COVID-19
Regístrese
metricas
covid
Medicina Clínica
Suscríbase a esta revista
Buscar en
Medicina Clínica
Toda la web
Inicio Medicina Clínica Ictus en adultos jóvenes: rasgos clínicos y frecuencia de presentación en 280...
Información de la revista
Volver al artículo

Estadísticas

Siga este enlace para acceder al texto completo del artículo

Nota clínica
Ictus en adultos jóvenes: rasgos clínicos y frecuencia de presentación en 280 pacientes según el subtipo etiológico
Stroke in young adults: incidence and clinical picture in 280 patients according to their aetiological subtype
Adrià Arboixa,
Autor para correspondencia
aarboix@hscor.com

Autor para correspondencia.
, Joan Massonsa, Luís García-Erolesb, Montserrat Oliveresa
a Unidad de Enfermedades Vasculares Cerebrales, Servicio de Neurología, Capio-Hospital Universitari del Sagrat Cor, Universitat de Barcelona, Barcelona, España
b Unitat d’Organització i Sistemes d’Informació, Hospital Germans Trias i Pujol, Badalona, Barcelona, España
Leído
46
Veces
se ha leído el artículo
27
Total PDF
19
Total HTML
Compartir estadísticas
 array:24 [
  "pii" => "S0025775315006338"
  "issn" => "00257753"
  "doi" => "10.1016/j.medcli.2015.10.032"
  "estado" => "S300"
  "fechaPublicacion" => "2016-03-04"
  "aid" => "3451"
  "copyright" => "Elsevier España, S.L.U.. Todos los derechos reservados"
  "copyrightAnyo" => "2015"
  "documento" => "simple-article"
  "crossmark" => 1
  "subdocumento" => "crp"
  "cita" => "Med Clin. 2016;146:207-11"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:2 [
    "total" => 41
    "formatos" => array:2 [
      "HTML" => 16
      "PDF" => 25
    ]
  ]
  "Traduccion" => array:1 [
    "en" => array:19 [
      "pii" => "S2387020616302376"
      "issn" => "23870206"
      "doi" => "10.1016/j.medcle.2016.05.033"
      "estado" => "S300"
      "fechaPublicacion" => "2016-03-04"
      "aid" => "3451"
      "copyright" => "Elsevier España, S.L.U."
      "documento" => "simple-article"
      "crossmark" => 1
      "subdocumento" => "crp"
      "cita" => "Med Clin. 2016;146:207-11"
      "abierto" => array:3 [
        "ES" => false
        "ES2" => false
        "LATM" => false
      ]
      "gratuito" => false
      "lecturas" => array:1 [
        "total" => 0
      ]
      "en" => array:13 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Clinical report</span>"
        "titulo" => "Stroke in young adults&#58; incidence and clinical picture in 280 patients according to their aetiological subtype"
        "tienePdf" => "en"
        "tieneTextoCompleto" => "en"
        "tieneResumen" => array:2 [
          0 => "en"
          1 => "es"
        ]
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "207"
            "paginaFinal" => "211"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "es" => array:1 [
            "titulo" => "Ictus en adultos j&#243;venes&#58; rasgos cl&#237;nicos y frecuencia de presentaci&#243;n en 280 pacientes seg&#250;n el subtipo etiol&#243;gico"
          ]
        ]
        "contieneResumen" => array:2 [
          "en" => true
          "es" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "en" => true
        ]
        "contienePdf" => array:1 [
          "en" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0005"
            "etiqueta" => "Fig&#46; 1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr1.jpeg"
                "Alto" => 1636
                "Ancho" => 1625
                "Tamanyo" => 87668
              ]
            ]
            "descripcion" => array:1 [
              "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Area under the ROC curve<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;845&#59; sensitivity<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>77&#46;5&#37;&#59; specificity<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>77&#46;4&#37;&#59; positive predictive value<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>17&#46;59&#37;&#59; negative predictive value<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>98&#46;12&#37;&#59; accuracy<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>76&#46;47&#37;&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Adri&#224; Arboix, Joan Massons, Lu&#237;s Garc&#237;a-Eroles, Montserrat Oliveres"
            "autores" => array:4 [
              0 => array:2 [
                "nombre" => "Adri&#224;"
                "apellidos" => "Arboix"
              ]
              1 => array:2 [
                "nombre" => "Joan"
                "apellidos" => "Massons"
              ]
              2 => array:2 [
                "nombre" => "Lu&#237;s"
                "apellidos" => "Garc&#237;a-Eroles"
              ]
              3 => array:2 [
                "nombre" => "Montserrat"
                "apellidos" => "Oliveres"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "en"
      "Traduccion" => array:1 [
        "es" => array:9 [
          "pii" => "S0025775315006338"
          "doi" => "10.1016/j.medcli.2015.10.032"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => false
            "ES2" => false
            "LATM" => false
          ]
          "gratuito" => false
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "es"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775315006338?idApp=UINPBA00004N"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2387020616302376?idApp=UINPBA00004N"
      "url" => "/23870206/0000014600000005/v1_201606230528/S2387020616302376/v1_201606230528/en/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S0025775315003218"
    "issn" => "00257753"
    "doi" => "10.1016/j.medcli.2015.04.028"
    "estado" => "S300"
    "fechaPublicacion" => "2016-03-04"
    "aid" => "3332"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46;"
    "documento" => "article"
    "crossmark" => 1
    "subdocumento" => "rev"
    "cita" => "Med Clin. 2016;146:212-7"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 107
      "formatos" => array:2 [
        "HTML" => 42
        "PDF" => 65
      ]
    ]
    "es" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Revisi&#243;n</span>"
      "titulo" => "Actualizaci&#243;n pr&#225;ctica en s&#237;ndrome de Takotsubo"
      "tienePdf" => "es"
      "tieneTextoCompleto" => "es"
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "212"
          "paginaFinal" => "217"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Practical update of Tsaktubo syndrome"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "es" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figura 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 1127
              "Ancho" => 3000
              "Tamanyo" => 186894
            ]
          ]
          "descripcion" => array:1 [
            "es" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">A&#41; Imagen ventriculogr&#225;fica en <span class="elsevierStyleUnderline">s&#237;stole</span> de una forma t&#237;pica &#40;silueta en &#171;bote de cazar pulpos&#187; o Takotsubo&#41;&#46; Las flechas muestran la parte afecta&#46; B&#41; Imagen equivalente a la anterior de un paciente con forma at&#237;pica&#44; de predominio medioventricular&#46; En este caso el &#225;pex se contra&#237;a normalmente&#46; Las flechas se&#241;alan la parte discin&#233;tica&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Iv&#225;n J&#46; N&#250;&#241;ez-Gil, Hern&#225;n D&#46; Mej&#237;a-Renter&#237;a, Pedro Mart&#237;nez-Losas"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "Iv&#225;n J&#46;"
              "apellidos" => "N&#250;&#241;ez-Gil"
            ]
            1 => array:2 [
              "nombre" => "Hern&#225;n D&#46;"
              "apellidos" => "Mej&#237;a-Renter&#237;a"
            ]
            2 => array:2 [
              "nombre" => "Pedro"
              "apellidos" => "Mart&#237;nez-Losas"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S2387020616302194"
        "doi" => "10.1016/j.medcle.2016.05.018"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => false
          "ES2" => false
          "LATM" => false
        ]
        "gratuito" => false
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2387020616302194?idApp=UINPBA00004N"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775315003218?idApp=UINPBA00004N"
    "url" => "/00257753/0000014600000005/v1_201602210227/S0025775315003218/v1_201602210227/es/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S0025775315005291"
    "issn" => "00257753"
    "doi" => "10.1016/j.medcli.2015.10.003"
    "estado" => "S300"
    "fechaPublicacion" => "2016-03-04"
    "aid" => "3400"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46;"
    "documento" => "article"
    "crossmark" => 1
    "subdocumento" => "sco"
    "cita" => "Med Clin. 2016;146:205-6"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 61
      "formatos" => array:2 [
        "HTML" => 29
        "PDF" => 32
      ]
    ]
    "es" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Editorial</span>"
      "titulo" => "Decisiones compartidas"
      "tienePdf" => "es"
      "tieneTextoCompleto" => "es"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "205"
          "paginaFinal" => "206"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Shared decision making"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "es" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Joan M&#46;V&#46; Pons R&#224;fols, Montse Moharra Franc&#233;s"
          "autores" => array:2 [
            0 => array:2 [
              "nombre" => "Joan M&#46;V&#46;"
              "apellidos" => "Pons R&#224;fols"
            ]
            1 => array:2 [
              "nombre" => "Montse"
              "apellidos" => "Moharra Franc&#233;s"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S2387020616302315"
        "doi" => "10.1016/j.medcle.2016.05.027"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => false
          "ES2" => false
          "LATM" => false
        ]
        "gratuito" => false
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2387020616302315?idApp=UINPBA00004N"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775315005291?idApp=UINPBA00004N"
