Hiperleptinemia como factor de riesgo en hipertensión arterial asociada a obesidad
Hyperleptinemia as a risk factor in obesity-related hypertension
Cleto álvarez-Aguilaraa,**
, I Lourdes Mondragón-Jiménezb, Anel Gómez-Garcíacc, Ramón Paniagua-Sierradd, Dante Amatodd
Autor para correspondencia
calvareza@yahoo.com.mx
Correspondencia:Dr. C. Álvarez-Aguilar. Unidad de Investigación en Epidemiología Clínica. Hospital General Regional No. 1 IMSS. Delegación Michoacán.Avda. Madero Poniente, 1200. 58000 Morelia. Michoacán. México
Correspondencia:Dr. C. Álvarez-Aguilar. Unidad de Investigación en Epidemiología Clínica. Hospital General Regional No. 1 IMSS. Delegación Michoacán.Avda. Madero Poniente, 1200. 58000 Morelia. Michoacán. México
a Unidad de Investigación en Epidemiología Clínica del HGR No. 1 IMSS. Morelia. Michoacán. México
b Laboratorio de Investigación en Diabetes Mellitus tipo 2. Centro de Investigación Biomédica de Michoacán. México
c Unidad de Investigación en Enfermedades Nefrológicas.Hospital de Especialidades Centro Médico
d Nacional Siglo XXI. IMSS. México, D.F. México
Jesús Ramírez-Enríquez
Leído
5915
Vecesse ha leído el artículo
1163
Total PDF
4752
Total HTML
Compartir estadísticas
array:23 [ "pii" => "S002577530474662X" "issn" => "00257753" "doi" => "10.1016/S0025-7753(04)74662-X" "estado" => "S300" "fechaPublicacion" => "2004-10-01" "aid" => "74662" "copyright" => "Elsevier España, S.L.. Todos los derechos reservados" "copyrightAnyo" => "2004" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2004;123:766-9" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 5313 "formatos" => array:3 [ "EPUB" => 8 "HTML" => 4749 "PDF" => 556 ] ] "itemSiguiente" => array:18 [ "pii" => "S0025775304746631" "issn" => "00257753" "doi" => "10.1016/S0025-7753(04)74663-1" "estado" => "S300" "fechaPublicacion" => "2004-10-01" "aid" => "74663" "copyright" => "Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2004;123:770-4" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 521 "formatos" => array:3 [ "EPUB" => 7 "HTML" => 337 "PDF" => 177 ] ] "en" => array:10 [ "idiomaDefecto" => true "titulo" => "Nature and extent of changes in the patient's information sheets of international multicentre clinical trials as requested by Spanish Research Ethics Committees" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "770" "paginaFinal" => "774" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Tipo y magnitud de los cambios requeridos por los Comités Éticos de Investigación Clínica en las hojas de información para el paciente en los ensayos clínicos multicéntricos internacionales" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Rafael Dal-Ré, Elena Morejón, Rafael Ortega" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Rafael" "apellidos" => "Dal-Ré" ] 1 => array:2 [ "nombre" => "Elena" "apellidos" => "Morejón" ] 2 => array:2 [ "nombre" => "Rafael" "apellidos" => "Ortega" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775304746631?idApp=UINPBA00004N" "url" => "/00257753/0000012300000020/v1_201307291640/S0025775304746631/v1_201307291640/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0025775304746618" "issn" => "00257753" "doi" => "10.1016/S0025-7753(04)74661-8" "estado" => "S300" "fechaPublicacion" => "2004-10-01" "aid" => "74661" "copyright" => "Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2004;123:761-5" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 3951 "formatos" => array:3 [ "EPUB" => 7 "HTML" => 3212 "PDF" => 732 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Déficit de alfa-1-antitripsina en España (variantes deficientes PI<span class="elsevierStyleSup">*</span>S y PI<span class="elsevierStyleSup">*</span>Z): prevalencia estimada y número de sujetos calculados para cada fenotipo" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "761" "paginaFinal" => "765" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "PI<span class="elsevierStyleSup">*</span>S and PI<span class="elsevierStyleSup">*</span>Z alpha 1-antitrypsin deficiency: estimated prevalence and number of deficient subjects in spain" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Ignacio Blanco, Enrique