Originales
Alteraciones hormonales en mujeres jóvenes con obesidad mórbida
Hormonal alterations on young morbid obese women
Ruth Vilàa, Rosa Gutiérrezb, María Luisa Granadac, Rosa María Masanésa, María del Mar Grasaa, José Antonio Fernández Lópeza, Xavier Remesara, Xavier Formiguerab, Màrius Fozb, Marià Alemanya,
Autor para correspondencia
alemany@bio.ub.es
Correspondencia: Centre de Recerca en Nutrició i Ciència dels Aliments. Facultad de Biología. Universidad de Barcelona. Avda. Diagonal, 645. 08028 Barcelona.
Correspondencia: Centre de Recerca en Nutrició i Ciència dels Aliments. Facultad de Biología. Universidad de Barcelona. Avda. Diagonal, 645. 08028 Barcelona.
a Centre de Recerca en Nutrició i Ciència dels Aliments. Facultad de Biología. Universidad de Barcelona
b Servicios de Medicina Interna Hospital Universitari Germans Trias i Pujol. Universidad Autónoma de Barcelona. Badalona. Barcelona
c Servicios de Bioquímica. Hospital Universitari Germans Trias i Pujol. Universidad Autónoma de Barcelona. Badalona. Barcelona
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Facultad de Biología. Universidad de Barcelona" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicios de Medicina Interna Hospital Universitari Germans Trias i Pujol. Universidad Autónoma de Barcelona. Badalona. Barcelona" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Servicios de Bioquímica. Hospital Universitari Germans Trias i Pujol. Universidad Autónoma de Barcelona. Badalona. Barcelona" "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Correspondencia: Centre de Recerca en Nutrició i Ciència dels Aliments. Facultad de Biología. Universidad de Barcelona. Avda. Diagonal, 645. 08028 Barcelona." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Hormonal alterations on young morbid obese women" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2000-09-14" "fechaAceptado" => "2001-01-23" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras Clave" "identificador" => "xpalclavsec220876" "palabras" => array:4 [ 0 => "Mujeres obesas jóvenes" 1 => "Insulina" 2 => "Leptina" 3 => "Acilestrona" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec220875" "palabras" => array:4 [ 0 => "Young obese women" 1 => "Insulin" 2 => "Leptin" 3 => "Acylestrone" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Fundamento</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La obesidad humana es una enfermedad de amplia distribución que presenta una considerable variabilidad en su gravedad, manifestaciones metabólicas y endocrinas y etiología. En el presente estudio hemos determinado si en mujeres adultas jóvenes la obesidad mórbida sin complicaciones afecta con diferente intensidad los valores circulantes de hormonas que se ha postulado que intervienen en el desarrollo y mantenimiento de la obesidad.</p> <span class="elsevierStyleSectionTitle">Sujetos y método</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se estudiaron y determinaron los valores circulantes medios (desviación estándar [DE]) de las hormonas y proteínas relacionadas con el control del peso corporal en 20 mujeres obesas mórbidas (índice de masa corporal, 52,6 [8,3] kg/m2) y 10 controles de peso normal (índice de masa corporal 19,9 [2,1] kg/m2) de edades similares.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">En las mujeres obesas se evidenciaron concentraciones más altas de insulina y leptina, y más bajas de cortisol y de la globulina que se une al cortisol (CBG). No se apreciaron diferencias para la tiroxina libre, hormona estimuladora del tiroides, estrona libre, acilestrona y sulfato de deshidroepiandrosterona.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Los resultados indican que la obesidad mórbida implica la alteración de los principales sistemas hormonales que controlan la disponibilidad de energía y la respuesta a los retos externos, con la notable excepción del tiroides. Hay claras alteraciones en la insulina y leptina mientras que los cambios en el cortisol pueden estar correlacionados con factores distintos a la obesidad. Los valores de acilestrona menores de lo esperado apuntan a un posible déficit de esta señal de ponderostato en las mujeres obesas. La edad relativamente joven de las mujeres del estudio puede ayudar a explicar la relativa suavidad de los cambios hormonales observados.</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Human obesity is a widespread disease with considerable variability as to its severity, metabolic and endocrine manifestations and etiology. In the present study we have determined whether the alterations of uncomplicated severe obesity in adult young women affect with different intensity the circulating levels of hormones that have been postulated to intervenein the development and maintenance of obesity.</p> <span class="elsevierStyleSectionTitle">Subjects and method</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Age-matched 20 morbidly obese (BMI 52.6 [8.3 SD] kg/m2) and 10 normal- weight control women (BMI 19.9 [2.1 SD] kg/m2) were studied and determined the basal circulating levels of hormones and proteins related with the control of body weight.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Obese women showed higher concentrations of insulin and leptin, and lower of cortisol and cortisol-binding globulin (CBG). No significant differences were appreciated for free thyroxine, TSH, free and acylestrone and dehydroepiandrosterone-sulphate.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">The results suggest that morbid obesity implies the alteration of the main hormonal systems controlling the availability of energy and the response to external challenges, with the noteworthy exception of the thyroid. There were clear alterations of insulin and leptin, but cortisol changes could be more related to factors other than obesity. The lower than expectedlevels of acylestrone point to a possible deficit of this ponderostat signal in obese women. 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| 2014 Octubre | 34 | 0 | 34 |
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| 2014 Febrero | 25 | 0 | 25 |
| 2014 Enero | 31 | 4 | 35 |
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| 2013 Octubre | 51 | 1 | 52 |
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| 2013 Agosto | 31 | 3 | 34 |
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| 2001 Marzo | 1221 | 0 | 1221 |
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