    "url" => "/00257753/0000014600000005/v1_201602210227/S0025775315005291/v1_201602210227/es/main.assets"
  ]
  "es" => array:20 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Nota cl&#237;nica</span>"
    "titulo" => "Ictus en adultos j&#243;venes&#58; rasgos cl&#237;nicos y frecuencia de presentaci&#243;n en 280 pacientes seg&#250;n el subtipo etiol&#243;gico"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "207"
        "paginaFinal" => "211"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Adri&#224; Arboix, Joan Massons, Lu&#237;s Garc&#237;a-Eroles, Montserrat Oliveres"
        "autores" => array:4 [
          0 => array:4 [
            "nombre" => "Adri&#224;"
            "apellidos" => "Arboix"
            "email" => array:1 [
              0 => "aarboix&#64;hscor&#46;com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Joan"
            "apellidos" => "Massons"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Lu&#237;s"
            "apellidos" => "Garc&#237;a-Eroles"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Montserrat"
            "apellidos" => "Oliveres"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Unidad de Enfermedades Vasculares Cerebrales&#44; Servicio de Neurolog&#237;a&#44; Capio-Hospital Universitari del Sagrat Cor&#44; Universitat de Barcelona&#44; Barcelona&#44; Espa&#241;a"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Unitat d&#8217;Organitzaci&#243; i Sistemes d&#8217;Informaci&#243;&#44; Hospital Germans Trias i Pujol&#44; Badalona&#44; Barcelona&#44; Espa&#241;a"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Autor para correspondencia&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "en" => array:1 [
        "titulo" => "Stroke in young adults&#58; incidence and clinical picture in 280 patients according to their aetiological subtype"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figura 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1639
            "Ancho" => 1625
            "Tamanyo" => 82995
          ]
        ]
        "descripcion" => array:1 [
          "es" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">&#193;rea bajo la curva ROC<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;845&#59; sensibilidad<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>77&#44;5&#37;&#59; especificidad<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>77&#44;4&#37;&#59; valor predictivo positivo<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>17&#44;59&#37;&#59; valor predictivo negativo<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>98&#44;12&#37;&#59; exactitud<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>76&#44;47&#37;&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">En las modernas sociedades industrializadas se observa un cambio en la edad cada m&#225;s avanzada de presentaci&#243;n de los ictus&#44; siendo el segmento de pacientes muy ancianos &#40;mayores de 85 a&#241;os&#41; el grupo de edad que est&#225; experimentando un mayor incremento en su frecuencia de presentaci&#243;n<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">1&#44;2</span></a>&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">En contrapartida&#44; los ictus en los adultos j&#243;venes suelen tener menos atenci&#243;n&#44; posiblemente por su menor incidencia&#44; a pesar de su significativa repercusi&#243;n sanitaria&#46; Es por ello que en el subgrupo de pacientes j&#243;venes con ictus existen aspectos de la historia natural que a&#250;n son poco conocidos&#44; como&#44; por ejemplo&#44; su perfil cl&#237;nico y su frecuencia de presentaci&#243;n en las diferentes entidades nosol&#243;gicas de la enfermedad cerebrovascular&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">El objetivo del presente estudio es doble&#46; Por un lado&#44; analizar la frecuencia de presentaci&#243;n y los rasgos cl&#237;nicos de los ictus en los adultos j&#243;venes de forma global&#44; analizando posteriormente la frecuencia en sus diferentes subtipos etiol&#243;gicos&#46; En segundo lugar&#44; efectuar un an&#225;lisis comparativo entre los adultos j&#243;venes con ictus y el resto de los pacientes&#46; Para ello analizamos una muestra de 280 pacientes consecutivos con ictus j&#243;venes&#44; extra&#237;da de un registro prospectivo hospitalario de 4&#46;592 pacientes consecutivos con enfermedad cerebrovascular aguda&#44; y que fueron asistidos durante un per&#237;odo de tiempo de 24 a&#241;os&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Pacientes y m&#233;todo</span><p id="par0020" class="elsevierStylePara elsevierViewall">Presentamos un estudio cl&#237;nico efectuado en el Servicio de Neurolog&#237;a del Hospital Universitari del Sagrat Cor de Barcelona durante 24 a&#241;os &#40;1986-2009&#44; ambos inclusive&#41; a partir del an&#225;lisis de su registro prospectivo de ictus&#46; Este registro ha sido publicado y validado previamente<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">3</span></a>&#46; Los subtipos de ictus&#44; los factores de riesgo cardiovascular y los rasgos cl&#237;nicos y etiol&#243;gicos se clasificaron de acuerdo con las recomendaciones del Comit&#233; de Expertos en Enfermedades Vasculares Cerebrales de la Societat Catalana de Neurologia<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">4</span></a>&#44; que son las utilizadas por nuestro grupo en otros trabajos<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">1&#44;5</span></a>&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Siguiendo la metodolog&#237;a y la clasificaci&#243;n de un estudio publicado recientemente&#44; se definieron los ictus en adultos j&#243;venes como aquellos ictus caracterizados por presentarse a los 55 o menos a&#241;os de edad<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">5</span></a>&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Para responder al objetivo de nuestro estudio&#44; inicialmente se incluyeron los 4&#46;597 pacientes del registro que estaban ingresados por presentar accidentes isqu&#233;micos transitorios &#40;AIT&#41;&#44; infartos cerebrales isqu&#233;micos &#40;cardioemb&#243;licos&#44; aterotromb&#243;ticos&#44; lacunares&#44; de causa inhabitual o de origen indeterminado&#41; y hemorragias cerebrales &#40;hemorragias intracerebrales&#44; hemorragias subaracnoideas&#44; hematomas subdurales y hematomas epidurales espont&#225;neos&#41;&#46; Se descartaron 5 pacientes por presentar datos cl&#237;nicos esenciales incompletos&#44; seleccion&#225;ndose finalmente la muestra definitiva de estudio que conten&#237;a un total de 4&#46;592 pacientes con ictus&#44; y que inclu&#237;a 760 pacientes con AIT&#44; 3&#46;266 pacientes con infartos cerebrales &#40;956 con infartos cardioemb&#243;licos&#44; 944 con infartos aterotromb&#243;ticos&#44; 864 con infartos lacunares&#44; 374 con infartos cerebrales de causa esencial y 128 con infartos cerebrales de etiolog&#237;a inhabitual&#41; y 566 hemorragias cerebrales &#40;473 hemorragias intracerebrales&#44; 52 hemorragias subaracnoideas&#44; 40 hematomas subdurales espont&#225;neos y un paciente con un hematoma epidural espont&#225;neo&#41;&#46; Finalmente&#44; se individualiz&#243; y analiz&#243; el subgrupo de 280 pacientes j&#243;venes con ictus de 55 o menos a&#241;os de edad&#44; que constituye la muestra del presente estudio&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Se recogieron las variables demogr&#225;ficas&#44; cl&#237;nicas y pron&#243;sticas de los pacientes incluidos en la base de datos del registro hospitalario de ictus&#46; Se consider&#243; que el infarto cerebral era de causa esencial o desconocida cuando el paciente no presentaba factores de riesgo cerebrovascular y no cumpl&#237;a criterios de cardioembolismo&#44; aterotrombosis&#44; isquemia lacunar o isquemia de causa inhabitual seg&#250;n la nomenclatura del Grupo de Estudio de Enfermedades Cerebrovasculares de la Sociedad Espa&#241;ola de Neurolog&#237;a o de las Gu&#237;as Oficiales de las Enfermedades Vasculares Cerebrales de la Societat Catalana de Neurologia<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">4</span></a>&#46; Se consider&#243; que el infarto cerebral era de causa inhabitual cuando se presentaba en un paciente en el que se hab&#237;an descartado el origen aterotromb&#243;tico&#44; cardioemb&#243;lico o lacunar y era producido&#44; entre otros&#44; por enfermedad hematol&#243;gica&#44; conectivopat&#237;a&#44; infecci&#243;n&#44; neoplasia&#44; alteraciones metab&#243;licas o por otras entidades como disecci&#243;n arterial&#44; displasia fibromuscular&#44; malformaci&#243;n arteriovenosa&#44; trombosis venosa cerebral&#44; s&#237;ndrome de moya-moya o migra&#241;a complicada<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">6</span></a>&#46; En dichos casos el ictus pod&#237;a ser la forma de inicio de la enfermedad o una complicaci&#243;n de su curso evolutivo&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Posteriormente se efectu&#243; un an&#225;lisis comparativo entre las variables analizadas en los pacientes j&#243;venes con ictus &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>280&#41; y en el resto de los pacientes &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>4&#46;312&#41;&#46; El an&#225;lisis univariante para cada variable en relaci&#243;n con la presencia de ictus j&#243;venes se efectu&#243; mediante la prueba de la t de Student para variables continuas y la prueba de la &#967;<span class="elsevierStyleSup">2</span>&#44; con la correcci&#243;n de Yates si era preciso&#44; para las variables categ&#243;ricas&#46; Se consider&#243; estad&#237;sticamente significativo un valor de p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#46; Posteriormente&#44; las variables significativas se sometieron a un estudio multivariante mediante el procedimiento de regresi&#243;n log&#237;stica utilizando un procedimiento <span class="elsevierStyleItalic">paso a paso</span>&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">El estudio fue aprobado por el Comit&#233; de &#201;tica institucional de nuestro centro hospitalario&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Resultados</span><p