metricas
covid
Buscar en
Medicina Clínica
Toda la web
Inicio Medicina Clínica Hiperleptinemia, hiperinsulinemia y síndrome metabólico en el riesgo cardiovas...
Información de la revista

Estadísticas

Siga este enlace para acceder al texto completo del artículo

Hiperleptinemia, hiperinsulinemia y síndrome metabólico en el riesgo cardiovascular: uno para todos y todos para uno
José Ignacio Botella Carretero**
Autor para correspondencia
jibotella@hotmail.com

Correspondencia: Dr. J.I. Botella.Servicio de Endocrinología. Hospital Ramón y Cajal.Ctra. Colmenar, Km 9,100. 28034 Madrid. España
Servicio de Endocrinología. Hospital Ramón y Cajal. Madrid. España
Leído
9728
Veces
se ha leído el artículo
4353
Total PDF
5375
Total HTML
Compartir estadísticas
 array:23 [
  "pii" => "S0025775304746679"
  "issn" => "00257753"
  "doi" => "10.1016/S0025-7753(04)74667-9"
  "estado" => "S300"
  "fechaPublicacion" => "2004-10-01"
  "aid" => "74667"
  "copyright" => "Elsevier España, S.L.. Todos los derechos reservados"
  "copyrightAnyo" => "2004"
  "documento" => "article"
  "crossmark" => 0
  "subdocumento" => "edi"
  "cita" => "Med Clin. 2004;123:780-1"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:2 [
    "total" => 5927
    "formatos" => array:3 [
      "EPUB" => 5
      "HTML" => 5373
      "PDF" => 549
    ]
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S0025775304746680"
    "issn" => "00257753"
    "doi" => "10.1016/S0025-7753(04)74668-0"
    "estado" => "S300"
    "fechaPublicacion" => "2004-10-01"
    "aid" => "74668"
    "copyright" => "Elsevier España, S.L."
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "rev"
    "cita" => "Med Clin. 2004;123:782-93"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 4532
      "formatos" => array:3 [
        "EPUB" => 6
        "HTML" => 4117
        "PDF" => 409
      ]
    ]
    "es" => array:8 [
      "idiomaDefecto" => true
      "titulo" => "Conocimientos y lagunas sobre la implicación de la nutrición y la actividad física en el desarrollo de la obesidad infantil y juvenil"
      "tienePdf" => "es"
      "tieneTextoCompleto" => 0
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "782"
          "paginaFinal" => "793"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Knowledge and gaps on the role of nutrition and physical activity on the onset of childhood obesity"
        ]
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Inmaculada Bautista-Castaño, Marta Sangil-Monroy, Lluís Serra-Majem"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "Inmaculada"
              "apellidos" => "Bautista-Castaño"
            ]
            1 => array:2 [
              "nombre" => "Marta"
              "apellidos" => "Sangil-Monroy"
            ]
            2 => array:2 [
              "nombre" => "Lluís"
              "apellidos" => "Serra-Majem"
            ]
            3 => array:1 [
              "colaborador" => "en nombre del Comité de Nutrición y Obesidad Infantil de la Sociedad Española de Nutrición Comunitaria"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775304746680?idApp=UINPBA00004N"
    "url" => "/00257753/0000012300000020/v1_201307291640/S0025775304746680/v1_201307291640/es/main.assets"
  ]
  "itemAnterior" => array:18 [
    "pii" => "S0025775304746667"
    "issn" => "00257753"
    "doi" => "10.1016/S0025-7753(04)74666-7"
    "estado" => "S300"
    "fechaPublicacion" => "2004-10-01"
    "aid" => "74666"
    "copyright" => "Elsevier España, S.L."
    "documento" => "simple-article"
    "crossmark" => 0
    "subdocumento" => "edi"
    "cita" => "Med Clin. 2004;123:778-9"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 2027
      "formatos" => array:3 [
        "EPUB" => 5
        "HTML" => 1522
        "PDF" => 500
      ]
    ]
    "es" => array:7 [
      "idiomaDefecto" => true
      "titulo" => "Enfisema por déficit de alfa-1-antitripsina: ¿es realmente una enfermedad infrecuente?"
