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Dermatomiositis asociada a cáncer ovárico
Dermatomyositis associated with ovarian cancer
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A la exploración se evidenciaban áreas de poiquilodermia en tórax y edema, y eritema palpebral bilateral (<a class="elsevierStyleCrossRef" href="#fig0005">fig. 1</a>). La biopsia cutánea demostró atrofia epidérmica y dermatitis de interfase, compatibles con dermatomiositis. Asimismo, el electromiograma mostró patrón de conducción miopático, y en la biopsia de deltoides se hallaron signos de miositis. En la analítica destacaban niveles de CK de 2.235<span class="elsevierStyleHsp" style=""></span>UI/L, LDH 276<span class="elsevierStyleHsp" style=""></span>UI/l y GOT 125<span class="elsevierStyleHsp" style=""></span>UI/l, así como elevación de los marcadores tumorales CA-125 (97,7<span class="elsevierStyleHsp" style=""></span>UI/ml) y CA 15.3 (64,11<span class="elsevierStyleHsp" style=""></span>UI/ml). En la resonancia magnética se evidenció una masa tumoral a nivel anexial izquierdo (<a class="elsevierStyleCrossRef" href="#fig0010">fig. 2</a>), así como infiltración de vía biliar y ascitis, confirmándose en la biopsia la presencia de un adenocarcinoma seroso papilar de alto grado de origen ovárico. La dermatomiositis es una enfermedad autoinmune que se asocia a neoplasia oculta en un 10% de los casos. Se caracteriza por la presencia de lesiones poiquilodérmicas en región periocular, tórax y dorso de manos junto a debilidad muscular proximal.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "multimedia" => array:2 [ 0 => array:6 [ "identificador" => "fig0005" "etiqueta" => "Figura 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1275 "Ancho" => 1700 "Tamanyo" => 204770 ] ] ] 1 => array:6 [ "identificador" => "fig0010" "etiqueta" => "Figura 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 602 "Ancho" => 900 "Tamanyo" => 65528 ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/00257753/0000014800000010/v1_201705050106/S0025775316303128/v1_201705050106/es/main.assets" "Apartado" => array:4 [ "identificador" => "64289" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Imágenes médicas" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/00257753/0000014800000010/v1_201705050106/S0025775316303128/v1_201705050106/es/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775316303128?idApp=UINPBA00004N" ]
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