metricas
covid
Buscar en
Medicina Clínica
Toda la web
Inicio Medicina Clínica La vía JAK-STAT de señalización intracelular y su repercusión en oncogénesi...
Información de la revista

Estadísticas

Siga este enlace para acceder al texto completo del artículo

La vía JAK-STAT de señalización intracelular y su repercusión en oncogénesis, inmunomodulación y desarrollo
Rafael F. Duartea,
Autor para correspondencia
duarte@rfhsm.ac.uk

Correspondencia: Dr. R.F. Duarte. The Anthony Nolan Research Institute. The Royal Free Hospital. Pond Street, Hampsted. London NW3 2QG, UK.
, David A. Frankb
a MD, PhD. Research Fellow in Medicine at Harvard Medical School. Dana-Farber Cancer Institute. Department of Adult Oncology. Boston. Massachusetts. EE.UU
b MD, PhD. Assistant Professor of Medicine at Harvard Medical School. Dana-Farber Cancer Institute. Department of Adult Oncology. Boston. Massachusetts. EE.UU
Leído
22313
Veces
se ha leído el artículo
11439
Total PDF
10874
Total HTML
Compartir estadísticas
 array:23 [
  "pii" => "S0025775300712528"
  "issn" => "00257753"
  "doi" => "10.1016/S0025-7753(00)71252-8"
  "estado" => "S300"
  "fechaPublicacion" => "2000-01-01"
  "aid" => "71252"
  "copyright" => "Elsevier España, S.L.. Todos los derechos reservados"
  "copyrightAnyo" => "2000"
  "documento" => "article"
  "crossmark" => 0
  "subdocumento" => "rev"
  "cita" => "Med Clin. 2000;114:227-34"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:2 [
    "total" => 11659
    "formatos" => array:3 [
      "EPUB" => 12
      "HTML" => 10873
      "PDF" => 774
    ]
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S002577530071253X"
    "issn" => "00257753"
    "doi" => "10.1016/S0025-7753(00)71253-X"
    "estado" => "S300"
    "fechaPublicacion" => "2000-01-01"
    "aid" => "71253"
    "copyright" => "Elsevier España, S.L."
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "exm"
    "cita" => "Med Clin. 2000;114:235-6"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 1235
      "formatos" => array:3 [
        "EPUB" => 6
        "HTML" => 1083
        "PDF" => 146
      ]
    ]
    "es" => array:7 [
      "idiomaDefecto" => true
      "titulo" => "Antiagregante de elección para prevenir la tromboembolia en los pacientes con prótesis valvulares tratados con anticoagoluantes orales"
      "tienePdf" => "es"
      "tieneTextoCompleto" => 0
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "235"
          "paginaFinal" => "236"
        ]
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Xavier Carbonell, Antònia Agustí"
          "autores" => array:2 [
            0 => array:2 [
              "nombre" => "Xavier"
              "apellidos" => "Carbonell"
            ]
            1 => array:2 [
              "nombre" => "Antònia"
              "apellidos" => "Agustí"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S002577530071253X?idApp=UINPBA00004N"
    "url" => "/00257753/0000011400000006/v1_201307291356/S002577530071253X/v1_201307291356/es/main.assets"
  ]
  "itemAnterior" => array:18 [
    "pii" => "S0025775300712516"
    "issn" => "00257753"
    "doi" => "10.1016/S0025-7753(00)71251-6"
    "estado" => "S300"
    "fechaPublicacion" => "2000-01-01"
    "aid" => "71251"
    "copyright" => "Elsevier España, S.L."
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "sco"
    "cita" => "Med Clin. 2000;114:222-6"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 2657
      "formatos" => array:3 [
        "EPUB" => 9
        "HTML" => 2482
        "PDF" => 166
      ]
    ]
    "es" => array:7 [
      "idiomaDefecto" => true
      "titulo" => "El factor humano en la relación clínica. El binomio razón-emoción"
      "tienePdf" => "es"
      "tieneTextoCompleto" => 0
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "222"
          "paginaFinal" => "226"
        ]
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Jaime Sanz Ortiz"
          "autores" => array:1 [
            0 => array:2 [
              "nombre" => "Jaime"
              "apellidos" => "Sanz Ortiz"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775300712516?idApp=UINPBA00004N"
    "url" => "/00257753/0000011400000006/v1_201307291356/S0025775300712516/v1_201307291356/es/main.assets"
  ]
  "es" => array:10 [
    "idiomaDefecto" => true
    "titulo" => "La vía JAK-STAT de señalización intracelular y su repercusión en oncogénesis, inmunomodulación y desarrollo"
    "tieneTextoCompleto" => 0
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "227"
        "paginaFinal" => "234"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Rafael F. Duarte, David A. Frank"
        "autores" => array:2 [
          0 => array:4 [
            "nombre" => "Rafael F."
            "apellidos" => "Duarte"
            "email" => array:1 [
              0 => "duarte@rfhsm.ac.uk"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff00005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "David A&#46;"
            "apellidos" => "Frank"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff00010"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "<span class="elsevierStyleItalic">MD&#44; PhD&#46; Research Fellow in Medicine at Harvard Medical School&#46; Dana-Farber Cancer Institute&#46; Department of Adult Oncology&#46; Boston&#46; Massachusetts&#46; EE&#46;UU</span>"
            "etiqueta" => "<span class="elsevierStyleSup">a</span>"
            "identificador" => "aff00005"
          ]
          1 => array:3 [
            "entidad" => "<span class="elsevierStyleItalic">MD&#44; PhD&#46; Assistant Professor of Medicine at Harvard Medical School&#46; Dana-Farber Cancer Institute&#46; Department of Adult Oncology&#46; Boston&#46; Massachusetts&#46; EE&#46;UU</span>"
            "etiqueta" => "<span class="elsevierStyleSup">b</span>"
            "identificador" => "aff00010"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#42;"
            "correspondencia" => "Correspondencia&#58; Dr&#46; R&#46;F&#46; Duarte&#46; The Anthony Nolan Research Institute&#46; The Royal Free Hospital&#46; Pond Street&#44; Hampsted&#46; London NW3 2QG&#44; UK&#46;"
          ]
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "1999-09-13"
    "fechaAceptado" => "1999-11-09"
    "bibliografia" => array:2 [
      "titulo" => "Referencias Bibliogr&#225;ficas"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:92 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cytokine signaling through nonreceptor protein tyrosine kinases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "T&#46; Taniguchi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Science"
                        "fecha" => "1995"
                        "volumen" => "268"
                        "paginaInicial" => "251"
                        "paginaFinal" => "255"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7716517"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Two putative protein-tyrosine kinases identified by application of the polymerase chain reaction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "A&#46;F&#46; Wilks"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Proc Natl Acad Sci USA"
                        "fecha" => "1989"
                        "volumen" => "86"
                        "paginaInicial" => "1&#46;603"
                        "paginaFinal" => "1&#46;707"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16594092"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Tyk2&#44; prototype of a novel class of non-receptor tyrosine kinase genes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "I&#46; Firmbach-Kraft"
                            1 => "M&#46; Byers"
                            2 => "T&#46; Shows"
                            3 => "R&#46; Dalla-Favera"
                            4 => "J&#46;J&#46; Krolewski"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Oncogene"
                        "fecha" => "1990"
                        "volumen" => "5"
                        "paginaInicial" => "1&#46;329"
                        "paginaFinal" => "1&#46;336"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2284104"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Two novel protein-tyrosine kinases&#44; each with a second phosphotransferase- related catalytic domain&#44; define a new class of protein kinase"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "A&#46;F&#46; Wilks"
                            1 => "A&#46;G&#46; Harpur"
                            2 => "R&#46;R&#46; Kurban"
                            3 => "S&#46;J&#46; Ralph"
                            4 => "G&#46; Zurcher"
                            5 => "A&#46; Ziemiecki"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Mol Cell Biol"
                        "fecha" => "1991"
                        "volumen" => "11"
                        "paginaInicial" => "2&#46;057"
                        "paginaFinal" => "2&#46;065"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1944288"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The protein tyrosine kinase JAK 1 complements defects in interferon- &#945;&#47;&#946; and -&#947; signal transduction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Muller"
                            1 => "J&#46; Briscoe"
                            2 => "C&#46; Laxton"
                            3 => "Guschin"
                            4 => "A&#46; Ziemecki"
                            5 => "O&#46; Silvennoinen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Nature &#40;Lond&#41;"
                        "fecha" => "1993"