      "tienePdf" => "es"
      "tieneTextoCompleto" => 0
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "778"
          "paginaFinal" => "779"
        ]
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Marc Miravitlles"
          "autores" => array:1 [
            0 => array:2 [
              "nombre" => "Marc"
              "apellidos" => "Miravitlles"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775304746667?idApp=UINPBA00004N"
    "url" => "/00257753/0000012300000020/v1_201307291640/S0025775304746667/v1_201307291640/es/main.assets"
  ]
  "es" => array:10 [
    "idiomaDefecto" => true
    "titulo" => "Hiperleptinemia, hiperinsulinemia y síndrome metabólico en el riesgo cardiovascular: uno para todos y todos para uno"
    "tieneTextoCompleto" => 0
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "780"
        "paginaFinal" => "781"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "José Ignacio Botella Carretero"
        "autores" => array:1 [
          0 => array:4 [
            "nombre" => "José"
            "apellidos" => "Ignacio Botella Carretero"
            "email" => array:1 [
              0 => "jibotella@hotmail.com"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:1 [
            "entidad" => "Servicio de Endocrinolog&#237;a&#46; Hospital Ram&#243;n y Cajal&#46; Madrid&#46; Espa&#241;a"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#42;&#42;"
            "correspondencia" => "Correspondencia&#58; Dr&#46; J&#46;I&#46; Botella&#46;Servicio de Endocrinolog&#237;a&#46; Hospital Ram&#243;n y Cajal&#46;Ctra&#46; Colmenar&#44; Km 9&#44;100&#46; 28034 Madrid&#46; Espa&#241;a"
          ]
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2004-08-27"
    "fechaAceptado" => "2004-09-08"
    "bibliografia" => array:2 [
      "titulo" => "REFERENCIAS BIBLIOGR&#193;FICAS"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:21 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Obese&#44; new mutation in the mouse"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "AM Ingalls"
                            1 => "MD Dickie"
                            2 => "GD Snell"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Hered"
                        "fecha" => "1950"
                        "volumen" => "41"
                        "paginaInicial" => "317"
                        "paginaFinal" => "318"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14824537"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Obese and diabetes&#58; two mutant genes causing diabetesobesity syndromes in mice"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "DL Coleman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Diabetologia"
                        "fecha" => "1978"
                        "volumen" => "14"
                        "paginaInicial" => "141"
                        "paginaFinal" => "148"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/350680"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Positional cloning of the mouse obese gene and its human homologue"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "Y Zhang"
                            1 => "R Proenca"
                            2 => "M Maffei"
                            3 => "M Barone"
                            4 => "L Leopold"
                            5 => "JM Friedman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/372425a0"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nature"
                        "fecha" => "1994"
                        "volumen" => "372"
                        "paginaInicial" => "425"
                        "paginaFinal" => "432"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7984236"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of the obese gene product on body weight regulation in ob&#47;ob mice"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "MA Pelleymounter"
                            1 => "MJ Cullen"
                            2 => "MB Baker"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Science"
                        "fecha" => "1995"
                        "volumen" => "265"
                        "paginaInicial" => "540"
                        "paginaFinal" => "543"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8036499"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Recombinant mouse ob protein&#58; evidence for a peripheral signal linking adiposity and central neural"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "LA Campfield"
                            1 => "FJ Smith"
                            2 => "Y Guisez"
                            3 => "R Devos"
                            4 => "P Burn"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Science"
                        "fecha" => "1995"
                        "volumen" => "269"
                        "paginaInicial" => "546"
                        "paginaFinal" => "549"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7624778"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Weight reducing effects of the plasma protein encoded by the obese gene&#46;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "JL Halaas"
                            1 => "KS Gajiwala"
                            2 => "M Maffei"
