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"documento" => "simple-article" "crossmark" => 1 "subdocumento" => "cor" "cita" => "Med Clin. 2016;146:e37" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 42 "formatos" => array:2 [ "HTML" => 23 "PDF" => 19 ] ] "es" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Carta al Editor</span>" "titulo" => "Utilidad de los anticuerpos antinucleares en el diagnóstico de la pleuritis lúpica" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "e37" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Usefulness of assessment of antinuclear antibodies in pleural effusion for diagnosis of lupus pleuritis" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "José Luis Callejas Rubio, Raquel Ríos Fernández, Manuela Moreno Higueras, Norberto Ortego Centeno" "autores" => array:4 [ 0 => array:2 [ "nombre" => "José Luis" "apellidos" => "Callejas Rubio" ] 1 => array:2 [ "nombre" => "Raquel" "apellidos" => "Ríos Fernández" ] 2 => array:2 [ "nombre" => "Manuela" "apellidos" => "Moreno Higueras" ] 3 => array:2 [ "nombre" => "Norberto" "apellidos" => "Ortego Centeno" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2387020616302613" "doi" => "10.1016/j.medcle.2016.05.041" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2387020616302613?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775315006363?idApp=UINPBA00004N" "url" => "/00257753/0000014600000007/v1_201603150321/S0025775315006363/v1_201603150321/es/main.assets" ] ] "es" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Carta al Editor</span>" "titulo" => "Respuesta" "tieneTextoCompleto" => true "saludo" => "<span class="elsevierStyleItalic">Sr. Editor:</span>" "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "e39" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Lucía Ferreiro, María Elena Toubes, Luis Valdés" "autores" => array:3 [ 0 => array:3 [ "nombre" => "Lucía" "apellidos" => "Ferreiro" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 1 => array:3 [ "nombre" => "María Elena" "apellidos" => "Toubes" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:4 [ "nombre" => "Luis" "apellidos" => "Valdés" "email" => array:1 [ 0 => "luis.valdes.cuadrado@sergas.es" ] "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Neumología, Complejo Hospitalario Clínico-Universitario de Santiago, Santiago de Compostela, La Coruña, España" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Grupo Interdisciplinar de Investigación en Neumología, Instituto de Investigaciones Sanitarias de Santiago (IDIS), Santiago de Compostela, La Coruña, España" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Autor para correspondencia." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Reply" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Callejas et al. hacen unos comentarios respecto al valor de la determinación de los anticuerpos antinucleares (ANA) en el líquido pleural para el diagnóstico del derrame pleural (DP) de origen lúpico, aspecto en el que no pudimos profundizar en nuestro artículo por problemas de espacio.</p><p id="par0010" class="elsevierStylePara elsevierViewall">En esta enfermedad, la pleuritis es el resultado de un proceso de inflamación inmune localizado, con activación del sistema del complemento y producción de inmunocomplejos. Los DP se comportan como exudados típicos con altos niveles de proteínas (><span class="elsevierStyleHsp" style=""></span>3,5<span class="elsevierStyleHsp" style=""></span>g/dl) y LDH (<<span class="elsevierStyleHsp" style=""></span>500<span class="elsevierStyleHsp" style=""></span>U/l); el recuento de leucocitos oscila entre 500-15.000<span class="elsevierStyleHsp" style=""></span>μl y el predomino de células nucleadas puede ser tanto de linfocitos como de polimorfonucleares. La concentración de glucosa suele ser baja y el pH es normalmente mayor de 7,30<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">1</span></a>.</p><p id="par0015" class="elsevierStylePara elsevierViewall">Los hallazgos de bajos niveles de complemento y altos títulos de ANA (><span class="elsevierStyleHsp" style=""></span>1/160) son sugestivos, pero no diagnósticos, de exudado lúpico<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">2–4</span></a> ya que algunos derrames neoplásicos, sobre todo linfomas, pueden cursar con títulos elevados<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">5</span></a>. Porcel et al. demuestran que la determinación de ANA en el líquido pleural no aporta información adicional a la de su determinación en suero, y solamente se recomienda su determinación en pacientes con un lupus y un DP de etiología incierta, ya que la ausencia de ANA en el líquido iría en contra del diagnóstico de pleuritis lúpica<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">6</span></a>.</p><p id="par0020" class="elsevierStylePara elsevierViewall">Por el contrario, la presencia de células de lupus eritematoso (LE) es altamente especifica<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">7</span></a>, si bien este test raramente se lleva a cabo debido al largo tiempo de preparación que precisa<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">8</span></a>.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:8 [ 0 => array:3 [ "identificador" => "bib0045" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Enfermedades sistémicas y pleura" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "L. 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