id="par0050" class="elsevierStylePara elsevierViewall">De los 4&#46;592 pacientes con ictus&#44; 280 &#40;6&#44;1&#37;&#41; ten&#237;an una edad de 55 a&#241;os o menos&#44; constituyendo el grupo de pacientes j&#243;venes con ictus&#46; La edad media &#40;DE&#41; de dichos pacientes era de 46&#44;1 &#40;9&#44;5&#41; a&#241;os&#46; El 67&#44;1&#37; eran varones &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>188&#41; y el 32&#44;9&#37; eran mujeres &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>92&#41;&#46; Los principales factores de riesgo cerebrovascular en orden decreciente de frecuencia fueron&#58; tabaquismo 37&#44;5&#37;&#44; HTA 33&#44;6&#37;&#44; dislipidemia 24&#44;6&#37;&#44; abuso de alcohol &#40;&#62;<span class="elsevierStyleHsp" style=""></span>80<span class="elsevierStyleHsp" style=""></span>g&#47;d&#237;a&#41; 15&#44;7&#37;&#44; diabetes mellitus 14&#44;3&#37;&#44; obesidad 6&#44;1&#37; y fibrilaci&#243;n auricular 3&#44;9&#46; La mortalidad hospitalaria fue del 2&#44;9&#37; &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>8&#41;&#46; Las causas de muerte fueron por herniaci&#243;n cerebral en 6 pacientes&#44; sepsis en uno e infecci&#243;n respiratoria en otro&#46; Se observ&#243; ausencia de limitaci&#243;n funcional al alta en el 13&#44;9&#37; de los casos&#46; La mediana de la estancia hospitalaria &#40;rango intercuartil&#41; fue de 11 &#40;7-19&#41; d&#237;as&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">La frecuencia de presentaci&#243;n de los ictus en pacientes j&#243;venes fue similar cuando se analizaron los AIT &#40;5&#44;7&#37;&#41;&#44; los infartos cerebrales &#40;5&#44;8&#37;&#41; y las hemorragias cerebrales &#40;8&#44;4&#37;&#41;&#46; Sin embargo&#44; cuando se efectu&#243; un an&#225;lisis a partir de sus diferentes subtipos etiol&#243;gicos se observaron diferencias con un porcentaje m&#237;nimo en los infartos cardioemb&#243;licos &#40;2&#44;1&#37;&#41; y en los infartos aterotromb&#243;ticos &#40;3&#44;4&#37;&#41;&#44; una frecuencia intermedia en los infartos lacunares &#40;5&#44;9&#37;&#41; y en los infartos esenciales &#40;10&#44;7&#37;&#41;&#44; y una frecuencia m&#225;xima en los infartos cerebrales de causa inhabitual &#40;36&#37;&#41;&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Cuando se efectu&#243; el an&#225;lisis comparativo entre los ictus j&#243;venes y el resto de los ictus &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#41; se observ&#243; que en los primeros eran significativamente m&#225;s frecuentes el sexo masculino&#44; el antecedente de cefalea&#44; el abuso de alcohol&#44; la toma de anovulatorios&#44; el tabaquismo y la presencia de infartos esenciales y de causa inhabitual&#46; En cambio&#44; eran menos habituales el sexo femenino&#44; la hipertensi&#243;n arterial&#44; la diabetes&#44; la cardiopat&#237;a isqu&#233;mica&#44; la fibrilaci&#243;n auricular&#44; la insuficiencia card&#237;aca congestiva&#44; la nefropat&#237;a&#44; la claudicaci&#243;n intermitente&#44; los infartos cardioemb&#243;licos y los aterotromb&#243;ticos&#44; las complicaciones respiratorias&#44; urinarias&#44; card&#237;acas e infecciosas durante el ingreso hospitalario y la mortalidad&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0065" class="elsevierStylePara elsevierViewall">Al efectuar el an&#225;lisis multivariante &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">tabla 2</a>&#41; a partir de los datos demogr&#225;ficos y cl&#237;nicos&#44; las variables significativamente asociadas a los ictus j&#243;venes de forma independiente fueron el tabaquismo &#40;OR 4&#44;23&#59; IC del 95&#37; 3&#44;02-5&#44;93&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;000&#41;&#44; la etiolog&#237;a inhabitual &#40;OR 4&#44;97&#59; IC del 95&#37; 3&#44;15-7&#44;84&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;000&#41;&#44; la cefalea &#40;OR 4&#44;57&#59; IC del 95&#37; 2&#44;59-8&#44;07&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;000&#41;&#44; el abuso de alcohol &#40;OR 3&#44;93&#59; IC del 95&#37; 2&#44;46-6&#44;29&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;000&#41;&#44; los anovulatorios &#40;OR 14&#44;07&#59; IC del 95&#37; 2&#44;37-83&#44;40&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;004&#41;&#44; la fibrilaci&#243;n auricular &#40;OR 0&#44;15&#59; IC del 95&#37; 0&#44;08-0&#44;28&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;000&#41;&#44; la hipertensi&#243;n arterial &#40;OR 0&#44;43&#59; IC del 95&#37; 0&#44;33-0&#44;57&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;000&#41;&#44; la EPOC &#40;OR 0&#44;20&#59; IC del 95&#37; 0&#44;09-0&#44;44&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;000&#41;&#44; el infarto aterotromb&#243;tico &#40;OR 0&#44;51&#59; IC del 95&#37; 0&#44;34-0&#44;77&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#44; el sexo femenino &#40;OR 0&#44;71&#59; IC del 95&#37; 0&#44;52-0&#44;97&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;029&#41;&#44; la diabetes mellitus &#40;OR 0&#44;66&#59; IC del 95&#37; 0&#44;46-0&#44;98&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;030&#41;&#44; la cardiopat&#237;a isqu&#233;mica &#40;OR 0&#44;56&#59; IC del 95&#37; 0&#44;33-0&#44;95&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;032&#41; y la claudicaci&#243;n intermitente &#40;OR 0&#44;48&#59; IC del 95&#37; 0&#44;24-0&#44;94&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;033&#41;&#46; Los resultados obtenidos del &#225;rea bajo la curva ROC se observan en la <a class="elsevierStyleCrossRef" href="#fig0005">figura 1</a>&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Discusi&#243;n</span><p id="par0070" class="elsevierStylePara elsevierViewall">En nuestro estudio se confirma que los ictus en los adultos j&#243;venes son infrecuentes&#44; present&#225;ndose en el 6&#44;1&#37; del total de los pacientes&#44; de forma similar a lo observado en otras series de la literatura m&#233;dica&#44; donde su frecuencia de presentaci&#243;n oscila entre el 5 y el 14&#37; de los casos<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">7&#8211;9</span></a>&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">Sin embargo&#44; es resaltable la existencia de una frecuencia distinta de presentaci&#243;n seg&#250;n el subtipo etiol&#243;gico&#46; En los infartos cardioemb&#243;licos y aterotromb&#243;ticos la frecuencia es baja &#40;2&#44;2 y 3&#44;5&#37;&#44; respectivamente&#41;&#46; Esto podr&#237;a ser debido a que la fibrilaci&#243;n auricular no valvular &#40;la principal cardiopat&#237;a embol&#237;gena&#41; y la enfermedad ateroscler&#243;tica de los troncos supraa&#243;rticos&#44; el substrato habitual del infarto cerebral aterotromb&#243;tico&#44; se presentan de forma caracter&#237;stica en edades avanzadas<a class="elsevierStyleCrossRefs" href="#bib0145"><span class="elsevierStyleSup">10&#8211;12</span></a>&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">En cambio&#44; es muy llamativa la elevada frecuencia del 36&#37; de adultos j&#243;venes en el subtipo etiol&#243;gico de los infartos cerebrales de causa inhabitual y del 11&#44;5&#37; de los infartos esenciales&#46; Esto coincide con lo observado en la serie de Ji et al&#46;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">13</span></a>&#44; en la que un 11&#37; de los ictus j&#243;venes son de causa indeterminada&#44; y con la serie de Balci et al&#46;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">14</span></a>&#44; que cuantifica en un 23&#37; las causas inhabituales de ictus&#44; principalmente por vasculopat&#237;as no ateroscler&#243;ticas o por una larga miscel&#225;nea de diferentes etiolog&#237;as&#46; Esto podr&#237;a relacionarse con el hecho de que las etiolog&#237;as no tradicionales de isquemia cerebral&#44; como la disecci&#243;n arterial&#44; las trombofilias y ciertas enfermedades hematol&#243;gicas y la migra&#241;a infarto&#44; se dan a edades m&#225;s tempranas y son entidades que en su historia natural pueden comenzar o pueden ocasionar precozmente un ictus<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">7&#44;9&#44;15</span></a>&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">La significativa frecuencia de ictus j&#243;venes de etiolog&#237;a esencial es un aspecto cl&#237;nico resaltable que constituye un reto diagn&#243;stico a&#250;n no resuelto y que merece los auspicios de una posterior l&#237;nea de investigaci&#243;n&#44; an&#225;lisis y estudio&#46; Trabajos recientes han demostrado&#44; sin embargo&#44; que la ateromatosis compleja del cayado a&#243;rtico y ciertas enfermedades gen&#233;ticas monocig&#243;ticas como la enfermedad de Fabry son etiolog&#237;as emergentes que deben ser prioritariamente consideradas en dicho subtipo etiol&#243;gico de ictus<a class="elsevierStyleCrossRefs" href="#bib0175"><span class="elsevierStyleSup">16&#44;17</span></a>&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">El sexo masculino m&#225;s habitual en los adultos j&#243;venes y la menor frecuencia de presentaci&#243;n en el sexo femenino se podr&#237;an relacionar con el papel protector de los estr&#243;genos en las mujeres premenop&#225;usicas&#46; Posteriormente&#44; con la menopausia&#44; el factor protector hormonal se pierde y la frecuencia de presentaci&#243;n de ictus se iguala&#44; siendo su incidencia en el subgrupo de edad muy avanzada &#40;&#62;<span class="elsevierStyleHsp" style=""></span>85 a&#241;os de edad&#41; incluso superior en el sexo femenino<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">1&#44;2</span></a>&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">Es llamativo que los factores de riesgo cerebrovascular cl&#225;sicos&#44; como la hipertensi&#243;n arterial&#44; la diabetes&#44; la cardiopat&#237;a isqu&#233;mica&#44; la claudicaci&#243;n intermitente y la fibrilaci&#243;n auricular&#44; sean menos frecuentes en los adultos j&#243;venes y&#44; en cambio&#44; el tabaquismo&#44; el abuso de alcohol y la toma de anovulatorios en las mujeres sean significativamente m&#225;s frecuentes&#46; Esto coincide con los resultados de otros estudios<a