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array:22 [ "pii" => "S0025775301717459" "issn" => "00257753" "doi" => "10.1016/S0025-7753(01)71745-9" "estado" => "S300" "fechaPublicacion" => "2001-01-01" "aid" => "71745" "copyright" => "Elsevier España, S.L.. Todos los derechos reservados" "copyrightAnyo" => "2001" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2001;116:121-4" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 3433 "formatos" => array:3 [ "EPUB" => 6 "HTML" => 2469 "PDF" => 958 ] ] "itemSiguiente" => array:18 [ "pii" => "S0025775301717460" "issn" => "00257753" "doi" => "10.1016/S0025-7753(01)71746-0" "estado" => "S300" "fechaPublicacion" => "2001-01-01" "aid" => "71746" "copyright" => "Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2001;116:125-8" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1688 "formatos" => array:3 [ "EPUB" => 7 "HTML" => 1389 "PDF" => 292 ] ] "es" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Originales</span>" "titulo" => "Riesgo de transmisión del virus de la hepatitis B de donantes de hígado anti-HBc positivos" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "125" "paginaFinal" => "128" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Risk of hepatitis B virus transmission from hepatitis B core antibody-positive liver donors" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:2 [ 0 => array:2 [ "autoresLista" => "Rafael Bárcena Marugán, S. García Garzón, A. López San Román, E. Peña González, A. García Plaza" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Rafael" "apellidos" => "Bárcena Marugán" ] 1 => array:2 [ "nombre" => "S." "apellidos" => "García Garzón" ] 2 => array:2 [ "nombre" => "A." "apellidos" => "López San Román" ] 3 => array:2 [ "nombre" => "E." "apellidos" => "Peña González" ] 4 => array:2 [ "nombre" => "A." "apellidos" => "García Plaza" ] ] ] 1 => array:2 [ "autoresLista" => "R. Nash, R. Férnandez Muñoza, M. Mateosa" "autores" => array:3 [ 0 => array:2 [ "nombre" => "R." "apellidos" => "Nash" ] 1 => array:2 [ "nombre" => "R." "apellidos" => "Férnandez Muñoza" ] 2 => array:2 [ "nombre" => "M." "apellidos" => "Mateosa" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775301717460?idApp=UINPBA00004N" "url" => "/00257753/0000011600000004/v1_201307291415/S0025775301717460/v1_201307291415/es/main.assets" ] "es" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Originales</span>" "titulo" => "Utilidad diagnóstica del cuestionario Alcohol Use Disorders Identification Test (AUDIT) para detectar el consumo de alcohol de riesgo en atención primaria" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "121" "paginaFinal" => "124" ] ] "autores" => array:2 [ 0 => array:4 [ "autoresLista" => "Alfredo Gómez Arnáiz, José Alberto Aguiar Bautista, José Manuel Santana Montesdeoca, Ascensión Manuel Santana Montesdeoca Jorrín Morenoy" "autores" => array:4 [ 0 => array:4 [ "nombre" => "Alfredo" "apellidos" => "Gómez Arnáiz" "email" => array:1 [ 0 => "agomezarnaiz@terra.es" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "José" "apellidos" => "Alberto Aguiar Bautista" ] 2 => array:2 [ "nombre" => "José" "apellidos" => "Manuel Santana Montesdeoca" ] 3 => array:2 [ "nombre" => "Ascensión" "apellidos" => "Manuel Santana Montesdeoca Jorrín Morenoy" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Medicina de Familia. Centro de Salud de San Gregorio" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Correspondence: Mary Sánchez, 21, apartamento 410. 35009 Las Palmas de Gran Canaria." ] ] ] 1 => array:3 [ "autoresLista" => "Alicia Conde Martel, Pedro Betancor León" "autores" => array:2 [ 0 => array:3 [ "nombre" => "Alicia" "apellidos" => "Conde Martel" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 1 => array:3 [ "nombre" => "Pedro" "apellidos" => "Betancor León" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:3 [ "entidad" => "Unidad de Medicina Interna. Hospital General de Gran Canaria Doctor Negrín" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Diagnostic usefulness of Alcohol Use Disorders Identification Test (AUDIT) for detecting hazardous alcohol consumption in primary care settings" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2000-01-31" "fechaAceptado" => "2001-01-10" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec220784" "palabras" => array:3 [ 0 => "AUDIT" 1 => "Alcohol" 2 => "Detección" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec220783" "palabras" => array:3 [ 0 => "AUDIT" 1 => "Alcohol" 2 => "Detection" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Fundamento</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Evaluar la utilidad diagnóstica del cuestionario AUDIT (Alcohol Use Disorders Identification Test) para detectar el consumo de alcohol de riesgo en atención primaria, valorar las posibles diferencias en función del sexo o la edad y comparar su utilidad con la de otros métodos utilizados habitualmente (CAGE y marcadores biológicos).</p> <span class="elsevierStyleSectionTitle">Pacientes y método:</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Estudio descriptivo transversal de evaluación de pruebas diagnósticas, en el que intervinieron 500 pacientes elegidos al azar de la consulta de un centro de salud. Se recogió el consumo de alcohol mediante una encuesta semiestructurada, considerándose consumo de riesgo la ingestión igual o superior a 35 UBE (unidades de bebida estándar) por semama en varones y 21 en mujeres. Se administraron los cuestionarios AUDIT y CAGE, y se determinaron los valores de GGT, VCM, AST, ALT, fosfatasa alcalina, plaquetas, triglicéridos y ácido úrico. Paracada uno de ellos se calcularon la sensibilidad, especificidad, valor global, valores predictivos y cocientes de probabilidad positivos y negativos, así como el área bajo la curva ROC de los cuestionarios.