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Prevalencia y significado clínico de los anticuerpos antifosfolipídicos en la hepatitis crónica por virus C
Manuel Romero Gómez
Autor para correspondencia
mromerog@meditex.es

Correspondencia: Dr. M. Romero Gómez. Juan Antonio Cavestany, 1, 4.° G. 41003 Sevilla.
, Enrique García-Díaz, Ana Guil, M. Ángeles Otero, Emilio Suárez García, Manuel Castro Fernández
Servicios de Digestivo y Hospital Universitario de Valme. Sevilla
Daniel López Lacombaa, Reyes Gutiérreza, Inmaculada Marchantea
a Servicios de Digestivo y Hematología. Hospital Universitario de Valme. Sevilla
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        "resumen" => "<span class="elsevierStyleSectionTitle">Fundamento</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Estudiar la prevalencia de anticuerpos antifosfolipidicos y analizar su relacion con laprogresion de la hepatitis cronica por virus C&#46;</p> <span class="elsevierStyleSectionTitle">Metodos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se incluyen 128 pacientes con hepatopatia cronica por VHC &#40;edad 46 &#91;14&#93; anos&#44; 70 varones&#41;&#44;no tratados con interferon y un grupo control sano de 93 personas&#46; Analizamos los factores deriesgo&#44; la duracion de la enfermedad&#44; el consumo de alcohol&#44; la cifra de plaquetas&#44; ALT&#44; ARN delVHC en suero e higado y anticuerpos antinucleares&#44; el grado de inflamacion y el estadio de fibrosisen la biopsia hepatica&#44; el estadio de Child-Pugh&#44; la existencia de hipertension portal y descompensacionesprevias&#46; Estudiamos la presencia de anticoagulante lupico y anticuerpos anticardiolipina&#40;ACA&#41; IgG e IgM&#46; En los pacientes con anticuerpos anticardiolipina positivos se detecto la presenciade anti-&#946;2 glucoproteina I mediante ELISA&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Presentaron anticuerpos antifosfolipidicos positivos 31&#47;128 &#40;25&#37;&#59; intervalo de confianza&#91;IC&#93; del 95&#37;&#58; 17&#44;8&#8211;33&#44;4&#41;&#46; La prevalencia de anticuerpos anticardiolipina IgG fue significativamentemayor en pacientes &#40;22&#37;&#41; que en controles 3&#47;93 &#40;3&#44;2&#37;&#41;&#44; p &#60; 0&#44;05&#59; en cambio&#44; no encontramosdiferencias en la prevalencia de anticuerpos anticardiolipina IgM ni de anticoagulante lupico&#46;No encontramos diferencias en las cifras de ALT&#44; viremia&#44; carga viral en higado&#44; plaquetas o ANA enlos pacientes con anticuerpos anticardiolipina IgG o sin ellos&#44; tampoco apreciamos relacion con laedad&#44; la duracion de la infeccion&#44; el consumo de alcohol ni los factores de riesgo&#46; En 4 de 44 pacientes&#40;9&#37;&#44; IC del 95&#37;&#58; 2&#44;5&#8211;21&#44;7&#41; con fibrosis F1&#44; en 7 de 39 &#40;18&#37;&#59; IC del 95&#37;&#58; 7&#44;5&#8211;33&#44;5&#41; conF2 y en 17 de 45 &#40;38&#37;&#59; IC del 95&#37;&#58; 23&#44;8&#8211;53&#44;5&#41; con cirrosis encontramos anticuerpos anticardiolipinaIgG positivo &#40;p &#60; 0&#44;005&#41;&#46; La presencia de ACA IgG se relaciono de forma significativa con laexistencia de hipertension portal&#44; de disfuncion hepatica y antecedentes de descompensacion&#46; En10 de 23 pacientes &#40;43&#44;5&#37;&#59; IC del 95&#37;&#58; 23&#44;2&#8211;65&#44;5&#41; con ACA positivo se detectaron anticuerposanti-&#946;2 glucoproteina I&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La cuarta parte de los pacientes con hepatitis cronica por VHC presentan anticuerposantifosfolipidicos&#46; Estos anticuerpos podrian estar implicados en la progresion de la enfermedad&#46;</p> <span class="elsevierStyleSectionTitle">Background</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To know the prevalence of antiphospholipid antibodies in chronic hepatitis C and theirrelationship with disease progression&#46;</p> <span class="elsevierStyleSectionTitle">Methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">One hundred and twenty-eight patients with chronic hepatitis C and 93 healthy controlswere enrolled up&#46; We determined platelets&#44; ALT&#44; &#947;GT&#44; RNAHCV in serum and liver and non-organspecific antibodies&#44; grade and stage in liver biopsy&#44; risk factors&#44; duration of disease and alcohol intakewere also included&#46; Portal hypertension and liver function parameters were studied&#46; Antiphospholipidantibodies &#40;APA&#41;&#58; lupus anticoagulant &#40;LA&#41; and anticardiolipin antibodies &#40;ACA&#41; &#40;IgGand IgM&#41; were measured by EIA&#46; Anti-&#946;2 glycoprotein I antibodies were also detected by EIA inACA positive patients&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Thirty one out of 128 &#40;25&#37;&#59; 95&#37;CI&#58; 17&#46;8&#37;&#8211;33&#46;4&#37;&#41; showed positive antiphospholipid antibodies&#46;Positive ACA-IgG was higher in patients than controls &#40;22&#37; vs 3&#46;2&#37;&#59; p &#60; 0&#46;05&#41;&#44; whereas&#44;ACA-IgM was similar &#40;5&#37; vs 3&#46;2&#37;&#59; p &#61; NS&#41;&#44; and LA was absent in both groups&#46; ALT levels&#44; viraemia&#44;viral load in liver&#44; platelets&#44; or ANA titre were similar in patients with and without positiveACA-IgG&#46; Risk factors&#44; duration of disease or alcohol intake were not related yet&#46; Patients with stagingF1 showed positive ACA-IgG 4 of 44 &#40;9&#37;&#59; 95&#37;CI&#58; 2&#46;5&#37;&#8211;21&#46;7&#37;&#41;&#44; in staging F2 7 of 39 &#40;18&#37;&#59;95&#37;CI&#58; 7&#46;5&#37;&#8211;33&#46;5&#37;&#41; and in staging F4 17 of 45 &#40;38&#37;&#59; 95&#37;CI&#58; 23&#46;8&#37;&#8211;53&#46;5&#37;&#59; p &#60; 0&#46;005&#41;&#46;ACA-IgG was significantly related to portal hypertension&#44; Child-Pugh stage and presence of cirrhosiscomplications&#46; Anti-&#946;2 glycoprotein I antibodies were detected in ten &#40;43&#46;5&#37;&#59; CI95&#37;&#58; 23&#46;2&#37;&#8211;65&#46;5&#37;&#41; out of 23 ACA positive patients&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">ACA-IgG seems to be associated with chronic hepatitis C&#44; and could play a potentialrole in fibrosis progression and liver disease in these patients&#46;</p>"
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Información del artículo
ISSN: 00257753
Idioma original: Español
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2020 Junio 4 0 4
2020 Febrero 1 0 1
2018 Noviembre 0 2 2
2017 Octubre 7 2 9
2017 Septiembre 6 6 12
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2017 Junio 15 9 24
2017 Mayo 15 1 16
2017 Abril 15 1 16
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2017 Enero 17 0 17
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2016 Noviembre 29 2 31
2016 Octubre 40 6 46
2016 Septiembre 22 4 26
2016 Agosto 15 3 18
2016 Julio 12 1 13
2016 Junio 28 1 29
2016 Mayo 26 3 29
2016 Abril 18 2 20
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2016 Febrero 16 2 18
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2015 Diciembre 24 0 24
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2015 Agosto 19 0 19
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2015 Mayo 34 0 34
2015 Abril 16 0 16
2015 Marzo 19 0 19
2015 Febrero 15 0 15
2015 Enero 21 0 21
2014 Diciembre 14 0 14
2014 Noviembre 7 0 7
2014 Octubre 6 0 6
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2014 Mayo 1 0 1
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2014 Enero 8 0 8
2013 Diciembre 5 0 5
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