class="elsevierStyleCrossRefs" href="#bib0160"><span class="elsevierStyleSup">13&#8211;15&#44;18&#44;19</span></a>&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">Cabe resaltar el mejor pron&#243;stico evolutivo que presentan los ictus en adultos j&#243;venes y que se traduce en una menor frecuencia de complicaciones m&#233;dicas y una menor mortalidad hospitalaria&#44; aunque no existan diferencias significativas en la duraci&#243;n de la estancia hospitalaria media&#46; Dicho aspecto asistencial podr&#237;a explicarse por la necesidad de efectuar en los adultos j&#243;venes un mayor n&#250;mero de pruebas diagn&#243;sticas necesarias para poder efectuar un correcto diagn&#243;stico etiol&#243;gico&#44; puesto que en dicho subgrupo de pacientes la frecuencia de etiolog&#237;as distintas es m&#225;s alta&#44; y para poder efectuar un adecuado abordaje diagn&#243;stico a veces es preciso un elevado &#237;ndice de sospecha cl&#237;nico&#44; situaciones que pueden alargar la estancia media hospitalaria&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">En conclusi&#243;n&#44; aproximadamente menos de uno de cada 10 pacientes ingresados por un ictus es un paciente joven de 55 o menos a&#241;os de edad&#46; En dicho subgrupo de pacientes son m&#225;s habituales los infartos cerebrales de etiolog&#237;a inhabitual y su perfil cl&#237;nico est&#225; claramente diferenciado en comparaci&#243;n con el perfil del resto de los ictus cerebrales&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Conflicto de intereses</span><p id="par0110" class="elsevierStylePara elsevierViewall">Los autores declaran no tener conflicto de intereses&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:10 [
        0 => array:3 [
          "identificador" => "xres607159"
          "titulo" => "Resumen"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "abst0005"
              "titulo" => "Fundamento y objetivo"
            ]
            1 => array:2 [
              "identificador" => "abst0010"
              "titulo" => "M&#233;todos"
            ]
            2 => array:2 [
              "identificador" => "abst0015"
              "titulo" => "Resultados"
            ]
            3 => array:2 [
              "identificador" => "abst0020"
              "titulo" => "Conclusiones"
            ]
          ]
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec621059"
          "titulo" => "Palabras clave"
        ]
        2 => array:3 [
          "identificador" => "xres607158"
          "titulo" => "Abstract"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "abst0025"
              "titulo" => "Background and objective"
            ]
            1 => array:2 [
              "identificador" => "abst0030"
              "titulo" => "Methods"
            ]
            2 => array:2 [
              "identificador" => "abst0035"
              "titulo" => "Results"
            ]
            3 => array:2 [
              "identificador" => "abst0040"
              "titulo" => "Conclusions"
            ]
          ]
        ]
        3 => array:2 [
          "identificador" => "xpalclavsec621060"
          "titulo" => "Keywords"
        ]
        4 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Pacientes y m&#233;todo"
        ]
        5 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "Resultados"
        ]
        6 => array:2 [
          "identificador" => "sec0015"
          "titulo" => "Discusi&#243;n"
        ]
        7 => array:2 [
          "identificador" => "sec0020"
          "titulo" => "Conflicto de intereses"
        ]
        8 => array:2 [
          "identificador" => "xack204512"
          "titulo" => "Agradecimientos"
        ]
        9 => array:1 [
          "titulo" => "Bibliograf&#237;a"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2015-09-01"
    "fechaAceptado" => "2015-10-22"
    "PalabrasClave" => array:2 [
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec621059"
          "palabras" => array:4 [
            0 => "Ictus en adultos j&#243;venes"
            1 => "Infarto cerebral"
            2 => "Hemorragia cerebral"
            3 => "Etiolog&#237;a"
          ]
        ]
      ]
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec621060"
          "palabras" => array:4 [
            0 => "Young adult stroke"
            1 => "Cerebral infarction"
            2 => "Brain hemorrhage"
            3 => "Etiology"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "es" => array:3 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Fundamento y objetivo</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Analizar los rasgos cl&#237;nicos y la frecuencia de presentaci&#243;n de los ictus en adultos j&#243;venes &#40;55 o menos a&#241;os de edad&#41;&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">M&#233;todos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Estudio hospitalario de 280 pacientes j&#243;venes consecutivos ingresados por presentar un ictus durante un per&#237;odo de 24 a&#241;os&#46; Se efect&#250;a una comparaci&#243;n con los 4&#46;312 pacientes restantes ingresados con ictus&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Los ictus en adultos j&#243;venes representan el 6&#44;1&#37; del total de los ictus&#44; el 5&#44;7&#37; de los ataques isqu&#233;micos transitorios&#44; el 5&#44;8&#37; de los infartos cerebrales y el 8&#44;4&#37; de las hemorragias cerebrales&#46; Su frecuencia fue m&#237;nima en los infartos cardioemb&#243;licos &#40;2&#44;1&#37;&#41; y en los aterotromb&#243;ticos &#40;3&#44;4&#37;&#41;&#46; Se observ&#243; en el 5&#44;9&#37; de los lacunares y en el 10&#44;7&#37; de los infartos esenciales&#44; y su frecuencia fue m&#225;xima en los infartos de causa inhabitual &#40;36&#37;&#41;&#46; Las variables asociadas a los ictus j&#243;venes de forma independiente fueron el tabaquismo &#40;OR 4&#44;23&#59; IC del 95&#37; 3&#44;02-5&#44;93&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;000&#41;&#44; la etiolog&#237;a inhabitual &#40;OR 4&#44;97&#59; IC del 95&#37; 3&#44;15-7&#44;84&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;000&#41;&#44; la cefalea &#40;OR 4&#44;57&#59; IC del 95&#37; 2&#44;59-8&#44;07&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;000&#41;&#44; el abuso de alcohol &#40;OR 3&#44;93&#59; IC del 95&#37; 2&#44;46-6&#44;29&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;000&#41;&#44; los anovulatorios &#40;OR 14&#44;07&#59; IC del 95&#37; 2&#44;37-83&#44;40&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;004&#41;&#44; la fibrilaci&#243;n auricular &#40;OR 0&#44;15&#59; IC del 95&#37; 0&#44;08-0&#44;28&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;000&#41;&#44; la hipertensi&#243;n arterial &#40;OR 0&#44;43&#59; IC del 95&#37; 0&#44;33-0&#44;57&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;000&#41;&#44; la EPOC &#40;OR 0&#44;20&#59; IC del 95&#37; 0&#44;09-0&#44;44&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;000&#41;&#44; el infarto aterotromb&#243;tico &#40;OR 0&#44;51&#59; IC del 95&#37; 0&#44;34-0&#44;77&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#44; el sexo femenino &#40;OR 0&#44;71&#59; IC del 95&#37; 0&#44;52-0&#44;97&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;029&#41;&#44; la diabetes mellitus &#40;OR 0&#44;66&#59; IC del 95&#37; 0&#44;46-0&#44;98&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;030&#41;&#44; la cardiopat&#237;a isqu&#233;mica &#40;OR 0&#44;56&#59; IC del 95&#37; 0&#44;33-0&#44;95&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;032&#41; y la claudicaci&#243;n intermitente &#40;OR 0&#44;48&#59; IC del 95&#37; 0&#44;24-0&#44;94&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;033&#41;&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Los ictus en adultos j&#243;venes son infrecuentes &#40;6&#44;1&#37; del total&#41;&#44; pero representan el 36&#37; de los infartos de causa inhabitual&#46; Las ictus en adultos j&#243;venes presentan un perfil cl&#237;nico propio y diferenciado&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Fundamento y objetivo"
          ]
          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "M&#233;todos"
          ]
          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Resultados"
          ]
          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Conclusiones"
          ]
        ]
      ]
      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Background and objective</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To assess the clinical features and incidence rate of stroke in young adults &#40;less than 55 years of age&#41;&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Hospital-based descriptive study of 280 young inpatients consecutively admitted for stroke over a period of 24 years&#46; We conducted a comparison with the remaining 4&#44;312 patients admitted for stroke&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Stroke in young adults represented 6&#46;1&#37; of all strokes&#44; 5&#46;7&#37; of transient ischaemic attacks&#44; 5&#46;8&#37; of cerebral infarctions and 8&#46;4&#37; of brain haemorrhages&#46; However&#44; reported minimal frequency of cardioembolic &#40;2&#46;1&#37;&#41; and atherothrombotic &#40;3&#46;4&#37;&#41; infarctions&#44; accounted for 5&#46;9&#37; of lacunar and for 10&#46;7&#37; of essential infarctions and showed a maximum frequency in those infarctions of unusual aetiology &#40;36&#37;&#41;&#46; Factors independently associated with stroke in young adults were cigarette smoking &#40;OR 4&#46;23&#59; 95&#37; CI 3&#46;02-5&#46;93&#59; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;000&#41;&#44; unusual aetiology &#40;OR 4&#46;97&#59; 95&#37; CI 3&#46;15-7&#46;84&#59; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;000&#41;&#44; headache &#40;OR 4&#46;57&#59; 95&#37; CI 2&#46;59-8&#46;07&#59; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;000&#41;&#44; alcohol abuse &#40;OR 3&#46;93&#59; 95&#37; CI 2&#46;46-6&#46;29&#59; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;000&#41;&#44; oral contraceptives &#40;OR 14&#46;07&#59; 95&#37; CI 2&#46;37-83&#46;40&#59; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;004&#41;&#44; atrial fibrillation &#40;OR 0&#46;15&#59; 95&#37; CI 0&#46;08-0&#46;28&#59; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;000&#41;&#44; arterial hypertension &#40;OR 0&#46;43&#59; 95&#37; CI 0&#46;33-0&#46;57&#59; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;000&#41;&#44; COPD &#40;OR 0&#46;20&#59; 95&#37; CI 0&#46;09-0&#46;44&#59; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;000&#41;&#44; atherothrombotic infarction &#40;OR 0&#46;51&#59; 95&#37; CI 0&#46;34-0&#46;77&#59; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;001&#41;&#44; female sex &#40;OR 0&#46;71&#59; 95&#37; CI 0&#46;52-0&#46;97&#59; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;029&#41;&#44; diabetes mellitus &#40;OR 0&#46;66&#59; 95&#37; CI 0&#46;46-0&#46;98&#59; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;030&#41;&#44; ischaemic heart disease &#40;OR 0&#46;56&#59; 95&#37; CI 0&#46;33-0&#46;95&#59; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;032&#41; and intermittent claudication &#40;OR 0&#46;48&#59; 95&#37; CI 0&#46;24-0&#46;94&#59; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;033&#41;&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Stroke in young adults is infrequent &#40;6&#46;1&#37; of the total&#41;&#44; but represents the highest frequency of cerebral infarcts of unusual aetiology &#40;36&#37;&#41;&#46; We conclude that stroke in younger patients presents its own and differentiated clinical profile&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Background and objective"
          ]
          1 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "Methods"
          ]
          2 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Results"
          ]
          3 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Conclusions"
          ]
        ]
      ]
    ]
    "multimedia" => array:3 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figura 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1639
            "Ancho" => 1625
            "Tamanyo" => 82995
          ]
        ]
        "descripcion" => array:1 [
          "es" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">&#193;rea bajo la curva ROC<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;845&#59; sensibilidad<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>77&#44;5&#37;&#59; especificidad<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>77&#44;4&#37;&#59; valor predictivo positivo<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>17&#44;59&#37;&#59; valor predictivo negativo<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>98&#44;12&#37;&#59; exactitud<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>76&#44;47&#37;&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "tbl0005"
        "etiqueta" => "Tabla 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:3 [
          "leyenda" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">DE&#58; desviaci&#243;n est&#225;ndar&#59; EPOC&#58; enfermedad pulmonar obstructiva cr&#243;nica&#59; RIC&#58; rango intercuartil&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Variable&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Pacientes j&#243;venes &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>280&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Resto de los pacientes &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>4&#46;312&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleItalic">Datos demogr&#225;ficos y cl&#237;nicos</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Sexo var&#243;n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">188 &#40;67&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#46;084 &#40;48&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Edad en a&#241;os&#44; media &#40;DE&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">46&#44;1 &#40;DE 9&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">77&#44;6 &#40;DE 8&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Edad igual o mayor a 85 a&#241;os&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;013 &#40;23&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Hipertensi&#243;n arterial&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">94 &#40;33&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#46;576 &#40;59&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Diabetes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">40 &#40;14&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">990 &#40;23&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Valvulopat&#237;a card&#237;aca&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">17 &#40;6&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">268 &#40;26&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;923&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Cardiopat&#237;a isqu&#233;mica&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">17 &#40;6&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">665 &#40;15&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Fibrilaci&#243;n auricular&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11 &#40;3&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;225 &#40;28&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Insuficiencia card&#237;aca congestiva&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3 &#40;1&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">218 &#40;5&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;003&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Ataque isqu&#233;mico transitorio&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">20 &#40;7&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">504 &#40;11&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;020&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Infarto cerebral previo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">23 &#40;8&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">670 &#40;15&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Cefalea&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">25 &#40;8&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">69 &#40;1&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>EPOC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7 &#40;2&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">391 &#40;9&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Nefropat&#237;a&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2 &#40;0&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">166 &#40;3&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;007&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Claudicaci&#243;n intermitente&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10 &#40;3&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">352 &#40;8&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;006&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Obesidad&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">17 &#40;6&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">182 &#40;4&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;141&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Abuso alcohol &#40;&#62;<span class="elsevierStyleHsp" style=""></span>80<span class="elsevierStyleHsp" style=""></span>g&#47;d&#237;a&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">44 &#40;15&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">90 &#40;2&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Anovulatorios&#47;tratamiento hormonal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7 &#40;2&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3 &#40;0&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Anticoagulantes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11 &#40;3&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">224 &#40;5&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;351&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Tabaquismo &#40;&#62;<span class="elsevierStyleHsp" style=""></span>20 cigarrillos&#47;d&#237;a&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">105 &#40;37&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">382 &#40;8&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Dislipidemia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">69 &#40;24&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">858 &#40;19&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;055&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Inicio s&#250;bito&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">150 &#40;53&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#46;286 &#40;53&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;856&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Cefalea&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">78 &#40;27&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">541 &#40;12&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Crisis comiciales precoces&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10 &#40;3&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">80 &#40;1&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;045&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>N&#225;useas&#47;v&#243;mitos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">38 &#40;13&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">346 &#40;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Disminuci&#243;n de conciencia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">32 &#40;11&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">818 &#40;19&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;002&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Hemiparesia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">169 &#40;60&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&#46;050 &#40;70&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>D&#233;ficit sensitivo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">135 &#40;48&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;364 &#40;31&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Hemianopsia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">44 &#40;15&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">657 &#40;15&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;829&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Trastorno del lenguaje&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">92 &#40;32&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#46;244 &#40;52&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Ataxia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">19 &#40;6&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">279 &#40;6&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;836&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Par&#225;lisis de nervios craneales&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">18 &#40;6&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">211 &#40;4&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;253&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleItalic">Subtipos etiol&#243;gicos</span><a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Ataques isqu&#233;micos transitorios&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">43 &#40;15&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">717 &#40;16&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Infartos cardioemb&#243;licos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">20 &#40;7&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">936 &#40;21&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Infartos aterotromb&#243;ticos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">32 &#40;11&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">912 &#40;21&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;004&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Infartos lacunares&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">51 &#40;18&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">813 &#40;18&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Infartos de etiolog&#237;a esencial&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">40 &#40;14&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">334 &#40;7&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;005&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Infartos de causa inhabitual<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">46 &#40;16&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">82 &#40;1&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Hemorragia intracerebral&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">40 &#40;14&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">433 &#40;10&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Hemorragia subaracnoidea&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7 &#40;2&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">45 &#40;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Hematoma subdural espont&#225;neo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1 &#40;0&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">39 &#40;0&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Hematoma epidural espont&#225;neo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1 &#40;0&#44;02&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleItalic">Datos pron&#243;sticos y evolutivos</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Ausencia de limitaci&#243;n al alta&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">39 &#40;13&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">550 &#40;12&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;569&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Complicaciones respiratorias&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5 &#40;1&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">400 &#40;9&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Infecciones urinarias&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5 &#40;1&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">332 &#40;7&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Complicaciones card&#237;acas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2 &#40;0&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">172 &#40;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;005&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Complicaciones vasculares&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4 &#40;1&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">60 &#40;1&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;959&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Complicaciones infecciosas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11 &#40;3&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">564 &#40;13&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Mortalidad hospitalaria&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8 &#40;2&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">550 &#40;12&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Estancia hospitalaria&#44; mediana &#40;RIC&#41;<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">c</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11 &#40;7-19&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11 &#40;7-19&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;639&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab994179.png"
              ]
            ]
          ]
          "notaPie" => array:3 [
            0 => array:3 [
              "identificador" => "tblfn0005"
              "etiqueta" => "a"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0005">&#967;<span class="elsevierStyleSup">2</span> con correcci&#243;n de Bonferroni&#46;</p>"
            ]
            1 => array:3 [
              "identificador" => "tblfn0010"
              "etiqueta" => "b"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Etiolog&#237;as inhabituales&#58; enfermedades hematol&#243;gicas 11&#44; migra&#241;a infarto 10&#44; arteritis inflamatorias 5&#44; trombosis venosa cerebral 5&#44; arteritis infecciosa 4&#44; embolismo desde malformaciones vasculares 4&#44; disecci&#243;n arterial 3&#44; homocistinuria uno&#44; coca&#237;na uno&#44; s&#237;ndrome moya-moya uno&#44; s&#237;ndrome MELAS uno&#46;</p>"
            ]
            2 => array:3 [
              "identificador" => "tblfn0015"
              "etiqueta" => "c"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0015">Prueba U de Mann-Whitney&#46;</p>"
            ]
          ]
        ]
        "descripcion" => array:1 [
          "es" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Resultados del an&#225;lisis comparativo univariante entre los pacientes j&#243;venes &#40;55 o menos a&#241;os de edad&#41; con ictus y el resto de los pacientes</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "tbl0010"
        "etiqueta" => "Tabla 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">EPOC&#58; enfermedad pulmonar obstructiva cr&#243;nica&#59; IC&#58; intervalo de confianza&#59; OR&#58; <span class="elsevierStyleItalic">odds ratio</span>&#46;</p><p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">&#946;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#8722;2&#44;156&#59; SE &#40;&#946;&#41;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;137&#59; bondad de ajuste &#967;<span class="elsevierStyleSup">2</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>6&#44;686&#59; <span class="elsevierStyleItalic">gl</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>8&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;571&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Variable&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">&#946;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">SE &#40;&#946;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">OR &#40;IC del 95&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " colspan="5" align="left" valign="top"><span class="elsevierStyleItalic">Modelo estad&#237;stico basado en variables demogr&#225;ficas&#44; factores de riesgo vascular cerebral y de subtipo etiol&#243;gico</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Tabaquismo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;443&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;172&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&#44;23 &#40;3&#44;02-5&#44;93&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Etiolog&#237;a inhabitual&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;603&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;233&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&#44;97 &#40;3&#44;15-7&#44;84&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Cefalea&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;520&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;290&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&#44;57 &#40;2&#44;59-8&#44;07&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Abuso de alcohol&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;369&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;240&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&#44;93 &#40;2&#44;46-6&#44;29&#41; 0&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Anovulatorios&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#44;644&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;908&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">14&#44;07 &#40;2&#44;37-83&#44;40&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;004&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Fibrilaci&#243;n auricular&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;1&#44;901&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;316&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;15 &#40;0&#44;08-0&#44;28&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Hipertensi&#243;n arterial&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#44;842&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;143&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;43 &#40;0&#44;33-0&#44;57&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>EPOC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;1&#44;626&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;411&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;20 &#40;0&#44;09-0&#44;44&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Infarto aterotromb&#243;tico&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#44;672&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;211&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;51 &#40;0&#44;34-0&#44;77&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Sexo femenino&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#44;346&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;158&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;71 &#40;0&#44;52-0&#44;97&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;029&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Diabetes mellitus&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#44;410&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;189&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;66 &#40;0&#44;46-0&#44;98&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;030&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Cardiopat&#237;a coronaria&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#44;575&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;268&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;56 &#40;0&#44;33-0&#44;95&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;032&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Claudicaci&#243;n intermitente&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#44;743&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;349&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;48 &#40;0&#44;24-0&#44;94&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;033&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab994180.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "es" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Variables cl&#237;nicas asociadas de forma independiente con los pacientes j&#243;venes &#40;55 o menos a&#241;os de edad&#41; con ictus</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "Bibliograf&#237;a"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:19 [
            0 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Stroke in the very old&#58; Myths and realities"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46; Serrano-Villar"
                            1 => "G&#46; Fresco"
                            2 => "P&#46; Ruiz-Artacho"
                            3 => "A&#46; Bravo"
                            4 => "C&#46; Valencia"
                            5 => "M&#46; Fuentes-Ferrer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Med Clin &#40;Barc&#41;"
                        "fecha" => "2013"
                        "volumen" => "140"
                        "paginaInicial" => "53"
                        "paginaFinal" => "58"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0105"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lacunar infarcts in patients aged 85 years and older"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "A&#46; Arboix"
                            1 => "L&#46; Garcia-Eroles"
                            2 => "J&#46; Massons"
                            3 => "M&#46; Oliveres"
                            4 => "C&#46; Targa"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Acta Neurol Scand"
                        "fecha" => "2000"
                        "volumen" => "101"
                        "paginaInicial" => "25"
                        "paginaFinal" => "29"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10660148"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0110"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "An&#225;lisis de 1&#46;000 pacientes consecutivos con enfermedad cerebrovascular aguda&#46; Registro de patolog&#237;a vascular cerebral de la Alianza-Hospital Central de Barcelona"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "A&#46; Arboix"
                            1 => "J&#46; Massons"
                            2 => "M&#46; Oliveres"
                            3 => "L&#46; Garc&#237;a"
                            4 => "F&#46; Titus"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Med Clin &#40;Barc&#41;"
                        "fecha" => "1993"
                        "volumen" => "101"
                        "paginaInicial" => "281"
                        "paginaFinal" => "285"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0115"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Official guidelines for diagnosis and treatment"
                      "autores" => array:1 [
                        0 => array:2 [
                          "colaboracion" => "Catalan Society of Neurology"
                          "etal" => false
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:7 [
                        "edicion" => "2nd ed&#46;"
                        "titulo" => "Cerebrovascular diseases"
                        "fecha" => "2011"
                        "paginaInicial" => "159"
                        "paginaFinal" => "240"
                        "editorial" => "Societat Catalana de Neurologia"
                        "editorialLocalizacion" => "Barcelona"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0120"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical characteristics of acute lacunar stroke in young adults"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "A&#46; Arboix"
                            1 => "S&#46; Est&#233;vez"
                            2 => "R&#46; Rouco"
                            3 => "M&#46; Oliveres"
                            4 => "M&#46; Garc&#237;a-Eroles"
                            5 => "J&#46; Massons"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1586/14737175.2015.1049997"
                      "Revista" => array:6 [
                        "tituloSerie" => "Expert Rev Neurother"
                        "fecha" => "2015"
                        "volumen" => "15"
                        "paginaInicial" => "825"
                        "paginaFinal" => "831"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26004806"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0125"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Ischemic stroke of unusual cause&#58; Clinical features&#44; etiology and outcome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "A&#46; Arboix"
                            1 => "S&#46; Bechich"
                            2 => "M&#46; Oliveres"
                            3 => "M&#46; Garc&#237;a-Eroles"
                            4 => "J&#46; Massons"
                            5 => "C&#46; Targa"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Neurol"
                        "fecha" => "2001"
                        "volumen" => "8"
                        "paginaInicial" => "133"
                        "paginaFinal" => "139"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11430270"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0130"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Classification analysis of young stroke in Zhuhai city&#44; China"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "Z&#46; Li"
                            1 => "J&#46; Wang"
                            2 => "S&#46; Luo"
                            3 => "J&#46; Wei"
                            4 => "X&#46; Hu"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.7243/2052-6946-1-2"
                      "Revista" => array:4 [
                        "tituloSerie" => "Neurosci Discov"
                        "fecha" => "2013"
                        "volumen" => "1"
                        "paginaInicial" => "2"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0135"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Causes of ischemic stroke in young adults in Thailand&#58; A pilot study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "P&#46;A&#46; Dharmasaroja"
                            1 => "S&#46; Muengtaweepongsa"
                            2 => "C&#46; Lechawanich"
                            3 => "J&#46; Pattaraarchachai"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jstrokecerebrovasdis.2010.01.004"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Stroke Cerebrovasc Dis"
                        "fecha" => "2011"
                        "volumen" => "20"
                        "paginaInicial" => "247"
                        "paginaFinal" => "250"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20580256"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0140"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Demographic and geographic vascular risk factor differences in European young adults with ischemic stroke&#58; The 15 cities young stroke study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; Putaala"
                            1 => "N&#46; Yesilot"
                            2 => "U&#46; Waje-Andreassen"
                            3 => "J&#46; Pitkaniemi"
                            4 => "S&#46; Vassilopoulou"
                            5 => "K&#46; Nardi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/STROKEAHA.112.662866"
                      "Revista" => array:6 [
                        "tituloSerie" => "Stroke"
                        "fecha" => "2012"
                        "volumen" => "43"
                        "paginaInicial" => "2624"
                        "paginaFinal" => "2630"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22798330"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0145"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Atrial fibrillation and stroke&#58; Clinical presentation of cardioembolic versus atherothrombotic infarction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "A&#46; Arboix"
                            1 => "L&#46; Garc&#237;a Eroles"
                            2 => "J&#46;B&#46; Massons"
                            3 => "M&#46; Oliveres"
                            4 => "R&#46; Pujades"
                            5 => "C&#46; Targa"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Cardiol"