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">La sensibilidad del AUDIT para detectar a bebedores de riesgo fue del 89%; la especificidad, del 93%, y el área bajo la curva ROC, de 0,98 (intervalo de confianza [IC] del 95%, 0,96-0,99). Su sensibilidad fue menor en las mujeres (el 60 frente al 78%) y en los pacientes menores de 60 años (el 86 frente al 100%). El CAGE obtuvo una sensibilidad del 48% y una especificidad del 97%. Los marcadores biológicos uvieron sensibilidades inferiores al 40% y especificidades superiores al 90%.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">El AUDIT es un cuestionario útil para detectar el consumo de alcohol de riesgo en atención primaria. Su sensibilidad es menor en mujeres y pacientes menores de 60 años, y su utilidad diagnóstica, claramente superior a la de otros métodos utilizados habitualmente.</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To evaluate the diagnostic usefulness of AUDIT (Alcohol Use Disorders Identification Test) for detecting hazardous alcohol consumption in primary care settings, to assess the potential differences according to age or sex and to compare its diagnostic value with that of other conventionally used measures (CAGE questionnaire and biological markers).</p> <span class="elsevierStyleSectionTitle">Patients and method</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">This is a descriptive cross-sectional study for evaluation of diagnostic tests with 500 participating patients randomly selected among those attending a family health care center. Data about alcohol intake were collected using a semistructured interview, considering as hazardous alcohol consumption a weekly intake of 35 SDUs (standard drink unit) or above for men and 21 for women. AUDIT and CAGE questionnaires were administered and blood levels of GGT, MCV, AST, ALT, alkaline phosphatase, platelets, tryglicerides and uric acid were determined. For each one of those sensitivity, specificity, global value, predictive values, positive and negative probability ratio were calculated as well as ROC analysis for the questionnaires.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Sensitivity of AUDIT in detecting current hazardous drinkers was 89%, specificity was 93% and area under ROC was 0.98 (95% CI, 0.96-0.99). Its sensitivity was found to be lower in the female group (60 vs. 78%) as well as for age group under 60 years (86 vs. 100%). CAGE questionnaire showed a sensitivity of 48% and a specificity of 97%. Biological markers offered sensitivities lower than 40% and specificities over 90%.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">AUDIT is a useful tool for detecting hazardous alcohol consumption in ambulatory care. Its sensitivity being lower for women and its diagnostic usefulness significantly exceeding that of other screening measures commonly used.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias Bibliográficas" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:20 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "titulo" => "Produktschap voor gedistilleerde dranken" ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:2 [ "titulo" => "World drink trend 1992" "serieFecha" => "1992" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cribado del consumo excesivo de alcohol" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M. Bruguera" 1 => "A. Gual" 2 => "L. Salleras" 3 => "J. Rodés" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Med Clin (Barc)" "fecha" => "1994" "volumen" => "102" "numero" => "Supl 1" "paginaInicial" => "85" "paginaFinal" => "92" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Estudio multicéntrico sobre la eficacia del consejo para la prevención del alcoholismo en atención primaria (EMPA)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "R. Altisent" 1 => "R. Córdoba" 2 => "M.T. Delgado" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Med Clin (Barc)" "fecha" => "1997" "volumen" => "109" "paginaInicial" => "121" "paginaFinal" => "124" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Development of the Alcohol Use Disorders Identification Test (AUDIT): WHO collaborative project on early detection of persons with harmful alcohol consumption II" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J.B. Saunders" 1 => "O.G. Aasland" 2 => "T.F. Babor" 3 => "J. De la Fuente" 4 => "M. Grant" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Addiction" "fecha" => "1993" "volumen" => "88" "paginaInicial" => "791" "paginaFinal" => "804" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8329970" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Criterios operativos para la prevención del alcoholismo" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "R. Altisent" 1 => "R. Córdoba" 2 => "J.M. Martín-Moros" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Med Clin (Barc)" "fecha" => "1992" "volumen" => "99" "paginaInicial" => "584" "paginaFinal" => "588" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "Sociedad Española de Medicina de Familia y Comunitaria" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:2 [ "titulo" => "Programa de actividades preventivas y promoción de la salud" "serieFecha" => "1994" ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Manual de alcoholismo para el médico de cabecera." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "A. Rodríguez-Martos" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:1 [ "serieFecha" => "1989" ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Validación de la prueba para la identificación de trastornos por uso de alcohol (AUDIT) en atención primaria" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "G. Rubio" 1 => "J. Bermejo" 2 => "M.C. Caballero" 3 => "J. Santo Domingo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Rev Clin Esp" "fecha" => "1998" "volumen" => "198" "paginaInicial" => "11" "paginaFinal" => "14" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9534342" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "La «unidad de bebida estándar» como registro simplificado del consumo de bebidas alcohólicas y su determinación en España" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A. Rodríguez-Martos" 1 => "A. Gual" 2 => "J.J. Llipis" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Med