                        "volumen" => "366"
                        "paginaInicial" => "129"
                        "paginaFinal" => "136"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A single phosphotyrosine residue of Stat91 required for gene activation by interferon-&#947;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "K&#46; Shuai"
                            1 => "G&#46;R&#46; Stark"
                            2 => "I&#46;M&#46; Kerr"
                            3 => "J&#46;E&#46; Darnell"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Science"
                        "fecha" => "1993"
                        "volumen" => "261"
                        "paginaInicial" => "1&#46;744"
                        "paginaFinal" => "1&#46;746"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8378775"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46;E&#46; Darnell"
                            1 => "I&#46;M&#46; Kerr"
                            2 => "G&#46;R&#46; Stark"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1126/science.264.5167.1910"
                      "Revista" => array:6 [
                        "tituloSerie" => "Science"
                        "fecha" => "1994"
                        "volumen" => "264"
                        "paginaInicial" => "1&#46;415"
                        "paginaFinal" => "1&#46;421"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17794076"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cellular responses to interferons and other cytokines&#58; the JAK-STAT paradigm"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "R&#46;M&#46; Ransohoff"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM199802263380911"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "1998"
                        "volumen" => "338"
                        "paginaInicial" => "616"
                        "paginaFinal" => "618"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9475772"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Polypeptide signaling to the nucleus through tyrosine phosphorylation of Jak and Stat proteins"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "K&#46; Shuai"
                            1 => "G&#46;R&#46; Stark"
                            2 => "I&#46;M&#46; Kerr"
                            3 => "J&#46;E&#46; Darnell"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/366580a0"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nature"
                        "fecha" => "1993"
                        "volumen" => "366"
                        "paginaInicial" => "580"
                        "paginaFinal" => "583"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7504784"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "10&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Interferon-induced nuclear signalling by Jak protein tyrosine kinases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "O&#46; Silvennoinen"
                            1 => "J&#46;N&#46; Ihle"
                            2 => "J&#46; Schlessinger"
                            3 => "D&#46;E&#46; Levy"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Nature &#40;Lond&#41;"
                        "fecha" => "1993"
                        "volumen" => "366"
                        "paginaInicial" => "583"
                        "paginaFinal" => "585"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "11&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "SH2&#47;SH3 signaling proteins"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "J&#46; Schlessinger"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Curr Opin Genet Dev"
                        "fecha" => "1994"
                        "volumen" => "4"
                        "paginaInicial" => "25"
                        "paginaFinal" => "30"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8193536"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "12&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The role of tyrosine kinases and their substrates in signal transmission of hematopoietic growth factors&#58; a short review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "C&#46; Belka"
                            1 => "M&#46;A&#46; Brach"
                            2 => "F&#46; Herrmann"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Leukemia"
                        "fecha" => "1995"
                        "volumen" => "9"
                        "paginaInicial" => "754"
                        "paginaFinal" => "761"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7769836"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "13&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Signalling through the hematopoietic cytokine receptors"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46;N&#46; Ihle"
                            1 => "B&#46;A&#46; Witthuhn"
                            2 => "F&#46;W&#46; Quelle"
                            3 => "K&#46; Yamamoto"
                            4 => "O&#46; Silvennoinen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Ann Rev Immunol"
                        "fecha" => "1995"
                        "volumen" => "13"
                        "paginaInicial" => "369"
                        "paginaFinal" => "398"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "p135<span class="elsevierStyleSup">tyk2</span>&#44; an interferon &#945; &#40;IFN-&#945;&#41;-activated tyrosine kinase&#44; associates with the IFN&#945; receptor"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "O&#46;R&#46; Colamonici"
                            1 => "H&#46; Uyttendacle"
                            2 => "P&#46; Domanski"
                            3 => "H&#46; Yan"
                            4 => "J&#46;J&#46; Krolewski"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Biol Chem"
                        "fecha" => "1994"
                        "volumen" => "269"
                        "paginaInicial" => "3&#46;518"
                        "paginaFinal" => "3&#46;522"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7806541"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "15&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Interaction between the components of the interferon gamma receptor complex"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46;V&#46; Kotenko"
                            1 => "L&#46;S&#46; Izotova"
                            2 => "B&#46;P&#46; Pollack"
                            3 => "T&#46;M&#46; Mariano"
                            4 => "R&#46;J&#46; Donelly"
                            5 => "G&#46; Muthukumaran"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Biol Chem"
                        "fecha" => "1995"
                        "volumen" => "270"
                        "paginaInicial" => "20&#46;915"
                        "paginaFinal" => "20&#46;921"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8537413"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "16&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "JAK2 associates with the erythropoietin receptor and is tyrosine phosporylated and activated following stimulation with erythropoietin"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:7 [
                            0 => "B&#46;A&#46; Withuhn"
                            1 => "F&#46;W&#46; Quelle"
                            2 => "O&#46; Silvennoinen"
                            3 => "T&#46; Yi"
                            4 => "B&#46; Tang"
                            5 => "O&#46; Miura"
                            6 => "J&#46;N&#46; Ihle"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cell"
                        "fecha" => "1993"
                        "volumen" => "74"
                        "paginaInicial" => "227"
                        "paginaFinal" => "236"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8343951"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "17&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Structure of the murine Jak2 protein-tyrosine kinase and its role in interleukin 3 signal transduction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "O&#46; Silvennoinen"
                            1 => "B&#46;A&#46; Witthuhn"
                            2 => "F&#46;W&#46; Quelle"
                            3 => "J&#46;L&#46; Cleveland"
                            4 => "T&#46; Yi"
                            5 => "J&#46;N&#46; Ihle"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Proc Natl Acad Sci USA"
                        "fecha" => "1993"
                        "volumen" => "90"
                        "paginaInicial" => "8&#46;429"
                        "paginaFinal" => "8&#46;433"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11607443"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "18&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Interferon activation of the transcription factor STAT91 involves dimerization of SH-2 phosphotyrosyl peptide interactions"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "K&#46; Shuai"
                            1 => "C&#46;M&#46; Horvath"
                            2 => "L&#46;H&#46; Tsai Huang"
                            3 => "S&#46;A&#46; Quereshi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cell"
                        "fecha" => "1994"
                        "volumen" => "76"
                        "paginaInicial" => "821"
