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array:23 [ "pii" => "S0025775300716265" "issn" => "00257753" "doi" => "10.1016/S0025-7753(00)71626-5" "estado" => "S300" "fechaPublicacion" => "2000-01-01" "aid" => "71626" "copyright" => "Elsevier España, S.L.. Todos los derechos reservados" "copyrightAnyo" => "2000" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2000;115:564-7" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1617 "formatos" => array:3 [ "EPUB" => 6 "HTML" => 1461 "PDF" => 150 ] ] "itemSiguiente" => array:18 [ "pii" => "S0025775300716277" "issn" => "00257753" "doi" => "10.1016/S0025-7753(00)71627-7" "estado" => "S300" "fechaPublicacion" => "2000-01-01" "aid" => "71627" "copyright" => "Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2000;115:568-72" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1948 "formatos" => array:3 [ "EPUB" => 8 "HTML" => 1805 "PDF" => 135 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Frecuencia cardíaca y taquicardia clínica aislada en pacientes con hipertensión arterial" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "568" "paginaFinal" => "572" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Heart rate and isolated clinical tachycardia in hypertensive patients" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Ernest Vinyoles, Mariano de la Figuera, Maria Bosom, Cristina González, Núria Moreno, Valeria Pacheco" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Ernest" "apellidos" => "Vinyoles" ] 1 => array:2 [ "nombre" => "Mariano" "apellidos" => "de la Figuera" ] 2 => array:2 [ "nombre" => "Maria" "apellidos" => "Bosom" ] 3 => array:2 [ "nombre" => "Cristina" "apellidos" => "González" ] 4 => array:2 [ "nombre" => "Núria" "apellidos" => "Moreno" ] 5 => array:2 [ "nombre" => "Valeria" "apellidos" => "Pacheco" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775300716277?idApp=UINPBA00004N" "url" => "/00257753/0000011500000015/v1_201307291747/S0025775300716277/v1_201307291747/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0025775300716253" "issn" => "00257753" "doi" => "10.1016/S0025-7753(00)71625-3" "estado" => "S300" "fechaPublicacion" => "2000-01-01" "aid" => "71625" "copyright" => "Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2000;115:561-3" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 5817 "formatos" => array:3 [ "EPUB" => 7 "HTML" => 5456 "PDF" => 354 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Levofloxacino oral frente a ceftriaxona y a amoxicilina/ácido clavulánico intravenosos en el tratamiento de la neumonía adquirida en la comunidad que requiere hospitalización" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "561" "paginaFinal" => "563" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Levofloxacin versus ceftriaxone and intravenous amoxicillin/clavulanate in the treatment of community-acquired pneumonia that require hospitalization" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Verónica Kalbermatter, Daniel Bagilet, Mario Diab, Eduardo Javkin" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Verónica" "apellidos" => "Kalbermatter" ] 1 => array:2 [ "nombre" => "Daniel" "apellidos" => "Bagilet" ] 2 => array:2 [ "nombre" => "Mario" "apellidos" => "Diab" ] 3 => array:2 [ "nombre" => "Eduardo" "apellidos" => "Javkin" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775300716253?idApp=UINPBA00004N" "url" => "/00257753/0000011500000015/v1_201307291747/S0025775300716253/v1_201307291747/es/main.assets" ] "es" => array:14 [ "idiomaDefecto" => true "titulo" => "Marcadores predictivos de progresión a sida en niños infectados por transmisión vertical por el virus de la inmunodeficiencia humana tipo 1" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "564" "paginaFinal" => "567" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Salvador Resino, José M.<span class="elsevierStyleSup">a</span> Bellóon, Dolores Gurbindo, José Tomás Ramos, Jesús Ruiz Contreras, M.<span class="elsevierStyleSup">a</span> Ángeles Muñoz-Fernández" "autores" => array:6 [ 0 => array:3 [ "nombre" => "Salvador" "apellidos" => "Resino" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 1 => array:3 [ "nombre" => "José M.<span class="elsevierStyleSup">a</span>" "apellidos" => "Bellóon" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "Dolores" "apellidos" => "Gurbindo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "José" "apellidos" => "Tomás Ramos" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 4 => array:3 [ "nombre" => "Jesús" "apellidos" => "Ruiz Contreras" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 5 => array:4 [ "nombre" => "M.