                        "fecha" => "2000"
                        "volumen" => "73"
                        "paginaInicial" => "33"
                        "paginaFinal" => "42"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10748308"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0150"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mechanisms of second and further strokes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "H&#46; Yamamoto"
                            1 => "J&#46; Bogousslavsky"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Neurol Neurosurg Psychiatry"
                        "fecha" => "1998"
                        "volumen" => "64"
                        "paginaInicial" => "771"
                        "paginaFinal" => "776"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9647308"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0155"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Guidelines for the management of spontaneous intracerebral hemorrhage&#58; A guideline for healthcare professionals from the American Heart Association&#47;American Stroke Association"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "American Heart Association Stroke Council and Council on Cardiovascular Nursing"
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46;B&#46; Morgenstern"
                            1 => "J&#46;C&#46; Hemphill 3rd"
                            2 => "C&#46; Anderson"
                            3 => "K&#46; Becker"
                            4 => "J&#46;P&#46; Broderick"
                            5 => "E&#46;S&#46; Connolly Jr&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/STR.0b013e3181ec611b"
                      "Revista" => array:6 [
                        "tituloSerie" => "Stroke"
                        "fecha" => "2010"
                        "volumen" => "41"
                        "paginaInicial" => "2108"
                        "paginaFinal" => "2129"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20651276"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0160"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Ischemic stroke and transient ischemic attack in young adults&#58; Risk factors&#44; diagnostic yield&#44; neuroimaging&#44; and thrombolysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "R&#46; Ji"
                            1 => "L&#46;H&#46; Schwamm"
                            2 => "M&#46;A&#46; Pervez"
                            3 => "A&#46;B&#46; Singhal"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/jamaneurol.2013.575"
                      "Revista" => array:6 [
                        "tituloSerie" => "JAMA Neurol&#46;"
                        "fecha" => "2013"
                        "volumen" => "70"
                        "paginaInicial" => "51"
                        "paginaFinal" => "57"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23108720"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0165"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Ischemic stroke in young adults&#58; Risk factors&#44; subtypes&#44; and prognosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "K&#46; Balci"
                            1 => "U&#46; Utku"
                            2 => "T&#46; Asil"
                            3 => "Y&#46; Celik"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/NRL.0b013e3181f954a7"
                      "Revista" => array:6 [
                        "tituloSerie" => "Neurologist&#46;"
                        "fecha" => "2011"
                        "volumen" => "17"
                        "paginaInicial" => "16"
                        "paginaFinal" => "20"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21192186"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0170"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Analysis of 1008 consecutive patients aged 15 to 49 with first-ever ischemic stroke&#58; The Helsinki young stroke registry"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; Putaala"
                            1 => "A&#46;J&#46; Metso"
                            2 => "T&#46;M&#46; Metso"
                            3 => "N&#46; Konkola"
                            4 => "Y&#46; Kraemer"
                            5 => "E&#46; Haapaniemi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/STROKEAHA.108.529883"
                      "Revista" => array:6 [
                        "tituloSerie" => "Stroke"
                        "fecha" => "2009"
                        "volumen" => "40"
                        "paginaInicial" => "1195"
                        "paginaFinal" => "1203"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19246709"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0175"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Acute cerebrovascular diseases in the young&#58; The Stroke in Young Fabry Patients study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Rolfs"
                            1 => "F&#46; Fazekas"
                            2 => "U&#46; Grittner"
                            3 => "M&#46; Dichgans"
                            4 => "P&#46; Martus"
                            5 => "M&#46; Holzhausen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/STROKEAHA.112.663708"
                      "Revista" => array:6 [
                        "tituloSerie" => "Stroke"
                        "fecha" => "2013"
                        "volumen" => "44"
                        "paginaInicial" => "340"
                        "paginaFinal" => "349"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23306324"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0180"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Ateromatosis compleja del cayado a&#243;rtico&#58; estudio de 71 pacientes con infartos lacunares"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46; Arboix"
                            1 => "M&#46; Rexach"
                            2 => "M&#46; Subir&#224;"
                            3 => "R&#46; Pujadas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Med Clin &#40;Barc&#41;"
                        "fecha" => "2012"
                        "volumen" => "138"
                        "paginaInicial" => "160"
                        "paginaFinal" => "164"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0185"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Predictive clinical factors of in-hospital mortality in 231 consecutive patients with cardioembolic cerebral infarction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46; Arboix"
                            1 => "L&#46; Garc&#237;a-Eroles"
                            2 => "J&#46; Massons"
                            3 => "M&#46; Oliveres"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cerebrovasc Dis"
                        "fecha" => "1998"
                        "volumen" => "8"
                        "paginaInicial" => "8"
                        "paginaFinal" => "13"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9767194"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0190"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cannabis use&#44; ischemic stroke&#44; and multifocal intracranial vasoconstriction&#58; A prospective study in 48 consecutive young patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "V&#46; Wolff"
                            1 => "V&#46; Lauer"
                            2 => "O&#46; Rouyer"
                            3 => "F&#46; Sellal"
                            4 => "N&#46; Meyer"
                            5 => "J&#46;S&#46; Raul"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/STROKEAHA.110.610915"
                      "Revista" => array:6 [
                        "tituloSerie" => "Stroke"
                        "fecha" => "2011"
                        "volumen" => "42"
                        "paginaInicial" => "1778"
                        "paginaFinal" => "1780"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21512186"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
    "agradecimientos" => array:1 [
      0 => array:4 [
        "identificador" => "xack204512"
        "titulo" => "Agradecimientos"
        "texto" => "<p id="par0115" class="elsevierStylePara elsevierViewall">A los Dres&#46; Emili Comes&#44; Sandra Est&#233;vez&#44; Rosana Rouco&#44; Susana Fontana&#44; Gabriel Rossell&#243;-Vicens&#44; Mireia Garc&#237;a-Batanero&#44; Marx Rivera-Zambrano y Luc&#237;a Mart&#237; por su colaboraci&#243;n y ayuda en el presente estudio&#46;</p>"
        "vista" => "all"
      ]
    ]
  ]
  "idiomaDefecto" => "es"
  "url" => "/00257753/0000014600000005/v1_201602210227/S0025775315006338/v1_201602210227/es/main.assets"
  "Apartado" => array:4 [
    "identificador" => "34461"
    "tipo" => "SECCION"
    "es" => array:2 [
      "titulo" => "Nota cl&#237;nica"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "es"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/00257753/0000014600000005/v1_201602210227/S0025775315006338/v1_201602210227/es/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775315006338?idApp=UINPBA00004N"
]
Información del artículo
ISSN: 00257753
Idioma original: Español
DOI:10.1016/j.medcli.2015.10.032
Datos actualizados diariamente
año/Mes Html Pdf Total
2023 Marzo 2 0 2
2022 Noviembre 1 2 3
2018 Marzo 1 0 1
2017 Marzo 1 1 2
2017 Enero 1 0 1
2016 Diciembre 1 6 7
2016 Noviembre 0 2 2
2016 Octubre 1 3 4
2016 Septiembre 0 4 4
2016 Julio 0 3 3
2016 Junio 0 2 2
2016 Abril 0 1 1
2016 Marzo 5 1 6
2016 Febrero 6 2 8
Mostrar todo

Siga este enlace para acceder al texto completo del artículo

Suscríbase a la newsletter

Publique en
Medicina Clínica
Artículos de acceso gratuito
Atrofia cortical precoz en el trastorno de conducta del...
Med Clin. 2024;163:70-3
Drug-induced hyponatraemia and possible related...
10.1016/j.medcli.2024.07.021
Revista relacionada


Medicina Clínica Práctica



Medicina Clínica sigue las recomendaciones para la preparación, presentación y publicación de trabajos académicos en revistas biomédicas

es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos