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array:23 [ "pii" => "S0025775301717629" "issn" => "00257753" "doi" => "10.1016/S0025-7753(01)71762-9" "estado" => "S300" "fechaPublicacion" => "2001-01-01" "aid" => "71762" "copyright" => "Elsevier España, S.L.. Todos los derechos reservados" "copyrightAnyo" => "2001" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2001;116:174-8" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1998 "formatos" => array:3 [ "EPUB" => 8 "HTML" => 1762 "PDF" => 228 ] ] "itemSiguiente" => array:18 [ "pii" => "S0025775301717630" "issn" => "00257753" "doi" => "10.1016/S0025-7753(01)71763-0" "estado" => "S300" "fechaPublicacion" => "2001-01-01" "aid" => "71763" "copyright" => "Elsevier España, S.L." "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "edi" "cita" => "Med Clin. 2001;116:179-81" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1908 "formatos" => array:3 [ "EPUB" => 7 "HTML" => 1724 "PDF" => 177 ] ] "es" => array:8 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Editorial</span>" "titulo" => "Evaluación de la etiología y del abordaje terapéutico de la neumonía adquirida en la comunidad" "tienePdf" => "es" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "179" "paginaFinal" => "181" ] ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Torres Antoni, N. Soler" "autores" => array:2 [ 0 => array:2 [ "nombre" => "Torres" "apellidos" => "Antoni" ] 1 => array:2 [ "nombre" => "N." "apellidos" => "Soler" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775301717630?idApp=UINPBA00004N" "url" => "/00257753/0000011600000005/v1_201307291416/S0025775301717630/v1_201307291416/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0025775301717617" "issn" => "00257753" "doi" => "10.1016/S0025-7753(01)71761-7" "estado" => "S300" "fechaPublicacion" => "2001-01-01" "aid" => "71761" "copyright" => "Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2001;116:167-73" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1993 "formatos" => array:3 [ "EPUB" => 6 "HTML" => 1756 "PDF" => 231 ] ] "es" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Originales</span>" "titulo" => "Diagnóstico y tratamiento de la tuberculosis en España: resultados del Proyecto Multicéntrico de Investigación en Tuberculosis (PMIT)" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "167" "paginaFinal" => "173" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Diagnosis and treatment of tuberculosis in Spain: results from the Multicenter Project for Tuberculosis Research (MPTR)" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "M. Díez Ruiz-Navarro" "autores" => array:2 [ 0 => array:1 [ "colaborador" => "Grupo de Trabajo del PMIT" ] 1 => array:2 [ "nombre" => "M." "apellidos" => "Díez Ruiz-Navarro" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775301717617?idApp=UINPBA00004N" "url" => "/00257753/0000011600000005/v1_201307291416/S0025775301717617/v1_201307291416/es/main.assets" ] "es" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Originales</span>" "titulo" => "Incidencia y supervivencia de las leucemias según el tipo histológico en Tarragona, en el período 1980-1994" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "174" "paginaFinal" => "178" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Juan R. González, Víctor Moreno, Josep Maria Borràs, Joan Borràs, Jaume Galceran, Albert Grañena, Francesc Xavier Bosch" "autores" => array:7 [ 0 => array:4 [ "nombre" => "Juan R." "apellidos" => "González" "email" => array:1 [ 0 => "jrgonzalez@ico.scs.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Víctor" "apellidos" => "Moreno" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "Josep" "apellidos" => "Maria Borràs" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "Joan" "apellidos" => "Borràs" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 4 => array:3 [ "nombre" => "Jaume" "apellidos" => "Galceran" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 5 => array:3 [ "nombre" => "Albert" "apellidos" => "Grañena" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] ] ] 6 => array:3 [ "nombre" => "Francesc" "apellidos" => "Xavier Bosch" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:4 [ 0 => array:3 [ "entidad" => "Servicios de Prevención y Control del Cáncer Instituto Catalán de Oncología" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicios de Epidemiología y Registro del Cáncer Instituto Catalán de Oncología" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Registro Poblacional de Cáncer de Tarragona" "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Servicios de Hematología Clínica. Instituto Catalán de Oncología" "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Correspondence: Servei de Prevenció i Control del Càncer. Institut Català d'Oncologia. Avda. Gran Via, s/n, km 2,7. 08907 L'Hospitalet de Llobregat. Barcelona." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Incidence and survival of leukemias according to the different histologic subsets, in tarragona, spain, between 1980-1994" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2000-09-20" "fechaAceptado" => "2000-12-21" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras Clave" "identificador" => "xpalclavsec220804" "palabras" => array:4 [ 0 => "Leucemias" 1 => "Incidencia" 2 => "Supervivencia" 3 => "Tipo histológico" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec220803" "palabras" => array:4 [ 0 => "Leukemias" 1 => "Incidence" 2 => "Survival" 3 => "Hystologic types" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Fundamento</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Estudiar la incidencia y supervivencia de las leucemias según los distintos subtiposhistológicos.</p> <span class="elsevierStyleSectionTitle">Material y método</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se analizan los datos del Registro Poblacional de Cáncer de Tarragona en el período 1980-1994. Las leucemias se han agrupado en: leucemia linfoblástica aguda (LLA), leucemia mieloblástica aguda (LMA), leucemia linfoide crónica (LLC) y leucemia mieloide crónic (LMC). Se han calculado las tasas de incidencia ajustadas a la población mundial, el porcentaje de cambio anual de la incidencia mediante modelos de regresión de Poisson y la supervivencia relativa utilizando la mortalidad general de Cataluña.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">La tasa ajustada para el total de las leucemias en el período 1990-1994 es de 8,0 por 100.000 habitantes en los varones y de 5,2 en las mujeres, siendo la LLC el subtipo más frecuente. En cuanto a la tendencia de la incidencia, destaca un aumento de la LLC del 2,2% anual (intervalo de confianza [IC] del 95%, 0,1-6,6) en los varones y del 7,7% (IC del 95%,1,4-14,4) en las mujeres. En los demás subtipos no se observa ninguna tendencia, pero las leucemias no clasificadas descienden un –10,8% anual (IC del 95%, –15,0 a –6,4) en los varones y un –9,9% anual (IC del 95%, –15,4 a –4,0) en las mujeres. La supervivencia relativa a los 5 años (SR5a) para el total de leucemias es del 37,7% en los varones y del 45,3% en las mujeres. Destacan la LLC, con una SR5a del 64,8% en los varones y del 75,7% en las mujeres, y la LLA en los menores de 15 años, con una SR5a del 83,0% en los niños y del 84,9% en las niñas.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">En el Registro Poblacional de Cáncer de Tarragona se ha observado un aumento de la incidencia de la LLC que sugiere una mejora en su diagnóstico, así como un descenso de las leucemias no clasificadas. La supervivencia de las leucemias es similar a la que se observa en otros registros europeos.</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To study the incidence and survival of leukemias according to the different hystologic types in Tarragona, Spain.</p> <span class="elsevierStyleSectionTitle">Material and method</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Analysis of the information obtained from the Cancer Registry of Tarragona (Spain) between 1980-1994. The leukemias were classified in: acute lymphoblastic leukemia (ALL), acute myelogenous leukemia (AML), chronic lymphoid leukemia (CLL) and chronic myeloid leukemia (CML). The estimated incidence rates have been adjusted to the worldwide population, the percentage of the incidence annual change through Poisson regression models and the relative survival using the registry of death rate of Catalonia.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">The adjusted rate for leukemias between the period 1990-1994 was 8.0 per 100,000 inhabitants in men and of 5.2 in women, being the CLL the most frequent subtype. Regarding the trend of incidence an increase of the CLL of 2.2% annual (CI 95%, 0.1-6.6) in men and of 7.7% (CI 95%, 1.4-14.4) in women was observed. In the remaining subtypes, there was no trend, but the non-classified leukemias decreased a –10.8% annual (CI 95%, –15.0 to –6.4) in men and a –9.9% annual (CI 95%, 15.4 to –4.0) in women. 5-year relative survival (RS5y) for the total leukemias was 37.7% in men and 45.3% in women. It stands out the CLL with a RS5y of 64.8% in men and of 75.7% in women and childhood ALL with a RS5y of 83.0% in boys and of 84.9% in girls.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">In Tarragona, Spain, an increase of the CLL incidence has been observed suggesting an improvement in the diagnosis, parallel to a decrease of the non-classified leukemias. The survival in this cohort of patients was similar to the that reported in other european registries.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias Bibliográficas" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:25 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." 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