                        "paginaFinal" => "828"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7510216"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "19&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hypothesis&#58; ligand&#47;receptor-assisted nuclear translocation of STAT"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:7 [
                            0 => "H&#46;M&#46; Johnson"
                            1 => "B&#46;A&#46; Torres"
                            2 => "M&#46;M&#46; Green"
                            3 => "B&#46;E&#46; Szente"
                            4 => "K&#46;I&#46; Siler"
                            5 => "J&#46; Larkin 3<span class="elsevierStyleSup">rd</span>"
                            6 => "P&#46;S&#46; Subramaniam"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Proc Soc Exp Biol Med"
                        "fecha" => "1998"
                        "volumen" => "218"
                        "paginaInicial" => "149"
                        "paginaFinal" => "155"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9648932"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "20&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "In vitro activation of Stat3 by epidermal growth factor receptor kinase"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "O&#46;K&#46; Park"
                            1 => "T&#46;S&#46; Schaffer"
                            2 => "D&#46; Nathans"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Proc Natl Acad Sci USA"
                        "fecha" => "1996"
                        "volumen" => "93"
                        "paginaInicial" => "13&#46;704"
                        "paginaFinal" => "13&#46;708"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11038534"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0105"
              "etiqueta" => "21&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Src kinases and not JAK activate STAT during IL-3 induced myeloid cell proliferation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "P&#46; Chaturvedi"
                            1 => "M&#46;V&#46; Ramana Reddy"
                            2 => "E&#46; Premkumar Reddy"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/sj.onc.1201901"
                      "Revista" => array:6 [
                        "tituloSerie" => "Oncogene"
                        "fecha" => "1998"
                        "volumen" => "16"
                        "paginaInicial" => "1&#46;749"
                        "paginaFinal" => "1&#46;758"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9692553"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0110"
              "etiqueta" => "22&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "JAK and STAT branch out"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46; Briscoe"
                            1 => "F&#46; Kohlhuber"
                            2 => "M&#46; Muller"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Trends Cell Biol"
                        "fecha" => "1996"
                        "volumen" => "6"
                        "paginaInicial" => "336"
                        "paginaFinal" => "340"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15157430"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0115"
              "etiqueta" => "23&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Requirement of serine phosphorylation for formation of STAT-promoter complexes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "X&#46; Zhan"
                            1 => "J&#46; Blenis"
                            2 => "H&#46;C&#46; Li"
                            3 => "C&#46; Schindler"
                            4 => "C&#46; Kiang"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1126/science.267.5206.1966"
                      "Revista" => array:6 [
                        "tituloSerie" => "Science"
                        "fecha" => "1995"
                        "volumen" => "267"
                        "paginaInicial" => "1&#46;990"
                        "paginaFinal" => "1&#46;994"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17770108"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib0120"
              "etiqueta" => "24&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Maximal activation of transcription by STAT1 and STAT3 requires both tyrosine and serine phosphorylation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "Z&#46; Wen"
                            1 => "Z&#46; Zhong"
                            2 => "J&#46;E&#46; Darnell"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cell"
                        "fecha" => "1995"
                        "volumen" => "82"
                        "paginaInicial" => "241"
                        "paginaFinal" => "250"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7543024"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib0125"
              "etiqueta" => "25&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cooperation of STAT2 and p300&#47;CBP in signalling induced by interferon- alpha"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46; Bhattacharya"
                            1 => "S&#46;R&#46; Eckner"
                            2 => "E&#46; Grossman"
                            3 => "Z&#46; Oldread"
                            4 => "Z&#46; Arany"
                            5 => "A&#46; D&#39;ndrea"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Nature &#40;Lond&#41;"
                        "fecha" => "1996"
                        "volumen" => "383"
                        "paginaInicial" => "344"
                        "paginaFinal" => "347"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib0130"
              "etiqueta" => "26&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Two contact regions between STAT1 and CBP&#47;p300 in interferon &#947; signalling"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46;J&#46; Zhang"
                            1 => "U&#46; Vinkemeyer"
                            2 => "W&#46; Gu"
                            3 => "D&#46; Chakravarti"
                            4 => "C&#46;M&#46; Horvath"
                            5 => "J&#46;E&#46; Darnell"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Proc Natl Acad Sci USA"
                        "fecha" => "1996"
                        "volumen" => "93"
                        "paginaInicial" => "15&#46;092"
                        "paginaFinal" => "15&#46;096"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11038532"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib0135"
              "etiqueta" => "27&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Functional interactions between STAT5 and the glucocorticoid receptor"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "E&#46; Stocklin"
                            1 => "M&#46; Wissler"
                            2 => "F&#46; Gouilleux"
                            3 => "B&#46; Groner"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Nature &#40;Lond&#41;"
                        "fecha" => "1996"
                        "volumen" => "383"
                        "paginaInicial" => "726"
                        "paginaFinal" => "728"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib0140"
              "etiqueta" => "28&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cross-talk between retinoic acid and interferons&#58; molecular mechanisms of interaction in acute promyelocytic leukemia cells"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "E&#46; Garattini"
                            1 => "L&#46; Mologni"
                            2 => "I&#46; Ponzanelli"
                            3 => "M&#46; Terao"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3109/10428199809057559"
                      "Revista" => array:6 [
                        "tituloSerie" => "Leuk Lymphoma"
                        "fecha" => "1998"
                        "volumen" => "30"
                        "paginaInicial" => "467"
                        "paginaFinal" => "475"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9711909"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib0145"
              "etiqueta" => "29&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The rapid inactivation of nuclear tyrosine phosphorylated STAT1 depends upon a protein tyrosine phosphatase"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "R&#46;L&#46; Haspel"
                            1 => "M&#46; Salditt-Georgieff"
                            2 => "J&#46;E&#46; Darnell"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "EMBO J"
                        "fecha" => "1996"
                        "volumen" => "15"
                        "paginaInicial" => "6&#46;262"
                        "paginaFinal" => "6&#46;268"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9003789"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib0150"
              "etiqueta" => "30&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Differential regulation of the alpha&#47;beta interferon-stimulated Jak&#47;Stat pathway by the SH2 domain- containing tyrosine phosphatase SHPTP1"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46; David"
                            1 => "H&#46;E&#46; Chen"
                            2 => "S&#46; Goelz"
                            3 => "A&#46;C&#46; Larner"
                            4 => "B&#46;G&#46; Neel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Mol Cell Biol"
