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Riesgo de transmisión del virus de la hepatitis B de donantes de hígado anti-HBc positivos
Risk of hepatitis B virus transmission from hepatitis B core antibody-positive liver donors
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García Garzón, A. López San Román, E. Peña González, A. García Plaza" "autores" => array:5 [ 0 => array:3 [ "nombre" => "Rafael" "apellidos" => "Bárcena Marugán" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "S." "apellidos" => "García Garzón" ] 2 => array:2 [ "nombre" => "A." "apellidos" => "López San Román" ] 3 => array:2 [ "nombre" => "E." "apellidos" => "Peña González" ] 4 => array:2 [ "nombre" => "A." "apellidos" => "García Plaza" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicios de Gastroenterología. Hospital Ramón y Cajal. Madrid" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Correspondence: Servicio de Gastroenterología. Hospital Ramón y Cajal. Ctra. de Colmenar, km 9,1. 28034 Madrid." ] ] ] 1 => array:3 [ "autoresLista" => "R. Nash, R. Férnandez Muñoza, M. Mateosa" "autores" => array:3 [ 0 => array:3 [ "nombre" => "R." "apellidos" => "Nash" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 1 => array:3 [ "nombre" => "R." "apellidos" => "Férnandez Muñoza" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "M." "apellidos" => "Mateosa" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:3 [ "entidad" => "Microbiología y Virología. Hospital Ramón y Cajal. Madrid" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Risk of hepatitis B virus transmission from hepatitis B core antibody-positive liver donors" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec220781" "palabras" => array:7 [ 0 => "Hepatitis B" 1 => "Trasplante hepático" 2 => "Anti-HBc" 3 => "Anti-HBs" 4 => "Donantes" 5 => "Receptores" 6 => "Transmisión" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec220782" "palabras" => array:7 [ 0 => "Hepatitis B" 1 => "Liver transplant" 2 => "Anti-HBc" 3 => "Anti-HBs" 4 => "Donors" 5 => "Recipients" 6 => "Transmission" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Fundamento</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Estudiar el riesgo de transmitir el virus de la hepatitis B (VHB) a los receptores dehígados de donantes AgHBs negativos y anti-HBc positivos.</p> <span class="elsevierStyleSectionTitle">Pacientes y método</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se han analizado retrospectivamente los marcadores séricos del VHB (MHB) (AgHBs, anti-HBc y anti-HBs) de 43 donantes, junto con los 41 receptores de estos órganos. La determinación de MHB se realizó por ELISA, y el ADN del VHB por técnica de hibridación molecular.