<span class="elsevierStyleSup">a</span>" "apellidos" => "Ángeles Muñoz-Fernández" "email" => array:1 [ 0 => "Mmunoz@cbm.uam.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Servicio de Inmunología.Hospital General Universitario Gregorio Marañón. Madrid" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Sección de Inmunopediatría. Hospital General Universitario Gregorio Marañón. Madrid" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Servicio de Pediatría.Hospital Universitario 12 de Octubre. Madrid." "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Correspondencia: Dr. M.A. Muñoz-Fernández. Servicio de Inmunología. Hospital General Universitario Gregorio Marañón. Dr. Esquerdo, 46. 28007 Madrid" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Prognostic markers of progression to aids in infants vertically infected by human immunodeficiency virus type-1" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2000-04-27" "fechaAceptado" => "2000-09-12" "PalabrasClave" => array:1 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec223108" "palabras" => array:4 [ 0 => "Niños" 1 => "Infección por VIH-1" 2 => "Carga viral" 3 => "Marcadores predictivos" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Fundamento</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Estudiar el valor predictivo, individual y en conjunto, del porcentaje de linfocitos T CD4+, CD8+ y la carga viral plasmática (copias/ml), de progresión a sida en niños infectados verticalmente por el VIH-1.</p> <span class="elsevierStyleSectionTitle">Pacientes y método</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">El estudio incluye una cohorte de 115 niños infectados por el VIH 1 mayores de 12 meses de edad. La carga viral se cuantificó en el plasma por un método molecular estandarizado. Las subpoblaciones linfocitarias se determinaron por citometría de flujo.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Los niños con una mediana de carga viral mayor de 4,5 log10 (p < 0,001) y porcentaje de CD8+ inferior a 25% (p = 0,05) durante el seguimiento tuvieron una media de tiempo de progresión a sida más baja. El riesgo relativo (RR) de progresión a sida fue mayor de 7 veces en los niños con una carga viral de más de 4,5 log10 de la mediana. En el caso de la carga viral como variable continua, encontramos que el riesgo de progresión a sida es superior a 3,5 por cada aumento de log10 de carga viral. El porcentaje de CD8+ tuvo un RR de progresión a sida de 0,95/% CD8+ a la entrada en el estudio y de 0,19/% CD8+ durante el seguimiento, indicando protección frente a la progresión a sida.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Los valores individuales durante el seguimiento, pero no los basales, del porcentaje de linfocitos T CD8+ y carga viral ayudan a determinar el riesgo de progresión a sida en niños infectados por el VIH-1, y el uso de los dos marcadores juntos predice con más precisión el pronóstico de la enfermedad.</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To study the prognostic AIDS progression value of the percentage of CD4+, CD8+, and plasma viral load (VL) (copies/ml) in HIV-1-vertically infected children.</p> <span class="elsevierStyleSectionTitle">Patients and method</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">We study a cohort of 115 HIV-1 infected children older than 12 months of age. The VL was quantified using standard molecular assay. CD4 and CD8 T lymphocytes were determined by flow cytometry.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">The children with a median of VL > 4.5 log10 (p < 0.001) and percentage of CD8+ < 25% (p = 0.05) during follow-up, progressed faster to AIDS than children with a median of VL < 4.5 log10 and CD8 > 25%. The relative risk (RR) of AIDS progression was 7-fold higher in children with median VL above 4.5 log10. When considering VL as a continuous variable, risk of progression to AIDS is 3.5-fold higher for each increase of one log10 of VL. The percentage of CD8+ T-cells had a RR of AIDS progression of 0.95/% CD8+ at entry to the study and of 0.19/% CD8+ during follow-up, indicating protection against progression to AIDS</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Our results indicate that each basal values at entry in the study and during the follow-up of the percentage of CD8+ and VL helps to determine the risk of AIDS progression in HIV-1-infected children. More interestingly, the use of the two predictive markers together had higher predictive value.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias bibliográficas" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:29 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." 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