                            3 => "SL Cohen"
                            4 => "BT Chait"
                            5 => "D Rabinowitz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Science"
                        "fecha" => "1995"
                        "volumen" => "269"
                        "paginaInicial" => "543"
                        "paginaFinal" => "546"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7624777"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Leptina&#58; implicaciones fisiol&#243;gicas y cl&#237;nicas"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "JI Botella-Carretero"
                            1 => "MD Lled&#237;n-Barbancho"
                            2 => "MA Valero-Gonz&#193;lez"
                            3 => "C Varela Dacosta"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "An Med Interna"
                        "fecha" => "2001"
                        "volumen" => "18"
                        "paginaInicial" => "152"
                        "paginaFinal" => "160"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11594183"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Leptin and hyperleptinemia &#226;&#39;&#34; from friend to foe for cardiovascular function"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "J Ren"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Endocrinol"
                        "fecha" => "2004"
                        "volumen" => "181"
                        "paginaInicial" => "1"
                        "paginaFinal" => "10"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15072562"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hiperleptinemia como factor de riesgo en hipertensi&#243;n arterial asociada a obesidad"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "C &#193;lvarez-Aguilar"
                            1 => "LI Mondrag&#243;n-Jim&#233;nez"
                            2 => "J Ram&#237;rez-Enr&#237;quez"
                            3 => "J G&#243;mez- Garc&#237;a"
                            4 => "R Paniagua-Sierra"
                            5 => "D Amato"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Med Clin &#40;Barc&#41;"
                        "fecha" => "2004"
                        "volumen" => "123"
                        "paginaInicial" => "766"
                        "paginaFinal" => "769"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "10&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Comparative analysis of plasma leptin levels in both genders of patients with essential hypertension and healthy subjects"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:7 [
                            0 => "H Canatan"
                            1 => "I Bakan"
                            2 => "M Akbulut"
                            3 => "G Baydas"
                            4 => "I Halifeoglu"
                            5 => "I Halifeoglu"
                            6 => "MF Gursu"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Endocr Res"
                        "fecha" => "2004"
                        "volumen" => "30"
                        "paginaInicial" => "95"
                        "paginaFinal" => "105"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15098923"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "11&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Serum leptin is elevated in Saudi Arabian pateints with the metabolic syndrome and coronary artery disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "N Al-Daghri"
                            1 => "K Al-Rubeau"
                            2 => "WA Bartlett"
                            3 => "O Al-Aattas"
                            4 => "AF Jones"
                            5 => "S Kumar"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Diabet Med"
                        "fecha" => "2003"
                        "volumen" => "20"
                        "paginaInicial" => "832"
                        "paginaFinal" => "837"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14510865"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "12&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Leptin&#58; a novel link between obesity&#44; diabetes&#44; cardiovascular risk and ventricular hypertrophy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "S Sader"
                            1 => "M Nian"
                            2 => "P Liu"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/01.CIR.0000081427.01306.7D"
                      "Revista" => array:6 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "2003"
                        "volumen" => "108"
                        "paginaInicial" => "644"
                        "paginaFinal" => "646"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12912793"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "13&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Interactions between leptin and the human sympathetic system"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "N Eikelis"
                            1 => "M Schlaich"
                            2 => "A Aggarwal"
                            3 => "D Kaye"