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Trece sueros de donantes (30,2%) presentaron algún MHB: 6 anti-HBc y anti-HBs(13,9%), 4 anti-HBc (9%) y tres anti-HBs (6,9%). De los receptores que recibieron un injertosin MHB, ninguno desarrolló infección después del trasplante de hígado. De los 13 receptores de órganos con MHB, 9 han sido controlados durante 39 (DE 17) meses. Los 5 receptores de un injerto anti-HBc positivo, con anti-HBs o sin él, y que no presentaban MHB desarrollaron hepatitis B (100%). Los dos receptores de órganos anti-HBs positivos únicamente y sin MHB no desarrollaron infección (0%). Entre los receptores 15 tenían algún MHB antes del trasplante de hígado (31,7%); 5 de ellos tenían anti-HBs positivo antes del trasplante. Los dos receptores de este grupo que recibieron un injerto anti-HBc positivo no desarrollaron infección (0%).</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">En este estudio la prevalencia de MHB entre los donantes y receptores es del 30,2 y del 31,7%, respectivamente. Los injertos anti-HBc positivos con anti-HBs o sin él transmitieronla enfermedad en el 100% de los receptores. La presencia de anti-HBs en el receptor protegió de la infección. Los injertos únicamente positivos para anti-HBs no ransmitieron la enfermedad.</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To study the hepatitis B virus (HBV) transmission from donors HBsAg–/AntiHBc+ to liver transplant recipients.</p> <span class="elsevierStyleSectionTitle">Patients and method</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">We studied retrospectively the HBV serological markers in 43 donors from our center and also the serological condition of the 41 recipients. The HBV serological markers were analyzed by ELISA and HBV DNA was detected by hybridation assays.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">13 donors samples showed some HBV serological markers: 6 anti-HBc and anti- HBs (13.9%), 4 anti-HBc (9%) and 3 anti- HBs (6.9%). There were no cases of hepatitis B amongliver recipients from donors with negative serological markers. Among the 13 recipients with HBV serological markers, 9 were followed during 39 (SD 17) months. The 5 recipients with no HBV markers, who received an anti- HBc+ with or without anti- HBs (100%) developed hepatitis B. The two liver recipients with anti-HBs solely, did not developed infection (0%). Of the 41 recipients, 15 had some HBV markers before transplant and two of them received an anti- HBc+ and did not develop the infection (0%).</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">In our study, the prevalence of serological HBV infection in donors and recipients was of 30.2 and 31.7%, respectively. Anti-HBc with or without anti-HBs donors transmitted the HBV infection in all the cases (100%) to the susceptible recipients. The presence of anti- HBs in recipients protected these against the infection. 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| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 0 | 2 | 2 |
| 2024 Octubre | 5 | 2 | 7 |
| 2024 Septiembre | 0 | 9 | 9 |
| 2024 Agosto | 0 | 3 | 3 |
| 2024 Julio | 0 | 1 | 1 |
| 2024 Junio | 0 | 2 | 2 |
| 2024 Mayo | 0 | 3 | 3 |
| 2024 Abril | 0 | 2 | 2 |
| 2024 Marzo | 0 | 18 | 18 |
| 2024 Febrero | 0 | 10 | 10 |
| 2024 Enero | 0 | 4 | 4 |
| 2023 Diciembre | 0 | 2 | 2 |
| 2023 Noviembre | 0 | 9 | 9 |
| 2023 Octubre | 0 | 8 | 8 |