                        "fecha" => "1995"
                        "volumen" => "15"
                        "paginaInicial" => "7&#46;050"
                        "paginaFinal" => "7&#46;058"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8524260"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            30 => array:3 [
              "identificador" => "bib0155"
              "etiqueta" => "31&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "U&#46; Klingmuller"
                            1 => "U&#46; Lorenz"
                            2 => "L&#46;C&#46; Cantley"
                            3 => "B&#46;G&#46; Neel"
                            4 => "H&#46;F&#46; Lodish"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cell"
                        "fecha" => "1995"
                        "volumen" => "80"
                        "paginaInicial" => "729"
                        "paginaFinal" => "738"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7889566"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            31 => array:3 [
              "identificador" => "bib0160"
              "etiqueta" => "32&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A family of cytokine-inducible inhibitors of signaling"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46; Starr"
                            1 => "T&#46;A&#46; Willson"
                            2 => "E&#46;M&#46; Viney"
                            3 => "L&#46;J&#46;L&#46; Murray"
                            4 => "R&#46;R&#46; Rayner"
                            5 => "B&#46;J&#46; Jenkins"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Nature &#40;Lond&#41;"
                        "fecha" => "1997"
                        "volumen" => "387"
                        "paginaInicial" => "917"
                        "paginaFinal" => "921"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            32 => array:3 [
              "identificador" => "bib0165"
              "etiqueta" => "33&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A new protein containing an SH2 domain that inhibits JAK kinases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "T&#46;A&#46; Endo"
                            1 => "M&#46; Masahura"
                            2 => "M&#46; Yokouchi"
                            3 => "R&#46; Suzuki"
                            4 => "H&#46; Sakamoto"
                            5 => "K&#46; Mitsui"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Nature &#40;Lond&#41;"
                        "fecha" => "1997"
                        "volumen" => "387"
                        "paginaInicial" => "921"
                        "paginaFinal" => "924"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            33 => array:3 [
              "identificador" => "bib0170"
              "etiqueta" => "34&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Structure and function of a new STAT-induced STAT inhibitor"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "T&#46; Naka"
                            1 => "M&#46; Narazaki"
                            2 => "M&#46; Hirata"
                            3 => "T&#46; Matsumoto"
                            4 => "S&#46; Minamoto"
                            5 => "A&#46; Aono"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Nature &#40;Lond&#41;"
                        "fecha" => "1997"
                        "volumen" => "387"
                        "paginaInicial" => "924"
                        "paginaFinal" => "928"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            34 => array:3 [
              "identificador" => "bib0175"
              "etiqueta" => "35&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A nuclear protein tyrosine phosphatase is required for the inactivation of STAT1"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "R&#46;L&#46; Haspel"
                            1 => "J&#46;E&#46; Darnell"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Proc Natl Acad Sci USA"
                        "fecha" => "1999"
                        "volumen" => "96"
                        "paginaInicial" => "10&#46;188"
                        "paginaFinal" => "10&#46;193"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10611346"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            35 => array:3 [
              "identificador" => "bib0180"
              "etiqueta" => "36&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Regulation of interferon-gamma-activated STAT1 by the ubiquitin-proteasome pathway"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "T&#46;K&#46; Kim"
                            1 => "T&#46; Maniatis"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Science"
                        "fecha" => "1996"
                        "volumen" => "273"
                        "paginaInicial" => "1&#46;717"
                        "paginaFinal" => "1&#46;719"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8815535"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            36 => array:3 [
              "identificador" => "bib0185"
              "etiqueta" => "37&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Control of inflammation&#44; cytokine expression and germinal center formation by BCL-6"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "A&#46;L&#46; Dent"
                            1 => "A&#46;L&#46; Shaffer"
                            2 => "X&#46; Yu"
                            3 => "D&#46; Allman"
                            4 => "L&#46;M&#46; Staudt"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Science"
                        "fecha" => "1997"
                        "volumen" => "276"
                        "paginaInicial" => "589"
                        "paginaFinal" => "592"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9110977"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            37 => array:3 [
              "identificador" => "bib0190"
              "etiqueta" => "38&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Specific inhibition of Stat3 signal transduction by PIAS3"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46;D&#46; Chung"
                            1 => "J&#46; Liao"
                            2 => "B&#46; Liu"
                            3 => "X&#46; Rao"
                            4 => "P&#46; Jay"
                            5 => "P&#46; Berta"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Science"
                        "fecha" => "1997"
                        "volumen" => "278"
                        "paginaInicial" => "1&#46;803"
                        "paginaFinal" => "1&#46;805"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9432722"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            38 => array:3 [
              "identificador" => "bib0195"
              "etiqueta" => "39&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Transcription factor p91 interacts with the epidermal growth factor receptor and mediates activation of the c-fos gene promoter"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "X&#46; Fu"
                            1 => "J&#46; Zhang"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cell"
                        "fecha" => "1993"
                        "volumen" => "74"
                        "paginaInicial" => "1&#46;135"
                        "paginaFinal" => "1&#46;145"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8402886"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            39 => array:3 [
              "identificador" => "bib0200"
              "etiqueta" => "40&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Contribution of both STAT and SRF&#47;TCF to c-fos promoter activation by granulocyte-macrophage colony stimulation factor"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46; Rajotte"
                            1 => "H&#46;B&#46; Sadowski"
                            2 => "A&#46; Haman"
                            3 => "K&#46; Gopalbhai"
                            4 => "S&#46; Meloche"
                            5 => "L&#46; Liu"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Blood"
                        "fecha" => "1996"
                        "volumen" => "88"
                        "paginaInicial" => "2&#46;906"
                        "paginaFinal" => "2&#46;916"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8977265"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            40 => array:3 [
              "identificador" => "bib0205"
              "etiqueta" => "41&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mammary gland factor &#40;MGF&#41; is a novel member of the cytokine regulated transcription factor gene family and confers the prolactin response"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "H&#46; Wakao"
                            1 => "F&#46; Gouilleux"
                            2 => "B&#46; Groner"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "EMBO J"
                        "fecha" => "1994"
                        "volumen" => "13"
                        "paginaInicial" => "2&#46;182"
                        "paginaFinal" => "2&#46;191"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7813453"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            41 => array:3 [
              "identificador" => "bib0210"