Fernández-Bustillo, Frederick J. de Serres, Daniel Alkassam, Carmen Rodríguez Menéndez" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Ignacio" "apellidos" => "Blanco" ] 1 => array:2 [ "nombre" => "Enrique" "apellidos" => "Fernández-Bustillo" ] 2 => array:2 [ "nombre" => "Frederick J." "apellidos" => "de Serres" ] 3 => array:2 [ "nombre" => "Daniel" "apellidos" => "Alkassam" ] 4 => array:2 [ "nombre" => "Carmen" "apellidos" => "Rodríguez Menéndez" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775304746618?idApp=UINPBA00004N" "url" => "/00257753/0000012300000020/v1_201307291640/S0025775304746618/v1_201307291640/es/main.assets" ] "es" => array:15 [ "idiomaDefecto" => true "titulo" => "Hiperleptinemia como factor de riesgo en hipertensión arterial asociada a obesidad" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "766" "paginaFinal" => "769" ] ] "autores" => array:2 [ 0 => array:4 [ "autoresLista" => "Cleto álvarez-Aguilara, I Lourdes Mondragón-Jiménez, Anel Gómez-Garcíac, Ramón Paniagua-Sierrad, Dante Amatod" "autores" => array:5 [ 0 => array:4 [ "nombre" => "Cleto" "apellidos" => "álvarez-Aguilara" "email" => array:1 [ 0 => "calvareza@yahoo.com.mx" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "I" "apellidos" => "Lourdes Mondragón-Jiménez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "Anel" "apellidos" => "Gómez-Garcíac" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 3 => array:3 [ "nombre" => "Ramón" "apellidos" => "Paniagua-Sierrad" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] ] ] 4 => array:3 [ "nombre" => "Dante" "apellidos" => "Amatod" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] ] ] ] "afiliaciones" => array:4 [ 0 => array:3 [ "entidad" => "Unidad de Investigación en Epidemiología Clínica del HGR No. 1 IMSS. Morelia. Michoacán. México" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Laboratorio de Investigación en Diabetes Mellitus tipo 2. Centro de Investigación Biomédica de Michoacán. México" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Unidad de Investigación en Enfermedades Nefrológicas.Hospital de Especialidades Centro Médico" "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Nacional Siglo XXI. IMSS. México, D.F. México" "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "**" "correspondencia" => "Correspondencia:Dr. C. Álvarez-Aguilar. Unidad de Investigación en Epidemiología Clínica. Hospital General Regional No. 1 IMSS. Delegación Michoacán.Avda. Madero Poniente, 1200. 58000 Morelia. Michoacán. México" ] ] ] 1 => array:2 [ "autoresLista" => "Jesús Ramírez-Enríquez" "autores" => array:1 [ 0 => array:2 [ "nombre" => "Jesús" "apellidos" => "Ramírez-Enríquez" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Hyperleptinemia as a risk factor in obesity-related hypertension" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2003-12-03" "fechaAceptado" => "2004-06-23" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec222462" "palabras" => array:4 [ 0 => "Asma" 1 => "Mortalidad por asma" 2 => "Asma de riesgo vital" 3 => "Alternaria alternata" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec222461" "palabras" => array:4 [ 0 => "Asthma" 1 => "Asthma-associated mortality" 2 => "Vital risk asthma" 3 => "Alternaria alternata" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">FUNDAMENTO Y OBJETIVO</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Algunas observaciones otorgan un papel relevante al hongo Alternaria alternata como desencadenante de crisis de asma de riesgo vital (ARV). El objetivo de este trabajo fue determinar si las crisis de ARV de los pacientes sensibilizados a Alternaria cursan con un perfil clínico diferencial.</p> <span class="elsevierStyleSectionTitle">Pacientes y método</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Estudio descriptivo y multicéntrico (33 hospitales españoles) de 194 pacientes incluidos de forma prospectiva por padecer una crisis de ARV. Se recogieron las características y el curso clínico de la crisis, y cuando alcanzaron la estabilidad clínica se les practicaron una espirometría, pruebas cutáneas de alergia y determinación de IgE a Alternaria. Se estableció la sensibilización a Alternaria cuando la prueba cutánea o bien la IgE específica resultaron positivas.