Clin (Barc)" "fecha" => "1999" "volumen" => "112" "paginaInicial" => "446" "paginaFinal" => "450" ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Efficacy of the Alcohol Use Disorders identification Test as a screening tool for hazardous alcohol intake and related disorders in primary care: a validity study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Piccinelli" 1 => "E. Tessari" 2 => "M. Bortolomasi" 3 => "O. Piasere" 4 => "M. Semenzin" 5 => "N. Garzotto" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Br Med J" "fecha" => "1997" "volumen" => "314" "paginaInicial" => "420" "paginaFinal" => "424" ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Alcohol Use Disorders Identification Test (AUDIT) and the SMAST-13 predictive validity in a rural primary care sample" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "K.L. Barry" 1 => "M.F. Fleming" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Alcohol Alcohol" "fecha" => "1993" "volumen" => "28" "paginaInicial" => "33" "paginaFinal" => "42" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8471085" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0060" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Detection of problem drinkers: the Alcohol Use Disorders Identification Test (AUDIT)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A. Schmidt" 1 => "K.L. Barry" 2 => "M.F. Fleming" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Southern Med J" "fecha" => "1995" "volumen" => "88" "paginaInicial" => "52" "paginaFinal" => "59" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7817228" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0065" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Screening for alcoholism in a national hospital sample" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M. Russell" 1 => "H. Yahr" 2 => "M.G. Burich" 3 => "M. Battaglia" 4 => "P. Chiapella" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:1 [ "serieFecha" => "1993" ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0070" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Alcohol screening questionnaires in women: a critical review" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "K.A. Bradley" 1 => "J. Boyd-Wickizer" 2 => "S.H. Powell" 3 => "M.L. Burman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "JAMA" "fecha" => "1998" "volumen" => "280" "paginaInicial" => "166" "paginaFinal" => "171" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9669791" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0075" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Ethnic and sex bias in primary care screening tests for alcohol use disorders" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J.R. Steinbauer" 1 => "S. Cantor" 2 => "C.E. Holzer III" 3 => "R.J. Volk" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Intern Med" "fecha" => "1998" "volumen" => "129" "paginaInicial" => "353" "paginaFinal" => "362" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9735062" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0080" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Performance of alcoholism screening questionnaires in elderly veterans" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J.L. Morton" 1 => "T.V. Jones" 2 => "M.A. Manganaro" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Med" "fecha" => "1996" "volumen" => "101" "paginaInicial" => "153" "paginaFinal" => "159" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8757354" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0085" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Detecting alcoholism: the CAGE questionnaire" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J.A. Ewing" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "JAMA" "fecha" => "1984" "volumen" => "252" "paginaInicial" => "1905" "paginaFinal" => "1907" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6471323" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0090" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Responses times for the CAGE, Short-MAST, AUDIT and Jellineck alcohol scales" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "R.D. Hays" 1 => "L. Hill" 2 => "J.J. Gillogoly" 3 => "M.W. Lewis" 4 => "R.M. Bell" 5 => "R. Nicholas" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3758/s13428-014-0476-9" "Revista" => array:6 [ "tituloSerie" => "Behav Res Methods, Instruments & computers" "fecha" => "1993" "volumen" => "25" "paginaInicial" => "304" "paginaFinal" => "307" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24903688" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0095" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Addiction medicine in ambulatory care: prevalence patterns in internal medicine" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "R.S. Rigmaiden" 1 => "J. Pistorello" 2 => "J. Johnson" 3 => "D. Mar" 4 => "T.L. Veach" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Subst Abuse" "fecha" => "1995" "volumen" => "16" "paginaInicial" => "49" "paginaFinal" => "57" ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0100" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The value of laboratory tests for the screening and recognition of alcohol abuse in primary care patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "H.L. Hoeksema" 1 => "G.H. Bock" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Fam Pract" "fecha" => "1993" "volumen" => "37" "paginaInicial" => "268" "paginaFinal" => "276" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8105021" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/00257753/0000011600000004/v1_201307291415/S0025775301717459/v1_201307291415/es/main.assets" "Apartado" => array:4 [ "identificador" => "24087" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Original breve" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/00257753/0000011600000004/v1_201307291415/S0025775301717459/v1_201307291415/es/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775301717459?idApp=UINPBA00004N" ]