              "etiqueta" => "42&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Regulation of gliogenesis in the central nervous system by the JAK-STAT signalling pathway"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Boni"
                            1 => "Y&#46; Sun"
                            2 => "M&#46; Nadal-Vicens"
                            3 => "A&#46; Bhatt"
                            4 => "D&#46;A&#46; Frank"
                            5 => "I&#46; Rozovski"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Science"
                        "fecha" => "1997"
                        "volumen" => "278"
                        "paginaInicial" => "477"
                        "paginaFinal" => "483"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9334309"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            42 => array:3 [
              "identificador" => "bib0215"
              "etiqueta" => "43&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "STAT3 activation accompanies keratinocyte differentiation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "P&#46;J&#46; Hauser"
                            1 => "D&#46; Agrawal"
                            2 => "J&#46; Hackney"
                            3 => "W&#46;J&#46; Pledger"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cell Growth Diff"
                        "fecha" => "1998"
                        "volumen" => "9"
                        "paginaInicial" => "847"
                        "paginaFinal" => "855"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9790496"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            43 => array:3 [
              "identificador" => "bib0220"
              "etiqueta" => "44&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Involvement of STAT3 in the granulocyte colony-stimulating factor-induced differentiation of myeloid cells"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "K&#46; Shimozaki"
                            1 => "K&#46; Nakajima"
                            2 => "T&#46; Hirano"
                            3 => "S&#46; Nagata"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Biol Chem"
                        "fecha" => "1997"
                        "volumen" => "272"
                        "paginaInicial" => "25&#46;184"
                        "paginaFinal" => "25&#46;189"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9395542"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            44 => array:3 [
              "identificador" => "bib0225"
              "etiqueta" => "45&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Regulation of T helper cell differentiation by STAT molecules"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46;H&#46; Kaplan"
                            1 => "M&#46;J&#46; Grusby"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Leukoc Biol"
                        "fecha" => "1998"
                        "volumen" => "64"
                        "paginaInicial" => "2"
                        "paginaFinal" => "5"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9665267"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            45 => array:3 [
              "identificador" => "bib0230"
              "etiqueta" => "46&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Th1 and Th2 cells&#58; different patterns of lymphocyte secretion lead to different functional properties"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "T&#46;R&#46; Mosmann"
                            1 => "R&#46;L&#46; Coffman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Ann Rev Immunol"
                        "fecha" => "1989"
                        "volumen" => "7"
                        "paginaInicial" => "145"
                        "paginaFinal" => "173"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            46 => array:3 [
              "identificador" => "bib0235"
              "etiqueta" => "47&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "IFN-&#947; induces growth inhibition by fas-mediated apoptosis&#58; requirement of STAT1 protein for up-regulation of Fas and FasL expression"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "F&#46; Xu"
                            1 => "X&#46;-Y&#46; Fu"
                            2 => "J&#46; Plate"
                            3 => "A&#46;S&#46;-F&#46; Chong"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer Res"
                        "fecha" => "1998"
                        "volumen" => "58"
                        "paginaInicial" => "2&#46;832"
                        "paginaFinal" => "2&#46;837"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9865745"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            47 => array:3 [
              "identificador" => "bib0240"
              "etiqueta" => "48&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Defective TNF-&#945;-induced apoptosis in STAT1-null cells due to low constitutive levels of caspases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "A&#46; Kumar"
                            1 => "M&#46; Commane"
                            2 => "T&#46;W&#46; Flickinger"
                            3 => "C&#46;M&#46; Horvath"
                            4 => "G&#46;R&#46; Stark"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Science"
                        "fecha" => "1997"
                        "volumen" => "278"
                        "paginaInicial" => "1&#46;630"
                        "paginaFinal" => "1&#46;632"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9432722"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            48 => array:3 [
              "identificador" => "bib0245"
              "etiqueta" => "49&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "H&#46; Yuan"
                            1 => "S&#46; Mahajan"
                            2 => "D&#46;A&#46; Frank"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:2 [
                        "tituloSerie" => "IL-6 induced cell survival is prevented by buryrate in colorectal carcinoma cells"
                        "fecha" => "1999"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            49 => array:3 [
              "identificador" => "bib0250"
              "etiqueta" => "50&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Signals through gp130 upregulate bcl-x gene expression via STAT1-binding cis-element in cardiac myocytes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "Y&#46; Fujio"
                            1 => "K&#46; Kunisada"
                            2 => "H&#46; Hirota"
                            3 => "K&#46; Yamauchi-Takihara"
                            4 => "T&#46; Kishimoto"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1172/JCI119498"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Invest"
                        "fecha" => "1997"
                        "volumen" => "99"
                        "paginaInicial" => "2&#46;898"
                        "paginaFinal" => "2&#46;905"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9185527"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            50 => array:3 [
              "identificador" => "bib0255"
              "etiqueta" => "51&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Murine JAK3 is preferentially expressed in hematopoietic tissues and lymphocyte precursor cells"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "C&#46;B&#46; Gurniak"
                            1 => "L&#46;J&#46; Berg"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Blood"
                        "fecha" => "1996"
                        "volumen" => "87"
                        "paginaInicial" => "3&#46;151"
                        "paginaFinal" => "3&#46;160"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8652847"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            51 => array:3 [
              "identificador" => "bib0260"
              "etiqueta" => "52&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Interleukin-2 receptor gamma chain mutation results in X-linked severe combined immunodeficiency in humans"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Noguchi"
                            1 => "H&#46; Yi"
                            2 => "H&#46;M&#46; Rosenblatt"
                            3 => "A&#46;H&#46; Filipovich"
                            4 => "S&#46; Adelstein"
                            5 => "W&#46;S&#46; Modi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cell"
                        "fecha" => "1993"
                        "volumen" => "73"
                        "paginaInicial" => "147"
                        "paginaFinal" => "157"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8462096"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            52 => array:3 [
              "identificador" => "bib0265"
              "etiqueta" => "53&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Defective lymphoid development in mice lacking Jak3"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "T&#46; Nosaka"
                            1 => "J&#46;M&#46; Van Deursen"
                            2 => "R&#46;A&#46; Tripp"
                            3 => "W&#46;E&#46; Thierfelder"
                            4 => "B&#46;A&#46; Witthuhn"
                            5 => "A&#46;P&#46; McMickele"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Science"
                        "fecha" => "1995"
                        "volumen" => "270"
                        "paginaInicial" => "800"
                        "paginaFinal" => "802"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7481769"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            53 => array:3 [
              "identificador" => "bib0270"
              "etiqueta" => "54&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency &#40;SCID&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "P&#46; Macchi"
                            1 => "A&#46; Villa"
                            2 => "S&#46; Gillani"
                            3 => "M&#46;G&#46; Sacco"
                            4 => "A&#46; Frattini"
                            5 => "E&#46; Porta"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Nature &#40;Lond&#41;"
                        "fecha" => "1995"
                        "volumen" => "376"
                        "paginaInicial" => "65"
                        "paginaFinal" => "68"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            54 => array:3 [
              "identificador" => "bib0275"
              "etiqueta" => "55&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mutation of Jak3 in a patient with SCID&#58; essential role of Jak3 in lymphoid development"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46;M&#46; Russel"
                            1 => "N&#46; Tayebi"
                            2 => "H&#46; Nakajima"
                            3 => "M&#46;C&#46; Riedy"
                            4 => "J&#46;L&#46; Roberts"
                            5 => "M&#46;J&#46; Aman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Science"
                        "fecha" => "1995"
                        "volumen" => "270"
                        "paginaInicial" => "797"
                        "paginaFinal" => "800"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7481768"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            55 => array:3 [
              "identificador" => "bib0280"
              "etiqueta" => "56&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Dysregulated myelopiesis in mice lacking JAK3"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "W&#46;J&#46; Grossman"
                            1 => "J&#46;W&#46; Verbsky"
                            2 => "L&#46; Yang"
                            3 => "L&#46;J&#46; Berg"
                            4 => "L&#46;E&#46; Fields"
                            5 => "D&#46;D&#46; Chaplin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Blood"
                        "fecha" => "1999"
                        "volumen" => "94"
                        "paginaInicial" => "932"
                        "paginaFinal" => "939"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10419884"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            56 => array:3 [
              "identificador" => "bib0285"
              "etiqueta" => "57&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Transcriptionally active STAT1 is required for the antiproliferative effects of both interferon alpha and interferon gamma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46;F&#46; Bromberg"
                            1 => "C&#46;M&#46; Horvath"
                            2 => "Z&#46; Wen"
                            3 => "A&#46;C&#46; Scheriber"
                            4 => "J&#46;E&#46; Darnell"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Proc Natl Acad Sci USA"
                        "fecha" => "1996"
                        "volumen" => "93"
                        "paginaInicial" => "7&#46;673"
                        "paginaFinal" => "7&#46;678"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8986834"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            57 => array:3 [
              "identificador" => "bib0290"
              "etiqueta" => "58&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The antiviral state induced by alpha interferon and gamma interferon requires transcriptionally active STAT1 protein"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "C&#46;M&#46; Horvath"
                            1 => "J&#46;E&#46; Darnell"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Virol"
                        "fecha" => "1996"
                        "volumen" => "70"
                        "paginaInicial" => "647"
                        "paginaFinal" => "650"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8523587"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            58 => array:3 [
              "identificador" => "bib0295"
              "etiqueta" => "59&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Targeted disruption of the STAT1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signalling pathway"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46;A&#46; Meraz"
                            1 => "J&#46;M&#46; White"
                            2 => "K&#46;C&#46; Sheehan"
                            3 => "E&#46;A&#46; Bach"
                            4 => "S&#46;J&#46; Rodig"
                            5 => "A&#46;S&#46; Dighe"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cell"
                        "fecha" => "1996"
                        "volumen" => "84"
                        "paginaInicial" => "431"
                        "paginaFinal" => "442"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8608597"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            59 => array:3 [
              "identificador" => "bib0300"
              "etiqueta" => "60&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Targeted disruption of the mouse STAT1 gene results in compromised innate immunity to viral disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46;E&#46; Durbin"
                            1 => "R&#46; Hackenmiller"
                            2 => "M&#46;C&#46; Simon"
                            3 => "D&#46;E&#46; Levy"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cell"
                        "fecha" => "1996"
                        "volumen" => "84"
                        "paginaInicial" => "443"
                        "paginaFinal" => "450"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8608598"
                             …1
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            60 => array:3 [
              "identificador" => "bib0305"
              "etiqueta" => "61&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "B Lymphocytes from patients with chronic lymphocytic leukemia contain signal transducer and activator of transcription &#40;STAT&#41; 1 and STAT3 constitutively phosphorylated on serine residues"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [ …3]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1172/JCI119840"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Invest"
                        "fecha" => "1997"
                        "volumen" => "100"
                        "paginaInicial" => "3&#46;140"
                        "paginaFinal" => "3&#46;148"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            61 => array:3 [
              "identificador" => "bib0310"
              "etiqueta" => "62&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The molecular genetics of Philadelphia chromosome-positive leukemias"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [ …3]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM198810133191506"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "1988"
                        "volumen" => "319"
                        "paginaInicial" => "990"
                        "paginaFinal" => "998"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            62 => array:3 [
              "identificador" => "bib0315"
              "etiqueta" => "63&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "An alteration of the human c-abl protein in K562 unmasks associated tyrosine kinase activity"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [ …3]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cell"
                        "fecha" => "1984"
                        "volumen" => "37"
                        "paginaInicial" => "1&#46;035"
                        "paginaFinal" => "1&#46;042"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            63 => array:3 [
              "identificador" => "bib0320"
              "etiqueta" => "64&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Transformation of an interleukin 3-dependent hematopoietic cell line by the chronic myelogenous leukemia-specific P210bcr&#47;abl protein"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Proc Natl Acad Sci USA"
                        "fecha" => "1988"
                        "volumen" => "85"
                        "paginaInicial" => "9&#46;312"
                        "paginaFinal" => "9&#46;316"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            64 => array:3 [
              "identificador" => "bib0325"
              "etiqueta" => "65&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Tyrosyl phosphorylation and DNA-binding activity of STAT proteins in hematopoietic cell lines transformed by Bcr&#47;Abl"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [ …3]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Exp Med"
                        "fecha" => "1996"
                        "volumen" => "183"
                        "paginaInicial" => "811"
                        "paginaFinal" => "820"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            65 => array:3 [