| 2023 Septiembre | 0 | 7 | 7 |
| 2023 Agosto | 0 | 14 | 14 |
| 2023 Julio | 0 | 13 | 13 |
| 2023 Junio | 0 | 6 | 6 |
| 2023 Mayo | 0 | 6 | 6 |
| 2023 Abril | 0 | 10 | 10 |
| 2023 Marzo | 1 | 22 | 23 |
| 2023 Febrero | 0 | 14 | 14 |
| 2023 Enero | 0 | 7 | 7 |
| 2022 Diciembre | 0 | 5 | 5 |
| 2022 Noviembre | 0 | 3 | 3 |
| 2022 Octubre | 0 | 2 | 2 |
| 2022 Septiembre | 0 | 2 | 2 |
| 2022 Agosto | 0 | 3 | 3 |
| 2022 Julio | 0 | 2 | 2 |
| 2022 Junio | 0 | 2 | 2 |
| 2022 Mayo | 0 | 1 | 1 |
| 2022 Abril | 0 | 1 | 1 |
| 2022 Marzo | 0 | 13 | 13 |
| 2022 Febrero | 0 | 21 | 21 |
| 2022 Enero | 0 | 13 | 13 |
| 2021 Diciembre | 0 | 31 | 31 |
| 2021 Noviembre | 0 | 27 | 27 |
| 2021 Octubre | 0 | 20 | 20 |
| 2021 Septiembre | 0 | 17 | 17 |
| 2021 Agosto | 0 | 16 | 16 |
| 2021 Julio | 0 | 5 | 5 |
| 2021 Junio | 0 | 7 | 7 |
| 2021 Mayo | 0 | 5 | 5 |
| 2021 Abril | 0 | 6 | 6 |
| 2021 Marzo | 0 | 14 | 14 |
| 2021 Febrero | 0 | 6 | 6 |
| 2021 Enero | 0 | 5 | 5 |
| 2020 Diciembre | 0 | 4 | 4 |
| 2020 Noviembre | 0 | 2 | 2 |
| 2020 Octubre | 0 | 4 | 4 |
| 2020 Agosto | 0 | 8 | 8 |
| 2020 Julio | 0 | 2 | 2 |
| 2020 Junio | 0 | 9 | 9 |
| 2020 Mayo | 0 | 4 | 4 |
| 2020 Abril | 0 | 2 | 2 |
| 2020 Marzo | 0 | 3 | 3 |
| 2020 Febrero | 0 | 3 | 3 |
| 2019 Diciembre | 0 | 9 | 9 |
| 2019 Octubre | 0 | 5 | 5 |
| 2019 Septiembre | 0 | 1 | 1 |
| 2019 Agosto | 0 | 3 | 3 |
| 2019 Julio | 0 | 2 | 2 |
| 2019 Junio | 0 | 7 | 7 |
| 2019 Mayo | 0 | 25 | 25 |
| 2017 Octubre | 3 | 2 | 5 |
| 2017 Septiembre | 10 | 3 | 13 |
| 2017 Agosto | 8 | 4 | 12 |
| 2017 Julio | 4 | 0 | 4 |
| 2017 Junio | 7 | 5 | 12 |
| 2017 Mayo | 10 | 8 | 18 |
| 2017 Abril | 7 | 0 | 7 |
| 2017 Marzo | 14 | 24 | 38 |
| 2017 Febrero | 19 | 2 | 21 |
| 2017 Enero | 8 | 1 | 9 |
| 2016 Diciembre | 26 | 3 | 29 |
| 2016 Noviembre | 28 | 4 | 32 |
| 2016 Octubre | 56 | 4 | 60 |
| 2016 Septiembre | 23 | 6 | 29 |
| 2016 Agosto | 19 | 5 | 24 |
| 2016 Julio | 11 | 5 | 16 |
| 2016 Junio | 21 | 3 | 24 |
| 2016 Mayo | 17 | 9 | 26 |
| 2016 Abril | 9 | 23 | 32 |
| 2016 Marzo | 11 | 10 | 21 |
| 2016 Febrero | 20 | 7 | 27 |
| 2016 Enero | 16 | 13 | 29 |
| 2015 Diciembre | 11 | 8 | 19 |
| 2015 Noviembre | 18 | 9 | 27 |
| 2015 Octubre | 26 | 13 | 39 |
| 2015 Septiembre | 13 | 6 | 19 |
| 2015 Agosto | 9 | 1 | 10 |
| 2015 Julio | 11 | 4 | 15 |
| 2015 Junio | 6 | 0 | 6 |
| 2015 Mayo | 9 | 3 | 12 |
| 2015 Abril | 12 | 7 | 19 |
| 2015 Marzo | 16 | 2 | 18 |
| 2015 Febrero | 11 | 2 | 13 |
| 2015 Enero | 14 | 1 | 15 |
| 2014 Diciembre | 25 | 1 | 26 |
| 2014 Noviembre | 10 | 1 | 11 |
| 2014 Octubre | 10 | 0 | 10 |
| 2014 Septiembre | 6 | 0 | 6 |
| 2014 Agosto | 11 | 0 | 11 |
| 2014 Julio | 13 | 0 | 13 |
| 2014 Junio | 12 | 1 | 13 |
| 2014 Mayo | 5 | 2 | 7 |
| 2014 Abril | 5 | 1 | 6 |
| 2014 Marzo | 8 | 0 | 8 |
| 2014 Febrero | 6 | 2 | 8 |
| 2014 Enero | 5 | 2 | 7 |
| 2013 Diciembre | 8 | 3 | 11 |
| 2013 Noviembre | 3 | 12 | 15 |
| 2013 Octubre | 9 | 6 | 15 |
| 2013 Septiembre | 6 | 7 | 13 |
| 2013 Agosto | 3 | 3 | 6 |
| 2013 Julio | 1 | 0 | 1 |
| 2001 Febrero | 740 | 0 | 740 |
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