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">En 20 de los pacientes (10%) se pudo constatar sensibilización a Alternaria. En comparación con el grupo de pacientes no sensibilizados, los sensibilizados a Alternaria resultaron ser significativamente más jóvenes, con una media (DE) de edad de 35 (15) frente a 50 (21) años (p < 0,001); su ingreso hospitalario fue más corto –6,5 (5,5) frente a 9 (7) días (p = 0,039)–; se constató una mayor proporción de muertes o secuelas neurológicas graves –el 15 frente al 3% (p = 0,026)–; presentaron un mayor porcentaje de casos con sensibilización a otros alérgenos –el 68 frente al 22% (p = 0,003)– y una menor broncodilatación tras la inhalación de salbutamol –el 6 frente al 10% (p = 0,013)–.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Las características clínicas constatadas en las crisis de ARV de los pacientes sensibilizados a Alternaria parecen distinguirlos como fenotipo particular. Una conducta de evitación específica podría comportar efectos beneficiosos al prevenir crisis de ARV en los pacientes sensibilizados.</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Background and objective</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Some studies have pointed to Alternaria alternata as a trigger of fatal and near-fatal asthma (NFA) crises. The objective of this study was to determine the clinical characteristics of fatal and NFA crisis in patients sensitized to Alternaria.</p> <span class="elsevierStyleSectionTitle">Patients and method</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">One hundred ninety four patients with fatal or NFA attacks were enrolled in a multicenter (33 Spanish hospitals), prospective study. We gathered the characteristics and clinical course of the crises. We performed the following tests: spirometry, prick-test to common allergens, and specific IgE to Alternaria when patients were in stable condition. The sensitization test to Alternaria was performed when the prick-test and/or specific IgE levels were positive.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Twenty (10%) patients were sensitized to Alternaria. When compared to non-sensitized patients, Alternaria sensitized patients were significantly younger, 35 (15) vs 50 (21) years old (p < 0.001); their hospital admission length was shorter, 6.5 (5.5) against 9 (7) days (p = 0.039); they had a higher number of deaths or severe neurological sequelae, 15 vs 3% (p = 0.026); they had a higher sensitization frequency to the remaining allergens, 68 against 22% (p = 0.003); and they exhibited a fewer broncodilation response upon inhaled salbutamol, 6 vs 10% (p = 0.013).</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">The clinical characteristics of Alternaria sensitised, fatal-and NFA-patients, seem to identify a particular phenotype. Specific avoidance strategies could be useful to prevent fatal and NFA attacks.</p>" ] ] "NotaPie" => array:1 [ 0 => array:1 [ "nota" => "<p class="elsevierStyleNotepara">Este trabajo fue financiado por la Coordinación de Investigación en Salud del Instituto Mexicano delSeguro Social</p>" ] ] "bibliografia" => array:2 [ "titulo" => "REFERENCIAS BIBLIOGRáFICAS" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:35 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Obesity and hypertension" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "HP Duncan" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Diabetes Care" "fecha" => "1991" "volumen" => "14" "paginaInicial" => "488" "paginaFinal" => "504" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1864221" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Obesity as an independent risk factor: a 26- year follow-up of participants in the Framingham Heart Study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "HB Hubert" 1 => "M Feinlieb" 2 => "PM McNamara" 3 => "WP Castelli" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Circulation" "fecha" => "1983" "volumen" => "67" "paginaInicial" => "968" "paginaFinal" => "977" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6219830" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Positional cloning of the mouse obese gene and its human homologue" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "Y Zhang" 1 => "R Proenca" 2 => "M Maffei" 3 => "M Barone" 4 => "L Leopold" 5 => "JM Fridman" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/372425a0" "Revista" => array:6 [ "tituloSerie" => "Nature" "fecha" => "1994" "volumen" => "372" "paginaInicial" => "425" "paginaFinal" => "432" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7984236" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Recombinant ob protein reduces feeding and body weight in the ob/ob mouse" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "DS Weigle" 1 => "TR Bukpwski" 2 => "DC Foster" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1172/JCI118254" "Revista" => array:6 [ "tituloSerie" => "J Clin Invest" "fecha" => "1995" "volumen" => "96" "paginaInicial" => "2065" "paginaFinal" => "2070" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7560100" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Serum inmunoreactive-leptin concentrations in normal weight and obese humans" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "RV Considine" 1 => "MK Sinha" 2 => "ML Heiman" 3 => "A Kriaunciunas" 4 => "TW Stephens" 5 => "MR Nyce" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM199602013340503" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "1996" "volumen" => "334" "paginaInicial" => "292" "paginaFinal" => "295" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8532024" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Depot-and Sex-specific differences in leptin mRNA expression" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "CT Montague" 1 => "JB Pirns" 2 => "L Sanders" 3 => "JE Digby" 4 => "S Oâ'™Rahilly" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Diabetes" "fecha" => "1997" "volumen" => "46" "paginaInicial" => "342" "paginaFinal" => "347" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9032087" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Adipose tissue leptin production and plasma leptin kinetics in humans" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "S Klein" 1 => "SW Coppack" 2 => "V Mohamed-Ali" 3 => "M Landt" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Diabetes" "fecha" => "1996" "volumen" => "45" "paginaInicial" => "984" "paginaFinal" => "987" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8666153" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Human obese gene expression" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "H Masuzaki" 1 => "Y Ogawa" 2 => "N Isse" 3 => "N Satoh" 4 => "T Okazaki" 5 => "M Shigemoto" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Diabetes" "fecha" => "1995" "volumen" => "44" "paginaInicial" => "855" "paginaFinal" => "858" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7789654" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The stomach is a source of leptin" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "A Budo" 1 => "S Levasseur" 2 => "S Attoub" 3 => "S Kermorgant" 4 => "JP Laigneau" 5 => "MN Bortoluzzi" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/29547" "Revista" => array:6 [ "tituloSerie" => "Nature" "fecha" => "1998" "volumen" => "394" "paginaInicial" => "790" "paginaFinal" => "793" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9723619" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Placental leptin: an important new growth factor in intrauterine and neonatal development?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "SG Hassink" 1 => "E de Lancey" 2 => "DV Sheslow" 3 => "SM Smith- Kirwin" 4 => "DM Oâ'™Connor" 5 => "RV Considine" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Pediatrics" "fecha" => "1997" "volumen" => "100" "paginaInicial" => "1" "paginaFinal" => "6" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9200353" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Leptin in human plasma is derived in part from the brain, and cleared by the kidneys" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M Esler" 1 => "M Vaz" 2 => "G Collier" 3 => "P Nestel" 4 => "G Jennings" 5 => "D Kaye" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0140-6736(05)70290-7" "Revista" => array:5 [ "tituloSerie" => "Lancet" "fecha" => "1998" "volumen" => "351" "paginaInicial" => "879" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9525370" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0060" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "LA Campfield" 1 => "FJ Smith" 2 => "Y Guisez" 3 => "R Devos" 4 => "P Burn" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Science" "fecha" => "1995" "volumen" => "269" "paginaInicial" => "546" "paginaFinal" => "549" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7624778" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0065" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The weight-reducing effect of an intracerebroventricular bolus inyection of leptin in genetically obese fa/fa rats: reduced sensitivity compared with lean animals" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "I Cusin" 1 => "F Rohner-Jeanrenaod" 2 => "A Stricker-Krongard" 3 => "B Jeanrenaud" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Diabetes" "fecha" => "1996" "volumen" => "45" "paginaInicial" => "1446" "paginaFinal" => "1450" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8826985" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0070" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Leptin activates neurons in ventrobasal hypothalamus and brainstem" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "JK Elmquist" 1 => "RS Ahima" 2 => "E Maratos-Flier" 3 => "JS Flier" 4 => "CB Saper" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1210/endo.138.2.5033" "Revista" => array:6 [ "tituloSerie" => "Endocrinology" "fecha" => "1997" "volumen" => "138" "paginaInicial" => "839" "paginaFinal" => "842" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9003024" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0075" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Receptor-mediated regional sympathetic nerve activation by leptin" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "WG Haynes" 1 => "DA Morgan" 2 => "SA SA" 3 => "AL Mark" 4 => "WI Sivitz" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1172/JCI119532" "Revista" => array:6 [ "tituloSerie" => "J Clin Invest" "fecha" => "1997" "volumen" => "100" "paginaInicial" => "270" "paginaFinal" => "278" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9218503" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0080" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hyperleptinemia as a component of a metabolic syndrome of cardiovascular risk" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "F Leyva" 1 => "IF Godsland" 2 => "M Ghatei" 3 => "AJ Proudler" 4 => "S Aldis" 5 => "Ch Walton" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arterioscler Thromb Vasc Biol" "fecha" => "1998" "volumen" => "18" "paginaInicial" => "928" "paginaFinal" => "933" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9633933" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0085" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Increased obese mRNA expression in omental fat cell from massively obese humans" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "BS Hamilton" 1 => "D Paglia" 2 => "AYM Kwan" 3 => "M Deitel" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Nature Med" "fecha" => "1995" "volumen" => "1" "paginaInicial" => "953" "paginaFinal" => "956" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7585224" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0090" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Leptin levels in human and rodents: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjets" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M Maffei" 1 => "J Halaas" 2 => "E Ravussin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Nature Med" "fecha" => "1995" "volumen" => "1" "paginaInicial" => "1155" "paginaFinal" => "1161" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7584987" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0095" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Over-expression of the obese (ob) gene in adipose tissue of human obese subjects" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "F Lönnqvist" 1 => "P Amer" 2 => "L Nordfors" 3 => "M Schalling" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Nature Med" "fecha" => "1995" "volumen" => "1" "paginaInicial" => "950" "paginaFinal" => "953" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7585223" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0100" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Relationship between insulin sensitivity and plasma leptin concentration in lean and obese men" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "KR Segal" 1 => "M Landt" 2 => "S Klein" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Diabetes" "fecha" => "1996" "volumen" => "45" "paginaInicial" => "988" "paginaFinal" => "991" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8666154" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0105" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "High plasma immunoreactive leptin level in essential hypertension" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J Agata" 1 => "A Masuda" 2 => "M Takada" 3 => "K Higahiura" 4 => "H Murakami" 5 => "Y Miyazaki" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Hypertens" "fecha" => "1997" "volumen" => "10" "paginaInicial" => "1171" "paginaFinal" => "1174" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9370390" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib0110" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prevalencia de insuficiencia renal crónica en la población derechohabiente del Instituto Mexicano del Seguro Social" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A Dante" 1 => "S Paniagua" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Las múltiples facetas de la investigación en salud: proyectos estratégicos del Instituto Mexicano del Seguro Social" "paginaInicial" => "153" "paginaFinal" => "170" "serieFecha" => "2001" ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib0115" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "titulo" => "The Sixth Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure" ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Arch Inter Med" "fecha" => "1997" "volumen" => "157" "paginaInicial" => "2413" "paginaFinal" => "2446" ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib0120" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "titulo" => "Norma Oficial Mexicana NOM-174-11998, para el Manejo Integral de la Obesidad. Diario Oficial de la Federación México" ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Rev Med IMSS" "fecha" => "2000" "volumen" => "38" "paginaInicial" => "397" "paginaFinal" => "403" ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib0125" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "titulo" => "National Cholesterol Education Program. Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation and treatment of high blood cholesterol in adults (Adult Treatment Panel III). Bethesda: National Heart, Lung, and Blood Institute, 2002. NIH Publication N.o 01-3670. May 2001" ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "JAMA" "fecha" => "2001" "volumen" => "285" "paginaInicial" => "248697" ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib0130" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Radioimmunoassay of leptin in human plasma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "Ma Zhongmin" 1 => "RL Gingerich" 2 => "JV Santiago" 3 => "S Klein" 4 => "CH Smith" 5 => "M Land" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Chem" "fecha" => "1996" "volumen" => "42" "paginaInicial" => "942" "paginaFinal" => "946" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8665687" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib0135" "etiqueta" => "27." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Insulin secretion in diabetes mellitus" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "MA Pfeifer" 1 => "JB Halter" 2 => "D Porte Jr" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Med" "fecha" => "1981" "volumen" => "70" "paginaInicial" => "579" "paginaFinal" => "588" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7011013" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib0140" "etiqueta" => "28." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cloning of rat obese<span class="elsevierStyleSup">a</span>DNA and its expression in obese rats" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "T Murakami" 1 => "K Shima" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1006/bbrc.1995.1589" "Revista" => array:5 [ "tituloSerie" => "Biochem Biophys Res Comm" "fecha" => "1995" "volumen" => "209" "paginaInicial" => "944" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7733988" "web" => "Medline" ] ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib0145" "etiqueta" => "29." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Increased expression in adipocytes of ob RNA in mice with lesions of the hypothalamus and with mutations at the db locus" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M Maffei" 1 => "H Fei" 2 => "GH Lee" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Proc Natl Acad Sci USA" "fecha" => "1995" "volumen" => "92" "paginaInicial" => "6957" "paginaFinal" => "6960" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7624352" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib0150" "etiqueta" => "30." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Regional adiposity and mortality" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "AH Kissebah" 1 => "GR Krakower" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Physiol Rev" "fecha" => "1994" "volumen" => "74" "paginaInicial" => "761" "paginaFinal" => "811" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7938225" "web" => "Medline" ] ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib0155" "etiqueta" => "31." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Acute and chronic effect of insulin on leptin production in humans" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "JW Kolaczynski" 1 => "MR Nyce" 2 => "RV Considine" 3 => "G Boden" 4 => "JJ Nolan" 5 => "R Henry" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Diabetes" "fecha" => "1996" "volumen" => "45" "paginaInicial" => "699" "paginaFinal" => "701" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8621027" "web" => "Medline" ] ] ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib0160" "etiqueta" => "32." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Evidence that glucose metabolism regulates leptin secretion from cultured rat adipocytes" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "WM Muller" 1 => "FM Gregoire" 2 => "KL Stanhope" 3 => "CV Mobbs" 4 => "TM Mizumo" 5 => "CH Warden" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1210/endo.139.2.5716" "Revista" => array:6 [ "tituloSerie" => "Endocrinology" "fecha" => "1998" "volumen" => "139" "paginaInicial" => "551" "paginaFinal" => "558" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9449624" "web" => "Medline" ] ] ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib0165" "etiqueta" => "33." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "MW Schwatz" 1 => "DG Baskin" 2 => "TR Bukowski" 3 => "JL Kuijper" 4 => "D Foster" 5 => "G Lasser" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Diabetes" "fecha" => "1996" "volumen" => "45" "paginaInicial" => "531" "paginaFinal" => "538" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8603777" "web" => "Medline" ] ] ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib0170" "etiqueta" => "34." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Chronic leptin infusion increases arterial pressure" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "EW Shek" 1 => "MW Brands" 2 => "JE Hall" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Hypertension" "fecha" => "1998" "volumen" => "31" "paginaInicial" => "409" "paginaFinal" => "414" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9453337" "web" => "Medline" ] ] ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib0175" "etiqueta" => "35." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Leptin and other components of the metabolic syndrome in Mauritus â'" a factor analysis. Int J Obes Relat" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "AM Hodge" 1 => "EJ Boyko" 2 => "M De Courten" 3 => "PZ Zimmet" 4 => "P Chitson" 5 => "J Tuomilehto" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Metab Disord" "fecha" => "2001" "volumen" => "25" "paginaInicial" => "126" "paginaFinal" => "131" ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/00257753/0000012300000020/v1_201307291640/S002577530474662X/v1_201307291640/es/main.assets" "Apartado" => array:4 [ "identificador" => "24087" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Original breve" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/00257753/0000012300000020/v1_201307291640/S002577530474662X/v1_201307291640/es/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S002577530474662X?idApp=UINPBA00004N" ]
| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 0 | 3 | 3 |
| 2024 Octubre | 0 | 18 | 18 |
| 2024 Septiembre | 0 | 24 | 24 |
| 2024 Agosto | 0 | 15 | 15 |
| 2024 Julio | 0 | 14 | 14 |
| 2024 Junio | 0 | 22 | 22 |
| 2024 Mayo | 0 | 23 | 23 |
| 2024 Abril | 0 | 44 | 44 |
| 2024 Marzo | 0 | 21 | 21 |
| 2024 Febrero | 0 | 15 | 15 |
| 2024 Enero | 0 | 16 | 16 |
| 2023 Diciembre | 0 | 8 | 8 |
| 2023 Noviembre | 0 | 8 | 8 |
| 2023 Octubre | 0 | 31 | 31 |
| 2023 Septiembre | 0 | 4 | 4 |
| 2023 Agosto | 0 | 5 | 5 |
| 2023 Julio | 0 | 25 | 25 |
| 2023 Junio | 0 | 11 | 11 |
| 2023 Mayo | 0 | 79 | 79 |
| 2023 Abril | 0 | 19 | 19 |
| 2023 Marzo | 0 | 30 | 30 |
| 2023 Febrero | 1 | 23 | 24 |
| 2023 Enero | 0 | 26 | 26 |
| 2022 Diciembre | 0 | 10 | 10 |
| 2022 Noviembre | 0 | 22 | 22 |
| 2022 Octubre | 0 | 19 | 19 |
| 2022 Septiembre | 0 | 20 | 20 |
| 2022 Agosto | 0 | 9 | 9 |
| 2022 Julio | 0 | 7 | 7 |
| 2022 Junio | 0 | 4 | 4 |
| 2022 Abril | 0 | 10 | 10 |
| 2021 Diciembre | 1 | 2 | 3 |
| 2021 Noviembre | 0 | 2 | 2 |
| 2021 Julio | 0 | 1 | 1 |
| 2021 Mayo | 0 | 2 | 2 |
| 2021 Abril | 0 | 1 | 1 |
| 2021 Marzo | 0 | 1 | 1 |
| 2021 Febrero | 1 | 0 | 1 |
| 2020 Octubre | 0 | 2 | 2 |
| 2020 Septiembre | 0 | 2 | 2 |
| 2020 Agosto | 0 | 3 | 3 |
| 2020 Junio | 0 | 3 | 3 |
| 2020 Mayo | 0 | 1 | 1 |
| 2020 Febrero | 0 | 3 | 3 |
| 2020 Enero | 0 | 1 | 1 |
| 2019 Diciembre | 0 | 6 | 6 |
| 2019 Noviembre | 0 | 4 | 4 |
| 2019 Octubre | 0 | 2 | 2 |
| 2019 Septiembre | 0 | 3 | 3 |
| 2019 Agosto | 0 | 2 | 2 |
| 2019 Julio | 0 | 7 | 7 |
| 2019 Junio | 0 | 6 | 6 |
| 2019 Mayo | 0 | 15 | 15 |
| 2019 Abril | 0 | 12 | 12 |
| 2019 Febrero | 0 | 7 | 7 |
| 2019 Enero | 0 | 1 | 1 |
| 2018 Diciembre | 0 | 7 | 7 |
| 2018 Noviembre | 0 | 2 | 2 |
| 2018 Octubre | 0 | 11 | 11 |
| 2018 Marzo | 1 | 1 | 2 |
| 2017 Noviembre | 1 | 0 | 1 |
| 2017 Octubre | 55 | 6 | 61 |
| 2017 Septiembre | 62 | 11 | 73 |
| 2017 Agosto | 68 | 7 | 75 |
| 2017 Julio | 55 | 8 | 63 |
| 2017 Junio | 147 | 10 | 157 |
| 2017 Mayo | 112 | 10 | 122 |
| 2017 Abril | 81 | 14 | 95 |
| 2017 Marzo | 75 | 26 | 101 |
| 2017 Febrero | 55 | 5 | 60 |
| 2017 Enero | 45 | 4 | 49 |
| 2016 Diciembre | 68 | 11 | 79 |
| 2016 Noviembre | 126 | 10 | 136 |
| 2016 Octubre | 175 | 15 | 190 |
| 2016 Septiembre | 192 | 23 | 215 |
| 2016 Agosto | 64 | 11 | 75 |
| 2016 Julio | 68 | 3 | 71 |
| 2016 Junio | 81 | 13 | 94 |
| 2016 Mayo | 103 | 15 | 118 |
| 2016 Abril | 76 | 19 | 95 |
| 2016 Marzo | 85 | 19 | 104 |
| 2016 Febrero | 65 | 22 | 87 |
| 2016 Enero | 54 | 17 | 71 |
| 2015 Diciembre | 35 | 13 | 48 |
| 2015 Noviembre | 74 | 16 | 90 |
| 2015 Octubre | 79 | 25 | 104 |
| 2015 Septiembre | 66 | 16 | 82 |
| 2015 Agosto | 80 | 10 | 90 |
| 2015 Julio | 78 | 6 | 84 |
| 2015 Junio | 55 | 6 | 61 |
| 2015 Mayo | 73 | 10 | 83 |
| 2015 Abril | 94 | 22 | 116 |
| 2015 Marzo | 75 | 12 | 87 |
| 2015 Febrero | 34 | 6 | 40 |
| 2015 Enero | 40 | 4 | 44 |
| 2014 Diciembre | 81 | 6 | 87 |
| 2014 Noviembre | 67 | 0 | 67 |
| 2014 Octubre | 50 | 3 | 53 |
| 2014 Septiembre | 57 | 4 | 61 |
| 2014 Agosto | 40 | 2 | 42 |
| 2014 Julio | 40 | 4 | 44 |
| 2014 Junio | 37 | 1 | 38 |
| 2014 Mayo | 35 | 1 | 36 |
| 2014 Abril | 18 | 3 | 21 |
| 2014 Marzo | 28 | 1 | 29 |
| 2014 Febrero | 38 | 5 | 43 |
| 2014 Enero | 27 | 2 | 29 |
| 2013 Diciembre | 30 | 3 | 33 |
| 2013 Noviembre | 32 | 1 | 33 |
| 2013 Octubre | 42 | 2 | 44 |
| 2013 Septiembre | 18 | 1 | 19 |
| 2013 Agosto | 42 | 2 | 44 |
| 2013 Julio | 25 | 2 | 27 |
| 2013 Mayo | 1 | 0 | 1 |
| 2004 Diciembre | 1344 | 0 | 1344 |
Mostrar todo
