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Resistencia de Mycobacterium tuberculosis en Zaragoza (1993–1997) y factores asociados
Resistance of Mycobacterium tuberculosis Zaragoza, Spain (1993–1997) and related factors.
Luis Torresa,
Autor para correspondencia
med023023@nacom.es

Correspondencia: Servicio de Microbiología. Hospital Universitario Miguel Servet.P.o Isabel la Católica, 1–3. 50009 Zaragoza
, Piedad Arazob, Juan Blas Pérezcc, María del Pilar Amadord, María Antonia Lezcanoa, María José Revilloa, Juan Bautista García-Moyaa
a Servicio de Microbiología y Hospital General San Jorge. Huesca.
b Unidad de Enfermedades Infecciosas. Hospital Universitario Miguel Servet. Zaragoza.
c Servicio de Medicina Interna. Hospital Provincial.Huesca.
d Servicio de Farmacia. Hospital General San Jorge. Huesca.
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        "resumen" => "<span class="elsevierStyleSectionTitle">Fundamento</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Conocer la frecuencia de resistencias de <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span> Zaragozay estudiar los factores asociados&#46;</p> <span class="elsevierStyleSectionTitle">Pacientes y m&#233;todo</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Estudio transversal de la sensibilidad de <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span> el Hospital Universitario Miguel Servet &#40;Zaragoza&#41; entre 1993 y 1997&#59; el m&#233;todo utilizado fue el de las proporciones&#46; Se realiz&#243; un an&#225;lisis estad&#237;stico con pruebas convencionales utilizando un nivel de significaci&#243;n de p &#60; 0&#44;05&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Se estudiaron 428 pacientes con cultivo positivo frente a <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span>&#58; 136 &#40;31&#44;8&#37;&#41; VIH positivos&#44; 121 &#40;28&#44;3&#37;&#41; VIH negativos y en 171 &#40;39&#44;9&#37;&#41; no constaba la serolog&#237;a&#46; Las resistencias al menos a un f&#225;rmaco se observaron en 47 pacientes &#40;10&#44;9&#37;&#41;&#46; En 22 fueron primarias &#40;5&#44;9&#37;&#41; y en 25 pacientes fueron adquiridas &#40;42&#44;4&#37;&#41;&#46; La resistencia primaria observada en los VIH positivos fue del 9&#44;2&#37;&#44; mientras que en los VIH negativos fue del 7&#44;5&#37;&#59; la resistencia adquirida tambi&#233;n fue mayor en los pacientes infectados por el VIH&#44; 51&#44;8&#37; frente al 42&#44;8&#37; de los seronegativos&#46; Cuando se compar&#243; la aparici&#243;n de resistencias entre ambos colectivos&#44; no se observaron diferencias estad&#237;sticamente significativas&#46; En 20 pacientes aparecieron resistencias m&#250;ltiples &#40;4&#44;7&#37;&#41;&#44; y 10 &#40;2&#44;3&#37;&#41; lo eran al menos a isoniacida y rifampicina&#46; Los factores asociados con la aparici&#243;n de resistencia adquirida fueron&#58; h&#225;bito en&#243;lico &#40;<span class="elsevierStyleItalic">odds ratio</span>&#91;OR&#93; &#61; 2&#44;65&#59; intervalo de confianza &#91;IC&#93; del 95&#37;&#44; 1&#44;24&#8211;5&#44;65&#41;&#44; usuarios de drogas por v&#237;a parenteral &#40;OR &#61; 2&#44;33&#59; IC del 95&#37;&#44; 1&#44;05&#8211;5&#44;17&#41;&#44; episodios previos de tuberculosis &#40;OR &#61; 109&#44;40&#59; IC del 95&#37;&#44; 15&#44;02&#8211;796&#44;43&#41; y ser transe&#250;nte &#40;OR &#61; 3&#44;75&#59; IC del 95&#37;&#44; 1&#44;26&#8211;11&#44;17&#41;&#59; cuando estudiamos la resistencia primaria&#44; no encontramos diferencias significativas entre los diferentes factores de riesgo&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">El porcentaje de resistencias a <span class="elsevierStyleItalic">M&#46; tuberculosis</span> observado en Zaragoza es similar a otros descritos en diferentes regiones de Espa&#241;a&#46; No se han observado diferencias significativas entre seropositivos y seronegativos para el VIH&#46; Los factores asociados significativamente con la aparici&#243;n de resistencia adquirida fueron&#58; h&#225;bito en&#243;lico&#44; adicci&#243;n a drogas por v&#237;a parenteral&#44; episodios previos de tuberculosis y ser transe&#250;nte&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To know the frequency of resistance of <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span> a general hospital and the related factors&#46;</p> <span class="elsevierStyleSectionTitle">Patients and method</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Transversal study of the sensitivity of <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span> the Hospital Miguel Servet &#40;Zaragoza&#44; Spain&#41; between 1993&#8211;1997&#59; the proportions method was used to study the susceptibility&#46; Statistical analysis of conventional tests and significance level at p &#60; 0&#46;05 were performed&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Four hundred and twenty height patients with culture positive to Mycobacterium tuberculosiswere studied&#59; 136 &#40;31&#46;8&#37;&#41; were HIV&#43;&#44; 121 &#40;28&#46;3&#37;&#41; were HIV&#8211; and in 171 &#40;39&#46;9&#37;&#41; this situation was unknown&#46; In 47 patients &#40;10&#46;9&#37;&#41; the strains isolated were resistant at least to one drug&#46; Primary resistance was 5&#46;9&#37; &#40;22 patients&#41; and acquired resistance was 42&#46;4&#37; &#40;25 patients&#41;&#46; Primary resistance in HIV&#43; patients was 9&#46;2&#37; and in HIV&#8211; patients was 7&#46;5&#37;&#59; acquired resistance in HIV&#43; patients was greater than in HIV&#8211; patients &#40;51&#46;8&#37; vs 42&#46;8&#37;&#41;&#46; When we compared the resistances between both HIV&#43; and HIV&#8211; patients we did not find significant differences&#46; Twenty isolates &#40;4&#46;7&#37;&#41; were resistant to more than one drug and 10 &#40;2&#46;3&#37;&#41; were resistant to at least isoniazid and rifampin&#46; The risk factors for acquired resistance were alcohol &#40;odds ratio&#91;OR&#93; &#61; 2&#46;65&#59; 95&#37; CI&#44; 1&#46;24&#8211;5&#46;65&#41;&#44; drugs users &#40;OR &#61; 2&#46;33&#59; 95&#37; CI&#44; 1&#46;05&#8211;5&#46;17&#41;&#44; previous episodes of tuberculosis &#40;OR &#61; 109&#46;40&#59; 95&#37; CI&#44; 15&#46;02&#8211;796&#46;43&#41; and homeless &#40;OR &#61; 3&#46;75&#59; 95&#37; CI&#44; 1&#46;26&#8211;11&#46;17&#41;&#59; we did not find significant differences between the different risk factors according to primary resistance&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">On one study&#44; the resistance of <span class="elsevierStyleItalic">M&#46; tuberculosisis</span> similar to other described in Spain&#46; We haven&#39;t found significant differences between both seropositive and seronegative patients&#46; The risk factors for acquired resistance were alcoholism&#44; drug users&#44; previous episodes of tuberculosis and homeless&#46; Med Clin &#40;Barc&#41;2000&#59; 115&#58; 605&#8211;609&#46;</p>"
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