              "identificador" => "bib0330"
              "etiqueta" => "66&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Bcr&#47;Abl leads to the constitutive activation of Stat proteins&#44; and shares an epitope with tyrosine phosphorylated Stats"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Leukemia"
                        "fecha" => "1996"
                        "volumen" => "10"
                        "paginaInicial" => "1&#46;724"
                        "paginaFinal" => "1&#46;730"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            66 => array:3 [
              "identificador" => "bib0335"
              "etiqueta" => "67&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "STAT5 activation by Bcr&#47;Abl is dependent on its intact SH3 and SH2 domains and is required for leukemogenesis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Exp Med"
                        "fecha" => "1999"
                        "volumen" => "189"
                        "paginaInicial" => "1&#46;229"
                        "paginaFinal" => "1&#46;242"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            67 => array:3 [
              "identificador" => "bib0340"
              "etiqueta" => "68&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Constitutive activation of STAT3 in fibroblasts transformed by diverse oncoproteins and in breast carcinoma cells"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cell Growth Diff"
                        "fecha" => "1997"
                        "volumen" => "8"
                        "paginaInicial" => "1&#46;267"
                        "paginaFinal" => "1&#46;276"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            68 => array:3 [
              "identificador" => "bib0345"
              "etiqueta" => "69&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Role of epidermal growth factor receptor and STAT3 activation in autonomous proliferation of SUM-102PT human breast cancer cells"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [ …5]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer Res"
                        "fecha" => "1997"
                        "volumen" => "57"
                        "paginaInicial" => "978"
                        "paginaFinal" => "987"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            69 => array:3 [
              "identificador" => "bib0350"
              "etiqueta" => "70&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Ornithine decarboxylase &#40;ODC&#41; overexpression activates Src and STAT signaling in MCF-10A human breast epithelial cells"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [ …4]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Proc Am Assoc Cancer Res"
                        "fecha" => "1999"
                        "volumen" => "40"
                        "paginaInicial" => "99"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            70 => array:3 [
              "identificador" => "bib0355"
              "etiqueta" => "71&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "STAT-related transcription factors are constitutively activated in peripheral blood cells from acute leukemia patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Blood"
                        "fecha" => "1996"
                        "volumen" => "87"
                        "paginaInicial" => "1&#46;692"
                        "paginaFinal" => "1&#46;697"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            71 => array:3 [
              "identificador" => "bib0360"
              "etiqueta" => "72&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Expression of signal transducers and activators of transcription proteins in acute myeloid leukemia blasts"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [ …5]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer Res"
                        "fecha" => "1998"
                        "volumen" => "58"
                        "paginaInicial" => "3&#46;173"
                        "paginaFinal" => "3&#46;180"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            72 => array:3 [
              "identificador" => "bib0365"
              "etiqueta" => "73&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Constitutive activation of a slowly migrating isoform of Stat3 in mycosis fungoides&#58; tyrophostin AG490 inhibits activation and growth of mycosis fungoides tumor cell lines"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Proc Natl Acad Sci USA"
                        "fecha" => "1997"
                        "volumen" => "94"
                        "paginaInicial" => "6&#46;764"
                        "paginaFinal" => "6&#46;769"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            73 => array:3 [
              "identificador" => "bib0370"
              "etiqueta" => "74&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Constituvely activated Jak-STAT pathway in T cells transformed with HTLV-1"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Science"
                        "fecha" => "1995"
                        "volumen" => "269"
                        "paginaInicial" => "79"
                        "paginaFinal" => "81"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            74 => array:3 [
              "identificador" => "bib0375"
              "etiqueta" => "75&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Proliferation of adult T cell leukemia&#47;lymphoma cells is associated with the constitutive activation of JAK&#47;STAT proteins"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Proc Natl Acad Sci USA"
                        "fecha" => "1997"
                        "volumen" => "94"
                        "paginaInicial" => "13&#46;879"
                        "paginaFinal" => "13&#46;902"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            75 => array:3 [
              "identificador" => "bib0380"
              "etiqueta" => "76&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Interleukin 6 is essential for in vivo development of B lineage neoplasms"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [ …5]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Exp Med"
                        "fecha" => "1995"
                        "volumen" => "182"
                        "paginaInicial" => "243"
                        "paginaFinal" => "248"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            76 => array:3 [
              "identificador" => "bib0385"
              "etiqueta" => "77&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Autocrine generation and requirement of BSF-2&#47;IL-6 for human multiple myelomas"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Nature &#40;Lond&#41;"
                        "fecha" => "1988"
                        "volumen" => "332"
                        "paginaInicial" => "83"
                        "paginaFinal" => "85"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            77 => array:3 [
              "identificador" => "bib0390"
              "etiqueta" => "78&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Constitutive activation of STAT3 signaling confers resistance to apoptosis in human U266 myeloma cells"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Immunity"
                        "fecha" => "1999"
                        "volumen" => "10"
                        "paginaInicial" => "105"
                        "paginaFinal" => "115"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            78 => array:3 [
              "identificador" => "bib0395"
              "etiqueta" => "79&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Distinct tumorigenic potential of abl and raf in B cell neoplasia&#58; abl activates the IL-6 signaling pathway"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [ …5]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Immunity"
                        "fecha" => "1996"
                        "volumen" => "5"
                        "paginaInicial" => "81"
                        "paginaFinal" => "89"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            79 => array:3 [
              "identificador" => "bib0400"
              "etiqueta" => "80&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Interleukin-6 and its receptor are expressed in human intestinal epithelial cells"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [ …4]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Virchows Arch B Cell Pathol"
                        "fecha" => "1990"
                        "volumen" => "58"
                        "paginaInicial" => "303"
                        "paginaFinal" => "308"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            80 => array:3 [
              "identificador" => "bib0405"
              "etiqueta" => "81&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Thanatophoric dysplasia &#40;types I and II&#41; caused by distinct mutations in fibroblast growth factor receptor 3"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Nature Gen"
                        "fecha" => "1995"
                        "volumen" => "9"
                        "paginaInicial" => "321"
                        "paginaFinal" => "328"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            81 => array:3 [
              "identificador" => "bib0410"
