Toxicidad asociada a efavirenz en personas infectadas por el VIH incluidas en el programa de acceso expandido
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Hospital Carlos III. Instituto de Salud Carlos III. Madrid." ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Correspondencia: Rafael Calvo, 7, 2.° A. 20810 Madrid." ] ] ] 1 => array:3 [ "autoresLista" => "Inmaculada Jiménez-Nácher" "autores" => array:1 [ 0 => array:3 [ "nombre" => "Inmaculada" "apellidos" => "Jiménez-Nácher" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:3 [ "entidad" => "Farmacia. Hospital Carlos III. Instituto de Salud Carlos III. Madrid." "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "1999-10-21" "fechaAceptado" => "2000-06-27" "PalabrasClave" => array:1 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec222515" "palabras" => array:4 [ 0 => "VIH Infección por VIH" 1 => "Antiretrovirales" 2 => "Efavirenz" 3 => "Toxicidad medicamentosa" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Fundamento</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">El efavirenz es uno de los antiretrovirales de más reciente comercialización. Su perfil de toxicidad no se conoce bien.</p> <span class="elsevierStyleSectionTitle">Pacientes y método</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se examinó la frecuencia de efectos adversos en 250 pacientes incluidos en el programa de acceso expandido de efavirenz en una institución de Madrid.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Se recogieron efectos adversos de grado ≥ 2 en la escala de la Organización Mundial de Salud en 33 (13,2%) pacientes. Los más frecuentes fueron los trastornos neuropsiquiátricos (8,4%), cutáneos (3,2%) y gastrointestinales (0,8%). En 17 pacientes (6,8%) tuvo que ser suspendido el efavirenz.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La frecuencia de efectos adversos por efavirenz de grado moderadograve es relativamente baja (13,4%), sin evidencia de toxicidad cruzada (p. ej., exantema por nevirapina). Las complicaciones más frecuentes son neuropsiquiátricas y/o cutáneas, y se resuelven espontáneamente en dos semanas.</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Efavirenz (EFV) is one of the latest antiretroviral compounds appeared in the market. Its toxicity profile is not well known.</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">The rate of adverse events was examined in 250 subjects enrolled in the expanded access program in a single institution located in Madrid, Spain.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Adverse events grade ≥ 2 (WHO) were recorded in 33 (13.2%) persons. The most common were neuropsychiatric disorders (8.4%), cutaneous lesions (3.2%), and gastrointestinal problems (0.8%). The drug needed to be discontinued in 17 (6.8%) patients.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">The rate of adverse events grade moderate-to-severe in patients receiving EFV is relatively low (13.4%), without evidence of cross-toxicity (i.e., rash by nevirapine). Neuropshychiatric and dermatological conditions are the most common, and ten to resolve spontaneously in two weeks.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias Bibliográficas" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:10 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Efavirenz" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J. Adkins" 1 => "S. Noble" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Drugs" "fecha" => "1998" "volumen" => "56" "paginaInicial" => "1055" "paginaFinal" => "1067" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9878993" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2." 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