Características y valor pronóstico del fracaso renal agudo en la pancreatitis aguda grave
Acute renal failure profile and prognostic value in severe acute pancreatitis.
Manuel E. Herrera Gutiérrez
, Gemma Seller Pérez, Carlos de la Rubia de Gracia, María José Chaparro Sánchez, Belén Nacle López
Autor para correspondencia
herrera@ctv.es
Correspondencia: Dr. M.E. Herrera Gutiérrez. UCI. Complejo Hospitalario Carlos Haya. Avda. Carlos Haya, s/n. 29010 Málaga
Correspondencia: Dr. M.E. Herrera Gutiérrez. UCI. Complejo Hospitalario Carlos Haya. Avda. Carlos Haya, s/n. 29010 Málaga
Servicio de Cuidados Críticos y Urgencias. Complejo Hospitalario Carlos Haya. Málaga
Leído
4259
Vecesse ha leído el artículo
655
Total PDF
3604
Total HTML
Compartir estadísticas
array:22 [ "pii" => "S0025775300716745" "issn" => "00257753" "doi" => "10.1016/S0025-7753(00)71674-5" "estado" => "S300" "fechaPublicacion" => "2000-01-01" "aid" => "71674" "copyright" => "Elsevier España, S.L.. Todos los derechos reservados" "copyrightAnyo" => "2000" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2000;115:721-5" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 3889 "formatos" => array:3 [ "EPUB" => 6 "HTML" => 3599 "PDF" => 284 ] ] "itemSiguiente" => array:18 [ "pii" => "S0025775300716757" "issn" => "00257753" "doi" => "10.1016/S0025-7753(00)71675-7" "estado" => "S300" "fechaPublicacion" => "2000-01-01" "aid" => "71675" "copyright" => "Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2000;115:726-9" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 8039 "formatos" => array:3 [ "EPUB" => 6 "HTML" => 7707 "PDF" => 326 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Dieta y riesgo cardiovascular en España (DRECE II). Descripción de la evolución del perfil cardiovascular" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "726" "paginaFinal" => "729" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Diet and cardiovascular risk in Spain (DRECE II study). Description of the evolution of cardiovascular profile" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "José Antonio Gutiérrez Fuentes, Juan Gómez-Jerique, Agustín Gómez de la Cámarac, Miguel Ángel Rubio, Alberto García Hernández, Ignacio Arístegui" "autores" => array:7 [ 0 => array:2 [ "nombre" => "José" "apellidos" => "Antonio Gutiérrez Fuentes" ] 1 => array:2 [ "nombre" => "Juan" "apellidos" => "Gómez-Jerique" ] 2 => array:2 [ "nombre" => "Agustín" "apellidos" => "Gómez de la Cámarac" ] 3 => array:2 [ "nombre" => "Miguel" "apellidos" => "Ángel Rubio" ] 4 => array:2 [ "nombre" => "Alberto" "apellidos" => "García Hernández" ] 5 => array:2 [ "nombre" => "Ignacio" "apellidos" => "Arístegui" ] 6 => array:1 [ "colaborador" => "en nombre del grupo Drece II" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775300716757?idApp=UINPBA00004N" "url" => "/00257753/0000011500000019/v1_201307291749/S0025775300716757/v1_201307291749/es/main.assets" ] "es" => array:14 [ "idiomaDefecto" => true "titulo" => "Características y valor pronóstico del fracaso renal agudo en la pancreatitis aguda grave" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "721" "paginaFinal" => "725" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Manuel E. Herrera Gutiérrez, Gemma Seller Pérez, Carlos de la Rubia de Gracia, María José Chaparro Sánchez, Belén Nacle López" "autores" => array:5 [ 0 => array:4 [ "nombre" => "Manuel E." "apellidos" => "Herrera Gutiérrez" "email" => array:1 [ 0 => "herrera@ctv.es" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "Gemma" "apellidos" => "Seller Pérez" ] 2 => array:2 [ "nombre" => "Carlos" "apellidos" => "de la Rubia de Gracia" ] 3 => array:2 [ "nombre" => "María" "apellidos" => "José Chaparro Sánchez" ] 4 => array:2 [ "nombre" => "Belén" "apellidos" => "Nacle López" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Cuidados Críticos y Urgencias. Complejo Hospitalario Carlos Haya. Málaga" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Correspondencia: Dr. M.E. Herrera Gutiérrez. UCI. Complejo Hospitalario Carlos Haya. Avda. Carlos Haya, s/n. 29010 Málaga" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Acute renal failure profile and prognostic value in severe acute pancreatitis." ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2000-01-20" "fechaAceptado" => "2000-11-09" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec223127" "palabras" => array:3 [ 0 => "Pancreatitis aguda grave" 1 => "Fracaso renal agudo" 2 => "Hemofiltración venovenosa continua" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec223126" "palabras" => array:3 [ 0 => "Severe acute pancreatitis" 1 => "Acute renal failure" 2 => "Hemofiltration" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Fundamento</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La aparición de fracaso renal agudo (FRA) en la pancreatitis aguda grave (PAG) supone una elevada mortalidad. No existen parámetros que definan los pacientes con mayor probabilidad de desarrollarlo. Pretendemos determinar la incidencia y definir variables predic-toras de aparición y mortalidad</p> <span class="elsevierStyleSectionTitle">Material y método</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Estudio