Originales Breves
Anticuerpos neutralizantes en pacientes con esclerosis múltiple tratados con interferón beta-1b
Neutralising antibodies in patients with multiple sclerosis treated with interferon beta-1b
Jordi Río
, Narcis Barberà, Mar Tintoré, Luis Brieva, Xavier Montalbán
Autor para correspondencia
jri@hg.vhebron.es
Correspondencia: Unidad de Neuroinmunología Clínica. Escuela de Enfermería, 5.aplanta. Hospital General Universitario Vall d'Hebron. P.o Vall d'Hebron, 119-129. 08035 Barcelona.
Correspondencia: Unidad de Neuroinmunología Clínica. Escuela de Enfermería, 5.aplanta. Hospital General Universitario Vall d'Hebron. P.o Vall d'Hebron, 119-129. 08035 Barcelona.
Unidad de Neuroinmunología Clínica. Servicio de Neurología. Hospital General Universitario Vall d'Hebron. Barcelona
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Servicio de Neurología. Hospital General Universitario Vall d'Hebron. Barcelona" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Correspondencia: Unidad de Neuroinmunología Clínica. Escuela de Enfermería, 5.<span class="elsevierStyleSup">a</span>planta. Hospital General Universitario Vall d'Hebron. P.o Vall d'Hebron, 119-129. 08035 Barcelona." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Neutralising antibodies in patients with multiple sclerosis treated with interferon beta-1b" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "1999-07-28" "fechaAceptado" => "1999-11-30" "PalabrasClave" => array:1 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec221273" "palabras" => array:3 [ 0 => "Anticuerpos neutralizantes" 1 => "Interferón beta-1b" 2 => "Esclerosis múltiple" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Fundamento</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Se ha descrito la aparición deanticuerpos neutralizantes (AN) en un terciode los pacientes con esclerosis múltiple tratadoscon interferón beta. Este estudio examinala frecuencia de aparición de dichosanticuerpos y sus implicaciones clínicas.</p> <span class="elsevierStyleSectionTitle">Pacientes y métodos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se han estudiado 68 pacientes.La determinación de AN se realizómediante la técnica de la proteína A del mixovirus.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Se detectaron AN en el 13% delos pacientes a los 2 años.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">No parece existir una relaciónentre la presencia de AN y una peor evoluciónde la esclerosis múltiple.</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Neutralising antibodies (NABs)against interferon beta have been describedin one third of patients with multiple sclerosistreated with interferon beta. We haveanalysed the frequency of NABs and theirclinical consequences.</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">We have studied 68patients. NABs were determined by proteinA Myxovirus assay.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Positive NABs were detected in 13%of the patients after 2 years of treatment.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">It does not seem to exist a relationshipbetween presence of NABs and apoor evolution of the disease in our patientswith multiple sclerosis treated with beta interferon.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias Bibliográficas" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:10 [ 0 => array:3 [ "identificador" => "bib00005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Interferon beta-1b in the treatment of multiple sclerosis. 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