                            4 => "M Esler"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/01.HYP.0000066289.17754.49"
                      "Revista" => array:6 [
                        "tituloSerie" => "Hypertension"
                        "fecha" => "2003"
                        "volumen" => "41"
                        "paginaInicial" => "1072"
                        "paginaFinal" => "1079"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12668587"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Oxidative stress&#44; nitric oside production&#44; and renal sodium handling in leptin-induced hypertension"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J Beltowsky"
                            1 => "G Wojcicka"
                            2 => "A Marciniak"
                            3 => "A Jamroz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.lfs.2003.10.029"
                      "Revista" => array:6 [
                        "tituloSerie" => "Life Sci"
                        "fecha" => "2004"
                        "volumen" => "74"
                        "paginaInicial" => "2987"
                        "paginaFinal" => "3000"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15051422"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "15&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of leptin on endotelial function with Ob-Rb gene transfer in Zucker fatty rats"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "X Jin"
                            1 => "N Fukuda"
                            2 => "J Su"
                            3 => "H Takagi"
                            4 => "Y Lai"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Atherosclerosis"
                        "fecha" => "2003"
                        "volumen" => "169"
                        "paginaInicial" => "225"
                        "paginaFinal" => "233"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12921973"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "16&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The association between leptin and left ventricular hypertrophy&#58; a population- based cross-sectional"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M Pladevall"
                            1 => "K Williams"
                            2 => "H Guyer"
                            3 => "J Sadurni"
                            4 => "C Falces"
                            5 => "A Ribes"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/01.hjh.0000084721.53355.e4"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Hypertens"
                        "fecha" => "2003"
                        "volumen" => "21"
                        "paginaInicial" => "1467"
                        "paginaFinal" => "1473"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12872039"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "17&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Insulin resistance and chronic cardiovascular inflammatory syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "JM Fern&#193;ndez-Real"
                            1 => "W Ricart"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1210/er.2002-0010"
                      "Revista" => array:6 [
                        "tituloSerie" => "Endocr Rev"
                        "fecha" => "2003"
                        "volumen" => "24"
                        "paginaInicial" => "278"
                        "paginaFinal" => "301"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12788800"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "18&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Obesity&#44; and not insulin resistance&#44; is the major determinant of serum inflammatory cardiovascular risk markers in premenopausal women"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "HF Escobar-Morreale"
                            1 => "G Villuendas"
                            2 => "JI Botella-Carretero"
                            3 => "J Sancho"
                            4 => "JL San Mill&#193;n"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00125-003-1090-z"
                      "Revista" => array:6 [
                        "tituloSerie" => "Diabetologia"
                        "fecha" => "2003"
                        "volumen" => "46"
                        "paginaInicial" => "625"
                        "paginaFinal" => "633"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12739017"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "19&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Soluble thrombomodulin and vascular adhesion molecule-1 are associated to leptin plasma levels in obese women"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "E Porreca"
                            1 => "C Di Febbo"
                            2 => "L Fusco"
                            3 => "V Moretta"
                            4 => "M Di Nisio"
                            5 => "F Cuccurullo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Ahterosclerosis"
                        "fecha" => "2004"
                        "volumen" => "172"
                        "paginaInicial" => "175"