retrospectivo de todas las PAG ingresadas en la unidad de cuidados intensivos entre 1991 y 1998 (n = 154)</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">La incidencia de FRA fue del 42% (60% durante el primer día). La alteración de los parámetros hemodinámicos, el índice APACHE II y la puntuación de Ranson se relacionaron con su aparición. El 62,2% de los casos graves aparecen tras un fracaso multiorgánico (FMO). La mortalidad fue del 71,2% frente al 6,8% en pacientes sin FRA (en episodios de gravedad media del 39,9%, y en graves del 94,6%). La etiología condicionó la mortalidad (prerrenal [46,4%], tras hipotensión mantenida [71,4%] y FMO [93,3%]; p < 0,005). Precisaron reemplazo renal el 63,6% de los pacientes (hemofiltración [HF] el 95,5%), con una mortalidad del 89,3% (100% en hemodiálisis intermitente [HI] frente al 88% con HF). En el 32% de los pacientes con HF mejoró o se resolvió el FRA (si se inició precozmente la mortalidad fue del 76,9% frente al 100% en los tratamientos tardíos) (p < 0,001). El análisis de regresión presenta una relación significativa con la mortalidad para la gravedad del episodio de FRA y fracaso hemodinámico al ingreso</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">El fracaso renal agudo en la pancreatitis aguda grave es frecuente, aparece pre-cozmente y ensombrece su pronóstico. La necesidad de tratamiento de depuración supone una mortalidad muy elevada. La hemofiltración parece presentar ventajas sobre la hemodiálisis intermitente</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Acute renal failure (ARF) complicating severe acute pancreatitis (SAP) carries a high mortality. Clinically useful scores to define patients who will develop this complication are lacking. We try to determine the incidence of ARF and variables predicting the appearance and severity of the episodes</p> <span class="elsevierStyleSectionTitle">Material and method</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Retrospective study of all SAP patients admitted in an intensive care unit between 1991 and 1998 (n = 154)</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">ARF incidence was 42%. Haemodynamic instability, APACHE II and Ranson score were related to ARF development. 62.2% of severe ARF patients had multiple organ failure (MOF). Mortality was 71.2% compared to 6.8% in patients without ARF (39.9% in mild ARF and 94.6% in severe ARF). Etiology relates to mortality (prerenal [46.4%], after severe hypo-tensive episode [71.4%], in MOF [93.3%]; p < 0.005). 63.6% patients required replacement therapy (hemofiltration [HF] 95.5%), with a mortality of 89.3% (100% for intermittent dialysis compared to 88% with HF). In 32% patients treated with HF, ARF improved (when initiated early mortality was 76.9% compared to a 100% when initiated in more advanced stages) (p < 0.001). Logistic regression analysis showed that ARF severity and haemodynamic failure were related with mortality</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">ARF is a frequent and early complication of SAP, worsening its prognosis. FRA severity is related to the outcome. Need of replacement therapy supposes a high mortality. In this setting, HF seems to have advantages over conventional dialysis</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias BibliogrÁficas" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:56 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pancreatite aigue hemorragique." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "C. Varlet" 1 => "J.L. Pourriat" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Press Med" "fecha" => "1996" "volumen" => "25" "paginaInicial" => "1453" "paginaFinal" => "1458" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Acute renal cortical necrosis -a study of 113 patients." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "K.S. Chugh" 1 => "V. Jha" 2 => "V. Sakhuja" 3 => "K. Joshi" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ren Fail" "fecha" => "1994" "volumen" => "16" "paginaInicial" => "37" "paginaFinal" => "47" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8184145" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Impairment of renal function in medical intensive care: predictability of acute renal failure." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "F. Jochimsen" 1 => "J.H. Schäfer" 2 => "A. Maurer" 3 => "A. Distler" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Crit Care Med" "fecha" => "1990" "volumen" => "18" "paginaInicial" => "480" "paginaFinal" => "485" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2183966" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Natural course of acute pancreatitis." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "H.G. Beger" 1 => "B. Rau" 2 => "J. Mayer" 3 => "U. Pralle" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "World J Surg" "fecha" => "1997" "volumen" => "21" "paginaInicial" => "130" "paginaFinal" => "135" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8995067" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A clinically based classification system for acute pancreatitis. Summary of the International Symposium on Acute Pancreatitis, Atlanta, Ga, 11-13 de septiembre de 1992." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "E.L. Bradley" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Surg" "fecha" => "1993" "volumen" => "128" "paginaInicial" => "586" "paginaFinal" => "590" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8489394" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "CT diagnosis and staging of acute pancreatitis." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "E.J. Balthazar" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Radiol Clin North Am" "fecha" => "1989" "volumen" => "27" "paginaInicial" => "19" "paginaFinal" => "25" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2642273" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prognostic sings and the role of operative management in acute pancreatitis." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J.H.C. Ranson" 1 => "K.M. Rifkins" 2 => "D.F. Roses" 3 => "S.D. Fink" 4 => "K. Eng" 5 => "F.C. Spencer" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Surg Gynecol Obs" "fecha" => "1974" "volumen" => "139" "paginaInicial" => "69" "paginaFinal" => "81" ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "APACHE II: a severity of disease classification system." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "W. Knaus" 1 => "E. Draper" 2 => "D. Wagner" 3 => "J. Zimmerman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Crit Care Med" "fecha" => "1985" "volumen" => "13" "paginaInicial" => "818" "paginaFinal" => "829" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3928249" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prognosis in acute organ-system failure." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "W. Knaus" 1 => "E. Draper" 2 => "D. Wagner" 3 => "J. Zimmerman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Surg" "fecha" => "1985" "volumen" => "202" "paginaInicial" => "685" "paginaFinal" => "693" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4073980" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prevalence and prediction of multiple organ system failure and mortality in acute pancreatitis." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "D.D. Tran" 1 => "M.A. Cuesta" 2 => "A.J. Schneider" 3 => "R.I. Wesdorp" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Crit Care" "fecha" => "1993" "volumen" => "8" "paginaInicial" => "145" "paginaFinal" => "153" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8275159" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Acute pancreatitis and rhabdomyolysis: a new association." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "B.J. Nankivell" 1 => "A.H. Gillies" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Aust N Z J Med" "fecha" => "1991" "volumen" => "21" "paginaInicial" => "414" "paginaFinal" => "417" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1953530" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0060" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Renal function in experimentally induced acute pancreatitis in dogs: how it is affected by the nephrotoxic substance in pancreatic exudate from ascitic fluid." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "K. Satake" 1 => "G. Kanazawa" 2 => "A. Hiura" 3 => "H. Nishiwaki" 4 => "S.S. Ha" 5 => "Y.S. Chung" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Jpn J Surg" "fecha" => "1991" "volumen" => "21" "paginaInicial" => "88" "paginaFinal" => "95" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2041247" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0065" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Renal microcirculation in experimental acute pancreatitis of dogs." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "H. Nishiwaki" 1 => "I. Ko" 2 => "A. Hiura" 3 => "S.S. Ha" 4 => "K. Satake" 5 => "M. Sowa" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ren Fail" "fecha" => "1993" "volumen" => "15" "paginaInicial" => "27" "paginaFinal" => "31" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8441833" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0070" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Acute pancreatitis and renal cortical necrosis." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J.G. Fox" 1 => "N.P. Sutcliffe" 2 => "J.M. Boulton Jones" 3 => "C.W. Imrie" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Nephrol Dial Transplant" "fecha" => "1990" "volumen" => "5" "paginaInicial" => "542" "paginaFinal" => "544" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2130302" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0075" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Apoptotic cell death of renal tubules in experimental severe acute pancreatitis." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "K. Takase" 1 => "Y. Takeyama" 2 => "J. Nishikawa" 3 => "T. Ueda" 4 => "Y. Hori" 5 => "M. Yamamoto" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Surgery" "fecha" => "1999" "volumen" => "125" "paginaInicial" => "411" "paginaFinal" => "420" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10216532" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0080" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Inflammatory response in the initial phase of acute pancreatitis: relationship to the onset and severity of the disease." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J.E. Domínguez-Muñoz" 1 => "J.A. Viedma" 2 => "M. Pérez-Mateo" 3 => "F. Carballo" 4 => "M. García Fe" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Rev Esp Enf Dig" "fecha" => "1995" "volumen" => "87" "paginaInicial" => "225" "paginaFinal" => "246" ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0085" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Acute pancreatitis as a model of sepsis." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "P.G. Wilson" 1 => "M. Manji" 2 => "J.P. Neoptolemos" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "J Antimicrob Chemother" "fecha" => "1998" "volumen" => "41" "numero" => "Supl A" "paginaInicial" => "51" "paginaFinal" => "63" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9688451" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0090" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The role of cytokines in the pathogenesis of acute pancreatitis." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J. Norman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Surg" "fecha" => "1998" "volumen" => "175" "paginaInicial" => "76" "paginaFinal" => "83" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9445247" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0095" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Acute pancreatitis and cytokines: «second attack» by septic complication leads to organ failure." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M. Ogawa" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Pancreas" "fecha" => "1998" "volumen" => "16" "paginaInicial" => "312" "paginaFinal" => "315" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9548672" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0100" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Acute renal failure complicating severe acute pancreatitis." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "P. Kes" 1 => "Z. Vucicevic" 2 => "I. Ratkovic Gusic" 3 => "A. Fotivec" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ren Fail" "fecha" => "1996" "volumen" => "18" "paginaInicial" => "621" "paginaFinal" => "628" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8875688" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0105" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Acute renal failure as a complication of acute pancreatitis." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "D. Ljutic" 1 => "T. Piplovic Vukovic" 2 => "V. Raos" 3 => "P. Andrews" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ren Fail" "fecha" => "1996" "volumen" => "18" "paginaInicial" => "629" "paginaFinal" => "633" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8875689" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib0110" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Acute renal failure in patients with acute pancreatitis: prevalence, risk factors, and outcome." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "D.D. Tran" 1 => "P.L. Oe" 2 => "C.W. De Fijter" 3 => "J. Van der Meulen" 4 => "M.A. Cuesta" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Nephrol Dial Transplant" "fecha" => "1993" "volumen" => "8" "paginaInicial" => "1079" "paginaFinal" => "1084" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8272219" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib0115" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Utility of risk models for renal failure and critically ill patients." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "W.K. Halstenberg" 1 => "M. Goormastic" 2 => "E.P. Paganini" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Semin Nephrol" "fecha" => "1994" "volumen" => "14" "paginaInicial" => "23" "paginaFinal" => "32" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8140338" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib0120" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Risk factors to predict renal failure and death in the medical intensive care unit." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "L.A. Ward" 1 => "G.N. Coritsidis" 2 => "C.P. Carvonis" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Int Care Med" "fecha" => "1996" "volumen" => "11" "paginaInicial" => "114" "paginaFinal" => "119" ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib0125" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Severity of acute renal failure: the need of measurement." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "F. Liaño NJM" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Nephrol Dial Transplant" "fecha" => "1994" "volumen" => "9" "paginaInicial" => "229" "paginaFinal" => "238" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7800263" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib0130" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Contrast-enganced abdominal computed tomography scanning and prediction of severity of acute pancreatitis. A prospective study." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "N.J.M. London" 1 => "J.P. Neoptolemos" 2 => "J. Lavelle" 3 => "I. Bailey" 4 => "D. James" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Br J Surg" "fecha" => "1989" "volumen" => "76" "paginaInicial" => "227" "paginaFinal" => "268" ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib0135" "etiqueta" => "27." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prognosis in acute pancreatitis complicated by acute renal failure requiring dialysis." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "L. Frost" 1 => "R.S. Pedersen" 2 => "S.E. Ostgaard" 3 => "H.E. Hansen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Scand J Urol Nephrol" "fecha" => "1990" "volumen" => "24" "paginaInicial" => "257" "paginaFinal" => "260" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2274748" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib0140" "etiqueta" => "28." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cardiovascular instability during hemodialysis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "V.M. Campese" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Kidney Int." "fecha" => "1988" "volumen" => "33" "numero" => "Supl 24" "paginaInicial" => "186" "paginaFinal" => "190" ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib0145" "etiqueta" => "29." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effect of the dialysis membrane in the treatment of patients with acute renal failure." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "R.M. Hakim" 1 => "R.L. Wingard" 2 => "R.A. Parker" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM199411173312003" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "1994" "volumen" => "331" "paginaInicial" => "1338" "paginaFinal" => "1342" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7935703" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib0150" "etiqueta" => "30." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Biocompatible membranes in acute renal failure prospective case control study." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "L.A. Schiffl" 1 => "S.M. Lang" 2 => "A. Koning" 3 => "T. Strasser" 4 => "M.C. Haider" 5 => "E. Held" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "1994" "volumen" => "344" "paginaInicial" => "570" "paginaFinal" => "572" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7914959" "web" => "Medline" ] ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib0155" "etiqueta" => "31." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The importance of biocompatible membranes in dialysis." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J. Hummelfard" 1 => "R.M. Hakim" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Semin Dial" "fecha" => "1996" "volumen" => "9" "paginaInicial" => "481" "paginaFinal" => "483" ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib0160" "etiqueta" => "32." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hemofiltración arteriovenosa continua. Fundamento y aplicación." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J. López-Ferré" 1 => "R. Abizanda" 2 => "F. Valle" 3 => "R. Jordá" 4 => "J.M. Raurich" 5 => "J. Ibáñez" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Med Intens" "fecha" => "1988" "volumen" => "13" "paginaInicial" => "177" "paginaFinal" => "184" ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib0165" "etiqueta" => "33." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hemofiltración arteriovenosa continua (HFAVC) como forma de depuración extrarrenal en los enfermos críticos." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J.L. De la Serna" 1 => "C. Torrecilla" 2 => "P. Luque" 3 => "P. Galdós" 4 => "V. Díez" 5 => "J.M. Mosquera" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Med Intens" "fecha" => "1988" "volumen" => "12" "numero" => "Supl" "paginaInicial" => "260" ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib0170" "etiqueta" => "34." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hemofiltración veno-venosa continua en pacientes críticos." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J.A. Sánchez-Izquierdo" 1 => "M.J. Lozano" 2 => "A. Ambrós" 3 => "J.L. Pérez" 4 => "R. Caballero" 5 => "E. Alted" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Med Intens" "fecha" => "1995" "volumen" => "19" "paginaInicial" => "171" "paginaFinal" => "176" ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib0175" "etiqueta" => "35." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Terapias continuas de sustitución renal en la unidad de cuidados intensivos." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "D. Daga Ruiz" 1 => "M.E. Herrera Gutiérrez" 2 => "M.V. De la Torre Prados" 3 => "R. Toro Sánchez" 4 => "L. Ruiz del Fresno" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Med Intens" "fecha" => "1999" "volumen" => "23" "paginaInicial" => "13" "paginaFinal" => "22" ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bib0180" "etiqueta" => "36." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tolerancia hemodinámica de los pacientes con síndrome de respuesta inflamatoria sistémica a la hemofiltración veno-venosa continua." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M.E. Herrera" 1 => "D. Daga" 2 => "G. Seller" 3 => "M. Lebrón" 4 => "J.M. García" 5 => "G. Suárez" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Med Intens" "fecha" => "1998" "volumen" => "22" "paginaInicial" => "60" "paginaFinal" => "65" ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bib0185" "etiqueta" => "37." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Continuous venovenous hemodiafiltraction compared with conventional dialysis in critically ill patients with acute renal failure." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "R. Bellomo" 1 => "N. Boyce" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Asaio J" "fecha" => "1993" "volumen" => "39" "paginaInicial" => "794" "paginaFinal" => "797" ] ] ] ] ] ] 37 => array:3 [ "identificador" => "bib0190" "etiqueta" => "38." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Controlled clinical trial of peritoneal lavage for the treatment of severe acute pancreatitis." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "A.D. Mayer" 1 => "M.J. McMahon" 2 => "A.P. Corfield" 3 => "M.J. Cooper" 4 => "R.C.N. Williamson" 5 => "M. Chir" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM198502143120703" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "1985" "volumen" => "312" "paginaInicial" => "399" "paginaFinal" => "404" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2578610" "web" => "Medline" ] ] ] ] ] ] ] ] 38 => array:3 [ "identificador" => "bib0195" "etiqueta" => "39." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Long peritoneal lavage decreases pancreatic sepsis in acute pancreatitis." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.C. Ranson" 1 => "R.S. Berman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Surg" "fecha" => "1990" "volumen" => "211" "paginaInicial" => "708" "paginaFinal" => "718" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2357134" "web" => "Medline" ] ] ] ] ] ] ] ] 39 => array:3 [ "identificador" => "bib0200" "etiqueta" => "40." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Continuous veno-venous hemofiltration with dialiysis removes cytokines from the circulation of septic patients." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "R. Bellomo" 1 => "P. Tipping" 2 => "N. Boyce" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Crit Care Med" "fecha" => "1993" "volumen" => "21" "paginaInicial" => "522" "paginaFinal" => "526" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8472571" "web" => "Medline" ] ] ] ] ] ] ] ] 40 => array:3 [ "identificador" => "bib0205" "etiqueta" => "41." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Impact of continuous hemofiltration on cytokines and cytokine inhibitors in oliguric patients suffering from systemic inflammatory response syndrome." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "E.F. Van Bommel" 1 => "C.J. Hesse" 2 => "N.H. Jutte" 3 => "R. Zietse" 4 => "H.A. Bruining" 5 => "W. Weimar" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ren Fail" "fecha" => "1997" "volumen" => "19" "paginaInicial" => "443" "paginaFinal" => "454" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9154661" "web" => "Medline" ] ] ] ] ] ] ] ] 41 => array:3 [ "identificador" => "bib0210" "etiqueta" => "42." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cytokines clearance during venovenous hemofiltration in the trauma patient." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J.A. Sánchez-Izquierdo" 1 => "J.L. Pérez" 2 => "M.J. Lozano" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Kidney Dis" "fecha" => "1997" "volumen" => "30" "paginaInicial" => "483" "paginaFinal" => "488" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9328361" "web" => "Medline" ] ] ] ] ] ] ] ] 42 => array:3 [ "identificador" => "bib0215" "etiqueta" => "43." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mediator removal with continuous renal replacement therapies: Complement and cytokines." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "W. Silvester" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Am J Kidney Dis" "fecha" => "1997" "volumen" => "30" "paginaInicial" => "38" "paginaFinal" => "43" ] ] ] ] ] ] 43 => array:3 [ "identificador" => "bib0220" "etiqueta" => "44." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cytokine kinetics (TNFalpha, IL-1 beta, IL-6) during continuous hemofiltration: a laboratory and clinical study." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "E.F. Van Bommel" 1 => "C.j. Hesse" 2 => "N.H. Jutte" 3 => "R. Zietse" 4 => "H.A. Bruining" 5 => "W. Weimar" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Contrib Nephrol" "fecha" => "1995" "volumen" => "116" "paginaInicial" => "62" "paginaFinal" => "75" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8529384" "web" => "Medline" ] ] ] ] ] ] ] ] 44 => array:3 [ "identificador" => "bib0225" "etiqueta" => "45." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The consequences of continuous haemofiltration on lung mechanics and extravascular lung water in a porcine endotoxic schock model." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "B. Stein" 1 => "E. Pfenninger" 2 => "A. Grunert" 3 => "J.E. Schmitz" 4 => "A. Deller" 5 => "F. Kocher" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Intens Care Med" "fecha" => "1991" "volumen" => "17" "paginaInicial" => "293" "paginaFinal" => "298" ] ] ] ] ] ] 45 => array:3 [ "identificador" => "bib0230" "etiqueta" => "46." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Continuous arteriovenous hemofiltration therapy for Staphylococcus aureus-induced septicemia in immature swine." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "P.A. Lee" 1 => "J.R. Matson" 2 => "R.W. Pryor" 3 => "L.B. Hinshaw" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Crit Care Med" "fecha" => "1993" "volumen" => "21" "paginaInicial" => "914" "paginaFinal" => "924" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8504662" "web" => "Medline" ] ] ] ] ] ] ] ] 46 => array:3 [ "identificador" => "bib0235" "etiqueta" => "47." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Continuous arteriovenous hemofiltration countercurrent dialysis (CAVH-D) in acute respiratory distress syndrome in a polyvalent intensive care unit." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "F. Garzia" 1 => "R. Todor" 2 => "T. Scalea" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Trauma" "fecha" => "1995" "volumen" => "38" "paginaInicial" => "370" "paginaFinal" => "374" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7897719" "web" => "Medline" ] ] ] ] ] ] ] ] 47 => array:3 [ "identificador" => "bib0240" "etiqueta" => "48." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Therapeutic optimization including inhaled nitric oxide in adult respiratory distress syndrome in a polyvalent intensive care unit." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "B. Levy" 1 => "P.E. Bollaert" 2 => "P. Bauer" 3 => "L. Nace" 4 => "G. Audibert" 5 => "A. Larcan" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Trauma" "fecha" => "1995" "volumen" => "38" "paginaInicial" => "370" "paginaFinal" => "374" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7897719" "web" => "Medline" ] ] ] ] ] ] ] ] 48 => array:3 [ "identificador" => "bib0245" "etiqueta" => "49." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Improved cardiovascular stability during continuous modes of renal replacement therapy in critically ill patients with acute hepatic and renal failure." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A. Davenprt" 1 => "E.J. Will" 2 => "A.M. Davidson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Crit Care Med" "fecha" => "1993" "volumen" => "21" "paginaInicial" => "328" "paginaFinal" => "338" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8440100" "web" => "Medline" ] ] ] ] ] ] ] ] 49 => array:3 [ "identificador" => "bib0250" "etiqueta" => "50." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Treatment of surgical and non-surgical septic multiorgan failure with bicarbonate hemodialysis and sequential hemofiltration." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "L. Gotloib" 1 => "A. Shostak" 2 => "A. Lev" 3 => "R. Fundin" 4 => "J. Jaichenko" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Intens Care Med" "fecha" => "1995" "volumen" => "21" "paginaInicial" => "104" "paginaFinal" => "111" ] ] ] ] ] ] 50 => array:3 [ "identificador" => "bib0255" "etiqueta" => "51." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "La hemofiltración arteriovenosa continua en el tratamiento del síndrome de distrés respiratorio del adulto y del síndrome de disfunción multiorgánica." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "G. Díaz-Regañón" 1 => "R. Fernández" 2 => "C. Martínez" 3 => "M. Ortiz" 4 => "L. García" 5 => "S. González" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Med Intens" "fecha" => "1995" "volumen" => "19" "paginaInicial" => "449" "paginaFinal" => "453" ] ] ] ] ] ] 51 => array:3 [ "identificador" => "bib0260" "etiqueta" => "52." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "La hemofiltración arteriovenosa continua en el tratamiento del síndrome de distrés respiratorio del adulto y del síndrome de disfunción multiorgánica." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "G. Díaz-Regañón" 1 => "R. Fernández" 2 => "C. Martínez" 3 => "Ortiz" 4 => "L. García" 5 => "S. González" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Med Intens" "fecha" => "1995" "volumen" => "19" "paginaInicial" => "449" "paginaFinal" => "453" ] ] ] ] ] ] 52 => array:3 [ "identificador" => "bib0265" "etiqueta" => "53." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Necrotizing pancreatitits: operating for life." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "B.J. Miller" 1 => "A. Henderson" 2 => "R.W. Strong" 3 => "G.A. Fielding" 4 => "A.M. DiMarco" 5 => "B.S. O'Loughlin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "World J Surg" "fecha" => "1994" "volumen" => "18" "paginaInicial" => "906" "paginaFinal" => "910" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7846917" "web" => "Medline" ] ] ] ] ] ] ] ] 53 => array:3 [ "identificador" => "bib0270" "etiqueta" => "54." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Influenze of zerobalanced hemofiltration on the course of severe experimental pancreatitis in pigs." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "E.F. Yekebas" 1 => "H. Treede" 2 => "W.T. Knoefel" 3 => "C. Bloechle" 4 => "E. Fink" 5 => "J.R. Ozbocki" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Surg" "fecha" => "1999" "volumen" => "229" "paginaInicial" => "514" "paginaFinal" => "522" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10203084" "web" => "Medline" ] ] ] ] ] ] ] ] 54 => array:3 [ "identificador" => "bib0275" "etiqueta" => "55." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Principii de reanimare in pancreatitele acute grave complicate cu disfunctii multiorganice." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "F. Purcaru" 1 => "F. Ghelase" 2 => "I. Gugila" 3 => "T. Curca" 4 => "R. Nemes" 5 => "I. Georgescu" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chirurgia" "fecha" => "1997" "volumen" => "92" "paginaInicial" => "309" "paginaFinal" => "323" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9462949" "web" => "Medline" ] ] ] ] ] ] ] ] 55 => array:3 [ "identificador" => "bib0280" "etiqueta" => "56." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Acute pancreatitis: overview of medical aspects." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "S. Watanabe" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Pancreas" "fecha" => "1998" "volumen" => "16" "paginaInicial" => "307" "paginaFinal" => "311" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9548671" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/00257753/0000011500000019/v1_201307291749/S0025775300716745/v1_201307291749/es/main.assets" "Apartado" => array:4 [ "identificador" => "24087" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Original breve" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/00257753/0000011500000019/v1_201307291749/S0025775300716745/v1_201307291749/es/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775300716745?idApp=UINPBA00004N" ]
| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 0 | 3 | 3 |
| 2024 Octubre | 0 | 24 | 24 |
| 2024 Septiembre | 0 | 17 | 17 |
| 2024 Agosto | 0 | 18 | 18 |
| 2024 Julio | 0 | 6 | 6 |
| 2024 Junio | 0 | 14 | 14 |
| 2024 Mayo | 0 | 10 | 10 |
| 2024 Abril | 0 | 15 | 15 |
| 2024 Marzo | 0 | 31 | 31 |
| 2024 Febrero | 0 | 9 | 9 |
| 2024 Enero | 0 | 12 | 12 |
| 2023 Diciembre | 0 | 16 | 16 |
| 2023 Noviembre | 0 | 14 | 14 |
| 2023 Octubre | 0 | 19 | 19 |
| 2023 Septiembre | 0 | 12 | 12 |
| 2023 Agosto | 0 | 11 | 11 |
| 2023 Julio | 0 | 5 | 5 |
| 2023 Junio | 0 | 2 | 2 |
| 2023 Mayo | 1 | 3 | 4 |
| 2023 Abril | 0 | 5 | 5 |
| 2023 Marzo | 2 | 6 | 8 |
| 2023 Febrero | 0 | 5 | 5 |
| 2023 Enero | 0 | 2 | 2 |
| 2022 Diciembre | 0 | 1 | 1 |
| 2022 Noviembre | 1 | 9 | 10 |
| 2022 Octubre | 0 | 3 | 3 |
| 2022 Septiembre | 0 | 8 | 8 |
| 2022 Agosto | 0 | 9 | 9 |
| 2022 Julio | 0 | 1 | 1 |
| 2022 Junio | 0 | 5 | 5 |
| 2022 Mayo | 0 | 15 | 15 |
| 2022 Abril | 0 | 4 | 4 |
| 2022 Marzo | 1 | 0 | 1 |
| 2022 Febrero | 0 | 3 | 3 |
| 2022 Enero | 0 | 1 | 1 |
| 2021 Diciembre | 0 | 10 | 10 |
| 2021 Agosto | 0 | 4 | 4 |
| 2021 Junio | 0 | 2 | 2 |
| 2021 Mayo | 0 | 2 | 2 |
| 2021 Abril | 0 | 1 | 1 |
| 2021 Enero | 0 | 3 | 3 |
| 2020 Diciembre | 0 | 1 | 1 |
| 2020 Octubre | 0 | 3 | 3 |
| 2020 Septiembre | 0 | 7 | 7 |
| 2020 Agosto | 0 | 2 | 2 |
| 2020 Julio | 0 | 1 | 1 |
| 2020 Mayo | 0 | 7 | 7 |
| 2020 Abril | 0 | 8 | 8 |
| 2020 Marzo | 0 | 2 | 2 |
| 2020 Febrero | 0 | 1 | 1 |
| 2020 Enero | 0 | 1 | 1 |
| 2019 Diciembre | 0 | 6 | 6 |
| 2019 Noviembre | 0 | 1 | 1 |
| 2019 Octubre | 0 | 2 | 2 |
| 2019 Agosto | 0 | 2 | 2 |
| 2019 Julio | 0 | 10 | 10 |
| 2019 Junio | 0 | 4 | 4 |
| 2019 Mayo | 0 | 21 | 21 |
| 2018 Enero | 1 | 0 | 1 |
| 2017 Octubre | 2 | 2 | 4 |
| 2017 Septiembre | 5 | 6 | 11 |
| 2017 Agosto | 9 | 1 | 10 |
| 2017 Julio | 5 | 2 | 7 |
| 2017 Junio | 8 | 7 | 15 |
| 2017 Mayo | 9 | 9 | 18 |
| 2017 Abril | 11 | 10 | 21 |
| 2017 Marzo | 28 | 29 | 57 |
| 2017 Febrero | 12 | 8 | 20 |
| 2017 Enero | 13 | 2 | 15 |
| 2016 Diciembre | 28 | 5 | 33 |
| 2016 Noviembre | 39 | 3 | 42 |
| 2016 Octubre | 48 | 9 | 57 |
| 2016 Septiembre | 19 | 5 | 24 |
| 2016 Agosto | 15 | 3 | 18 |
| 2016 Julio | 10 | 4 | 14 |
| 2016 Junio | 16 | 4 | 20 |
| 2016 Mayo | 17 | 13 | 30 |
| 2016 Abril | 10 | 3 | 13 |
| 2016 Marzo | 15 | 4 | 19 |
| 2016 Febrero | 16 | 4 | 20 |
| 2016 Enero | 20 | 9 | 29 |
| 2015 Diciembre | 14 | 4 | 18 |
| 2015 Noviembre | 19 | 1 | 20 |
| 2015 Octubre | 26 | 5 | 31 |
| 2015 Septiembre | 22 | 6 | 28 |
| 2015 Agosto | 14 | 9 | 23 |
| 2015 Julio | 9 | 6 | 15 |
| 2015 Junio | 4 | 2 | 6 |
| 2015 Mayo | 13 | 2 | 15 |
| 2015 Abril | 12 | 8 | 20 |
| 2015 Marzo | 20 | 4 | 24 |
| 2015 Febrero | 7 | 4 | 11 |
| 2015 Enero | 13 | 2 | 15 |
| 2014 Diciembre | 15 | 3 | 18 |
| 2014 Noviembre | 2 | 3 | 5 |
| 2014 Octubre | 3 | 1 | 4 |
| 2014 Septiembre | 14 | 3 | 17 |
| 2014 Agosto | 9 | 3 | 12 |
| 2014 Julio | 9 | 1 | 10 |
| 2014 Junio | 15 | 1 | 16 |
| 2014 Mayo | 6 | 4 | 10 |
| 2014 Abril | 8 | 1 | 9 |
| 2014 Marzo | 3 | 3 | 6 |
| 2014 Febrero | 3 | 3 | 6 |
| 2014 Enero | 3 | 3 | 6 |
| 2013 Diciembre | 2 | 3 | 5 |
| 2013 Noviembre | 4 | 5 | 9 |
| 2013 Octubre | 6 | 2 | 8 |
| 2013 Septiembre | 5 | 1 | 6 |
| 2013 Agosto | 2 | 1 | 3 |
| 2000 Diciembre | 2961 | 0 | 2961 |
Mostrar todo