              "etiqueta" => "82&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Activation of Stat1 mutant fibroblast growth-factor receptor in thanatophoric dysplasia type II dwarfism"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Nature &#40;Lond&#41;"
                        "fecha" => "1997"
                        "volumen" => "386"
                        "paginaInicial" => "288"
                        "paginaFinal" => "292"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            82 => array:3 [
              "identificador" => "bib0415"
              "etiqueta" => "83&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "STAT5a and STAT5b proteins have essential and nonessential&#44; or redundant&#44; roles in cytokine responses"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cell"
                        "fecha" => "1998"
                        "volumen" => "93"
                        "paginaInicial" => "841"
                        "paginaFinal" => "850"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            83 => array:3 [
              "identificador" => "bib0420"
              "etiqueta" => "84&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Murine antiinterleukin-6 monoclonal antibody therapy for a patient with plasma cell leukemia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Blood"
                        "fecha" => "1991"
                        "volumen" => "78"
                        "paginaInicial" => "1&#46;198"
                        "paginaFinal" => "1&#46;204"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            84 => array:3 [
              "identificador" => "bib0425"
              "etiqueta" => "85&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Inhibition of acute lymphoblastic leukemia by a Jak-2 inhibitor"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Nature &#40;Lond&#41;"
                        "fecha" => "1996"
                        "volumen" => "379"
                        "paginaInicial" => "645"
                        "paginaFinal" => "648"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            85 => array:3 [
              "identificador" => "bib0430"
              "etiqueta" => "86&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Interferon-&#947;-mediated activation of STAT1&#945; regulates growth factor-induced mitogenesis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [ …3]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1172/JCI119118"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Invest"
                        "fecha" => "1996"
                        "volumen" => "98"
                        "paginaInicial" => "1&#46;218"
                        "paginaFinal" => "1&#46;230"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            86 => array:3 [
              "identificador" => "bib0435"
              "etiqueta" => "87&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Suppression of interleukin-3-induced gene expression by a C-terminal truncated STAT5&#58; role of Stat5 in proliferation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [ …5]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "EMBO J"
                        "fecha" => "1996"
                        "volumen" => "15"
                        "paginaInicial" => "2&#46;425"
                        "paginaFinal" => "2&#46;433"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            87 => array:3 [
              "identificador" => "bib0440"
              "etiqueta" => "88&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Fludarabine-induced immunosuppression is associated with inhibition of STAT1 signaling"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [ …3]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/7445"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nature Med"
                        "fecha" => "1999"
                        "volumen" => "5"
                        "paginaInicial" => "444"
                        "paginaFinal" => "447"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            88 => array:3 [
              "identificador" => "bib0445"
              "etiqueta" => "89&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "STAT and gene regulation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Science"
                        "fecha" => "1997"
                        "volumen" => "277"
                        "paginaInicial" => "1&#46;630"
                        "paginaFinal" => "1&#46;635"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            89 => array:3 [
              "identificador" => "bib0450"
              "etiqueta" => "90&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "STAT&#58; signal transducers and activators of transcription"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cell"
                        "fecha" => "1996"
                        "volumen" => "84"
                        "paginaInicial" => "331"
                        "paginaFinal" => "334"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            90 => array:3 [
              "identificador" => "bib0455"
              "etiqueta" => "91&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "JAKs and STATs&#58; biological implications"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Ann Rev Immunol"
                        "fecha" => "1998"
                        "volumen" => "16"
                        "paginaInicial" => "293"
                        "paginaFinal" => "322"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            91 => array:3 [
              "identificador" => "bib0460"
              "etiqueta" => "92&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical efficacy and safety of an Abl specific tyrosine kinase inhibitor as targeted therapy for chronic myelogenous leukemia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:2 [
                        "tituloSerie" => "Nueva Orleans&#58; 41st Annual Meeting of the American Society of Hematology&#44; 3-7 de diciembre de"
                        "fecha" => "1999"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "es"
  "url" => "/00257753/0000011400000006/v1_201307291356/S0025775300712528/v1_201307291356/es/main.assets"
  "Apartado" => array:4 [
    "identificador" => "64287"
    "tipo" => "SECCION"
    "es" => array:2 [
      "titulo" => "Revisi&#243;n"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "es"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/00257753/0000011400000006/v1_201307291356/S0025775300712528/v1_201307291356/es/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775300712528?idApp=UINPBA00004N"
]
Información del artículo
ISSN: 00257753
Idioma original: Español
Datos actualizados diariamente
año/Mes Html Pdf Total
2024 Noviembre 0 18 18
2024 Octubre 0 389 389
2024 Septiembre 0 284 284
2024 Agosto 0 110 110
2024 Julio 0 179 179
2024 Junio 0 236 236
2024 Mayo 0 286 286
2024 Abril 0 303 303
2024 Marzo 0 276 276
2024 Febrero 0 244 244
2024 Enero 0 181 181
2023 Diciembre 0 116 116
2023 Noviembre 0 491 491
2023 Octubre 0 485 485
2023 Septiembre 0 436 436
2023 Agosto 0 146 146
2023 Julio 0 269 269
2023 Junio 0 271 271
2023 Mayo 0 441 441
2023 Abril 0 332 332
2023 Marzo 1 596 597
2023 Febrero 0 359 359
2023 Enero 0 283 283
2022 Diciembre 0 252 252
2022 Noviembre 0 394 394
2022 Octubre 0 461 461
2022 Septiembre 0 421 421
2022 Agosto 0 271 271
2022 Julio 0 224 224
2022 Junio 0 227 227
2022 Mayo 0 280 280
2022 Abril 0 245 245
2022 Marzo 0 288 288
2022 Febrero 0 153 153
2022 Enero 0 174 174
2021 Diciembre 0 136 136
2021 Noviembre 0 210 210
2021 Octubre 0 15 15
2021 Septiembre 0 1 1
2021 Agosto 0 1 1
2021 Julio 0 8 8
2021 Junio 0 2 2
2021 Mayo 0 3 3
2021 Abril 0 2 2
2021 Marzo 0 4 4
2021 Febrero 0 5 5
2021 Enero 0 6 6
2020 Diciembre 0 5 5
2020 Noviembre 0 10 10
2020 Octubre 0 7 7
2020 Septiembre 0 5 5
2020 Agosto 0 52 52
2020 Julio 0 13 13
2020 Junio 0 18 18
2020 Mayo 0 21 21
2020 Abril 0 6 6
2020 Marzo 0 10 10
2020 Febrero 0 12 12
2020 Enero 0 8 8
2019 Diciembre 0 13 13
2019 Noviembre 0 12 12
2019 Octubre 0 24 24
2019 Septiembre 0 14 14
2019 Agosto 0 5 5
2019 Julio 0 6 6
2019 Junio 3 14 17
2019 Mayo 0 32 32
2019 Marzo 0 2 2
2018 Agosto 0 1 1
2018 Enero 1 0 1
2017 Noviembre 0 1 1
2017 Octubre 131 93 224
2017 Septiembre 173 132 305
2017 Agosto 130 86 216
2017 Julio 124 61 185
2017 Junio 114 79 193
2017 Mayo 195 32 227
2017 Abril 146 21 167
2017 Marzo 190 8 198
2017 Febrero 305 1 306
2017 Enero 130 2 132
2016 Diciembre 199 9 208
2016 Noviembre 298 5 303
2016 Octubre 313 26 339
2016 Septiembre 176 29 205
2016 Agosto 91 27 118
2016 Julio 159 16 175
2016 Junio 348 0 348
2016 Mayo 469 2 471
2016 Abril 447 1 448
2016 Marzo 224 3 227
2016 Febrero 300 1 301
2016 Enero 145 0 145
2015 Diciembre 228 0 228
2015 Noviembre 406 0 406
2015 Octubre 307 0 307
2015 Septiembre 283 0 283
2015 Agosto 220 0 220
2015 Julio 200 0 200
2015 Junio 132 0 132
2015 Mayo 168 0 168
2015 Abril 114 0 114
2015 Marzo 102 0 102
2015 Febrero 46 0 46
2015 Enero 12 0 12
2014 Diciembre 25 0 25
2014 Noviembre 13 0 13
2014 Octubre 13 0 13
2014 Septiembre 15 0 15
2014 Agosto 19 0 19
2014 Julio 13 0 13
2014 Junio 20 0 20
2014 Mayo 9 0 9
2014 Abril 7 0 7
2014 Marzo 12 0 12
2014 Febrero 12 0 12
2014 Enero 7 0 7
2013 Diciembre 7 0 7
2013 Noviembre 56 0 56
2013 Octubre 163 0 163
2013 Septiembre 57 0 57
2013 Agosto 40 0 40
2013 Julio 5 0 5
2013 Junio 1 0 1
2013 Mayo 1 0 1
2000 Febrero 3349 0 3349
Mostrar todo

Siga este enlace para acceder al texto completo del artículo

es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos