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array:23 [ "pii" => "S0025775300716642" "issn" => "00257753" "doi" => "10.1016/S0025-7753(00)71664-2" "estado" => "S300" "fechaPublicacion" => "2000-01-01" "aid" => "71664" "copyright" => "Elsevier España, S.L.. Todos los derechos reservados" "copyrightAnyo" => "2000" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2000;115:687-9" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2730 "formatos" => array:3 [ "EPUB" => 6 "HTML" => 2489 "PDF" => 235 ] ] "itemSiguiente" => array:18 [ "pii" => "S0025775300716654" "issn" => "00257753" "doi" => "10.1016/S0025-7753(00)71665-4" "estado" => "S300" "fechaPublicacion" => "2000-01-01" "aid" => "71665" "copyright" => "Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2000;115:690-4" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2698 "formatos" => array:3 [ "EPUB" => 8 "HTML" => 2446 "PDF" => 244 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "El proyecto multinacional europeo y multicéntrico español de mejora de calidad asistencial en psiquiatría de enlace en el hospital general: el perfil clínico en España" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "690" "paginaFinal" => "694" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Multinational European project and multicenter Spanish study of quality improvement of assistance on consultation-liaison psychiatry in general hospital: clinical profile in Spain" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Manuel Valdés, Joan de Pablo, Ricardo Campos, Josep Maria Farré, Manuel Girón, Maximino Lozano, Carlos Aibar, Eduardo García-Camba, Ana Martínez Calvo, Sonia Carreras, Barbara Stein, Frits Huyse, Thomas Herzog, Antonio Lobo" "autores" => array:14 [ 0 => array:2 [ "nombre" => "Manuel" "apellidos" => "Valdés" ] 1 => array:2 [ "nombre" => "Joan" "apellidos" => "de Pablo" ] 2 => array:2 [ "nombre" => "Ricardo" "apellidos" => "Campos" ] 3 => array:2 [ "nombre" => "Josep" "apellidos" => "Maria Farré" ] 4 => array:2 [ "nombre" => "Manuel" "apellidos" => "Girón" ] 5 => array:2 [ "nombre" => "Maximino" "apellidos" => "Lozano" ] 6 => array:2 [ "nombre" => "Carlos" "apellidos" => "Aibar" ] 7 => array:2 [ "nombre" => "Eduardo" "apellidos" => "García-Camba" ] 8 => array:2 [ "nombre" => "Ana" "apellidos" => "Martínez Calvo" ] 9 => array:2 [ "nombre" => "Sonia" "apellidos" => "Carreras" ] 10 => array:2 [ "nombre" => "Barbara" "apellidos" => "Stein" ] 11 => array:2 [ "nombre" => "Frits" "apellidos" => "Huyse" ] 12 => array:2 [ "nombre" => "Thomas" "apellidos" => "Herzog" ] 13 => array:2 [ "nombre" => "Antonio" "apellidos" => "Lobo" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775300716654?idApp=UINPBA00004N" "url" => "/00257753/0000011500000018/v1_201307291652/S0025775300716654/v1_201307291652/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0025775300716630" "issn" => "00257753" "doi" => "10.1016/S0025-7753(00)71663-0" "estado" => "S300" "fechaPublicacion" => "2000-01-01" "aid" => "71663" "copyright" => "Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2000;115:681-6" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 12559 "formatos" => array:3 [ "EPUB" => 7 "HTML" => 12244 "PDF" => 308 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "El período de incubación del sida en España antes de la terapia antirretroviral de alta eficacia" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "681" "paginaFinal" => "686" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "AIDS incubation period in Spain before highly active antiretroviral therapy" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "I. Hernández-Aguado" "autores" => array:2 [ 0 => array:2 [ "nombre" => "I." "apellidos" => "Hernández-Aguado" ] 1 => array:1 [ "colaborador" => "GEMES (Grupo Espa ñol Multicéntrico para el Estudio de Seroconversores)" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775300716630?idApp=UINPBA00004N" "url" => "/00257753/0000011500000018/v1_201307291652/S0025775300716630/v1_201307291652/es/main.assets" ] "es" => array:14 [ "idiomaDefecto" => true "titulo" => "Prevalencia y repercusión clínica de la deficiencia de inmunoglobulina A en la enfermedad celíaca" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "687" "paginaFinal" => "689" ] ] "autores" => array:2 [ 0 => array:4 [ "autoresLista" => "José Sardi, Francesc Casellas, Juan Ramón Malagelada" "autores" => array:3 [ 0 => array:2 [ "nombre" => "José" "apellidos" => "Sardi" ] 1 => array:3 [ "nombre" => "Francesc" "apellidos" => "Casellas" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 2 => array:2 [ "nombre" => "Juan" "apellidos" => "Ramón Malagelada" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Aparato Digestivo. Hospital General Vall d'Hebron. Barcelona." ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Correspondencia: Dr. F. Casellas. Servicio de Aparato Digestivo. Hospital General Vall d'Hebron. Passeig de la Vall d'Hebron, 119. 08035 Barcelona." ] ] ] 1 => array:3 [ "autoresLista" => "Inés de Torres" "autores" => array:1 [ 0 => array:3 [ "nombre" => "Inés" "apellidos" => "de Torres" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:3 [ "entidad" => "Departamento de Anatomía Patológica. Hospital General Vall d'Hebron. Barcelona." "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Clinical relevance of immunoglobulin A deficiency in celiac disease" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2000-05-17" "fechaAceptado" => "2000-09-28" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec222549" "palabras" => array:4 [ 0 => "Celiac disease" 1 => "Immunodeficiency" 2 => "Immonuglobulin A deficiency" 3 => "Malabsorption" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec222548" "palabras" => array:4 [ 0 => "Celiac disease" 1 => "Immunodeficiency" 2 => "Immonuglobulin A deficiency" 3 => "Malabsorption" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Fundamento</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Determinar la prevalencia de la deficiencia de inmunoglobulina A (IgA) en pacientes diagnosticados de enfermedad celíaca, y establecer la influencia que tiene en la presentación y evolución de esta enfermedad.</p> <span class="elsevierStyleSectionTitle">Pacientes y método</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se han revisado los datos clínicos y biológicos de 47 pacientes diagnosticados clínica e histológicamente de enfermedad celíaca, en quienes se ha determinado la concentración de inmunoglobulinas séricas.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">En 5 pacientes los valores séricos de IgA fueron inferiores a 7 mg/dl (grupo con deficiencia de IgA) y en 42 fueron normales (grupo sin deficiencia de IgA). La edad y la relación varón/mujer fueron similares entre ambos grupos, al igual que la forma de presentación, las manifestaciones clínicas, los datos analíticos de malabsorción (anemia, hipocolesterolemia, hipoproteinemia e hipoprotrombinemia) y el patrón radiológico. Se detectó la existencia de bronquiectasias en dos de los 5 con deficiencia de IgA y en sólo uno de los 42 pacientes sin deficiencia de IgA (p < 0,05). Ningún paciente con deficiencia de IgA presentó complicaciones atribuibles a la enfermedad celíaca, mientras que 3 pacientes del grupo sin deficiencia de IgA desarrollaron linfoma intestinal (p = NS).</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La deficiencia de IgA se asocia con frecuencia a la enfermedad celíaca. Sin embargo, esta asociación no parece influir de forma significativa en la presentación y evolución clínicas ni interfiere con las pruebas de cribado para la enfermedad celíaca.</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To determine the prevalence of the IgA deficiency in patients with celiac disease and its influence on the presentation and evolution of celiac disease.</p> <span class="elsevierStyleSectionTitle">Patients and method</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">47 patients with clinical and histological diagnosis of celiac disease were included. Seric immunoglobulin levels were determined in all patients.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Five patients presented a low level of IgA (IgA-deficient group) and 42 patients presented normal levels (non-IgA-deficient group). The age and the relation male/female were similar between both groups. Presentation, clinical manifestations, analytic data of intestinal malabsorption, and the radiologic pattern were also similar between both groups of patients. There were bronchiectasies in two out of 5 IgA-deficient patients and in only one out of 42 non-IgA-deficient patients (p < 0.05). None of the IgA-deficient group showed complications due to the celiac disease, meanwhile 3 non-IgA deficient patients developed intestinal lymphoma (p = NS).</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">The IgA deficiency is frequently associated to celiac disease. This association does not seem to influence in a significant way the presentation or the evolution of celiac disease.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias Bibliográficas" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:22 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Severe combined immunodeficiencies" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "A. 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