/1.000 personas. En modelos multivariados de regresión logística, la tolerancia anormal a la glucosa resultó ser el predictor más importante (OR = 4,17; intervalo confianza del 95%: 1,80-9,63). La edad y el sexo también resultaron predictores significativos (p < 0,05) y casi significativos los antecedentes familiares de diabetes mellitus tipo 2 (p = 0,057). No lo fue el índice de masa corporal, aunque su incremento fue mayor en los enfermos que progresaron a diabetes mellitus tipo 2 frente a los que no.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La incidencia acumulada de diabetes mellitus tipo 2 en Lejona fue similar a la encontrada en otros países europeos. La presencia de tolerancia anormal a la glucosa y cifras más elevadas de glucemia favorecen la progresión a diabetes mellitus tipo 2. El incremento del índice de masa corporal parece desempeñar un papel precipitante en la progresión a diabetes mellitus tipo 2.</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">The aims of this study were to determine the incidence of diabetes mellitus type 2 and to define the associated risk factors.</p> <span class="elsevierStyleSectionTitle">Patients and method</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">A 10-year prospective study was done over 584 people identified by screening of the Lejona (Vizcaya, Spain) adult population in 1985. Data on age, sex, body mass index, family history of diabetes mellitus and blood pressure were collected. Also an oral glucose tolerance test was done following the criteria recommended by the WHO.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Age-adjusted cumulative incidence per year was 8 per 1,000 persons. In a multivaria-te logistic regression analysis, impaired glucose tolerance was the major predictor of worsening to diabetes (relative risk 4.17; 95% confidence interval 1.80-9.63). Age and sex were also statistically significant predictors (p < 0.05), and family history of diabetes was almost significant (p = 0.057). Body mass index was not an independent and significant risk factor in this study. However, the rise in body mass index was larger in those who progressed to diabetes mellitus type 2 than in those who did not.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">The incidende of diabetes mellitus type 2 found in Lejona was similar to that reported in other european countries. Subjects having impaired glucose tolerance as well as those with elevated blood glucose levels are at higher risk of worsenning to diabetes mellitus type 2. Body mass index seems to play a precipitating role in the progression to diabetes mellitus type 2.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias Bibliográficas" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:29 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." 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