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Sustitución valvular urgente en la endocarditis infecciosa: evolución hospitalaria y a largo plazo. Análisis de 45 pacientes
Urgent valve heart replacement in infectious endocarditis: short and long-term prognosis. Analysis of 45 patients
Josep Maria Alegretc,*, Xavier Borràsa, Concepción Alonsoa, Francesc Carrerasa, Mercè Gurguíb, María Luisa Cámaraa, Blai Collc, Guillem Pons-Lladóa
a Departament de Cardiologia i Cirurgia Cardiaca
b Unitat de Malalties Infeccioses. Hospital de la Santa Creu i Sant Pau. Barcelona
c Departament de Medicina Interna. Secció de Cardiologia. Hospital Universitari de Sant Joan. Reus. Tarragona
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        "resumen" => "<span class="elsevierStyleSectionTitle">Fundamento</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Definir en nuestro medio la evoluci&#243;n de los pacientes afectados de endocarditisinfecciosa que requieren una sustituci&#243;n valvular urgente&#46;</p> <span class="elsevierStyleSectionTitle">Pacientes Y M&#233;todos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Analizamos 45 pacientes consecutivos que requirieron sustituci&#243;n valvulardurante el ingreso hospitalario por endocarditis infecciosa&#44; 32 correspondieron a endocarditissobre v&#225;lvula nativa&#44; 7 a prot&#233;sica precoz y 6 a prot&#233;sica tard&#237;a&#46; Se ha realizado un seguimientoa largo plazo cl&#237;nico y ecocardiogr&#225;fico&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">En 39 casos&#44; la sustituci&#243;n valvular debi&#243; realizarse antes de finalizar el tratamientoantibi&#243;tico&#46; Las principales indicaciones fueron insuficiencia card&#237;aca refractaria &#40;24 pacientes&#41;y shock &#40;11 pacientes&#41;&#46; La mortalidad global fue del 24&#37;&#58; 19&#37; en endocarditis sobre v&#225;lvulanativa&#44; 43&#37; en prot&#233;sica precoz y 33&#37; en prot&#233;sica tard&#237;a&#46; La primera causa de muertefue el shock s&#233;ptico &#40;46&#37;&#41;&#46; Se han seguido 31 de los 4 supervivientes durante una media de 65 &#40;DE 49&#41; meses&#44; registr&#225;ndose 2 recidivas y 6 fallecimientos &#40;1 muerte s&#250;bita y 2 por endocarditis&#41;&#46; El 72&#37; de los pacientespresenta una clase I de la NYHA&#46; Se detect&#243; una dehiscencia significativa en el 17&#37;&#40;38&#37; en el grupo con endocarditis prot&#233;sica&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La sustituci&#243;n valvular urgente en la endocarditis infecciosa es una situaci&#243;n gravey con elevada mortalidad&#46; El pron&#243;stico a largo plazo es aceptable&#44; aunque algunos pacientespresentaron dehiscencias significativas&#44; especialmente en endocarditis prot&#233;sicas&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To define the evolution of patients with infective endocarditis who require urgentvalve replacement in our environment&#46;</p> <span class="elsevierStyleSectionTitle">Patients and Methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">We followed 45 consecutive cases of infective endocarditis that requirevalve replacement during their hospitalization&#46; 32 patients had native valve infective endocarditis&#44;7 early prosthesis valve endocarditis and 6 late prosthesis valve endocarditis&#46; Patients werefollowed for a long-term period&#44; clinical and echocardiographycally&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">In 39 cases valve replacement was performed before ending antibiotic therapy&#46; Themain indications for surgery were refractory heart failure &#40;24 patients&#41; and shock &#40;11 patients&#41;&#46;The mortality rate was 24&#37;&#58; 19&#37; in native valve infective endocarditis&#44; 43&#37; in early prostheticvalve endocarditis and 33&#37; in late prosthesis valve endocarditis&#46; The first cause of deathwas septic shock &#40;46&#37;&#41;&#46; We followed 31 over 34 survivors for a mean time 65 &#40;DS 49&#41;months&#46; We found two relapses and six deaths &#40;1 sudden death&#44; 2 endocarditis&#41; and 72&#37; ofpatients presented class I NYHA&#46; We detected 17&#37; prosthetic leaks &#40;34&#37; in the prostheticvalve endocarditis group&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">The need of urgent valve replacement in the context of infective endocarditis isassociated with a high mortality rate&#44; and should be considered a serious condition&#46; Long termprognosis is&#44; however&#44; acceptable&#44; although 17&#37; of patients had prosthesis leak&#44; specially thosewith prosthetic valve endocarditis&#46;</p>"
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ISSN: 00257753
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