                        "paginaFinal" => "180"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "20&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Fasting plasma leptin&#44; tumor necrosis factor-alpha receptor and monocyte chemoattracting protein I concentrations in a population of glucose- tolerant and glucose-intolerant women&#58; impact on cardiovascular mortality"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "L Piemonti"
                            1 => "G Calori"
                            2 => "A Mercalli"
                            3 => "P Monti"
                            4 => "MP Garancini"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Diabetes Care"
                        "fecha" => "2003"
                        "volumen" => "26"
                        "paginaInicial" => "2883"
                        "paginaFinal" => "2889"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14514596"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0105"
              "etiqueta" => "21&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Relationship between IL-6&#44; leptin and adiponectin and variables of fibrinolysis in overweight and obese hypertensive patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "T Skurk"
                            1 => "V van Harmelen"
                            2 => "YM Lee"
                            3 => "A Wirth"
                            4 => "H Hauner"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1055/s-2002-38253"
                      "Revista" => array:6 [
                        "tituloSerie" => "Horm Metab Res"
                        "fecha" => "2002"
                        "volumen" => "34"
                        "paginaInicial" => "659"
                        "paginaFinal" => "663"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12660878"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "es"
  "url" => "/00257753/0000012300000020/v1_201307291640/S0025775304746679/v1_201307291640/es/main.assets"
  "Apartado" => array:4 [
    "identificador" => "55623"
    "tipo" => "SECCION"
    "es" => array:2 [
      "titulo" => "Editorial retrospectivo"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "es"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/00257753/0000012300000020/v1_201307291640/S0025775304746679/v1_201307291640/es/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775304746679?idApp=UINPBA00004N"
]
Información del artículo
ISSN: 00257753
Idioma original: Español
Datos actualizados diariamente
año/Mes Html Pdf Total
2024 Noviembre 0 6 6
2024 Octubre 0 55 55
2024 Septiembre 0 56 56
2024 Agosto 0 36 36
2024 Julio 0 57 57
2024 Junio 0 60 60
2024 Mayo 0 90 90
2024 Abril 0 72 72
2024 Marzo 0 52 52
2024 Febrero 0 56 56
2024 Enero 0 58 58
2023 Diciembre 0 78 78
2023 Noviembre 0 101 101
2023 Octubre 0 138 138
2023 Septiembre 0 120 120
2023 Agosto 0 103 103
2023 Julio 0 157 157
2023 Junio 0 112 112
2023 Mayo 0 103 103
2023 Abril 0 96 96
2023 Marzo 2 83 85
2023 Febrero 0 70 70
2023 Enero 0 60 60
2022 Diciembre 0 48 48
2022 Noviembre 0 102 102
2022 Octubre 0 113 113
2022 Septiembre 0 106 106
2022 Agosto 0 79 79
2022 Julio 0 75 75
2022 Junio 0 81 81
2022 Mayo 0 115 115
2022 Abril 0 77 77
2022 Marzo 0 110 110
2022 Febrero 0 58 58
2022 Enero 0 111 111
2021 Diciembre 0 70 70
2021 Noviembre 0 118 118
2021 Octubre 0 75 75
2021 Septiembre 0 43 43
2021 Agosto 0 31 31
2021 Julio 0 34 34
2021 Junio 0 41 41
2021 Mayo 0 80 80
2021 Abril 0 115 115
2021 Marzo 0 92 92
2021 Febrero 0 50 50
2021 Enero 0 39 39
2020 Diciembre 0 26 26
2020 Noviembre 0 28 28
2020 Octubre 0 29 29
2020 Septiembre 0 10 10
2020 Agosto 0 9 9
2020 Julio 0 2 2
2020 Junio 0 2 2
2020 Mayo 0 3 3
2020 Abril 0 4 4
2020 Marzo 0 8 8
2020 Febrero 0 2 2
2020 Enero 0 6 6
2019 Diciembre 0 8 8
2019 Noviembre 0 4 4
2019 Octubre 0 2 2
2019 Septiembre 0 4 4
2019 Agosto 0 2 2
2019 Julio 0 3 3
2019 Junio 0 16 16
2019 Mayo 0 51 51
2019 Abril 0 48 48
2019 Marzo 0 2 2
2019 Febrero 0 12 12
2018 Diciembre 0 8 8
2018 Noviembre 0 8 8
2018 Octubre 0 12 12
2017 Noviembre 2 0 2
2017 Octubre 56 5 61
2017 Septiembre 51 11 62
2017 Agosto 49 6 55
2017 Julio 50 13 63
2017 Junio 102 12 114
2017 Mayo 69 14 83
2017 Abril 54 6 60
2017 Marzo 58 35 93
2017 Febrero 40 7 47
2017 Enero 37 3 40
2016 Diciembre 50 7 57
2016 Noviembre 124 10 134
2016 Octubre 89 13 102
2016 Septiembre 34 8 42
2016 Agosto 10 5 15
2016 Julio 39 1 40
2016 Junio 80 15 95
2016 Mayo 95 12 107
2016 Abril 63 8 71
2016 Marzo 73 7 80
2016 Febrero 73 8 81
2016 Enero 55 9 64
2015 Diciembre 49 5 54
2015 Noviembre 106 17 123
2015 Octubre 96 10 106
2015 Septiembre 87 12 99
2015 Agosto 89 6 95
2015 Julio 103 3 106
2015 Junio 84 10 94
2015 Mayo 131 9 140
2015 Abril 87 14 101
2015 Marzo 135 4 139
2015 Febrero 132 3 135
2015 Enero 57 2 59
2014 Diciembre 116 4 120
2014 Noviembre 132 3 135
2014 Octubre 121 2 123
2014 Septiembre 89 5 94
2014 Agosto 85 4 89
2014 Julio 98 1 99
2014 Junio 120 2 122
2014 Mayo 102 2 104
2014 Abril 74 2 76
2014 Marzo 71 2 73
2014 Febrero 104 2 106
2014 Enero 68 3 71
2013 Diciembre 84 4 88
2013 Noviembre 96 1 97
2013 Octubre 115 10 125
2013 Septiembre 62 1 63
2013 Agosto 71 2 73
2013 Julio 47 2 49
2013 Junio 1 0 1
2013 Mayo 1 0 1
2004 Diciembre 1207 0 1207
Mostrar todo

Siga este enlace para acceder al texto completo del artículo

es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos